{"id":5912,"date":"2023-03-28T15:35:26","date_gmt":"2023-03-28T07:35:26","guid":{"rendered":"http:\/\/case.ntu.edu.tw\/scinarrator\/wordpress\/?p=5912"},"modified":"2023-06-17T14:21:11","modified_gmt":"2023-06-17T06:21:11","slug":"%e3%80%902022%e5%8f%b0%e7%a9%8d%e9%9b%bb%e7%9b%83%e9%9d%92%e5%b9%b4%e5%b0%ac%e7%a7%91%e5%ad%b8%e3%80%91%e3%80%8c%e7%a7%91%e6%99%ae%e6%9b%b8%e7%b1%8d%e5%b0%8e%e8%ae%80%e6%96%87%e7%ab%b6%e8%b3%bd-14","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/scinarrator\/?p=5912","title":{"rendered":"\u30102022\u53f0\u7a4d\u96fb\u76c3\u9752\u5e74\u5c2c\u79d1\u5b78\u3011\u300c\u79d1\u666e\u66f8\u7c4d\u5c0e\u8b80\u6587\u7af6\u8cfd\u300d\u512a\u9078\u5c0e\u8b80\u6587\uff08\u738b\u99ff\u7dad\uff09"},"content":{"rendered":"<p><span style=\"color: #000000;\"><strong>\u64b0\u6587\uff1a\u738b\u99ff\u7dad\uff5c\u5ef6\u5e73\u9ad8\u4e2d<\/strong><\/span><\/p>\n<p><strong><span style=\"color: #000000;\">\u57fa\u56e0\u526a\u5200\uff1a\u8b80\u300a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\u300b<\/span><\/strong><\/p>\n<p><span style=\"color: #000000;\">\u672c\u66f8\u662f\u6709\u95dc\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u4e3b<u>\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d<\/u>\u7684\u6545\u4e8b\uff0c\u4e5f\u53ef\u4ee5\u8aaa\u662f\u4e00\u672cCRISPR\/Cas9 \u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u7684\u5e74\u53f2\uff0c\u4f5c\u8005<u>\u83ef\u7279\uff0e\u827e\u85a9\u514b\u68ee<\/u>\u85c9\u7531\u591a\u6b21\u8a2a\u8ac7<u>\u73cd\u59ae\u4f5b\uff0e \u9053\u7d0d<\/u>\u3001\u5979\u7684\u5de5\u4f5c\u5925\u4f34\u4ee5\u53ca\u7af6\u722d\u5c0d\u624b\uff0c\u5c07<u>\u9053\u7d0d<\/u>\u7684\u6210\u9577\u904e\u7a0b\u3001\u7814\u7a76 CRISPR \u7684\u9806\u8207\u9006\u3001\u79d1\u5b78\u5bb6\u5011\u5c0d CRISPR \u5c08\u5229\u6b0a\u7533\u8acb\u6230\u7684\u8ffd\u9010\u548c CRISPR \u5728\u75be\u75c5\u4e0a\u7684\u61c9\u7528\u4ee5\u53ca\u884d\u751f\u7684\u502b\u7406\u8b70\u984c\uff0c\u4e00\u4e00\u5a13\u5a13\u9053\u4f86\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u5230\u5e95\u662f\u4ec0\u9ebc\u4e8b\u7269\u9a45\u52d5\u4e86<u>\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d<\/u>\u9032\u5165\u751f\u7269\u5316\u5b78\u7684\u9818\u57df\uff0c\u4e26\u4e14\u548c\u57fa\u56e0\u7de8\u8f2f\u7684\u9769\u547d\u6709\u4e86\u4e0d\u53ef\u5206\u5272\u7684\u4ea4\u96c6\uff0c\u9019\u4e00\u5207\u8981\u5f9e\u5979\u7684\u597d\u5947\u5fc3\u548c\u4e00\u672c\u66f8\u27ea\u96d9\u87ba\u65cb\u27eb\u958b\u59cb\u8aaa\u8d77\u3002\u5979\u81ea\u5c0f\u5c31\u5c0d\u5927\u81ea\u7136\u842c\u7269\u90fd\u60f3\u53bb\u4e86\u89e3\uff0c\u540c\u5e74\u9f61\u7684\u5c0f\u5973\u751f\u53ef\u80fd\u5728\u73a9\u82ad\u6bd4\u5a03 \u5a03\u3001\u8fa6\u5bb6\u5bb6\u9152\uff0c\u5979\u5247\u662f\u559c\u6b61\u7814\u7a76\u8568\u985e\u3001\u8718\u86db\uff0c\u7814\u7a76\u751f\u7269\u754c\u7684\u6709\u8da3\u73fe\u8c61\u3001\u767c\u554f\u4e26\u60f3\u8981\u627e\u51fa\u7b54\u6848\u3002\u800c\u27ea\u96d9\u87ba\u65cb\u27eb\u9019\u672c\u66f8\u5247\u662f\u626e\u6f14\u4e86\u628a<u>\u9053\u7d0d<\/u>\u63a8\u9032\u79d1\u5b78\u9818\u57df\u7684\u63a8\u624b\uff0c<u>\u9053\u7d0d<\/u>\u8aaa\u79d1\u5b78\u7684\u672c\u8cea\u4e0d\u8a72\u662f\u53ea\u6709\u5be6\u9a57\u5ba4\u3001\u8a66\u7ba1\u3001\u986f\u5fae\u93e1\u9019\u4e9b\u523b\u677f\u5370\u8c61\uff0c\u5979\u89ba\u5f97\u79d1\u5b78 \u5c31\u50cf\u63a8\u7406\u5c0f\u8aaa\uff0c\u4fef\u62fe\u7686\u662f\u7dda\u7d22\uff0c\u7b49\u8457\u4eba\u5011\u53bb\u89e3\u8b0e\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u800c\u9019\u500b\u5538\u8d77\u4f86\u5f88\u50cf\u5403\u6d0b\u828b\u7247\u8072\u97f3\u7684 CRISPR\u00a0 \u53c8\u662f\u4f55\u65b9\u795e\u8056\u5462\uff1f\u5b83\u7684\u5168\u540d\u662f\u300c\u5e38\u9593\u56de\u6587\u91cd\u8907\u5e8f\u5217\u53e2\u96c6\u300d\uff0c\u6700\u65e9\u662f\u7531\u65e5\u672c\u79d1\u5b78\u5bb6\u5728\u5927\u8178\u687f\u83cc\u4e2d\u767c\u73fe\u7684\uff0c\u5f8c\u4f86\u6709\u66f4\u591a\u767c\u73fe\u8b49\u5be6\u8a31\u591a\u7d30\u83cc\u90fd\u6709 CRISPR\uff0c\u53ef\u4ee5\u628a\u5b83\u770b\u6210\u662f\u4e00\u7a2e\u514d\u75ab\u7cfb\u7d71\uff0c\u66f8\u4e2d\u63d0\u5230<u>\u9053\u7d0d<\/u>\u4e00\u958b\u59cb\u662f\u7814\u7a76 RNA \u7d50\u69cb\uff0c\u56e0\u7de3\u969b\u6703\u9032\u5165\u5230 CRISPR \u9019\u500b\u9818\u57df\uff0c\u548c<u>\u57c3\u746a\u7d10\u57c3\u723e\uff0e\u590f\u5f6d\u8482\u8036<\/u>\u5408\u4f5c\uff0c\u7814\u7a76 CRISPR \u7684\u904b\u4f5c\u65b9\u5f0f\u3002\u9019\u904b\u4f5c\u65b9\u5f0f\u7c21\u55ae\u8aaa\u660e\u5c31\u662f\u7576\u75c5\u6bd2\u5927\u8ecd\u653b\u6253\u7d30\u83cc\uff0c\u7d30\u83cc\u88e1\u7684\u9175\u7d20 Cas9 \u6703\u300c\u526a\u4e0b\u3001\u5b58\u653e\u300d\u75c5\u6bd2\u7684\u67d0\u4e9b\u62db\u5f0f\uff08\u5c31\u662f\u75c5\u6bd2\u7684 DNA\uff09\uff0c\u5132\u5b58\u5728\u81ea\u5df1\u7684 CRISPR RNA \u88e1\uff08\u7c21\u7a31\u70ba crRNA\uff09\uff0c\u4e26\u88fd\u4f5c\u4e00\u689d\u8207\u5176\u6709\u4e92\u88dc\u95dc\u4fc2\u7684\u5f15\u5c0e RNA\uff08\u4e5f\u5c31\u662f tracrRNA\uff09\uff0c\u4e0b\u4e00\u6b21\u540c\u6a23\u7684\u75c5\u6bd2\u4f86\u4fb5\u72af\uff0c\u5c31\u53ef\u4ee5\u88ab\u8fa8\u8b58\u51fa\u4f86\uff0c\u5c31\u50cf\u8b66\u5bdf\u624b\u4e2d\u6709\u72af\u4eba\u7684\u5927\u982d\u7167\u4e00\u6a23\uff0c\u770b\u5230\u76f8\u4f3c\u81c9\u5b54\u4fbf\u8ffd\u6355\uff0c\u7d30\u83cc\u770b\u5230\u75c5\u6bd2\u548c\u5f15\u5c0e RNA \u9577\u5f97\u662f\u5de6\u53f3\u76f8\u53cd\u7684\uff0c\u5c31\u628a\u5b83\u6bba\u6389\u3002\u5728\u66f8\u4e2d\uff0c \u4f5c\u8005\u76e1\u529b\u5730\u63cf\u8ff0\u5c07\u9019\u5957\u8271\u6f80\u96e3\u61c2\u7684\u6280\u8853\u8b93\u5927\u773e\u4e86\u89e3\uff0c\u4f46\u5c0d\u65bc\u4e0d\u662f\u5c08\u653b\u751f\u7269\u5b78\u7684\u8b80\u8005\uff0c\u53ef\u80fd\u9700\u8981\u53cd\u8986\u95b1\u8b80\u4e26\u518d\u4e09\u7d30\u56bc\uff0c\u624d\u6709\u53ef\u80fd\u7565\u77e5\u4e00\u4e8c\u3002\u56e0\u6b64\u76f8\u5c0d\u7684\uff0c\u6211\u66f4\u559c\u6b61<u>\u9053\u7d0d<\/u>\u662f\u5982\u4f55\u63cf\u8ff0\u7d66\u5979 9 \u6b72\u7684\u5152\u5b50\u660e\u77ad\u81ea\u5df1\u6240\u7814\u7a76\u7684\uff0c\u5176\u5be6\u79d1\u5b78\u5bb6\u5229\u7528\u4e86\u5927\u81ea\u7136\u7684\u751f\u5b58\u6cd5\u5247\uff0c\u4e5f\u5c31\u662f\u7d30\u83cc\u82b1\u4e86\u5f88\u9577\u7684\u6642\u9593\u5c07\u81ea\u8eab\u6f14\u5316\uff0c\u4ee5\u671f\u9632\u79a6\u75c5\u6bd2\uff0c\u9019\u689d\u6578\u5341\u5104\u5e74\u88ab\u53cd\u8986\u9a57\u8b49\u7684\u771f\u7406\uff0c\u958b\u555f\u4e86\u57fa\u56e0\u7de8\u8f2f\u5de5\u5177\u7684\u5927\u9580\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u7576\u7136\uff0c\u7814\u7a76 CRISPR \u7684\u79d1\u5b78\u5bb6\u4e0d\u662f\u53ea\u6709<u>\u9053\u7d0d<\/u>\u548c<u>\u590f\u5f6d\u8482\u8036<\/u>\u9019\u7d44\u5718\u968a\u800c\u5df2\uff0c\u4e16\u754c\u4e0a\u9802\u5c16\u5927\u5b78\u7684\u5be6\u9a57\u5ba4\u7d1b\u7d1b\u52a0\u5165\u9019\u5834\u7af6\u8cfd\uff0c\u300c\u5065\u5eb7\u7684\u7af6\u722d\u6703\u70ba\u4eba\u985e\u7684\u767c\u660e\u6dfb\u67f4\u52a0\u85aa\u3002\u300d<u>\u9053\u7d0d<\/u>\u9019\u6a23\u5b50\u8aaa\uff0c\u6709\u7af6\u722d\u66f4\u6703\u71c3\u8d77\u79d1\u5b78\u5bb6\u7684\u9b25\u5fd7\uff0c\u4f46\u4e0d\u53ef\u8af1\u8a00\u7684\uff0c\u88ab\u51a0\u4e0a\u7b2c\u4e00\u500b\u767c\u73fe\u8005\u3001\u767c\u660e\u8005\u7684\u982d\u929c\u4e5f\u662f\u8a31\u591a\u79d1\u5b78\u5bb6\u5922\u5bd0\u4ee5\u6c42\u7684\u3002\u5176\u4e2d\u4e00\u5b9a\u8981\u63d0\u7684\u7af6\u722d\u8005\u5c31\u662f MIT \u7684<u>\u5f35\u92d2<\/u>\u5718\u968a\uff0c\u4e0d\u6b62\u7af6\u722d\u8ad6\u6587\u767c\u8868\uff0c\u9084\u5728\u5c08\u5229\u6b0a\u4e0a\u722d\u9b25\uff0c\u76f4\u5230\u73fe\u5728\u9019\u5834\u6230\u5f79\u5c1a\u672a\u843d\u5e55\uff0c\u8ab0\u90fd\u4e0d\u80af\u8b93\u6b65\uff0c\u7562\u7adf\u9019\u727d\u6d89\u5230\u4e86\u5de8\u984d\u6b0a\u5229\u91d1\u4ee5\u53ca\u69ae\u8000\u7684\u6b78\u5c6c\uff0c\u96d6\u7136\u6211\u89ba\u5f97\u8a55\u65b7\u9019\u7af6\u722d\u80cc\u5f8c\u7684\u610f\u5716\u662f\u6c92\u6709\u610f\u7fa9\u7684\uff0c\u4f46\u6211\u8d0a\u6210\u4f5c\u8005\u7684\u898b\u89e3\uff0c \u4ed6\u8aaa\u82e5\u9019\u5e7e\u4f4d\u79d1\u5b78\u5bb6\u662f\u5408\u975e\u7af6\uff0c\u90a3\u9ebc\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u7684\u6210\u9577\u662f\u5426\u6703\u66f4\u8e8d\u9032\uff0c\u7576\u524d\u7121\u89e3\u75be\u75c5\u770b\u5230\u66d9\u5149\u7684\u6a5f\u6703\u53ef\u4ee5\u63d0\u524d\u4f86\u5230\u5462\uff1f<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">\u5168\u66f8\u5728\u95e1\u8ff0<u>\u9053\u7d0d<\/u>\u5982\u4f55\u5229\u7528 CRISPR \u6280\u8853\u5e36\u8d77\u57fa\u56e0\u7de8\u8f2f\u9769\u547d\u7684\u6545\u4e8b\u4e4b\u9918\uff0c\u4e5f\u540c\u6642\u5f15\u5c0e\u8b80\u8005\u601d\u8003\u57fa\u56e0\u7de8\u8f2f\u7684\u9053\u5fb7\u8b70\u984c\uff0c\u4ee5\u53ca\u7576\u524d\u65b0\u51a0\u75ab\u60c5\u5e2d\u6372\u5168\u7403\u7684\u7576\u4e0b\uff0c \u57fa\u56e0\u7de8\u8f2f\u53ef\u4ee5\u70ba\u4eba\u985e\u505a\u4e9b\u4ec0\u9ebc\u3002\u63d0\u5230\u502b\u7406\u8b70\u984c\uff0c\u6700\u722d\u8b70\u7684\u5c31\u662f\u4e2d\u570b\u751f\u7269\u5b78\u5bb6\u8cc0\u5efa\u594e\u5229\u7528 CRISPR \u6280\u8853\u4f86\u4fee\u6539\u53d7\u7cbe\u5375\u7684 CCR5 \u57fa\u56e0\uff0c\u70ba\u7684\u662f\u8b93\u80ce\u5152\u5c0d\u611b\u6ecb\u75c5\u6bd2\u514d\u75ab\uff0c\u9019\u5be6\u9a57\u5f15\u8d77\u4e86\u5f88\u591a\u7684\u64bb\u4f10\u3002\u5927\u591a\u6578\u79d1\u5b78\u5bb6\u8a8d\u70ba\u5728\u6c92\u6709\u4eba\u80fd\u4fdd\u8b49\u7de8\u8f2f\u4eba\u985e\u80da\u80ce\u57fa\u56e0\u4e0d\u6703\u7522\u751f\u5176\u4ed6\u7a81\u8b8a\u98a8\u96aa\u7684\u60c5\u6cc1\u4e0b\uff0c\u5c31\u8cbf\u7136\u628a\u6b64\u6280\u8853\u76f4\u63a5\u61c9\u7528\u5230\u4eba\u985e \u4e0a\uff0c\u5be6\u5728\u662f\u5f0a\u5927\u65bc\u5229\u3002\u6b64\u5916\u4f5c\u8005\u4e5f\u63d0\u5230\u6709\u4e9b\u751f\u7269\u99ed\u5ba2\u4e3b\u5f35\u9019\u6a23\u7684\u6280\u8853\u61c9\u8a72\u8981\u50cf\u8edf\u9ad4\u7a0b\u5f0f\u4e00\u6a23\u958b\u653e\u6240\u6709\u8cc7\u6e90\uff0c\u8b93\u6bcf\u500b\u4eba\u90fd\u6709\u9014\u5f91\u53ef\u4ee5\u63a5\u89f8\u5f97\u5230\uff0c\u5982\u6b64\u4e3b\u5f35\u8b93\u4fdd\u5b88\u7684\u79d1\u5b78\u5bb6\u64d4\u5fc3\u4e00\u65e6\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u843d\u5165\u6709\u5fc3\u4eba\u58eb\u4e4b\u624b\uff0c\u6703\u963b\u7919\u5176\u767c\u5c55\u3002\u96d6\u7136\u9019\u662f\u5169\u500b\u622a\u7136\u4e0d\u540c\u7684\u6848\u4f8b\uff0c\u4f46\u672c\u8cea\u7d42\u6b78\u90fd\u662f\u56de\u5230\u4f60\u6211\u5fc3\u4e2d\u7684\u9053\u5fb7\u5e95\u7dda\u53bb\u505a\u5224\u65b7\uff0c \u6211\u60f3\u9019\u4e5f\u662f\u4f5c\u8005\u60f3\u8981\u8b80\u8005\u53bb\u9ad4\u6703\u7684\u5427\uff01<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong><span style=\"color: #000000;\">\u4f5c\u54c1\u8a55\u8a9e<\/span><\/strong><br \/>\n<span style=\"color: #000000;\">\u80fd\u6e05\u695a\u8aaa\u51fa\u672c\u66f8\u5b9a\u4f4d: \u65e2\u662f\u50b3\u8a18\uff0c\u4e5f\u662f\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u7684\u6b77\u53f2\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-5385\" src=\"https:\/\/case.ntu.edu.tw\/scinarrator\/wp-content\/uploads\/2023\/03\/\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba.jpg\" alt=\"\" width=\"300\" height=\"300\" \/><\/span><\/p>\n<p><span style=\"color: #000000;\">\u66f8\u540d\uff1a\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\uff1a\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d\u3001\u57fa\u56e0\u7de8\u8f2f\uff0c\u4ee5\u53ca\u4eba\u985e\u7684\u672a\u4f86<\/span><br \/>\n<span style=\"color: #000000;\">\u4f5c\u8005\uff1a\u83ef\u7279\uff0e\u827e\u85a9\u514b\u68ee\uff08Walter Isaacson\uff09<\/span><br 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