{"id":5933,"date":"2023-03-28T14:37:22","date_gmt":"2023-03-28T06:37:22","guid":{"rendered":"http:\/\/case.ntu.edu.tw\/scinarrator\/wordpress\/?p=5933"},"modified":"2023-06-17T14:25:38","modified_gmt":"2023-06-17T06:25:38","slug":"%e3%80%902022%e5%8f%b0%e7%a9%8d%e9%9b%bb%e7%9b%83-%e9%9d%92%e5%b9%b4%e5%b0%ac%e7%a7%91%e5%ad%b8%e3%80%91%e3%80%8c%e7%a7%91%e6%99%ae%e6%9b%b8%e7%b1%8d%e9%96%b1%e8%ae%80%e5%af%ab%e4%bd%9c%e7%ab%b6","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/scinarrator\/?p=5933","title":{"rendered":"\u30102022\u53f0\u7a4d\u96fb\u76c3\u9752\u5e74\u5c2c\u79d1\u5b78\u3011\u300c\u79d1\u666e\u66f8\u7c4d\u5c0e\u8b80\u6587\u7af6\u8cfd\u300d\u4f73\u4f5c\u5c0e\u8b80\u6587\uff08\u5433\u6600\u6a3a\uff09"},"content":{"rendered":"<p><span style=\"color: #000000;\"><strong>\u64b0\u6587\uff1a\u5433\u6600\u6a3a\uff5c\u5c4f\u6771\u5973\u4e2d<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>\u751f\u547d\u79d1\u5b78\u7684\u4e00\u628a\u5200\uff1a\u8b80\u300a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\u300b<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\">\u5982\u679c\u4f60\u7684\u5c0f\u5b69\u80fd\u5920\u4e00\u8f29\u5b50\u6c92\u6709\u4efb\u4f55\u75be\u75c5\u7e8f\u8eab\uff0c\u53c8\u6216\u662f\u6bd4\u4e00\u822c\u4eba\u9ad8\u5927\u3001\u58ef\u78a9\u3001\u751a\u81f3\u66f4\u6709\u667a\u6167\uff0c\u4f60\u9858\u610f\u55ce\uff1f\u9084\u662f\u6703\u9078\u64c7\u8b93\u4ed6\u7dad\u6301\u539f\u8c8c\uff0c\u5118\u7ba1\u53ef\u80fd\u4e0d\u662f\u6700\u5b8c\u7f8e\u7684\uff1f<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u300a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\u300b\u4e2d\u7684\u73cd\u59ae\u4f5b\u30fb\u9053\u7d0d\u5728\u5341\u4e8c\u6b72\u6642\u95b1\u8b80\u4e86\u7236\u89aa\u9001\u7d66\u5979\u7684\u300a\u96d9\u87ba\u65cb\u300b\u5f8c\uff0c\u5c0d\u79d1\u5b78\u7522\u751f\u4e86\u61a7\u61ac\uff0c\u4e0b\u5b9a\u6c7a\u5fc3\u8981\u6210\u70ba\u4e00\u4f4d\u79d1\u5b78\u5bb6\u3002\u5373\u4f7f\u5979\u5728\u6c42\u5b78\u8def\u9014\u53d7\u5230\u8a31\u591a\u8cea\u7591\uff0c\u4f8b\u5982\u5979\u7684\u5927\u5b78\u6559\u6388\u66fe\u548c\u5979\u8aaa\u904e\uff1a\u300c\u5973\u5b69\u5b50\u4e0d\u641e\u79d1\u5b78\u3002\u300d\u5979\u4f9d\u820a\u5805\u6301\u81ea\u5df1\u7684\u8def\uff0c\u5b8c\u6210\u4e86\u8a31\u591a\u9a5a\u8277\u5927\u773e\u7684\u79d1\u5b78\u5275\u8209\uff0c\u800c\u672c\u66f8\u8457\u91cd\u8a0e\u8ad6\u7684\u4fbf\u662f\u5979\u7372\u5f97\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u7684\u8ca2\u737b\u2014\u5c07 CRISPR \u5e36\u5165\u4e16\u754c\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">CRISPR \u662f\u4e00\u7a2e\u57fa\u56e0\u7de8\u8f2f\u7684\u6280\u8853\uff0c\u900f\u904e tracrRNA \u53ca crRNA \u5206\u5de5\u5408\u4f5c\u627e\u5230\u6b63\u78ba\u7684 DNA \u5e8f\u5217\u76ee\u6a19\u5f8c\uff0c\u7528\u57fa\u56e0\u526a\u5200 Cas9 \u9032\u884c\u88c1\u526a\uff0c\u518d\u5c07\u65b0 DNA \u7247\u6bb5\u653e\u5165\u5f8c\u9ecf\u5728\u65b7\u53e3\u8655\u3002\u76f8\u8f03\u65bc\u5176\u4ed6\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\uff0cCRISPR \u7684\u9ad8\u6548\u7387\u3001\u4f4e\u6210\u672c\u7279\u8272\uff0c\u5438\u5f15\u8a31\u591a\u79d1\u5b78\u5bb6\u6295\u5165\u7814\u7a76\uff0c\u671f\u5f85 CRISPR \u672a\u4f86\u80fd\u8b93\u4eba\u985e\u6709\u66f4\u597d\u7684\u751f\u6d3b\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">CRISPR \u7684\u767c\u660e\u8005\u4e26\u4e0d\u662f\u4eba\u985e\uff0c\u800c\u662f\u6beb\u4e0d\u8d77\u773c\u7684\u7d30\u83cc\u3002\u7d30\u83cc\u5229\u7528 CRISPR \u8a18\u4f4f\u66fe\u7d93\u653b\u64ca\u5b83\u5011\u7684\u75c5\u6bd2 DNA\uff0c\u800c\u4e14\u66f4\u9032\u4e00\u6b65\u523b\u5728\u5b83\u5011\u7684\u8eab\u9ad4\u88e1\u3002\u5728\u7d30\u83cc\u7684 DNA \u9e7c\u57fa\u4e2d\uff0c\u90e8\u5206\u7247\u6bb5\u4e2d\u593e\u8457\u4e00\u4e9b\u5177\u6709\u610f\u7fa9\u7684\u5e8f\u5217\uff0c\u9019\u4e9b\u5e8f\u5217\u5c31\u662f\u75c5\u6bd2\u7684 DNA\u3002\u7d30\u83cc\u8eab\u9ad4\u4e2d\u7684\u75c5\u6bd2 DNA \u5e8f\u5217\uff0c\u662f\u70ba\u4e86\u9019\u4e9b\u4e0d\u901f\u4e4b\u5ba2\u6240\u5efa\u7acb\u7684\u8cc7\u6599\u5eab\uff0c\u7b49\u4e0b\u6b21\u76f8\u540c\u75c5\u6bd2\u518d\u8a2a\uff0c\u7d30\u83cc\u8b58\u5225\u51fa\u5b83\u7684\u8eab\u5206\u5f8c\uff0c\u5c31\u80fd\u5c55\u958b\u653b\u52e2\uff0c\u628a\u5b83\u5011\u6bba\u7684\u7247\u7532\u4e0d\u7559\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u8981\u5c07\u7d30\u83cc\u514d\u75ab\u7684\u53e4\u8001\u6a5f\u5236\u8f49\u63db\u6210\u666e\u904d\u7684\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\uff0c\u662f\u5426\u662f\u500b\u56f0\u96e3\u7684\u6b65\u9a5f\uff1f \u9053\u7d0d\u5805\u6301 CRISPR \u6240\u9700\u7684\u6210\u5206\u53ca\u6b65\u9a5f\u7686\u5df2\u5728\u8a66\u7ba1\u5be6\u9a57\u4e2d\u5b8c\u6210\uff0c\u904b\u7528\u5230\u4eba\u9ad4\u662f\u4ef6\u300c\u986f\u800c\u6613\u77e5\u300d\u7684\u4e8b\uff0c\u4e0d\u904e\u5979\u7684\u7af6\u722d\u8005\u8a8d\u70ba\u5be6\u969b\u61c9\u7528\u9700\u8981\u5275\u65b0\u7684\u6b65\u9a5f\uff0c\u96d9\u65b9\u4e4b\u9593\u706b\u85e5\u5473\u5341\u5206\u6fc3\u539a\uff0c\u751a\u81f3\u6253\u4e86\u4e00\u5834\u9577\u9054\u5341\u4e5d\u500b\u6708\u7684\u5c08\u5229\u6b0a\u5b98\u53f8\u3002\u800c\u6cd5\u5b98\u6700\u5f8c\u5224\u6c7a\u7d50\u679c\u5982\u4f55\uff1f\u5c08\u5229\u6b0a\u53c8\u6703\u843d\u5728\u8ab0\u5bb6\uff1f<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u5728\u904b\u7528 CRISPR \u65bc\u4eba\u9ad4\u7684\u6280\u8853\u6f38\u8da8\u7a69\u5b9a\u5f8c\uff0c\u79d1\u5b78\u5bb6\u5011\u958b\u59cb\u601d\u8003\u7a76\u7adf\u57fa\u56e0\u7de8\u8f2f\u5728\u4eba\u9ad4\u80fd\u7528\u5230\u4ec0\u9ebc\u7a0b\u5ea6\uff1f\u300c\u6cbb\u7642\u300d\u8207\u300c\u80fd\u529b\u5f37\u5316\u300d\u7684\u5206\u754c\u5728\u54ea\u88e1\uff1f\u56e0\u70ba\u57fa\u56e0\u7a81\u8b8a\u3001\u7236\u6bcd\u907a\u50b3\u5c0e\u81f4\u7684\u77ee\u5c0f\uff0c\u90fd\u80fd\u5920\u4f7f\u7528\u57fa\u56e0\u7de8\u8f2f\u55ce\uff1f\u5df2\u7d93 180 \u516c\u5206\u60f3\u9577\u5f97\u66f4\u9ad8\u5462\uff1f<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">CRISPR \u7a76\u7adf\u662f\u4e00\u628a\u9748\u6d3b\u7684\u57fa\u56e0\u526a\u5200\uff0c\u9084\u662f\u4e00\u628a\u6d88\u78e8\u4eba\u985e\u591a\u6a23\u6027\u7684\u5241\u5200\uff1f\u4e00\u65e6\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u767c\u63da\u5149\u5927\uff0c\u6bcf\u500b\u5bb6\u9577\u90fd\u628a\u5c0f\u5b69\u6539\u9020\u6210\u4ed6\u5011\u5fc3\u76ee\u4e2d\u7684\u300c\u5b8c\u7f8e\u5c0f\u5b69\u300d\uff0c \u6bcf\u500b\u5152\u7ae5\u90fd\u5065\u5eb7\u3001\u8070\u660e\uff0c\u64c1\u6709\u91d1\u9aee\u78a7\u773c\u3001\u767d\u7699\u76ae\u819a\uff0c\u9019\u500b\u4e16\u754c\u9084\u6703\u50cf\u73fe\u5728\u4e00\u6a23\u8c50\u5bcc\u591a\u5f69\u55ce\uff1f\u4eba\u985e\u7684\u907a\u50b3\u591a\u6a23\u6027\u4e5f\u53ef\u80fd\u5c31\u5f9e\u6b64\u6d88\u5931\uff0c\u5931\u53bb\u6f14\u5316\u539f\u52d5\u529b\uff0c\u6709\u4e00\u5929\u7576\u5730\u7403\u74b0\u5883\u5287\u70c8\u6539\u8b8a\uff0c\u4eba\u985e\u7684\u7d50\u5c40\u5c31\u662f\u6ec5\u7d55\uff0c\u800c\u6211\u5011\u5728\u90a3\u4e4b\u524d\u80fd\u6539\u8b8a\u4ec0\u9ebc\u55ce\uff1f\u800c\u5728\u89e3\u6c7a\u4e0a\u8ff0\u554f\u984c\u524d\uff0c\u79d1\u5b78\u5bb6\u5011\u90fd\u540c\u610f\u66ab\u6642\u4e0d\u5c0d\u751f\u6b96\u7d30\u80de\u9032\u884c\u7de8\u8f2f\uff0c\u6015\u6703\u9020\u6210\u4e0d\u53ef\u633d\u56de\u7684\u7d50\u5c40\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u7b2c\u4e00\u500b\u5617\u8a66\u6253\u7834\u9019\u500b\u898f\u5247\u7684\u4eba\u5c31\u662f\u4e2d\u570b\u751f\u7269\u5b78\u5bb6\u8cc0\u5efa\u594e\u3002\u5728\u3008CRISPR \u5bf6\u5bf6\u3009\u4e00\u7bc0\u4e2d\uff0c\u8b1b\u8ff0\u4e86\u8cc0\u5efa\u594e\u5354\u52a9\u4e16\u754c\u7b2c\u4e00\u5c0d\u57fa\u56e0\u7de8\u8f2f\u5b30\u5152\u8a95\u751f\u7684\u6545\u4e8b\uff0c\u4ed6\u7684\u8d77\u521d\u60f3\u6cd5\u985e\u4f3c\u512a\u751f\u5b78\uff0c\u5e0c\u671b\u900f\u904e CRISPR \u6280\u8853\u8b93\u4e00\u5c0d\u7f79\u60a3 HIV \u7684\u592b\u59bb\u64c1\u6709\u5065\u5eb7\u7684\u5b69\u5b50\uff0c\u7576\u6642\u4ed6\u7684\u8209\u52d5\u5728\u79d1\u5b78\u754c\u6380\u8d77\u4e00\u9663\u98a8\u6ce2\uff0c\u8a55\u8ad6\u5927\u81f4\u5012\u5411\u8ca0\u9762\u7684\u4e00\u908a\uff0c\u79d1\u5b78\u5bb6\u5011\u8a8d\u70ba\u8cc0\u5efa\u594e\u7684\u884c\u70ba\u760b\u72c2\u3001\u50b2\u6162\u3001\u4e0d\u8ca0\u8cac\u4efb\u3002\u6700\u5f8c\u4ed6\u88ab\u5224\u4e09\u5e74\u76e3\u7981\u3001\u7f70\u9370\u4eba\u6c11\u5e63\u4e09\u767e\u842c\u5143\uff0c \u8207\u4ed6\u5e7b\u60f3\u4e2d\u6210\u70ba\u53d7\u4eba\u63a8\u5d07\u7684\u300c\u5168\u7403\u82f1\u96c4\u300d\u5357\u8f45\u5317\u8f4d\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u300c\u79d1\u5b78\u4e0d\u662f\u70ba\u4e86\u500b\u4eba\u69ae\u8b7d\uff0c\u4e0d\u662f\u70ba\u4e86\u79c1\u5229\uff0c\u800c\u662f\u70ba\u4eba\u985e\u8b00\u5e78\u798f\u3002\u300d\u4e2d\u570b\u7269\u7406\u5b78\u5bb6\u9322\u4e09\u5f37\u7684\u9019\u53e5\u8a71\uff0c\u8cab\u7a7f\u4e86\u6b64\u66f8\u7684\u6838\u5fc3\u50f9\u503c\u3002\u96d6\u7136\u79d1\u5b78\u5bb6\u5011\u5728\u767c\u8868\u8ad6\u6587\u3001\u722d\u596a\u5c08\u5229\u4e2d\u4e00\u76f4\u8655\u65bc\u7dca\u7e43\u7684\u7af6\u722d\u72c0\u614b\uff0c\u7dca\u8981\u95dc\u982d\u6642\u4ed6\u5011\u4ecd\u4e0d\u8a08\u524d\u5acc\uff0c\u4e00\u540c\u5408\u4f5c\u3002\u81ea2019 \u5e74\u4f86\uff0c\u65b0\u51a0\u80ba\u708e\u8b93\u4eba\u5011\u8eab\u9677\u82e6\u6d77\uff0c\u9053\u7d0d\u65bc\u662f\u53ec\u96c6\u5404\u5927\u9818\u57df\u7684\u79d1\u5b78\u5bb6\uff0c\u540c\u5fc3\u5354\u529b\u4e00\u8d77\u5c0b\u6c42\u5404\u7a2e\u6aa2\u6e2c\u3001\u9810\u9632\u3001\u6cbb\u7642\u7684\u65b9\u6cd5\uff0c\u904b\u7528 CRISPR \u6280\u8853\u4e0d\u65b7\u6539\u826f\u5404\u7a2e\u6aa2\u6e2c\u5668\u3001\u75ab\u82d7\u7b49\u5de5\u5177\uff0c\u4ee5\u6c42\u64fa\u812b\u75c5\u6bd2\u7684\u90a3\u5929\u5230\u4f86\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u300a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\u300b\u5b8c\u6574\u63cf\u7e6a\u4e86 CRISPR \u958b\u767c\u7684\u5fc3\u8def\u6b77\u7a0b\uff0c\u5f9e\u767c\u73fe\u3001\u6539\u826f\u9047\u5230\u7684\u7a2e\u7a2e\u56f0\u96e3\uff0c\u4e00\u76f4\u5230\u7372\u5f97\u8afe\u8c9d\u723e\u734e\u7684\u6fc0\u6602\u3001\u611f\u52d5\uff0c\u6bcf\u500b\u7d30\u7bc0\u90fd\u4e0d\u8f15\u6613\u653e\u904e\u3002\u8b93\u6211\u5011\u4e00\u8d77\u7ffb\u958b\u9019\u672c\u66f8\uff0c\u642d\u4e0a\u751f\u547d\u79d1\u5b78\u7684\u6642\u5149\u6a5f\uff0c\u518d\u6b21\u56de\u5230\u73cd\u59ae\u4f5b\u30fb\u9053\u7d0d\u7684\u5be6\u9a57\u5ba4\u88e1\u5427\uff01<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-5385\" src=\"https:\/\/case.ntu.edu.tw\/scinarrator\/wp-content\/uploads\/2023\/03\/\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba.jpg\" alt=\"\" width=\"300\" height=\"300\" \/><\/span><\/p>\n<p><span style=\"color: #000000;\">\u66f8\u540d\uff1a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\uff1a\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d\u3001\u57fa\u56e0\u7de8\u8f2f\uff0c\u4ee5\u53ca\u4eba\u985e\u7684\u672a\u4f86<\/span><br \/>\n<span style=\"color: #000000;\">\u4f5c\u8005\uff1a\u83ef\u7279\uff0e\u827e\u85a9\u514b\u68ee\uff08Walter Isaacson\uff09<\/span><br \/>\n<span style=\"color: #000000;\">\u8b6f\u8005\uff1a\u9ea5\u6167\u82ac<\/span><br \/>\n<span style=\"color: #000000;\">\u51fa\u7248\u793e\uff1a\u5546\u5468\u51fa\u7248<\/span><br \/>\n<span style=\"color: #000000;\">\u51fa\u7248\u5e74\uff1a2021<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u64b0\u6587\uff1a\u5433\u6600\u6a3a\uff5c\u5c4f\u6771\u5973\u4e2d \u751f\u547d\u79d1\u5b78\u7684\u4e00\u628a\u5200\uff1a\u8b80\u300a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba 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