{"id":5914,"date":"2023-03-28T15:34:44","date_gmt":"2023-03-28T07:34:44","guid":{"rendered":"http:\/\/case.ntu.edu.tw\/scinarrator\/wordpress\/?p=5914"},"modified":"2023-06-17T14:21:26","modified_gmt":"2023-06-17T06:21:26","slug":"%e3%80%902022%e5%8f%b0%e7%a9%8d%e9%9b%bb%e7%9b%83%e9%9d%92%e5%b9%b4%e5%b0%ac%e7%a7%91%e5%ad%b8%e3%80%91%e3%80%8c%e7%a7%91%e6%99%ae%e6%9b%b8%e7%b1%8d%e5%b0%8e%e8%ae%80%e6%96%87%e7%ab%b6%e8%b3%bd-13","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/scinarrator\/?p=5914","title":{"rendered":"\u30102022\u53f0\u7a4d\u96fb\u76c3\u9752\u5e74\u5c2c\u79d1\u5b78\u3011\u300c\u79d1\u666e\u66f8\u7c4d\u5c0e\u8b80\u6587\u7af6\u8cfd\u300d\u512a\u9078\u5c0e\u8b80\u6587\uff08\u6851\u5a49\u5be7\uff09"},"content":{"rendered":"<p><span style=\"color: #000000;\"><strong>\u64b0\u6587\uff1a\u6851\u5a49\u5be7\uff5c\u5ef6\u5e73\u9ad8\u4e2d<\/strong><\/span><\/p>\n<p><strong><span style=\"color: #000000;\">\u5fae\u5c0f\u57fa\u56e0\u80cc\u5f8c\u7684\u5de8\u5927\u79d8\u5bc6\uff1a\u8b80\u300a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\u300b<\/span><\/strong><\/p>\n<p><span style=\"color: #000000;\">\u676d\u6c40\u9813\u821e\u8e48\u75c7\uff0c\u60a3\u8005\u5f9e\u4e00\u958b\u59cb\u808c\u8089\u4e0d\u81ea\u4e3b\u62bd\u52d5\uff0c\u6f38\u6f38\u667a\u529b\u55aa\u5931\uff0c\u7121\u6cd5\u884c\u52d5\u3001\u8aaa\u8a71\u3001\u9032\u98df\uff0c\u6700\u7d42\u8166\u7d30\u80de\u58de\u6b7b\u800c\u6b7b\u4ea1\u3002\u942e\u5200\u578b\u8ca7\u8840\u75c7\uff0c\u672c\u662f\u8ca0\u8cac\u50b3\u9001\u6c27\u6c23\u5230\u5168\u8eab\u7684\u91cd\u8981\u529f\u81e3\u2014\u2014\u7d05\u8840\u7403\uff0c\u56e0\u70ba\u8b8a\u5f62\u6210\u942e\u5200\u72c0\u53cd\u53db\u6210\u4e86\u5065\u5eb7\u6bba\u624b\u3002\u60a3\u8005\u53ef\u80fd\u65e9\u592d\uff0c\u5118 \u7ba1\u6d3b\u904e\u6210\u5e74\uff0c\u4e00\u8f29\u5b50\u4ecd\u8981\u6d3b\u5728\u8eab\u9ad4\u5404\u8655\u56e0\u7f3a\u6c27\u800c\u9020\u6210\u7684\u5287\u70c8\u75bc\u75db\u4e2d\u3002\u9664\u4e86\u4e0a\u8ff0\u5169\u500b\u4f8b\u5b50\u5916\uff0c\u9084\u6709\u8a31\u591a\u4ee4\u4eba\u805e\u4e4b\u8272\u8b8a\u7684\u75be\u75c5\uff0c\u81f4\u75c5\u539f\u56e0\u7686\u662f\u300c\u770b\u4f3c\u300d\u4e0d\u53ef\u6297\u9006\u7684\u57fa\u56e0\u907a\u50b3\u3002\u7136\u800c\uff0c\u5c31\u5728\u4e00\u9805\u65e2\u65b9\u4fbf\u53c8\u7c21\u55ae\u7684\u57fa\u56e0\u7de8\u8f2f\u5de5\u5177 CPISPR \u88ab\u767c\u660e\u4e4b\u5f8c\uff0c\u4eba\u985e\u5c0d\u4ed8\u9019\u4e9b\u907a\u50b3\u6027\u75be\u75c5\u4f3c\u4e4e\u4e0d\u518d\u662f\u4e0d\u53ef\u80fd\u7684\u4efb\u52d9\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">\u5c07 CPISPR \u4f5c\u70ba\u57fa\u56e0\u7de8\u8f2f\u5de5\u5177\u7684\u904e\u7a0b\uff0c\u593e\u96dc\u8457\u79d1\u5b78\u754c\u7684\u7af6\u722d\u3001\u5408\u4f5c\u8207\u8a31\u591a\u4e0d\u70ba\u4eba\u77e5\u7684\u6545\u4e8b\u3002\u672c\u66f8\u4f5c\u8005\u83ef\u7279\uff0e\u827e\u85a9\u514b\u68ee\uff0c\u4ee5\u300a\u8cc8\u4f2f\u65af\u50b3\u300b\u3001\u300a\u9054\u6587\u897f\u50b3\u300b\u7b49\u591a\u672c\u4eba\u7269\u50b3\u8a18\u805e\u540d\u3002\u300c\u6211\u7684\u9019\u8d9f\u65c5\u7a0b\uff0c\u8d77\u6e90\u65bc\u751f\u7269\u79d1\u6280\u6703\u662f\u4e0b\u4e00\u500b\u5049\u5927\u7684\u79d1\u5b78\u9769\u547d\u601d\u8003\u300d\u4ed6\u5728\u5f8c\u8a18\u5beb\u5230\uff0c\u9019\u500b\u52d5\u6a5f\u4f7f\u4ed6\u57f7\u7b46\u5beb\u4e0b\u9019\u672c\u4ee5\u4e3b\u89d2\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d\u70ba\u4e3b\u8ef8\u7684\u6545\u4e8b\uff0c\u5e36\u9818\u8b80\u8005\u8e0f\u4e0a\u9019\u6bb5\u57fa\u56e0\u7684\u5947\u5e7b\u4e4b\u65c5\u2026\u2026<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\"><strong>\u6545\u4e8b\u7684\u958b\u7aef\u2014\u2014\u597d\u5947\u5fc3\u7684\u9a45\u52d5<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\">\u73cd\u59ae\u4f5b\u2027\u9053\u7d0d\u662f\u5c07 CRISPR \u8207\u57fa\u56e0\u7de8\u8f2f\u5de5\u7a0b\u5169\u8005\u9023\u63a5\u8d77\u4f86\u7684\u91cd\u8981\u6a4b\u6881\u4e4b\u4e00\u3002\u4fc3\u4f7f\u4ed6\u8d70\u4e0a\u79d1\u5b78\u9019\u689d\u8def\u7684\u91cd\u8981\u56e0\u7d20\u6709\u5169\u500b\uff1a\u771f\u8aa0\u71b1\u5207\u7684\u597d\u5947\u5fc3\u548c\u5979\u7684\u7236\u89aa\u3002\u5f9e\u7ae5\u5e74\u5728\u91ce\u5916\u767c\u6398\u5927\u81ea\u7136\u7684\u7f8e\uff0c\u52a0\u4e0a\u7236\u89aa\u5c0d\u5979\u5728\u79d1\u5b78\u71b1\u60c5\u4e0a\u7684\u555f\u8499\uff0c\u5c0f\u9053\u7d0d\u5fc3\u4e2d\u4fbf\u7a2e\u4e0b\u4e86\u5c0d\u79d1\u5b78\u597d\u5947\u5fc3\u7684\u7a2e\u5b50\u3002\u9019\u9846\u7a2e\u5b50\u5f37\u70c8\u5730\u8b93\u5979\u60f3\u70ba\u81ea\u5df1\u5c0d\u81ea\u7136\u7684\u7a2e\u7a2e\u7591\u60d1\u627e\u51fa\u89e3\u7b54\uff0c\u56e0\u6b64\u6700\u7d42\u6c7a\u5b9a\u8e0f\u4e0a\u4e86\u79d1\u5b78\u4e4b\u8def\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">\u9760\u8457\u81ea\u8eab\u5929\u8ce6\u548c\u52aa\u529b\uff0c\u9053\u7d0d\u4e00\u6b65\u6b65\u524d\u9032\u3002\u5118\u7ba1\u904e\u7a0b\u4e2d\u8207\u5230\u74f6\u9838\u8207\u4ed6\u4eba\u61f7\u7591\u7684\u773c\u5149\uff0c\u4f46\u5728\u81ea\u8eab\u5c0d\u79d1\u5b78\u7684\u71b1\u611b\u548c\u7238\u7238\u7684\u652f\u6301\u4e0b\uff0c\u5979\u6162\u6162\u5f9e\u56f0\u5883\u4e2d\u8d70\u4e86\u51fa\u4f86\u3002\u300c\u6211\u6703\u8b49\u660e\u7d66\u4f60\u770b\uff0c\u5982\u679c\u6211\u60f3\u8d70\u79d1\u5b78\u9019\u689d\u8def\uff0c\u6211\u5c31\u6703\u505a\u5230\u3002\u300d\u5979\u5728\u5167\u5fc3\u767c\u8a93\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">\u800c\u5979\u78ba\u5be6\u505a\u5230\u4e86\uff0c\u4e0d\u4f46\u6210\u70ba\u67cf\u514b\u840a\u7684\u6559\u6388\uff0c\u64c1\u6709\u81ea\u5df1\u7684\u5be6\u9a57\u5ba4\uff0c\u66f4\u5728 2020 \u5e74\u8207\u5408\u4f5c\u4eba\u57c3\u746a\u7d10\u57c3\u723e\uff0e\u590f\u5f6d\u8482\u56e0\u5c0d CRISPR \u4f5c\u70ba\u57fa\u56e0\u7de8\u8f2f\u526a\u5200\u7684\u6709\u8457\u5de8\u5927\u8ca2\u737b\uff0c \u6210\u4e86\u8afe\u8c9d\u723e\u5316\u5b78\u5316\u5b78\u734e\u5f97\u4e3b\u3002\u300c\u9019\u4e9b\u57fa\u56e0\u526a\u5200\u5c07\u751f\u547d\u79d1\u5b78\u5e36\u76e1\u4e86\u4e00\u65b0\u7684\u7d00\u5143\u3002\u300d\u745e\u5178\u7687\u5bb6\u79d1\u5b78\u9662\u79d8\u66f8\u9577\u5728\u516c\u5e03\u5f97\u4e3b\u6642\u5ba3\u7a31\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\"><strong>\u6210\u529f\u80cc\u5f8c\u7684\u79d8\u5bc6\u8207\u62c9\u626f\u2014\u2014\u5408\u4f5c\u7af6\u722d\u8207\u79d1\u6280\u9053\u5fb7<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\">CRISPR \u7684\u6210\u529f\uff0c\u7d55\u5c0d\u4e0d\u53ea\u9053\u7d0d\u4e00\u500b\u4eba\u7684\u529f\u52de\u3002\u4e8b\u5be6\u4e0a\uff0cCPISPR \u4e00\u8a5e\u65e9\u5c31\u88ab\u63d0\u51fa\uff0c\u5728\u5f8c\u7e8c\u8a31\u591a\u79d1\u5b78\u5bb6\u7684\u5408\u4f5c\u8207\u7814\u7a76\uff0c\u70ba\u9019\u9805\u79d1\u5b78\u9769\u547d\u6027\u7684\u6280\u8853\u62fc\u4e0a\u4e86\u4e00\u584a\u584a\u4e0d\u53ef\u6216\u7f3a\u7684\u7684\u62fc\u5716\u3002\u7136\u800c\u9664\u4e86\u5408\u4f5c\u4e4b\u5916\uff0c\u7af6\u722d\u4e5f\u662f\u63a8\u52d5 CPISPR \u524d\u9032\u7684\u91cd\u8981\u52d5\u529b\u4e4b\u4e00\u3002\u5408\u4f5c\u662f\u6211\u5011\u5c0d\u79d1\u5b78\u666e\u904d\u7684\u8a8d\u77e5\u8207\u60f3\u6cd5\uff0c\u4f46\u807d\u5230\u7af6\u722d\u5c08\u5229\u3001\u734e\u9805\u3001\u540d\u8072\u6642\uff0c\u8a31\u591a\u4eba\u8166\u4e2d\u537b\u6703\u4e0d\u81ea\u89ba\u628a\u5176\u8207\u81ea\u79c1\u756b\u4e0a\u7b49\u865f\u3002\u7136\u800c\u7af6\u722d\u5e36\u52d5\u767c\u73fe\uff0c\u5f15\u7528\u9053\u7d0d\u6240\u8aaa\u7684\u7af6\u722d\u662f\u300c\u7d66\u5f15\u64ce\u589e\u52a0\u52d5\u529b\u7684\u706b\u7130\u300d\u3002CPISPR \u7684\u767c\u73fe\u8207\u61c9\u7528\u5b8c\u6574\u5448\u73fe\u4e86\u79d1\u5b78\u754c\u7684\u5408\u4f5c\u8207\u7af6\u722d\u3002\u672c\u66f8\u7b2c\u4e09\u7bc7\u5f88\u5927\u7bc7\u5e45\u5728\u8b1b\u8ff0\u5728\u67cf\u514b\u840a\u9053\u7d0d\u8207\u5728\u5e03\u6d1b\u5fb7\u7814\u7a76\u6240\u7684\u5f35\u92d2\u4e4b\u9593\u7684\u7af6\u722d\u662f\u5982\u4f55\u5e36\u52d5 CRISPR \u7a81\u7834\u6027\u7684\u767c\u73fe\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">CRISPR \u7684\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u9762\u5c0d\u7684\u9664\u4e86\u79d1\u5b78\u5bb6\u4e4b\u9593\u7684\u611b\u6068\u60c5\u4ec7\u5916\uff0c\u66f4\u96e3\u7684\u95dc\u5361\u662f\u5728\u9762\u5c0d\u79d1\u6280\u9053\u5fb7\u8207\u502b\u7406\u65b9\u9762\u3002\u7576 CRISPR \u904b\u7528\u5728\u6cbb\u7642\u907a\u50b3\u6027\u75be\u75c5\u807d\u8d77\u4f86\u662f\u500b\u5f88\u7f8e\u597d\u7684\u5de5\u5177\u3002\u4e0d\u904e\uff0c\u5be6\u969b\u4e0a\u6703\u50cf\u7406\u60f3\u4e2d\u7684\u90a3\u9ebc\u7f8e\u597d\u55ce\uff1f\u7576\u9019\u9805\u64cd\u4f5c\u7c21\u55ae\u7684\u5de5\u5177\u88ab\u62ff\u4f86\u6feb\u7528\u6642\uff0c\u6703\u4e0d\u6703\u9020\u6210\u4eba\u985e\u907a\u50b3\u4e0a\u6c38\u4e45\u6027\u7684\u50b7\u5bb3\uff1f\u7576\u6211\u5011\u62ff\u4f86\u7de8\u8f2f\u4eba\u985e\u7684\u667a\u5546\u3001\u8eab\u9ad8\u3001\u819a\u8272\u7b49\u57fa\u56e0\u6642\uff0c\u6703\u4e0d\u6703\u52a0\u5287\u793e\u6703\u7684\u4e0d\u516c\u5e73\u3001\u7e2e\u6e1b\u57fa\u56e0\u907a\u50b3\u7684\u591a\u8b8a\u6027\uff1f\u9019\u4e9b\u90fd\u662f\u9053\u7d0d\u5341\u5206\u6182\u616e\u7684\uff0c\u5982\u4f55\u5728\u9053\u5fb7\u8207\u57fa\u56e0\u7de8\u8f2f\u4e0b\u53d6\u5f97\u5e73\u8861\u4e5f\u6210\u4e86\u79d1\u5b78\u754c\u71b1\u70c8\u8a0e\u8ad6\u7684\u8a71\u984c\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\"><strong>\u667a\u8005\u4e4b\u59ff\u2014\u2014\u5ba2\u89c0\u7684\u5224\u65b7\u529b<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\">\u672c\u66f8\u662f\u4ee5\u9053\u7d0d\u7684\u89d2\u5ea6\u51fa\u767c\uff0c\u56e0\u6b64\u66f8\u4e2d\u4e3b\u7dda\u591a\u5c11\u90fd\u6703\u5e36\u8457\u9053\u7d0d\u7684\u7acb\u5834\uff0c\u5c24\u5176\u8b1b\u5230\u5f8c\u9762\u7684\u5c08\u5229\u6b0a\u4e4b\u722d\u6642\uff0c\u9053\u7d0d\u7684\u7af6\u722d\u5c0d\u624b\u5f35\u92d2\u770b\u8d77\u4f86\u6709\u9ede\u50cf\u5c0f\u8aaa\u4e2d\u7684\u53cd\u6d3e\u3002\u7136\u800c\u5728\u79d1\u5b78\u7684\u4e16\u754c\u6c92\u6709\u7d55\u5c0d\u7684\u597d\u4eba\u6216\u58de\u4eba\uff0c\u82e5\u8b80\u8005\u81ea\u52d5\u5e36\u5165\u7acb\u5834\u800c\u5426\u5b9a\u4e86\u5176\u4ed6\u79d1\u5b78\u5bb6\u7684\u8ca2\u737b\uff0c\u90a3\u4fbf\u4e0d\u662f\u63a2\u7a76\u79d1\u5b78\u8a72\u6709\u7684\u7cbe\u795e\u3002\u56e0\u6b64\u51b7\u975c\u7684\u5224\u65b7\u8207\u53d6\u6368\u662f\u8b80\u9019\u672c\u66f8\u6642\u61c9\u8a72\u5177\u6709\u7684\u80fd\u529b\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u60f3\u4e86\u89e3\u9053\u7d0d\u5728\u79d1\u5b78\u8def\u4e0a\u9762\u5c0d\u7684\u6311\u6230\u8207\u5fc3\u8def\u6b77\u7a0b\uff1f\u60f3\u77e5\u9053\u66f4\u591a CRISPR \u80cc\u5f8c\u9ad8\u6f6e\u8fed\u8d77\u7684\u6545\u4e8b\uff1f\u60f3\u9ad4\u6703\u79d1\u5b78\u5bb6\u5bb6\u5011\u5f6d\u6e43\u7684\u71b1\u60c5\uff1f\u8d95\u5feb\u7ffb\u958b\u9019\u672c\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\uff0c \u8ddf\u8457\u4f5c\u8005\u7684\u7dda\u7d22\uff0c\u62bd\u7d72\u525d\u7e6d\u3001\u4e00\u63a2\u7a76\u7adf\u5427\uff01<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong><span style=\"color: #000000;\">\u4f5c\u54c1\u8a55\u8a9e<\/span><\/strong><br \/>\n<span style=\"color: #000000;\">\u7d50\u69cb\u5b8c\u6574\uff0c\u8ad6\u64da\u6e05\u6670\uff0c\u689d\u7406\u5206\u660e\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-5385\" 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