{"id":73176,"date":"2016-07-19T09:00:10","date_gmt":"2016-07-19T01:00:10","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=73176"},"modified":"2021-10-06T16:04:05","modified_gmt":"2021-10-06T08:04:05","slug":"%e9%8f%a1%e5%83%8f%e7%95%b0%e6%a7%8b%e7%89%a9%e7%9a%84%e5%88%86%e9%9b%a2%e6%96%b9%e6%b3%95%ef%bc%88%e4%b8%8a%ef%bc%89","status":"publish","type":"post","link":"http:\/\/localhost\/%e9%8f%a1%e5%83%8f%e7%95%b0%e6%a7%8b%e7%89%a9%e7%9a%84%e5%88%86%e9%9b%a2%e6%96%b9%e6%b3%95%ef%bc%88%e4%b8%8a%ef%bc%89\/","title":{"rendered":"\u93e1\u50cf\u7570\u69cb\u7269\u7684\u5206\u96e2\u65b9\u6cd5\uff08\u4e0a\uff09"},"content":{"rendered":"

\u93e1\u50cf\u7570\u69cb\u7269\u7684\u5206\u96e2\u65b9\u6cd5\uff08\u4e0a\uff09(Separation of Enantiomeric (I))<\/strong><\/span>
\n\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u78a9\u58eb\u73ed \u859b\u5712\u99a8<\/strong><\/span><\/p>\n

\u76ee\u524d\u91ab\u5b78\u4e0a\u5f88\u591a\u85e5\u7269\u90fd\u662f\u64c1\u6709\u4e00\u500b\u6216\u591a\u500b\u7acb\u9ad4\u4e2d\u5fc3\u7684\u5316\u5b78\u5206\u5b50\uff0c\u5728\u9019\u4e9b\u85e5\u7269\u4e2d\uff0c\u6709\u4e9b\u85e5\u7269\u7684\u93e1\u50cf\u7570\u69cb\u7269\u5c0d\u4eba\u9ad4\u6709\u5f37\u70c8\u526f\u4f5c\u7528\uff0c\u6700\u8457\u540d\u7684\u5c31\u662f 1953 \u5e74\u5fb7\u570b\u683c\u862d\u6cf0\u516c\u53f8\u767c\u660e\u7684\u6297\u598a\u5a20\u53cd\u61c9\u85e5\u7269\u6c99\u5229\u7ac7\u9081 (thalidomide)\uff08\u5716\u4e00\uff09\uff0c1956 \u5e74\u8ca9\u552e\uff0c\u4f46\u5728 1960 \u5e74\u6642\u767c\u73fe\u7522\u4e0b\u7578\u5f62\u5152\u7684\u6578\u91cf\u6709\u4e0d\u5c0b\u5e38\u63d0\u5347\uff0c\u5728\u8abf\u67e5\u904e\u7578\u5f62\u5152\u7684\u6bcd\u89aa\u5f8c\u767c\u73fe\u5927\u591a\u90fd\u6709\u670d\u7528\u6c99\u5229\u7ac7\u9081\uff0c\u6700\u5f8c\u5fb7\u570b\u683c\u862d\u6cf0\u516c\u53f8\u5728 1961 \u5e74 11 \u6708\u64a4\u56de\u5e02\u5834\u4e0a\u6240\u6709\u6c99\u5229\u7ac7\u9081\uff0c\u4f46\u5728\u9019\u77ed\u77ed\u4e94\u5e74\u671f\u9593\uff0c\u9020\u6210\u4e86\u4e0a\u842c\u540d\u6d77\u8c79\u80a2\u75c7 (phocomelia) \u7684\u5b69\u7ae5\uff08\u5716\u4e8c\uff09\u3002<\/p>\n

\"73176_p1\"<\/a>

\u5716\u4e00\u3001\u6c99\u5229\u7ac7\u9081\u7684\u5316\u5b78\u7d50\u69cb\u5f0f\u3002\uff08\u5716\u7247\u4f86\u6e90:\u81ea\u88fd\uff09<\/p><\/div>\n

\"73176_p2\"<\/a>

\u5716\u4e8c\u3001\u60a3\u6709\u6d77\u8c79\u80a2\u75c7\u7684\u5c0f\u5b69\u3002\uff08\u5716\u7247\u4f86\u6e90:Leonard McCombe \/ Time Life Pictures \/ Getty Images\uff09<\/p><\/div>\n

\u7d93\u904e\u5316\u5b78\u5bb6\u7684\u7814\u7a76\u5f8c\u767c\u73fe\uff0c(R<\/em>)-Thalidomide \u662f\u5c0d\u4eba\u9ad4\u662f\u7121\u5bb3\u7684\uff0c\u4f46 (S<\/em>)-Thalidomide \u5c31\u662f\u9020\u6210\u6d77\u8c79\u80a2\u75c7\u7684\u4e3b\u56e0\uff0c\u9019\u4ef6\u4e8b\u8b93\u5316\u5b78\u5bb6\u4e86\u89e3\u4e0d\u540c\u7684\u93e1\u50cf\u7570\u69cb\u7269\u5728\u4eba\u9ad4\u88e1\u9762\u7684\u53cd\u61c9\u662f\u5927\u76f8\u9015\u5ead\u7684\uff0c\u60f3\u8981\u5f97\u5230\u55ae\u4e00\u93e1\u50cf\u85e5\u7269\u53ef\u4ee5\u4f7f\u7528\u4e0d\u5c0d\u7a31\u5408\u6210 (asymmetric synthesis)\uff0c\u85c9\u7531\u52a0\u5165\u4e00\u4e9b\u6709\u5149\u5b78\u6d3b\u6027\u7684\u5206\u5b50\uff08\u5f88\u591a\u662f\u7531\u5929\u7136\u7269\u5206\u96e2\u51fa\u4f86\uff09\u4f86\u63a7\u5236\u5176\u7522\u7269\u7684\u7acb\u9ad4\u9078\u64c7\u6027\uff0c\u9019\u4e5f\u662f\u8fd1\u5e74\u4f86\u6709\u6a5f\u5316\u5b78\u5bb6\u52aa\u529b\u767c\u5c55\u7684\u9818\u57df\uff0c\u4f46\u6709\u4e9b\u85e5\u7269\u7684\u88fd\u7a0b\u5f88\u96e3\u9054\u5230\u53ea\u6709\u55ae\u4e00\u93e1\u50cf\u7522\u7269\uff0c\u56e0\u6b64\u8981\u7d14\u5316\u9019\u4e9b\u93e1\u50cf\u7570\u69cb\u7269\u4fbf\u662f\u5316\u5b78\u5bb6\u5fc5\u9808\u9762\u5c0d\u7684\u6311\u6230\u3002<\/p>\n

\u93e1\u50cf\u7570\u69cb\u7269\u7684\u5927\u90e8\u5206\u7269\u7406\u6027\u8cea\uff08\u5982\u6cb8\u9ede\u3001\u7194\u9ede\u3001\u6975\u6027\u2026\u2026\u7b49\u7b49\uff09\u5728\u975e\u624b\u6027\u74b0\u5883\u4e0b\u90fd\u76f8\u540c\uff0c\u56e0\u6b64\u4e0d\u80fd\u7528\u50b3\u7d71\u5206\u96e2\u65b9\u6cd5\u5982\uff08\u84b8\u993e\u3001\u55ae\u7d14\u518d\u7d50\u6676\u3001\u7ba1\u67f1\u5c64\u6790\u2026\u2026\u7b49\uff09\u5206\u96e2\uff0c\u4e16\u754c\u4e0a\u7b2c\u4e00\u500b\u4f7f\u7528\u7269\u7406\u65b9\u6cd5\u5206\u96e2\u93e1\u50cf\u7570\u69cb\u7269\u7684\u662f\u5df4\u65af\u5fb7 (Louis Pasteur)\uff0c\u4ed6\u5229\u7528\u5149\u5728 (R<\/em>)-form \u8207 (S<\/em>)-form \u5176\u504f\u8f49\u89d2\u5ea6\u76f8\u540c\uff0c\u65b9\u5411\u76f8\u53cd\u7684\u6027\u8cea\uff0c\u4f7f\u7528\u7269\u7406\u65b9\u6cd5\u5206\u96e2\u539f\u672c\u662f\u5916\u6d88\u65cb\u6df7\u5408\u7269 (racemic mixture) \u7684\u9152\u77f3\u9178\u9209\u6c28\u9e7d \uff08\u5716\u4e09\uff09\u3002<\/p>\n

\"73176_p3\"<\/a>

\u5716\u4e09\u3001\u9152\u77f3\u9178\u9209\u6676\u9ad4\u3002\uff08\u5716\u7247\u4f86\u6e90:\u81ea\u88fd\uff09<\/p><\/div>\n

\u5728\u5316\u5b78\u5bb6\u591a\u5e74\u52aa\u529b\u4e0b\uff0c\u5206\u96e2\u5916\u6d88\u65cb\u6df7\u5408\u7269\u7684\u65b9\u6cd5\u8b8a\u6210\u4e86\u4e00\u500b\u7814\u7a76\u9818\u57df\uff1a\u624b\u6027\u62c6\u5206 (chiral resolution)\uff0c\u624b\u6027\u62c6\u5206\uff08\u5716\u56db\uff09\u53c8\u7d30\u5206\u70ba\u5f88\u591a\u7a2e\u65b9\u6cd5\uff1a\u7d50\u6676\u6cd5\u3001\u5316\u5b78\u62c6\u5206\u6cd5\u3001\u7ba1\u67f1\u6cd5\u3001\u751f\u7269\u62c6\u5206\u6cd5\u3001\u52d5\u529b\u5b78\u62c6\u5206\u6cd5\u3001\u8403\u53d6\u62c6\u5206\u6cd5\u2026\u2026\u7b49\u5404\u5f0f\u5404\u6a23\u7684\u6280\u8853\u4f86\u56e0\u61c9\u4e0d\u540c\u7684\u5916\u6d88\u65cb\u6df7\u5408\u72692<\/sup>\u3002<\/p>\n

\"73176_p4\"<\/a>

\u5716\u56db\u3001\u624b\u6027\u62c6\u5206\u6cd5\u3002\uff08\u5716\u7247\u4f86\u6e90:\u81ea\u88fd\uff09<\/p><\/div>\n

I<\/strong>\u3001<\/strong>\u7ba1\u67f1\u5c64\u6790\u6cd5\uff08\u7ba1\u67f1\u6cd5\uff09\uff1a<\/strong><\/span><\/p>\n

\u5728\u5be6\u9a57\u5ba4\u6700\u666e\u904d\u7684\u5206\u96e2\u65b9\u6cd5\u662f\u9ad8\u6548\u6db2\u76f8\u624b\u6027\u7ba1\u67f1\u5c64\u6790\u6cd53<\/sup>\uff0c\u662f\u5be6\u9a57\u5ba4\u4e2d\u5e38\u6709\u7684\u624b\u6027\u5206\u96e2\u8a2d\u5099\uff08\u5716\u4e94\uff09\u3002\u5176\u539f\u7406\u662f\u5728\u7ba1\u67f1\u4e0a\u5857\u88dd (coating) \u4e0a\u4e00\u5c64\u55ae\u4e00\u5149\u5b78\u7570\u69cb\u7269\uff0c\u5229\u7528\u5149\u5b78\u7570\u69cb\u7269\u5728\u624b\u6027\u74b0\u5883\u4e2d\u7269\u7406\u6027\u8cea\u4e0d\u540c\u4f86\u5206\u96e2\uff0c\u5982\u5716\u516d\u6240\u793a\uff1b\u5c31\u597d\u50cf\u4eba\u7fa4\u6bcf\u500b\u4eba\u90fd\u4f38\u51fa\u53f3\u624b\u60f3\u548c\u4f60\u63e1\u624b\uff0c\u4f60\u4f38\u51fa\u5de6\u624b\u7684\u5c31\u6c92\u8fa6\u6cd5\u63e1\u624b\u800c\u9806\u5229\u901a\u904e\uff0c\u4f46\u4f38\u51fa\u53f3\u624b\u7684\u4eba\u5c31\u6703\u4e00\u76f4\u63e1\u624b\u800c\u7559\u4e0b\u3002\u4f46\u4e26\u4e0d\u662f\u6240\u6709\u5916\u6d88\u65cb\u6df7\u5408\u7269\u90fd\u53ef\u4ee5\u5229\u7528\u6b64\u65b9\u6cd5\uff0c\u56e0\u6b64\u5be6\u969b\u64cd\u4f5c\u53c8\u5206\u70ba\u5169\u7a2e\u65b9\u6cd5\uff0c\u4e00\u500b\u662f\u627e\u5230\u6700\u597d\u7684\u624b\u6027\u56fa\u5b9a\u76f8 (chiral stationary phases) \u5857\u88dd\u5728\u7ba1\u67f1\u4e0a\uff0c\u4e8c\u662f\u5c07\u6b32\u5206\u96e2\u7684\u5916\u6d88\u65cb\u6df7\u5408\u7269\u4f5c\u5ef6\u4f38\uff0c\u4f7f\u5176\u9069\u7528\u5728\u5df2\u6709\u7684\u624b\u6027\u7ba1\u67f1\u5206\u96e2\uff0c\u7ba1\u67f1\u6cd5\u7684\u512a\u9ede\u662f\u80fd\u61c9\u7528\u5728\u5927\u90e8\u5206\u7684\u5149\u5b78\u7570\u69cb\u7269\uff0c\u7f3a\u9ede\u662f\u6602\u8cb4\u3001\u5206\u96e2\u91cf\u5c11\u3002<\/p>\n

\"73176_p5\"<\/a>

\u5716\u4e94\u3001\u9ad8\u6548\u6db2\u76f8\u624b\u6027\u7ba1\u67f1\u5c64\u6790\u5100\u8207\u624b\u6027\u7ba1\u67f1\u3002\uff08\u5716\u7247\u4f86\u6e90:\u81ea\u88fd\uff09<\/p><\/div>\n

\"73176_p6\"<\/a>

\u5716\u516d\u3001\u624b\u6027\u62c6\u5206\u6cd5\u539f\u7406\u793a\u610f\u5716\u3002\uff08\u5716\u7247\u4f86\u6e90:\u81ea\u88fd\uff09<\/p><\/div>\n

\u9023\u7d50\uff1a\u93e1\u50cf\u7570\u69cb\u7269\u7684\u5206\u96e2\u65b9\u6cd5\uff08\u4e2d\uff09<\/a><\/p>\n

\n

\u53c3\u8003\u6587\u737b<\/strong><\/p>\n

    \n
  1. Pasteur, L. (1848). Recherches sur les relations qui peuvent exister entre la forme cristalline, la composition chimique et les sens de la polarisation rotatoire<\/em>. Impr. Bachelier.<\/li>\n
  2. Carvalho, P. O., Cass, Q. B., Calafatti, S. A., Contesini, F. J., & Bizaco, R. (2006). Review-Alternatives for the separation of drug enantiomers: ibuprofen as a model compound. Brazilian Journal of Chemical Engineering<\/em>, 23<\/em>(3), 291-300.<\/li>\n
  3. \u00d4i, N., Kitahara, H., Aoki, F., & Kisu, N. (1995). Direct separation of carboxylic acid enantiomers by high-performance liquid chromatography with amide and urea derivatives bonded to silica gel as chiral stationary phases. Journal of Chromatography A<\/em>, 689<\/em>(2), 195-201.<\/li>\n
  4. Tung et al.<\/em> (1995)<\/strong>. AIChE Symposium Series<\/em>, 91<\/em>, 64.<\/li>\n
  5. Maier, N. M., Franco, P., & Lindner, W. (2001). Separation of enantiomers: needs, challenges, perspectives. Journal of Chromatography A<\/em>, 906<\/em>(1), 3-33.<\/li>\n
  6. Nadin, A., & Harrison, T. (1999). Synthesis of tricyclic pyridones by radical cyclization. Tetrahedron letters<\/em>, 40<\/em>(21), 4073-4076.<\/li>\n
  7. Lee, W. H., Kim, K. J., Kim, M. G., & Lee, S. B. (1995). Enzymatic resolution of racemic ibuprofen esters: effects of organic cosolvents and temperature. Journal of fermentation and bioengineering<\/em>, 80<\/em>(6), 613-615.<\/li>\n
  8. \u674e\u4fca\u3001\u8521\u6c34\u6d2a\u7b49 (2001)\u3002\u5316\u5b66\u4e16\u754c\u3002233\u3002<\/li>\n<\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"

    \u93e1\u50cf\u7570\u69cb\u7269\u7684\u5206\u96e2\u65b9\u6cd5\uff08\u4e0a\uff09(Separation of Enantiomeric (I)) \u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,108,78,77,54],"tags":[2611,10340,10341,10339,7127,2610],"class_list":["post-73176","post","type-post","status-publish","format-standard","hentry","category-chemistry02-03","category-chemistry00","category-chemistry08-01","category-chemistry08","category-chemistry02","tag-enantiomer","tag-separation","tag-thalidomide","tag-10339","tag-7127","tag-2610","loop-entry","cat-57","cat-108","cat-78","cat-77","cat-54","no-thumbnail"],"views":12300,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/73176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=73176"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/73176\/revisions"}],"predecessor-version":[{"id":86059,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/73176\/revisions\/86059"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=73176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=73176"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=73176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}