{"id":5739,"date":"2022-07-06T11:28:22","date_gmt":"2022-07-06T03:28:22","guid":{"rendered":"http:\/\/case.ntu.edu.tw\/scinarrator\/wordpress\/?p=5739"},"modified":"2022-07-06T11:28:22","modified_gmt":"2022-07-06T03:28:22","slug":"%e3%80%902022%e5%b0%8e%e8%ae%80%e6%96%87%e7%a4%ba%e7%af%84%e5%b0%88%e6%ac%84%e3%80%91%e7%94%9f%e5%91%bd%e5%af%86%e7%a2%bc%e7%9a%84%e9%a7%ad%e5%ae%a2%e4%bb%bb%e5%8b%99%ef%bc%88%e9%bb%83%e8%b2%9e","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/scinarrator\/?p=5739","title":{"rendered":"\u30102022\u5c0e\u8b80\u6587\u793a\u7bc4\u5c08\u6b04\u3011\u751f\u547d\u5bc6\u78bc\u7684\u99ed\u5ba2\u4efb\u52d9\uff08\u9ec3\u8c9e\u7965\uff09"},"content":{"rendered":"<p><span style=\"color: #000000;\"><strong>\u64b0\u6587\uff1a\u9ec3\u8c9e\u7965\uff5c\u4f86\u81ea\u99ac\u4f86\u897f\u4e9e\uff0c\u73fe\u4efb\u6559\u65bc\u6e05\u83ef\u5927\u5b78\u5206\u5b50\u8207\u7d30\u80de\u751f\u7269\u5b78\u7814\u7a76\u6240\uff0c\u5f9e\u4e8b\u9ce5\u985e\u7684\u6f14\u5316\u907a\u50b3\u5b78\u3001\u57fa\u56e0\u9ad4\u5b78\u53ca\u6f14\u5316\u767c\u80b2\u751f\u7269\u5b78\u7814\u7a76\u3002<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\">\u7576\u521d\u6211\u5728\u5b78\u7fd2\u5206\u5b50\u751f\u7269\u5b78\u7684\u57fa\u56e0\u8f49\u6b96\uff08transgenesis\uff09\u6280\u8853\u6642\uff0c\u624d\u77e5\u9053\u539f\u4f86\u8981\u628a\u4e00\u6bb5\u5916\u4f86\u7684\u57fa\u56e0\u8f49\u6b96\u5230\u751f\u7269\u9ad4\u5167\uff0c\u4e0d\u50cf\u79d1\u5e7b\u96fb\u5f71\u4e2d\u90a3\u6a23\u7528\u9375\u76e4\u6572\u5e7e\u4e0b\u5c31\u641e\u5b9a\u2014\u2014\u57fa\u56e0\u7247\u6bb5\u8981\u7528\u805a\u5408\u9176\u9023\u9396\u53cd\u61c9\uff08polymerase chain reaction\uff0c PCR\uff09\u64f4\u589e\u4e26\u5728\u96fb\u6cf3\u51dd\u81a0\u4e2d\u5206\u96e2\uff0c\u518d\u501f\u52a9\u8a31\u591a\u9175\u7d20\u5728\u7ba1\u5b50\u88e1\u548c\u8f09\u9ad4\u526a\u63a5\uff0c\u7136\u5f8c\u5229\u7528\u75c5\u6bd2\u3001\u96fb\u7a7f\u5b54\uff08electroporation\uff09\u3001\u57fa\u56e0\u69cd\uff08gene gun\uff0c biolistics\uff09\u7b49\u65b9\u6cd5\u8b93\u57fa\u56e0\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\u3002\u66f4\u96e3\u4ee5\u9810\u6599\u7684\u662f\uff0c\u5916\u4f86\u57fa\u56e0\u6703\u63d2\u5165\u57fa\u56e0\u9ad4\u7684\u54ea\u4e9b\u4f4d\u7f6e\u5e7e\u4e4e\u5168\u6191\u904b\u6c23\u3002\u63a5\u8457\u9084\u8981\u8fa8\u8b58\u51fa\u5df2\u88ab\u8f49\u6b96\u7684\u500b\u9ad4\uff0c\u6700\u5f8c\u8a2d\u8a08\u907a\u50b3\u5be6\u9a57\uff0c\u8b93\u5916\u4f86\u57fa\u56e0\u80fd\u4ee3\u4ee3\u76f8\u50b3\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">\u8209\u4f8b\u4f86\u8aaa\uff0c\u57fa\u56e0\u8f49\u6b96\u5c31\u50cf\u662f\u4e00\u4f4d\u7de8\u8f2f\u5728\u5927\u4f5c\u5bb6\u7684\u5c0f\u8aaa\u4e2d\u767c\u73fe\uff0c\u53ef\u4ee5\u518d\u63d2\u5165\u4e00\u500b\u5c0f\u6545\u4e8b\u8b93\u5287\u60c5\u66f4\u7cbe\u5f69\uff0c\u6216\u8005\u539f\u8457\u4e2d\u6709\u500b\u660e\u986f\u7684\u758f\u5931\uff0c\u53ef\u662f\u537b\u53ea\u80fd\u628a\u60f3\u8981\u52a0\u5165\u7684\u5c0f\u6545\u4e8b\u6216\u8a72\u4fee\u6b63\u6bb5\u843d\u7684\u7bc7\u7ae0\uff0c\u4ee5\u96a8\u6a5f\u8907\u88fd\u3001\u8cbc\u4e0a\u7684\u65b9\u5f0f\u63d2\u5165\u5c0f\u8aaa\u4e2d\uff0c\u9084\u8981\u671f\u5f85\u4e0d\u6703\u7834\u58de\u539f\u672c\u5c0f\u8aaa\u7684\u91cd\u8981\u60c5\u7bc0\u3002\u56e0\u70ba\u7121\u6cd5\u63a7\u5236\u63d2\u5165\u4e4b\u8655\uff0c\u53ea\u597d\u589e\u52a0\u8a31\u591a\u7248\u672c\u4e26\u91cd\u8986\u540c\u6a23\u7684\u52d5\u4f5c\uff0c\u7136\u5f8c\u518d\u6d77\u9078\u51fa\u9084\u7b97\u9069\u7576\u7684\u7248\u672c\u51fa\u7248\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">\u4ee5\u4e0a\u72c0\u6cc1\u5728\u8fd1\u5e74\u6709\u4e86\u5f88\u5927\u7684\u6539\u8b8a\uff0c\u79d1\u5b78\u5bb6\u5f9e\u7d30\u83cc\u7684\u514d\u75ab\u7cfb\u7d71\u4e2d\u767c\u73fe\u4e86\u4e00\u500b\u7d55\u4f73\u7684\u65b9\u6cd5\u2014\u2014\u7d30\u83cc\u8a18\u61b6\u75c5\u6bd2\u611f\u67d3\u7684\u5206\u5b50\u6a5f\u5236\uff08CRISPR\uff09\uff0c\u53ef\u4ee5\u8b93\u6211\u5011\u7528\u4f86\u7de8\u8f2f\u57fa\u56e0\uff0c\u5c31\u50cf\u7528\u6587\u66f8\u8655\u7406\u8edf\u9ad4\u7de8\u8f2f\u6587\u5b57\u6a94\u6848\u3002\u9019\u500b\u57fa\u56e0\u7de8\u8f2f\u65b9\u6cd5\u6210\u70ba\u4e86\u5283\u6642\u4ee3\u7684\u65b0\u5de5\u5177\uff0c\u8b93\u6cd5\u570b\u5fae\u751f\u7269\u5b78\u5bb6\u590f\u5f6d\u63d0\u8036\uff08Emmanuelle Charpentier\uff09\u8207\u7f8e\u570b\u5206\u5b50\u751f\u7269\u5b78\u5bb6\u9053\u7d0d\uff08Jennifer Doudna\uff09\u69ae\u7372\u4e862020 \u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u7684\u6842\u51a0\uff0c\u4e5f\u662f\u751f\u7269\u6280\u8853\u53f2\u4e0a\u6700\u91cd\u8981\u7684\u91cc\u7a0b\u7891\u4e4b\u4e00\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">\u5728 CRISPR \u57fa\u56e0\u7de8\u8f2f\u7684\u65b0\u6280\u8853\u51fa\u73fe\u4e4b\u5f8c\uff0c\u4e0d\u5c11\u5c08\u5bb6\u5b78\u8005\u958b\u59cb\u4e3b\u5f35\uff0cCRISPR \u53ef\u4ee5\u53d6\u4ee3\u50b3\u7d71\u7684\u57fa\u56e0\u6539\u9020\u65b9\u6cd5\u3002\u56e0\u70ba CRISPR \u6280\u8853\u53ef\u4ee5\u7cbe\u6e96\u5730\u7de8\u8f2f\u57fa\u56e0\uff0c\u5c31\u50cf\u90a3\u4f4d\u51fa\u7248\u793e\u7de8\u8f2f\uff0c\u53ea\u9700\u8981\u5728\u6587\u66f8\u8655\u7406\u8edf\u9ad4\u4e2d\u627e\u5230\u9069\u5408\u7684\u4f4d\u7f6e\uff0c\u518d\u76f4\u63a5\u63d2\u5165\u6587\u5b57\uff0c\u6216\u8005\u5c07\u90a3\u500b\u758f\u6f0f\u7684\u7bc7\u7ae0\u76f4\u63a5\u4fee\u6b63\u5c31\u597d\u3002\u65b0\u820a\u6280\u8853\u7684\u5dee\u7570\u4e4b\u5927\uff0c\u5c31\u50cf\u662f\u5f9e\u925b\u5b57\u6392\u7248\u9032\u5316\u5230\u96fb\u8166\u6587\u66f8\u8655\u7406\u4e00\u6a23\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">\u7136\u800c\uff0c\u9019\u4e00\u5207\u5c31\u958b\u59cb\u8b8a\u5f97\u5b8c\u7f8e\u4e86\u55ce\uff1f\u5982\u679c\u8b93\u57fa\u56e0\u7de8\u8f2f\u548c\u5929\u7136\u7684\u7a81\u8b8a\u4e00\u6a23\u6539\u8b8a\u4e86\u67d0\u500b\u57fa\u56e0\u7684\u529f\u80fd\uff0c\u5b83\u5011\u771f\u7684\u5b8c\u5168\u5b89\u5168\u7121\u865e\uff1f\u6211\u5011\u4eba\u985e\u7684\u907a\u50b3\u7f3a\u9677\uff0c\u662f\u5426\u4e5f\u80fd\u7528\u6b64\u65b9\u6cd5\u9032\u884c\u6539\u9020\u5462\uff1f\u7576\u6211\u5011\u5df2\u7d93\u80fd\u5920\u7cbe\u6e96\u5730\u6539\u8b8a\u57fa\u56e0\uff0c\u751a\u81f3\u8a02\u88fd\u5b30\u5152\u5df2\u7d93\u5f9e\u300c\u8fa6\u4e0d\u8fa6\u5f97\u5230\u300d\u8b8a\u6210\u300c\u61c9\u4e0d\u61c9\u8a72\u53bb\u505a\u300d\u7684\u554f\u984c\u6642\uff0c\u7a76\u7adf\u9084\u6709\u4ec0\u9ebc\u9700\u8981\u6211\u5011\u518d\u4e09\u601d\u616e\uff1f<\/span><\/p>\n<p><span style=\"color: #000000;\">\u82f1\u570b\u5206\u5b50\u907a\u50b3\u5b78\u5bb6\u5361\u96f7\uff08Nessa Carey\uff09\u64b0\u5beb\u7684\u300a\u7ac4\u6539\u57fa\u56e0\uff1a\u6539\u5beb\u4eba\u985e\u672a\u4f86\u7684 CRISPR \u548c\u57fa\u56e0\u7de8\u8f2f\u300b\uff08Hacking the Code of Life: How Gene Editing Will Rewrite Our Futures\uff09\u5c31\u662f\u8981\u5e36\u6211\u5011\u63a2\u8a0e\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u6240\u5e36\u4f86\u7684\u5f62\u5f62\u8272\u8272\u7684\u554f\u984c\u3002\u76f8\u4fe1\u5c0d\u5927\u591a\u6578\u975e\u751f\u547d\u79d1\u5b78\u76f8\u95dc\u79d1\u7cfb\u51fa\u8eab\u7684\u8b80\u8005\u4f86\u8aaa\uff0c\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u7684\u61c9\u7528\u548c\u502b\u7406\u554f\u984c\u6bd4\u6280\u8853\u672c\u8eab\u66f4\u91cd\u8981\u8a31\u591a\u3002\u9019\u672c\u5165\u9580\u66f8\u76e1\u53ef\u80fd\u5730\u4f7f\u7528\u5e73\u6613\u8fd1\u4eba\u7684\u6587\u5b57\uff0c\u8b93\u6211\u5011\u7406\u89e3\u5230\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u89e3\u653e\u51fa\u7684\u5f37\u5927\u529b\u91cf\uff0c\u4ee5\u53ca\u6211\u5011\u5c07\u5728\u502b\u7406\u9053\u5fb7\u4e0a\u9762\u5c0d\u4ec0\u9ebc\u6a23\u7684\u6311\u6230\u3002<\/span><\/p>\n<p><span style=\"color: #000000;\">\u5728\u300a\u7ac4\u6539\u57fa\u56e0\u300b\u4e00\u66f8\u4e2d\uff0c\u9084\u662f\u6709\u5c0d\u57fa\u56e0\u7de8\u8f2f\u505a\u4e86\u7c21\u55ae\u7684\u89e3\u91cb\uff0c\u8b93\u6211\u5011\u7406\u89e3\u9019\u500b\u6280\u8853\u7684\u65b0\u7a4e\u548c\u7368\u5230\u4e4b\u8655\u3002\u63a5\u8457\uff0c\u5361\u96f7\u7528\u4e86\u5404\u7a2e\u52d5\u3001\u690d\u7269\u751a\u81f3\u4eba\u985e\u70ba\u4f8b\uff0c\u8b93\u6211\u5011\u898b\u8b58\u5230\u5584\u7528\u9019\u500b\u6280\u8853\u5c07\u6703\u5982\u4f55\u63d0\u9ad8\u52d5\u690d\u7269\u7684\u7522\u91cf\u3001\u6297\u75c5\u6027\u7b49\uff0c\u4e5f\u70ba\u65b0\u85e5\u958b\u767c\u5e36\u4f86\u5e0c\u671b\uff0c\u751a\u81f3\u6839\u6cbb\u907a\u50b3\u75be\u75c5\u3002\u5979\u4e5f\u5c0d\u6b50\u76df\u628a\u57fa\u56e0\u7de8\u8f2f\u548c\u50b3\u7d71\u57fa\u56e0\u6539\u9020\u6df7\u70ba\u4e00\u8ac7\u3001\u505a\u540c\u6a23\u7684\u7ba1\u5236\u611f\u5230\u6cae\u55aa\u3002\u4e8b\u5be6\u4e0a\u57fa\u56e0\u7de8\u8f2f\u53ef\u80fd\u6bd4\u8d77\u50b3\u7d71\u8a98\u5c0e\u96a8\u6a5f\u7a81\u8b8a\u7684\u65b9\u5f0f\u66f4\u7cbe\u6e96\u4e14\u5b89\u5168\uff0c\u4f46\u5f8c\u8005\u53cd\u800c\u662f\u88ab\u5141\u8a31\u7684\u3002<\/span><\/p>\n<p><span style=\"color: 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