{"id":5931,"date":"2023-03-28T15:37:29","date_gmt":"2023-03-28T07:37:29","guid":{"rendered":"http:\/\/case.ntu.edu.tw\/scinarrator\/wordpress\/?p=5931"},"modified":"2023-06-17T14:16:20","modified_gmt":"2023-06-17T06:16:20","slug":"%e3%80%902022%e5%8f%b0%e7%a9%8d%e9%9b%bb%e7%9b%83%e9%9d%92%e5%b9%b4%e5%b0%ac%e7%a7%91%e5%ad%b8%e3%80%91%e3%80%8c%e7%a7%91%e6%99%ae%e6%9b%b8%e7%b1%8d%e5%b0%8e%e8%ae%80%e6%96%87%e7%ab%b6%e8%b3%bd-19","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/scinarrator\/?p=5931","title":{"rendered":"\u30102022\u53f0\u7a4d\u96fb\u76c3\u9752\u5e74\u5c2c\u79d1\u5b78\u3011\u300c\u79d1\u666e\u66f8\u7c4d\u5c0e\u8b80\u6587\u7af6\u8cfd\u300d\u512a\u9078\u5c0e\u8b80\u6587\uff08\u8521\u5b9c\u5ead\uff09"},"content":{"rendered":"<p><span style=\"color: #000000;\"><strong>\u64b0\u6587\uff1a\u8521\u5b9c\u5ead\uff5c\u5ef6\u5e73\u9ad8\u4e2d<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>\u6539\u8b8a\u4eba\u985e\u6b77\u53f2\u7684CRISPR\uff1a\u8b80\u300a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\u300b<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\">\u5f9e<u>\u5b5f\u5fb7\u723e<\/u>\u89e3\u958b\u4e86\u907a\u50b3\u7684\u79d8\u5bc6\uff0c\u5230<u>\u83ef\u751f<\/u>\u548c<u>\u514b\u91cc\u514b<\/u>\u7834\u89e3 DNA \u7684\u96d9\u80a1\u87ba\u65cb\u7d50\u69cb\uff0c\u4eba\u985e\u5c0d\u65bc\u300c\u57fa\u56e0\u300d\u7684\u7814\u7a76\u6709\u4e86\u5927\u5e45\u5ea6\u7684\u6f14\u9032\u3002\u9019\u672c\u66f8\u5728\u4e00\u6bb5\u6545\u4e8b\u4e2d\u7121\u5f62\u7684\u52a0\u5165\u79d1\u666e\u77e5\u8b58\uff0c\u4f7f\u8b80\u8005\u80fd\u81ea\u7136\u800c\u7136\u7684\u5b78\u7fd2\u5230\u8a31\u591a\u6709\u95dc\u907a\u50b3\u548c\u91ab\u5b78\u65b9\u9762\u7684\u4e8b\u7269\uff0c\u4e5f\u4e0d\u6703\u5728\u95b1\u8b80\u7684\u904e\u7a0b\u4e2d\u611f\u5230\u56f0\u60d1\u8207\u4e0d\u77e5\u6240\u63aa\u3002\u4e26\u85c9\u7531\u4ecb\u7d39<u>\u73cd\u59ae\u4f5b\u2027 \u9053\u7d0d<\/u>\u4ee5\u53ca\u767c\u73fe CRISPR \u9019\u9805\u6280\u8853\u7684\u79d1\u5b78\u5bb6\u5011\u5f7c\u6b64\u5207\u78cb\u3001\u7af6\u722d\u7684\u7a2e\u7a2e\u6545\u4e8b\uff0c\u5e36\u9818\u8b80\u8005\u5011\u9032\u5165\u79d1\u7814\u4eba\u7684\u4e16\u754c\u3002\u540c\u6642\u9593\uff0c\u4f5c\u8005\u4e5f\u5f15\u5165\u4e86\u4e00\u4e9b\u9053\u5fb7\u8b70\u984c\uff0c \u4f8b\u5982\uff1a\u300cCRISPR \u80fd\u88ab\u904b\u7528\u5728\u751f\u6b96\u7d30\u80de\u7684\u7de8\u8f2f\u4e0a\u55ce\uff0c\u5b83\u7684\u5e95\u7dda\u8a72\u600e\u9ebc\u5b9a\u7fa9\u300d\uff1f\u6216\u662f\u300c\u7236\u6bcd\u662f\u5426\u61c9\u8a72\u70ba\u81ea\u5df1\u7684\u5b69\u5b50\u9078\u64c7\u6700\u512a\u826f\u7684\u57fa\u56e0\u300d\uff1f<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u5148\u4f86\u8ac7\u8ac7\u672c\u66f8\u4e3b\u4eba\u7fc1\u7684\u6545\u4e8b\u5427\u3002<u>\u73cd\u59ae\u4f5b\u2027\u9053\u7d0d<\/u> 7 \u6b72\u6642\u8209\u5bb6\u9077\u79fb\u5230\u590f\u5a01\u5937\u3002\u56e0\u70ba\u590f\u5a01\u5937\u64c1\u6709\u8c50\u5bcc\u7684\u300c\u81ea\u7136\u751f\u614b\u300d\u518d\u52a0\u4e0a<u>\u9053\u7d0d<\/u>\u5929\u751f\u5177\u5099\u7684\u5f37\u70c8\u300c\u597d\u5947\u5fc3\u300d\uff0c\u4f7f\u5f97\u5176\u5c0d\u65bc\u81ea\u7136\u79d1\u5b78\u6709\u8457\u6df1\u539a\u7121\u6bd4\u7684\u8208\u8da3\u3002\u5f8c\u4f86\uff0c\u5728\u5076\u7136\u9082\u9005\u300a\u96d9\u87ba\u65cb\u300b\u9019\u672c\u66f8\u5f8c\uff0c\u4f7f<u>\u9053\u7d0d<\/u>\u9818\u609f\u5230\u5927\u81ea\u7136\u4e0d\u4f46\u7b26\u5408\u908f\u8f2f\uff0c\u4e5f\u4ee4\u4eba\u656c\u754f\u3002\u4e26\u78ba\u7acb\u4e86\u81ea\u5df1\u672a\u4f86\u7684\u5fd7\u5411\u6210\u70ba\u4e00\u540d\u79d1\u5b78\u5bb6\u3002\u5c31\u662f\u5728\u9019\u80a1\u6eff\u8154\u71b1\u60c5\u4e0b\uff0c<u>\u9053\u7d0d<\/u>\u5275\u9020\u51fa\u4e86\u4e00\u500b\u7e7c\u96d9\u87ba\u65cb\u7d50\u69cb\u4e4b\u5f8c\u7684\u751f\u7269\u5b78\u5947\u8e5f\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u662f\u4ec0\u9ebc\u9a45\u4f7f\u79d1\u5b78\u5bb6\u5011\u65e5\u4ee5\u7e7c\u591c\u7684\u7814\u7a76\u5462\uff1f\u672c\u66f8\u6709\u975e\u5e38\u5927\u7684\u4e00\u90e8\u5206\u90fd\u5728\u8ac7\u8ad6\u79d1\u5b78\u5bb6\u4e4b\u9593\u7684\u7af6\u722d\u3002\u7af6\u722d\u4e26\u4e0d\u610f\u5473\u8457\u9032\u884c\u6fc0\u70c8\u8faf\u8ad6\u7684\u90a3\u822c\u722d\u5435\uff0c\u5c0d\u65bc<u>\u9053\u7d0d<\/u>\u4f86\u8aaa\uff0c\u7af6\u722d\u662f\u300c\u7d66\u5f15\u64ce\u589e\u52a0\u52d5\u529b\u7684\u706b\u7130\u300d\u3002\u5979\u66fe\u8868\u793a\uff1a\u300c\u5065\u5eb7\u7684\u7af6\u722d\uff0c \u66fe\u70ba\u4eba\u985e\u6700\u5049\u5927\u7684\u8a31\u591a\u767c\u660e\u6dfb\u67f4\u52a0\u85aa\u3002\u300d\u5c31\u50cf<u>\u83ef\u751f<\/u>\u3001<u>\u514b\u91cc\u514b<\/u>\u548c<u>\u5a01\u723e\u91d1\u65af<\/u>\u3001<u>\u6cd5\u862d\u514b\u6797<\/u>\u90a3\u6642\u7834\u89e3\u96d9\u87ba\u65cb\u7d50\u69cb\u7684\u77e5\u540d\u6545\u4e8b\u4e00\u822c\uff0cCRISPR \u7684\u767c\u73fe\u5c31\u5982\u540c\u91cd\u73fe\u7576\u5e74\u7684\u5834\u666f\uff0c\u4e0a\u6f14\u4e86\u4e00\u5834\u6fc0\u70c8\u7684\u7af6\u8cfd\u3002CRISPR \u7684\u7814\u7a76\u904e\u7a0b\u4e2d\uff0c\u4e3b\u8981\u7684\u7af6\u722d\u8005\u6709 3 \u4f4d<u>\u73cd\u59ae\u4f5b\u2027\u9053\u7d0d<\/u>\u3001<u>\u5f35\u92d2<\/u>\u4ee5\u53ca<u>\u55ac\u6cbb\u2027\u79cb\u5947<\/u>\u3002\u5404\u500b\u90fd\u5728\u904e\u7a0b\u4e2d\u5275\u4e0b\u4e86\u5341\u5206\u91cd\u8981\u7684\u91cc\u7a0b\u7891\u3002\u4f5c\u8005\u9bae\u660e\u7684\u7b46\u6cd5\uff0c\u80fd\u8b93\u8b80\u8005\u5b9b\u5982\u8eab\u6b77\u5176\u5883\u822c\u7684\u9ad4\u9a57\u7af6\u722d\u6642\u7684\u523a\u6fc0\u8207\u7dca\u5f35\u611f\u3002\u7576\u5176\u4e2d\u4e00\u4f4d\u6709\u4e86\u91cd\u5927\u7a81\u7834\u4e26\u767c\u8868\u8ad6\u6587\u6642\uff0c\u53e6\u5916\u5169\u4f4d\u5c31\u6703\u66f4\u52a0\u7763\u4fc3\u81ea\u5df1\uff0c\u60f3\u8981\u5728\u5176\u4e4b\u4e0a\u518d\u6b21\u6709\u5275\u65b0\u7684\u767c\u73fe\u3002\u79d1\u5b78\u5bb6\u6703\u56e0\u70ba\u66f4\u52a0\u4e86\u89e3\u81ea\u7136\u800c\u559c\u6085\uff0c\u4e5f\u6703\u56e0\u70ba\u81ea\u5df1\u7372\u5f97\u4e86\u67d0\u500b\u734e\u9805\u3001\u6210\u70ba\u4e86\u67d0\u500b\u9818\u57df\u7684\u7b2c\u4e00\u4eba\u6216\u8005\u662f\u5f97\u5230\u4e86\u67d0\u500b\u982d\u929c\u800c\u7522\u751f\u4e86\u6210\u5c31\u611f\u3002\u70ba\u4e86\u6eff\u8db3\u81ea\u5df1\u7684\u597d\u52dd \u5fc3\uff0c\u79d1\u5b78\u5bb6\u5011\u6703\u5f7c\u6b64\u722d\u596a\u734e\u9805\u4ee5\u53ca\u5c08\u5229\u6b0a\uff0c\u800c\u5728 CRISPR \u9019\u5834\u9f8d\u722d\u864e\u9b25 \u4e2d\uff0c\u6700\u5f8c\u7684\u52dd\u5229\u8005\u70ba<u>\u73cd\u59ae\u4f5b\u2027\u9053\u7d0d<\/u>\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u5728 CRISPR \u9019\u500b\u4e0d\u540c TALENs \u7b49\u904e\u53bb\u8907\u96dc\u7684\u57fa\u56e0\u7de8\u8f2f\u5de5\u5177\u88ab\u958b\u767c\u5f8c\uff0c \u7b2c\u4e00\u500b\u9762\u5c0d\u7684\u8b70\u984c\u5c31\u662f\uff1aCRISPR \u61c9\u8a72\u88ab\u4f7f\u7528\u65bc\u90a3\u4e9b\u7528\u9014\uff0c\u61c9\u8a72\u5982\u4f55\u9632\u7bc4\u88ab\u6050\u6016\u5206\u5b50\u6210\u70ba\u88fd\u4f5c\u751f\u5316\u6b66\u5668\u7684\u5de5\u5177\uff1f\u300c\u57fa\u56e0\u7642\u6cd5\u300d\u662f\u5176\u4e2d\u722d\u8b70\u6027\u9817\u9ad8\u7684\u8b70\u984c\u3002\u900f\u904e\u57fa\u56e0\u7de8\u8f2f\u80fd\u6709\u6548\u7684\u6cbb\u7642\u942e\u5200\u578b\u8ca7\u8840\u3001\u5148\u5929\u6027\u5931\u660e\u3001\u62b5\u6297\u6216\u8a3a\u65b7\u764c\u75c7\u7b49\u6211\u5011\u4e00\u822c\u8a8d\u70ba\u4e0d\u53ef\u9006\u7684\u8eab\u9ad4\u75be\u75c5\u3002\u9019\u6642\uff0c<u>\u8cc0\u5efa\u594e<\/u>\u537b\u8de8\u8d8a\u4e86\u79d1\u5b78\u5bb6\u5011\u6240\u8a2d\u5b9a\u7684\u9053\u5fb7\u7d05\u7dda\uff1a\u7de8\u8f2f\u4eba\u985e\u751f\u6b96\u7d30\u80de\u9054\u5230\u6297 HIV\uff0c\u8b93\u53f2\u4e0a\u7b2c\u4e00\u5c0d\u57fa\u56e0\u7de8\u8f2f\u5bf6\u5bf6\u51fa\u751f\u3002<u>\u8cc0\u5efa\u594e<\/u>\u8072\u7a31\u4ed6\u60f3\u8981\u627e\u5230\u4e00\u500b\u80fd\u5e6b\u52a9\u6578\u767e\u842c HIV \u5152\u7ae5\u7684\u65b9\u6cd5\u3002\u4f46\u79d1\u5b78\u5bb6\u5011\u56e0\u6b64\u6b21\u57fa\u56e0\u7de8\u8f2f\u611f\u5230\u9707\u9a5a\uff0c\u6307\u63a7\u9019\u662f\u4e00\u7a2e\u300c\u4e0d\u8ca0\u8cac\u4efb\u300d\u4e14\u4e0d\u5177\u300c\u91ab\u7642\u5fc5\u8981\u6027\u300d\u7684\u884c\u70ba\u3002<u>\u9053\u7d0d<\/u>\u5c0d\u65bc CRISPR \u88ab\u9019\u6a23\u904b\u7528\u611f\u5230\u53cd\u611f\uff0c\u4e26\u5728\u8207\u591a\u540d\u79d1\u5b78\u5bb6\u8a0e\u8ad6\u5f8c\u9054\u6210\u5171\u8b58\uff1a\u300c\u5e0c\u671b\u6709\u4eba\u6709\u4e00\u5929\u53ef\u4ee5\u8b49\u660e CRISPR-Cas9 \u662f\u4e00\u7a2e\u6709\u52a9\u65bc\u4eba\u985e\u798f\u7949\u7684\u5f37\u5927\u5de5\u5177\u3002\u300d\u4e26\u5f37\u8abf\u7de8\u8f2f\u4eba\u985e\u751f\u6b96\u7d30\u80de\u7684\u98a8\u96aa\u592a\u9ad8\uff0c\u4f46\u5982\u679c\u672a\u4f86\u80fd\u6392\u9664\u7a2e\u7a2e\u98a8\u96aa\uff0c\u6216\u8a31\u7de8\u8f2f\u751f\u6b96\u7d30\u80de\u5c07\u4e0d\u518d\u662f\u4e00\u9053\u4e0d\u53ef\u8de8\u8d8a\u7684\u7d05\u7dda\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u300c\u6211\u5011\u662f\u5426\u8a72\u70ba\u81ea\u5df1\u7684\u5c0f\u5b69\u6311\u9078\u512a\u8cea\u57fa\u56e0\uff1f\u300d\u6210\u70ba\u4e86\u4e00\u500b\u56b4\u8085\u7684\u9053\u5fb7\u8b70\u984c\u3002\u8d0a\u6210\u300c\u751f\u6b96\u53d7\u76ca\u300d\u7684\u4e00\u6d3e\u8a8d\u540c\u70ba\u81ea\u5df1\u7684\u5b69\u5b50\u9078\u64c7\u57fa\u56e0\u624d\u662f\u5408\u4e4e\u9053\u5fb7\u7684\u4e8b\uff0c\u5118\u7ba1\u793e\u6703\u56e0\u6b64\u8b8a\u5f97\u66f4\u52a0\u4e0d\u5e73\u7b49\u3002\u53cd\u5c0d\u6d3e\u7684\u4eba\u5247\u8a8d\u70ba\u57fa\u56e0\u7de8\u8f2f\u6703\u964d\u4f4e\u4eba\u985e\u7684\u57fa\u56e0\u591a\u6a23\u6027\u4e14\u504f\u96e2\u5e38\u614b\uff0c\u9019\u500b\u793e\u6703\u5c07\u4e0d\u518d\u6709\u8a31\u591a\u5275\u610f\u8207\u6fc0\u52f5\u3002\u9762\u5c0d\u9019\u500b\u554f\u984c\u4eba\u985e\u8a72\u5982\u4f55\u9078\u64c7\uff1f\u662f\u8a72\u9806\u61c9\u5929\u64c7\uff0c\u8b93\u5927\u81ea\u7136\u6dd8\u6c70\u7be9\u9078\u57fa\u56e0\uff1f\u9084\u662f\u7531\u6211\u5011\u81ea\u5df1\u626e\u6f14\u4e0a\u5e1d\u7684\u89d2\u8272\u81ea\u7531\u7de8\u8f2f\u57fa\u56e0\uff1f\u9019\u662f\u8eab\u70ba\u9019\u500b\u79d1\u6280\u65e5\u65b0\u6708\u7570\u7684\u6642\u4ee3\u6240\u5fc5\u9808\u9762\u5c0d\u8207\u627f\u53d7\u7684\u9078\u64c7\u984c\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-5385\" src=\"https:\/\/case.ntu.edu.tw\/scinarrator\/wp-content\/uploads\/2023\/03\/\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba.jpg\" alt=\"\" width=\"300\" height=\"300\" \/><\/span><\/p>\n<p><span style=\"color: #000000;\">\u66f8\u540d\uff1a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\uff1a\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d\u3001\u57fa\u56e0\u7de8\u8f2f\uff0c\u4ee5\u53ca\u4eba\u985e\u7684\u672a\u4f86<\/span><br \/>\n<span style=\"color: #000000;\">\u4f5c\u8005\uff1a\u83ef\u7279\uff0e\u827e\u85a9\u514b\u68ee\uff08Walter Isaacson\uff09<\/span><br \/>\n<span style=\"color: #000000;\">\u8b6f\u8005\uff1a\u9ea5\u6167\u82ac<\/span><br \/>\n<span style=\"color: #000000;\">\u51fa\u7248\u793e\uff1a\u5546\u5468\u51fa\u7248<\/span><br \/>\n<span style=\"color: #000000;\">\u51fa\u7248\u5e74\uff1a2021<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u64b0\u6587\uff1a\u8521\u5b9c\u5ead\uff5c\u5ef6\u5e73\u9ad8\u4e2d \u6539\u8b8a\u4eba\u985e\u6b77\u53f2\u7684CRISPR\uff1a\u8b80\u300a\u7834\u89e3 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