{"id":9295,"date":"2010-09-29T03:26:01","date_gmt":"2010-09-28T19:26:01","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=9295"},"modified":"2021-10-06T16:31:32","modified_gmt":"2021-10-06T08:31:32","slug":"rna%e8%81%9a%e5%90%88%e9%85%b6%ef%bc%88rna-polymerase%ef%bc%89%ef%bc%88i%ef%bc%89","status":"publish","type":"post","link":"http:\/\/localhost\/rna%e8%81%9a%e5%90%88%e9%85%b6%ef%bc%88rna-polymerase%ef%bc%89%ef%bc%88i%ef%bc%89\/","title":{"rendered":"RNA\u805a\u5408\u9176\uff08RNA Polymerase\uff09\uff08I\uff09"},"content":{"rendered":"

RNA\u805a\u5408\u9176\uff08RNA Polymerase\uff09\uff08I\uff09<\/strong>
\n<\/span>\u570b\u7acb\u65b0\u838a\u9ad8\u7d1a\u4e2d\u5b78\u9673\u5049\u6c11\u9000\u4f11\u6559\u5e2b\/\u570b\u7acb\u53f0\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u8449\u540d\u5009\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/p>\n

<\/span><\/strong>RNA\u805a\u5408\u9176\uff08\u7e2e\u5beb\u70baRNAP\u6216RNApol\uff09\u70ba\u5408\u6210RNA\u6240\u9700\u7684\u9176\u3002\u5728\u7d30\u80de\u4e2d\uff0c\u4ee5DNA\u57fa\u56e0\u505a\u70ba\u6a21\u677f\uff0c\u88fd\u9020RNA\u93c8\u7684\u904e\u7a0b\u7a31\u70ba\u8f49\u9304\uff0cRNAP\u70ba\u8f49\u9304\u5fc5\u9700\u7684\u9176\u3002RNA\u805a\u5408\u9176\u662f\u751f\u547d\u5fc5\u9700\u7684\u7269\u8cea\uff0c\u5728\u6240\u6709\u751f\u7269\u53ca\u8a31\u591a\u75c5\u6bd2\u4e2d\u5747\u5b58\u5728\u6b64\u7a2e\u9176\u3002\u4ee5\u5316\u5b78\u8853\u8a9e\u4f86\u8aaa\uff0cRNAP\u662f\u4e00\u7a2e\u6838\u82f7\u9178\u8f49\u79fb\u9176\uff08nucleotidyl transferase\uff09\uff0c\u5728RNA\u8f49\u9304\u672c\u76843\u2019\u7aef\u9032\u884c\u6838\u7cd6\u6838\u82f7\u9178\u7684\u805a\u5408\u53cd\u61c9\u3002<\/p>\n

\u6b77\u53f2<\/strong>
\n\u57281960\u5e74\uff0c\u61f7\u65af\uff08Sam Weiss\uff09\u3001\u53f2\u5e1d\u6587\u65af\uff08Audrey Stevens\uff09\u548c\u4f55\u5a01\u8332\uff08Jerard Hurwitz\uff09\u4e09\u4eba\u5404\u81ea\u767c\u73feRNAP\u3002\u4e0d\u904e\uff0c1959\u5e74\u8afe\u8c9d\u723e\u91ab\u5b78\u596c\u9812\u7d66\u4e86\u6b50\u79cb\u96c5\uff08Severo Ochoa\uff09\u548c\u4e9e\u745f\u2027\u79d1\u6069\u67cf\u683c\uff08Arthur Kornberg\uff09\uff0c\u8868\u5f70\u4ed6\u5011\u767c\u73fe\u4e86RNAP\uff0c\u4e0d\u904e\u4e8b\u5f8c\u8b49\u5be6\u4ed6\u5011\u767c\u73fe\u7684\u662f\u805a\u6838\u82f7\u9178\u78f7\u9178\u89e3\u9176\uff08polynucleotide phosphorylase.\uff09\u3002
\n\u57282006\u5e74\uff0c\u8afe\u8c9d\u723e\u5316\u5b78\u596c\u9812\u7d66\u7f85\u5091\u2027\u79d1\u6069\u67cf\u683c\uff08Roger Kornberg\uff09\uff0c\u4ee5\u8868\u5f70\u4ed6\u5efa\u7acb\u4e86\u8f49\u9304\u904e\u7a0b\u7684\u5404\u500b\u6b65\u9a5f\u4e2d\uff0cRNA\u805a\u5408\u9176\u7684\u8a73\u7d30\u5206\u5b50\u5f71\u50cf\u3002<\/p>\n

\u8f49\u9304\u4e4b\u64cd\u63a7<\/strong>
\n\u64cd\u63a7\u57fa\u56e0\u8f49\u9304\u7684\u904e\u7a0b\uff0c\u6703\u5f71\u97ff\u57fa\u56e0\u8868\u73fe\u7684\u6a21\u5f0f\uff0c\u56e0\u6b64\uff0c\u4f7f\u7d30\u80de\u80fd\u9069\u61c9\u8b8a\u9077\u4e2d\u7684\u74b0\u5883\uff0c\u5728\u751f\u7269\u9ad4\u5167\u767c\u63ee\u7279\u6b8a\u7684\u529f\u80fd\uff0c\u7dad\u6301\u751f\u5b58\u6240\u9700\u7684\u57fa\u672c\u4ee3\u8b1d\u53cd\u61c9\u3002
\nRNAP\u53ef\u4ee5\u53d7\u7279\u5b9a\u7684DNA\u5e8f\u5217\u5f71\u97ff\uff0c\u555f\u52d5\u8f49\u9304\uff0c\u9019\u6bb5\u7279\u5b9a\u7684DNA\u5e8f\u5217\u5c31\u7a31\u70ba\u555f\u52d5\u5b50\u3002\u63a5\u4e0b\u4f86\uff0c\u5408\u6210RNA\u93c8\uff0c\u8207\u505a\u70ba\u6a21\u677f\u7684DNA\u80a1\u4e92\u88dc\u3002\u5728RNA\u80a1\u4e0a\u589e\u52a0\u6838\u82f7\u9178\uff0c\u7a31\u70ba\u5ef6\u9577\u3002\u5728\u771f\u6838\u751f\u7269\u4e2d\uff0cRNAP\u53ef\u4ee5\u5408\u6210\u5169\u767e\u56db\u5341\u842c\u500b\u6838\u82f7\u7684\u9577\u93c8\uff08\u808c\u8089\u840e\u7e2e\u86cb\u767d\uff08dystrophin\uff09\u57fa\u56e0\u7684\u5168\u9577\uff09\u3002RNAP\u6703\u53d7\u7279\u5b9a\u7684DNA\u5e8f\u5217\u5f71\u97ff\uff0c\u91cb\u51faRNA\u8f49\u9304\u672c\uff0c\u9019\u6bb5\u7279\u5b9a\u7684DNA\u5e8f\u5217\u4f4d\u65bc\u57fa\u56e0\u672b\u7aef\uff0c\u7a31\u70ba\u7d42\u6b62\u5b50\uff08terminator\uff09\u3002<\/p>\n

RNAP\u7684\u7522\u7269\u5305\u62ec\uff1a<\/strong>
\n\u50b3\u8a0aRNA\uff08mRNA\uff09\u2500\u2500\u5728\u6838\u7cd6\u9ad4\u5408\u6210\u86cb\u767d\u8cea\u6642\uff0c\u505a\u70ba\u6a21\u677f\u3002<\/p>\n

\u975e\u7de8\u78bcRNA\uff0c\u53c8\u7a31\u300cRNA\u57fa\u56e0\u300d\u2500\u2500\u53ef\u70baRNA\u7de8\u78bc\u7684\u4e00\u5927\u7fa4\u57fa\u56e0\uff0c\u9019\u4e9bRNA\u4e0d\u6703\u8f49\u8b6f\u70ba\u86cb\u767d\u8cea\u3002RNA\u57fa\u56e0\u4e2d\uff0c\u6700\u91cd\u8981\u7684\u5be6\u4f8b\u70ba\u8f49\u9001RNA\uff08tRNA\uff09\u548c\u6838\u7cd6\u9ad4RNA\uff08rRNA\uff09\uff0c\u4e8c\u8005\u7686\u53c3\u8207\u8f49\u8b6f\u3002\u7136\u800c\uff0c\u81ea\u5f9e1990\u5e74\u4ee3\u665a\u671f\u4ee5\u4f86\uff0c\u767c\u73fe\u8a31\u591a\u65b0\u7684RNA\u57fa\u56e0\uff0c\u5176\u626e\u6f14\u7684\u89d2\u8272\uff0c\u53ef\u80fd\u9060\u8f03\u904e\u53bb\u60f3\u50cf\u7684\u91cd\u8981\u3002<\/p>\n

\u8f49\u9001RNA\uff08tRNA\uff09\u2500\u2500\u5408\u6210\u86cb\u767d\u8cea\u6642\uff0c\u5728\u8f49\u8b6f\u968e\u6bb5\uff0c\u8f49\u9001\u7279\u5b9a\u80fa\u57fa\u9178\u5230\u6210\u9577\u4e2d\u7684\u591a\u80bd\u93c8\u4e0a\u7684\u6838\u7cd6\u9ad4\u4f4d\u7f6e\u3002<\/p>\n

\u6838\u7cd6\u9ad4RNA\uff08rRNA\uff09\u2500\u2500\u6838\u7cd6\u9ad4\u7684\u6210\u5206\u4e4b\u4e00\u3002<\/p>\n

\u5faeRNA\uff08micro RNA\uff09\u2500\u2500\u8abf\u7bc0\u57fa\u56e0\u6d3b\u6027\u3002<\/p>\n

\u50ac\u5316\u6027RNA\uff08\u6838\u7cd6\u6838\u9178\u9175\u7d20\uff08Ribozyme\uff09\uff09\u2500\u2500\u9175\u7d20\u6d3b\u6027RNA\u5206\u5b50\u3002<\/p>\n

RNAP\u5b8c\u6210\u91cd\u751f\u5408\u6210\uff08de novo synthesis\uff09\u3002\u56e0\u70ba\u8d77\u59cb\u6838\u82f7\u9178\u7262\u7262\u56fa\u5b9aRNAP\uff0c\u4f7f\u5176\u8207\u8d77\u59cb\u6838\u82f7\u9178\u767c\u751f\u7279\u5b9a\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u6709\u5229\u65bc\u5c0d\u5916\u4f86\u7684\u6838\u82f7\u9178\u9032\u884c\u5316\u5b78\u653b\u64ca\uff0cRNAP\u624d\u6709\u8fa6\u6cd5\u5b8c\u6210\u91cd\u751f\u5408\u6210\u3002\u9019\u7a2e\u7279\u5b9a\u7684\u4ea4\u4e92\u4f5c\u7528\u53ef\u4ee5\u89e3\u91cb\u70ba\u4f55RNAP\u559c\u6b61\u7531ATP\u958b\u59cb\u8f49\u9304\uff08\u5176\u6b21\u662fGTP\u3001UTP\uff0c\u63a5\u8457\u662fCTP\uff09\u3002\u8207DNA\u805a\u5408\u9176\u76f8\u8f03\uff0cRNAP\u5305\u542b\u4e86\u89e3\u65cb\u9176\uff08helicase\uff09\u7684\u6d3b\u6027\uff0c\u56e0\u6b64\uff0c\u4e0d\u9700\u8981\u984d\u5916\u7684\u9176\u4f86\u89e3\u958bDNA\u7684\u87ba\u65cb\u3002
\n
\n\u53c3\u8003\u8cc7\u6599\uff1a<\/strong>
\nhttp:\/\/en.wikipedia.org\/wiki\/RNA_polymerase<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

RNA\u805a\u5408\u9176\uff08RNA Polymerase\uff09\uff08I\uff09 \u570b\u7acb\u65b0\u838a\u9ad8\u7d1a\u4e2d\u5b78\u9673\u5049\u6c11\u9000\u4f11\u6559\u5e2b\/\u570b\u7acb\u53f0\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u8449\u540d…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108,78,77],"tags":[1293,1292,1247],"class_list":["post-9295","post","type-post","status-publish","format-standard","hentry","category-chemistry00","category-chemistry08-01","category-chemistry08","tag-rna-polymerase","tag-rna","tag-1247","loop-entry","cat-108","cat-78","cat-77","no-thumbnail"],"views":12446,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/9295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=9295"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/9295\/revisions"}],"predecessor-version":[{"id":89546,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/9295\/revisions\/89546"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=9295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=9295"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=9295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}