{"id":5935,"date":"2023-03-28T15:37:53","date_gmt":"2023-03-28T07:37:53","guid":{"rendered":"http:\/\/case.ntu.edu.tw\/scinarrator\/wordpress\/?p=5935"},"modified":"2023-06-17T11:15:34","modified_gmt":"2023-06-17T03:15:34","slug":"%e3%80%902022%e5%8f%b0%e7%a9%8d%e9%9b%bb%e7%9b%83%e9%9d%92%e5%b9%b4%e5%b0%ac%e7%a7%91%e5%ad%b8%e3%80%91%e3%80%8c%e7%a7%91%e6%99%ae%e6%9b%b8%e7%b1%8d%e5%b0%8e%e8%ae%80%e6%96%87%e7%ab%b6%e8%b3%bd-20","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/scinarrator\/?p=5935","title":{"rendered":"\u30102022\u53f0\u7a4d\u96fb\u76c3\u9752\u5e74\u5c2c\u79d1\u5b78\u3011\u300c\u79d1\u666e\u66f8\u7c4d\u5c0e\u8b80\u6587\u7af6\u8cfd\u300d\u512a\u9078\u5c0e\u8b80\u6587\uff08\u752f\u6cf0\u7fd4\uff09"},"content":{"rendered":"<p><span style=\"color: #000000;\"><strong>\u64b0\u6587\uff1a\u752f\u6cf0\u7fd4\uff5c\u5ef6\u5e73\u9ad8\u4e2d<\/strong><\/span><\/p>\n<p><strong><span style=\"color: #000000;\">\u5148\u9a45\u5011\u53ca CRISPR \u6280\u8853\u7684\u7121\u5230\u5c55\u671b\u65b0\u4e16\u754c\uff1a\u8b80\u300a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\u300b<\/span><\/strong><\/p>\n<p><span style=\"color: #000000;\">\u672a\u4f86\u7684\u8da8\u52e2\u662f\u9ebc\uff1f\u9019\u5c07\u6703\u662f\u672c\u66f8\u4ee4\u4f60\u5927\u611f\u9a5a\u8c54\u7684\u5730\u65b9\uff0c\u5f9e CRISPR \u6280\u8853\u7684\u8301\u58ef\u5230\u6210\u719f\uff0c\u4e5f\u6703\u662f\u4e00\u822c\u8b80\u8005\u5011\uff0c\u5f9e\u641e\u4e0d\u592a\u61c2\uff0c\u5230\u7a81\u7136\u4e86\u89e3\u4f60\u5011\u2014\u73fe\u5728\u7684\u4eba\u985e\u624b\u4e2d\uff0c\u5be6\u969b\u4e0a\u63e1\u6709\u591a\u5927\u5175\u6b0a\u3002\u800c\u5728\u9019\u9805\u5de8\u5927\u7a81\u7834\u7684\u80cc\u5f8c\uff0c\u7a76\u7adf\u662f\u8ab0\u5728\u64cd\u5200\u7814\u7a76\u3001\u7ad9\u5728\u4e16\u754c\u7684\u9802\u7aef\uff0c\u4e26\u4e14\u65e9\u5148\u4e16\u4eba\u770b\u900f\u5730\u7403\u6700\u539f\u59cb\u7684\u6f5b\u5728\u904b\u4f5c\u6a21\u5f0f\uff1f<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u9019\u672c\u66f8\uff0c\u4ee5\u4e3b\u89d2\u73cd\u59ae\u4f5b\u2022\u9053\u7d0d\u7279\u6b8a\u7684\u6210\u9577\u7d93\u6b77\u958b\u982d\uff0c\u4ee5\u7b2c\u4e09\u4eba\u7a31\u8996\u89d2\uff0c\u5faa\u8457\u9053\u7d0d\u7684\u6210\u9577\u8ecc\u8de1\uff0c\u4e00\u8def\u5230\u9032\u5165\u5404\u500b\u540d\u5927\u5b78\u505a\u7814\u7a76\uff0c\u9082\u9005\u4e86\u4e00\u751f\u7684\u597d\u6559\u6388\uff0c\u5f9e\u8ddf\u5728\u65c1\u505a\u7814\u7a76\u7684\u5b78\u751f\uff0c\u5230\u9818\u5c0e\u5be6\u9a57\u5ba4\u7684\u8a08\u756b\u4e3b\u5c0e\u4eba\uff0c\u7136\u5f8c\uff0c\u5373\u662f CRISPR \u7684\u51fa\u73fe\uff0c\u4e0d\u8ad6\u662f\u67d0\u4e9b\u73fe\u8c61\u7684\u767c\u73fe\u8005\uff0c\u6216\u63a5\u89f8\u5230\u6b64\u4e00\u5167\u5bb9\u7684\u7814\u7a76\u8005\uff0c\u5404\u500b\u6771\u88dc\u4e00\u9ede\u3001\u897f\u586b\u4e00\u4e9b\uff0c\u96c6\u5408\u5927\u773e\u4e4b\u529b\uff0c\u6700\u5f8c\u9053\u7d0d\u9818\u929c\u7684\u5718\u968a\u8d95\u5728\u548c\u53e6\u4e00\u4e9b\u52e2\u5747\u529b\u6575\u7684\u5718\u968a\u4e00\u540c\u505a\u4e86\u6536\u5c3e\uff0c\u5efa\u69cb\u4e86\u5c0d\u65bc\u6b64\u7a2e\u57fa\u56e0\u7de8\u8f2f\u65b9\u5f0f\u7684\u57fa\u672c\u904b\u4f5c\u539f\u7406\uff0c\u5373\u5176\u5982\u4f55\u4ee5\u986f\u8457\u7684\u512a\u52e2\uff0c\u6253\u6557\u5176\u4ed6\u539f\u5148\u5b78\u754c\u6b63\u5728\u767c\u5c55\u7684\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u3002\u524d\u8ff0\u50c5\u4f5c\u70ba\u6b64\u66f8\u7684\u524d\u4e09\u7bc7\uff0c\u800c\u5176\u4ed6\u516d\u7bc7\u5247\u662f CRISPR \u8868\u6f14\u7684\u821e\u53f0\u4e86\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u5f9e\u7b2c\u56db\u7bc7\u8d77\uff0c\u81f3\u7b2c\u516b\u7bc7\u5373\u662f\u5c0d CRISPR \u61c9\u7528\u65b9\u9762\u7684\u5168\u9762\u89e3\u8aaa\uff0c\u4f46\uff0c\u5728\u5c55\u671b\u7a2e\u7a2e\u300c\u7591\u96e3\u96dc\u75c7\u300d\u6703\u5f9e\u6b64\u5fb9\u5e95\u6839\u9664\u4e4b\u5916\uff0c\u5176\u4e2d\u4e5f\u82b1\u4e86\u597d\u4e00\u5927\u7bc7\u5e45\u5728\u8a0e\u8ad6\u6709\u95dcCRISPR \u5728\u672a\u4f86\u7684\u767c\u5c55\u4e2d\u5fc5\u5b9a\u6703\u9762\u81e8\u7684\u9053\u5fb7\u554f\u984c\uff0c\u7531\u65bc\u525b\u597d\u5728\u8fd1\u671f\u767c\u751f\u4e86\u76f4\u63a5\u548c\u9053\u5fb7\u8b70\u984c\u885d\u649e\u7684\u53f2\u7121\u524d\u4f8b\u7684\u5927\u4e8b\u4ef6\u2014\u5168\u7403\u7b2c\u4e00\u4f4d\u57fa\u56e0\u7de8\u8f2f\u5bf6\u5bf6\u7684\u8a95\u751f\uff0c\u65bc\u662f\u96b1\u85cf\u5728\u6578\u4e0d\u6e05\u7684\u7f8e\u597d\u5e95\u4e0b\u7684\u9053\u5fb7\u554f\u984c\uff0c\u4e5f\u5728 CRIPSR \u83ef\u9e97\u767b\u5834\u4e0d\u4e45\u5f8c\uff0c\u50cf\u7a81\u7136\u88ab\u67e5\u7372\u7684\u72af\u7f6a\u8b49\u64da\u4e00\u6a23\u5730\u88ab\u63a8\u4e0a\u4e86\u6aaf\u9762\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u81f3\u65bc\u672c\u66f8\u6709\u5225\u65bc\u5176\u4ed6\u7bc7\u7684\u7b2c\u4e5d\u7bc7\uff0c\u4ee5\u5ef6\u7e8c\u81f3\u4eca\u65e5\u7684\u65b0\u51a0\u80ba\u708e\uff0c\u64ec\u4f5c CRISPR \u5f97\u5feb\u901f\u6bb2\u6ec5\u7684\u76ee\u6a19\uff0c\u63a2\u8a0e\u5b83\u80fd\u5728\u9019\u6050\u6016\u7a81\u8972\u4e2d\uff0c\u626e\u6f14\u751a\u9ebc\u6a23\u7684\u95dc\u9375\u6551\u63f4\u89d2\u8272\u3002\u800c\u7d42\u65bc\u5728\u6b64\u7bc7\u7684\u6700\u5f8c\uff0c\u73cd\u59ae\u4f5b\u2022\u9053\u7d0d\u548c\u5176\u968a\u53cb\u4e00\u540c\u7372\u5f97\u4e86\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u95dc\u65bc\u4f5c\u8005\u7684\u5beb\u4f5c\u52d5\u6a5f\uff0c\u6211\u7d55\u5c0d\u4e0d\u8a8d\u70ba\u4ed6\u55ae\u55ae\u53ea\u662f\u70ba\u4e86\u5e6b\u4e00\u500b\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u5beb\u4e0b\u5979\u61c9\u5f97\u7684\u50b3\u8a18\uff0c\u7562\u7adf\u4f5c\u8005\u5728\u6b64\u66f8\u7684\u6bcf\u4e00\u8655\u90fd\u5728\u544a\u8a34\u6211\u9019\u4e00\u9ede\uff0c\u5728\u66a2\u904a\u66f8\u6d77\u7684\u540c\u6642\uff0c\u4e0d\u65b7\u63d0\u5230\u7684\u65b0\u4eba\u540d\u7576\u4e2d\uff0c\u6709\u5e7e\u4e4e\u4e00\u534a\u90fd\u662f\u66fe\u7d93\u7684\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\uff0c\u800c\u90a3\u9ebc\u591a\u9802\u5c16\u4eba\u58eb\u7576\u4e2d\uff0c\u70ba\u4f55\u4f5c\u8005\u50c5\u6311\u9078\u4e86\u9053\u7d0d\u4e00\u4eba\uff1f\u6839\u64da\u81ea\u8eab\u731c\u6e2c\uff0c\u7d55\u5c0d\u662f\u5979\u7684\u7814\u7a76\u6210\u679c\u628a\u5979\u63a8\u5411\u4e86\u7121\u4eba\u80fd\u53ca\u7684\u81f3\u9ad8\u8655\uff0c\u66f4\u53ef\u4ee5\u8aaa\uff0c\u90a3\u4e9b\u5148\u524d\u7684\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u7684\u7814\u7a76\u6210\u679c\uff0c\u4e5f\u662f\u5728\u671f\u5f85\u8457\u5c07\u4f86\u6709\u4e00\u5929\uff0c\u6703\u6709\u4e00\u500b\u96c6\u5927\u6210\u8005\uff0c\u628a\u6240\u6709\u4e00\u5207\u8f49\u8b8a\u6210\u70ba\u4e00\u500b\u4e0d\u55ae\u53ea\u662f\u7814\u7a76\u6210\u679c\u7684\uff0c\u4e00\u500b\u5c0d\u65bc\u4eba\u985e\u79d1\u6280\u767c\u5c55\u7684\u5de8\u5927\u9032\u5c55\u3002\u5c31\u662f\u7531\u65bc\u5979\u662f CRISPR \u6280\u8853\u7684\u6536\u5c3e\u4eba\uff0c\u5979\u6bd4\u4efb\u4f55\u5176\u4ed6\u7522\u51fa\u7247\u6bb5\u7814\u7a76\u6210\u679c\u7684\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u66f4\u6709\u7406\u7531\u88ab\u5beb\u5165\u4eba\u985e\u5927\u6b77\u53f2\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u6b64\u66f8\u7684\u512a\u9ede\uff0c\u5148\u4ee5\u6574\u672c\u66f8\u7684\u683c\u5c40\u4f86\u8ad6\uff0c\u9996\u5148\u5b83\u7684\u76ee\u9304\u5373\u8b93\u4eba\u5b8c\u5168\u660e\u77ad\u5f9e\u982d\u81f3\u5c3e\u7684\u5927\u8108\u7d61\uff0c\u7bc7\u7ae0\u5206\u660e\uff0c\u5404\u500b\u4e3b\u984c\u8a73\u7d30\u7684\u5283\u5206\u958b\u4f86\uff0c\u518d\u52a0\u4e0a\u7ae0\u540d\u4e0b\u65b9\u8cbc\u5fc3\u7684\u95dc\u9375\u5b57\uff0c\u9019\u5df2\u7d93\u4f7f\u4e00\u672c\u4e94\u767e\u9801\u7684\u66f8\u8b80\u8d77\u4f86\u8f15\u9b06\u5bb9\u6613\uff0c\u53e6\u5916\uff0c\u975e\u5e38\u591a\u7684\u5716\u7247\u4e5f\u8b93\u6587\u5b57\u4eba\u540d\u589e\u52a0\u4e86\u578b\u614b\uff0c\u4f7f\u8b80\u8005\u5011\u80fd\u76f4\u63a5\u7684\u806f\u60f3\u90a3\u4e9b\u4eba\u7684\u500b\u6027\u3002\u4f5c\u8005\u7b46\u6cd5\u7684\u8a00\u7c21\u610f\u8cc5\uff0c\u66f4\u4f7f\u5f97\u8b80\u8005\u5011\u6709\u8fa6\u6cd5\u8f15\u6613\u3001\u5feb\u901f\u7684\u6293\u5230\u6b64\u7ae0\u7684\u91cd\u9ede\uff0c\u4e26\u4e14\uff0c\u6211\u8a8d\u70ba\u4f5c\u8005\u4e5f\u76e1\u53ef\u80fd\u5f97\u4f7f\u672c\u66f8\u7684\u6838\u5fc3\u8b70\u984c\u8868\u9732\u7121\u907a\uff0c\u4ee5\u6211\u7684\u63a5\u6536\uff0c\u9019\u672c\u66f8\u7576\u7136\u662f\u63d0\u5230\u4e86\u4e3b\u89d2\u9053\u7d0d\u53ca CRISPR \u7684\u51fa\u5834\uff0c\u4f46\u53e6\u4e00\u9ede\u66f4\u91cd\u8981\u7684\uff0c\u6211\u60f3\u4f5c\u8005\u662f\u7528\u7bc7\u5e45\u5360\u6bd4\u4f86\u986f\u9732\u771f\u6b63\u91cd\u8981\u7684\u6838\u5fc3\uff0c\u90a3\u5373\u662f\u5728 CRISPR \u9019\u628a\u795e\u7684\u624b\u8853\u5200\u51fa\u73fe\u4ee5\u5f8c\uff1b\u5728\u6211\u5011\u4eba\u985e\u80fd\u638c\u63a7\u7684\u4e00\u5207\uff0c\u7a81\u7136\u7206\u70b8\u6027\u6210\u9577\u5f8c\uff0c\u6211\u5011\u5c07\u6703\u5982\u4f55\u904b\u7528\u9019\u4e9b\u9032\u6b65\uff1f\u5957\u53e5\u4fd7\u8a71\uff0c\u300c\u4e00\u500b\u4eba\u7684\u80fd\u529b\u8d8a\u5927\uff0c\u8cac\u4efb\u4e5f\u5c31\u8d8a\u91cd\u300d\uff0c\u7576\u57fa\u56e0\u7de8\u8f2f\uff0c\u9019\u807d\u8d77\u4f86\u6975\u70ba\u8907\u96dc\u7684\u6280\u8853\uff0c\u666e\u53ca\u65bc\u5168\u4e16\u754c\u5404\u500b\u89d2\u843d\uff0c\uff0c\u7576\u6240\u6709\u4eba\u90fd\u6709\u80fd\u529b\u6539\u8b8a\u539f\u5148\u5df2\u7d93\u8a8d\u547d\u7684\u4e8b\u5be6\uff0c\u800c\u6cd5\u5f8b\u4e5f\u6b63\u70ba\u9019\u4e9b\u610f\u60f3\u4e0d\u5230\u7684\u554f\u984c\u82e6\u60f1\u6642\uff0c\u9019\u4e16\u754c\uff0c\u7a76\u7adf\u6ce8\u5b9a\u6703\u9762\u81e8\u591a\u5927\u898f\u6a21\u7684\u6df7\u4e82\uff1f<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u53c8\uff0c\u8981\u5982\u4f55\u8d95\u5728\u4e8b\u767c\u4e4b\u524d\u6b62\u4f4f\u4e00\u5207\u7684\u904e\u65bc\u98db\u5feb\uff1b\u4e00\u5207\u7684\u6e34\u671b\uff0c\u7684\u904e\u65bc\u885d\u52d5\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-5385\" src=\"https:\/\/case.ntu.edu.tw\/scinarrator\/wp-content\/uploads\/2023\/03\/\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba.jpg\" alt=\"\" width=\"300\" height=\"300\" \/><\/span><\/p>\n<p><span style=\"color: #000000;\">\u66f8\u540d\uff1a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\uff1a\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d\u3001\u57fa\u56e0\u7de8\u8f2f\uff0c\u4ee5\u53ca\u4eba\u985e\u7684\u672a\u4f86<\/span><br \/>\n<span style=\"color: #000000;\">\u4f5c\u8005\uff1a\u83ef\u7279\uff0e\u827e\u85a9\u514b\u68ee\uff08Walter Isaacson\uff09<\/span><br \/>\n<span style=\"color: #000000;\">\u8b6f\u8005\uff1a\u9ea5\u6167\u82ac<\/span><br \/>\n<span style=\"color: #000000;\">\u51fa\u7248\u793e\uff1a\u5546\u5468\u51fa\u7248<\/span><br \/>\n<span style=\"color: #000000;\">\u51fa\u7248\u5e74\uff1a2021<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u64b0\u6587\uff1a\u752f\u6cf0\u7fd4\uff5c\u5ef6\u5e73\u9ad8\u4e2d \u5148\u9a45\u5011\u53ca CRISPR \u6280\u8853\u7684\u7121\u5230\u5c55 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