{"id":74680,"date":"2016-12-10T16:22:23","date_gmt":"2016-12-10T08:22:23","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=74680"},"modified":"2021-10-06T16:03:42","modified_gmt":"2021-10-06T08:03:42","slug":"%e8%aa%bf%e6%8e%a7%e7%b4%b0%e8%83%9e%e5%85%a7%e9%88%a3%e9%9b%a2%e5%ad%90%e6%81%86%e5%ae%9a%e6%96%b0%e7%99%bc%e7%8f%be","status":"publish","type":"post","link":"http:\/\/localhost\/%e8%aa%bf%e6%8e%a7%e7%b4%b0%e8%83%9e%e5%85%a7%e9%88%a3%e9%9b%a2%e5%ad%90%e6%81%86%e5%ae%9a%e6%96%b0%e7%99%bc%e7%8f%be\/","title":{"rendered":"\u8abf\u63a7\u7d30\u80de\u5167\u9223\u96e2\u5b50\u6046\u5b9a\u65b0\u767c\u73fe"},"content":{"rendered":"<div class=\"pf-content\"><p><span style=\"color: #ff6600;\"><strong>\u8abf\u63a7\u7d30\u80de\u5167\u9223\u96e2\u5b50\u6046\u5b9a\u65b0\u767c\u73fe(New breakthrough to regulate calcium homeostasis of the cell)<\/strong><\/span><br \/>\n<span style=\"color: #008000;\"><strong>\u570b\u7acb\u81fa\u7063\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u8303\u59dc\u6587\u69ae\u7de8\u8b6f\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u674e\u51a0\u7fa4\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/strong><\/span><\/p>\n<p><span style=\"color: #333399;\"><strong>\u7de8\u8b6f\u4f86\u6e90\uff1a<a style=\"color: #333399;\" href=\"https:\/\/www.jst.go.jp\/pr\/announce\/20161001\/index.html\">\u7d30\u80de\u5185\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u4e00\u5b9a\u306b\u4fdd\u3064\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e<\/a><\/strong><\/span><\/p>\n<p>\u7d30\u80de\u5167\u9223\u96e2\u5b50\u6fc3\u5ea6\uff0c\u53d7\u7d30\u80de\u5916\u523a\u6fc0\u8b8a\u52d5\uff0c\u5c0d\u7d30\u80de\u589e\u6b96\u3001\u7d30\u80de\u6b7b\u4ea1\u3001\u808c\u8089\u6536\u7e2e\u3001\u514d\u75ab\u53cd\u61c9\u7b49\u5404\u7a2e\u751f\u547d\u73fe\u8c61\uff0c\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002\u7d30\u80de\u5167\u5c0f\u80de\u5668-\u5167\u8cea\u7db2(endoplasmic reticulum)\uff0c\u4f5c\u70ba\u9223\u96e2\u5b50\u5132\u5b58\u5eab\uff0c\u76f8\u8f03\u65bc\u300c\u7d30\u80de\u8cea\u6db2(cytosol)\u300d\uff0c\u7d04\u6709\u4e00\u842c\u500d\u7684\u9223\u96e2\u5b50\u6fc3\u5ea6\u3002\u53e6\u5916\u5167\u8cea\u7db2\u5b58\u5728\u8a31\u591a\u9175\u7d20\u6216\u5206\u5b50\u4f34\u8b77\u86cb\u767d(molecular 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id=\"attachment_74693\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2016\/12\/74680_p1.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-74693\" class=\"wp-image-74693\" src=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2016\/12\/74680_p1.png\" alt=\"74680_p1\" width=\"500\" height=\"375\" \/><\/a><p id=\"caption-attachment-74693\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90 : https:\/\/www.jst.go.jp\/pr\/announce\/20161001\/index.html<\/p><\/div>\n<p>\u904e\u53bb\u5df2\u77e5SERCA2b\u819c\u86cb\u767d\u5728\u5167\u8cea\u7db2\u5167\u5074\u5177\u67092\u8655\u63a5\u53d7\u6c27\u5316\u9084\u539f\u8abf\u63a7\u7684\u534a\u80f1\u80fa\u9178(cysteine)\uff0c\u7576\u5176\u786b\u6c2b\u57fa(-SH)\u6c27\u5316(\u4ea6\u5373\u5f62\u6210S-S\u96d9\u786b\u9375\u7d50)\uff0c\u9223\u96e2\u5b50\u651d\u53d6\u4fbf\u53d7\u6291\u5236\uff1b\u4f46\u4ecd\u672a\u77e5\u5982\u4f55\u9084\u539f\u88ab\u6c27\u5316\u7684\u534a\u80f1\u80fa\u9178\uff0c\u4ee5\u6d3b\u5316SERCA2b\u7684\u6a5f\u5236\u3002\u65e5\u672c\u4eac\u90fd\u7522\u696d\u5927\u5b78\u7b49\u7814\u7a76\u5718\u968a\uff0c\u5728\u672c\u7814\u7a76\u767c\u73fe\u5b58\u5728\u65bc\u5167\u8cea\u7db2\u5167\u7684S-S\u9375\u7d50\u9084\u539f\u9175\u7d20ERdj5\uff0c\u80fd\u5207\u65b7SERCA2b\u7684S-S\u9375\u7d50\uff0c\u9054\u5230\u9084\u539f\u6548\u679c\u3002<\/p>\n<p>\u4f7f\u7528\u4e0d\u5b58\u5728\u9084\u539f\u9175\u7d20ERdj5\u7684\u7d30\u80de\u4f86\u89c0\u5bdf\u9223\u96e2\u5b50\u651d\u53d6\uff0c\u767c\u73fe\u76f8\u8f03\u65bc\u5177\u6709ERdj5\u7684\u6b63\u5e38\u7d30\u80de\uff0cSERCA2b\u651d\u53d6\u9223\u96e2\u5b50\u7684\u6d3b\u6027\u986f\u8457\u4f4e\u4e0b\uff0c\u7121\u6cd5\u7dad\u6301\u5167\u8cea\u7db2\u5167\u6b63\u5e38\u7684\u9223\u96e2\u5b50\u6fc3\u5ea6\u3002\u4f34\u96a8\u5167\u8cea\u7db2\u9223\u96e2\u5b50\u6fc3\u5ea6\u4f4e\u4e0b\uff0c\u8a72\u7d30\u80de\u51fa\u73fe\u5167\u8cea\u7db2\u58d3\u529b(ER 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https:\/\/www.jst.go.jp\/pr\/announce\/20161001\/index.html<\/p><\/div>\n<p>\u8a72\u5718\u968a\u65bc2008\u5e74\u767c\u73feERdj5\u662f\u5206\u89e3\u8b8a\u6027\u86cb\u767d\u8cea\u5fc5\u8981\u7684\u9084\u539f\u9175\u7d20\uff0c\u70ba\u86cb\u767d\u8cea\u54c1\u8cea\u7ba1\u7406\u6709\u95dc\u5206\u5b50\uff1b\u672c\u6b21\u7814\u7a76\u9032\u4e00\u6b65\u767c\u73fe\u5b83\u4e5f\u5c0d\u9223\u96e2\u5b50\u6fc3\u5ea6\u6046\u5b9a\u7684\u7dad\u6301\uff0c\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n<p>\u7d30\u80de\u5167\u9223\u96e2\u5b50\u626e\u6f14\u591a\u91cd\u89d2\u8272\uff0c\u82e5\u9223\u96e2\u5b50\u6046\u5b9a\u53d7\u7834\u58de\uff0c\u6703\u51fa\u73fe\u7d30\u80de\u6a5f\u80fd\u4f4e\u4e0b\uff0c\u751a\u81f3\u6b7b\u4ea1\uff0c\u53ef\u80fd\u662f\u9020\u6210\u764c\u75c7\u3001\u7cbe\u795e\u75c5\u60a3\u7b49\u8a31\u591a\u56b4\u91cd\u75be\u75c5\u7684\u539f\u56e0\u3002\u8a72\u7814\u7a76\u5c0d\u9223\u96e2\u5b50\u6fc3\u5ea6\u6046\u5b9a\u6a5f\u5236\u7684\u65b0\u767c\u73fe\uff0c\u6709\u52a9\u65bc\u672a\u4f86\u958b\u767c\u9019\u4e9b\u75be\u75c5\u6cbb\u7642\u6cd5\u3002\u8a72\u7814\u7a76\u6210\u679c2016\u5e74 9\u6708\u520a\u8f09\u65bc\u79d1\u5b78\u671f\u520a\u300cProceedings of the National Academy of Sciences\u300d\u3002<\/p>\n<hr \/>\n<p><strong>\u540d\u8a5e\u89e3\u91cb<\/strong><\/p>\n<ol>\n<li>\u5167\u8cea\u7db2 : \u7d30\u80de\u5167\u7db2\u72c0\u76f8\u9023\u7684\u819c\u72c0\u5c0f\u80de\u5668\uff0c\u9664\u4e86\u5132\u5b58\u9223\u96e2\u5b50\uff0c\u4e5f\u8ca0\u8cac\u5206\u6ccc\u6027\u86cb\u767d\u8cea\u7684\u647a\u758a(folding)\u6216\u4fee\u98fe\u3001\u8102\u8cea\u4ee3\u8b1d\u3001\u7d30\u80de\u5167\u7269\u8cea\u904b\u8f38\u7b49\u3002<\/li>\n<li>S-S\u9375\u7d50 : \u76f8\u9130\u76842\u500b\u534a\u80f1\u80fa\u9178(cysteine)\u4e0a\u7684\u786b\u6c2b\u57fa(-SH)\u53d7\u5230\u6c27\u5316\uff0c\u786b\u539f\u5b50\u9593\u7d50\u5408\u70baS-S\u9375\u7d50\u3002<\/li>\n<li>\u5167\u8cea\u7db2\u58d3\u529b : 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