{"id":7163,"date":"2010-09-10T07:37:38","date_gmt":"2010-09-09T23:37:38","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=7163"},"modified":"2021-10-06T16:32:17","modified_gmt":"2021-10-06T08:32:17","slug":"%e5%96%ae%e6%a0%aa%e6%8a%97%e9%ab%94%ef%bc%88monoclonal-antibody%ef%bc%89-%e4%b8%8a","status":"publish","type":"post","link":"http:\/\/localhost\/%e5%96%ae%e6%a0%aa%e6%8a%97%e9%ab%94%ef%bc%88monoclonal-antibody%ef%bc%89-%e4%b8%8a\/","title":{"rendered":"\u55ae\u682a\u6297\u9ad4\uff08Monoclonal Antibody\uff09-\u4e0a"},"content":{"rendered":"<div class=\"pf-content\"><p><strong><span style=\"color: #ff6600;\">\u55ae\u682a\u6297\u9ad4\uff08Monoclonal Antibody\uff09-\u4e0a<br \/>\n<\/span><span style=\"color: #008000;\">\u570b\u7acb\u5609\u7fa9\u9ad8\u7d1a\u5546\u696d\u8077\u696d\u5b78\u6821\u751f\u7269\u79d1\u88d8\u6587\u99a5\u8001\u5e2b\/\u570b\u7acb\u53f0\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u674e\u51a0\u7fa4\u52a9\u7406\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/span><\/strong><\/p>\n<p>\u7576\u8eab\u9ad4\u6709\u5916\u4f86\u7684\u7269\u8cea\uff08\u7a31\u70ba\u6297\u539f\uff0cantigen\uff09\u4fb5\u5165\u6642\uff0c\u9ad4\u5167\u6703\u63a1\u53d6\u8a31\u591a\u9632\u79a6\u63aa\u65bd\u4f86\u7834\u58de\u6216\u963b\u64cb\u9019\u4e9b\u7269\u8cea\uff0c\u800cB\u7d30\u80de\u6240\u5206\u6ccc\u7684\u6297\u9ad4\uff08antibody\uff09\u4fbf\u662f\u5176\u4e2d\u4e00\u7a2e\u65b9\u5f0f\u3002\u6bcf\u7a2e\u6297\u539f\u5206\u5b50\u4e0a\u901a\u5e38\u6709\u8a31\u591a\u53ef\u8a98\u5c0e\u51fa\u6297\u9ad4\u7684\u90e8\u5206\uff0c\u7a31\u70ba\u6297\u539f\u6c7a\u5b9a\u57fa (antigenic determinant)\uff0c\u800c\u6bcf\u500bB\u7d30\u80de\u53ea\u80fd\u91dd\u5c0d\u4e00\u7a2e\u6297\u539f\u6c7a\u5b9a\u57fa\uff0c\u7522\u751f\u4e00\u7a2e\u6297\u9ad4\uff0c\u56e0\u6b64\u5728\u50b3\u7d71\u7684\u8840\u6e05\u4e2d\uff0c\u542b\u6709\u8a31\u591a\u7a2e\u4e0d\u540c\u7684\u6297\u9ad4\uff0c\u5206\u5225\u5c0d\u6297\u4e0d\u540c\u7684\u6297\u539f\u6c7a\u5b9a\u57fa\u3002\u82e5\u80fd\u6311\u51fa\u5404\u500bB\u7d30\u80de\uff0c\u55ae\u7368\u57f9\u990a\u6210\u7d30\u80de\u682a\uff0c\u5247\u80fd\u7372\u5f97\u55ae\u4e00\u7a2e\u985e\u7684\u6297\u9ad4\uff0c\u53ea\u6703\u5c0d\u67d0\u4e00\u7279\u5b9a\u6297\u539f\u6c7a\u5b9a\u57fa\u53cd\u61c9\uff0c\u5247\u6b64\u6297\u9ad4\u7a31\u70ba\u55ae\u682a\u6297\u9ad4\uff08monoclonal antibody\uff09\u3002<!--more--><\/p>\n<p>\u4e00\u822c\u7d30\u80de\uff0c\u5305\u62ecB\u7d30\u80de\uff0c\u90fd\u6709\u4e00\u5b9a\u7684\u751f\u547d\uff0c\u5230\u9054\u4e00\u6bb5\u6642\u9593\u4e4b\u5f8c\u5c31\u6703\u6b7b\u4ea1\uff0c\u82e5\u60f3\u8981\u5728\u9ad4\u5916\u5927\u91cf\u57f9\u990aB\u7d30\u80de\u662f\u4e0d\u5bb9\u6613\u7684\u4e8b\u30021975\u5e74\u6642\uff0c\u67ef\u52d2\uff08George K&amp;ouml;hler\uff09\u8207\u9ea5\u723e\u65af\u5766\uff08Cesar Milstein\uff09\u5c07B\u7d30\u80de\u8207\u9aa8\u9ad3\u7624\u7d30\u80de\uff08myeloma cells\uff09\u6210\u529f\u5730\u878d\u5408\uff0c\u7a31\u70ba\u878d\u5408\u7624\uff08hybridoma\uff09\uff0c\u56e0\u764c\u7d30\u80de\uff08cancer cell\uff09\u53ef\u4e0d\u65b7\u5206\u88c2\u3001\u589e\u6b96\uff0c\u6240\u4ee5\u878d\u5408\u7624\u5247\u540c\u6642\u5177\u6709B\u7d30\u80de\u5206\u6ccc\u6297\u9ad4\u3001\u548c\u764c\u7d30\u80de\u4e0d\u65b7\u5206\u88c2\u7684\u7279\u6027\uff0c\u82e5\u57f9\u990a\u6b64\u7d30\u80de\u682a\uff0c\u53ef\u88fd\u9020\u51fa\u5927\u91cf\u7d14\u5ea6\u9ad8\u7684\u5c08\u4e00\u6027\u55ae\u682a\u6297\u9ad4\uff0c\u53ef\u7528\u4f86\u5f9e\u4e8b\u5404\u9805\u7814\u7a76\u5de5\u4f5c\u3002<\/p>\n<p>\uff08\u4e00\uff09\u55ae\u682a\u6297\u9ad4\u7684\u88fd\u4f5c<br \/>\n<a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2010\/09\/3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7162\" title=\"3\" src=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2010\/09\/3.jpg\" alt=\"\" width=\"413\" height=\"452\" \/><\/a><br \/>\n\u5716\u7247\u4f86\u6e90\uff1a<\/p>\n<p>1.\u5c07\u6297\u539f\u6253\u5165\u8001\u9f20\u9ad4\u5167\uff0c\u5247\u8001\u9f20\u6703\u7522\u751f\u514d\u75ab\u53cd\u61c9\u3002\u6297\u539f\u901a\u5e38\u5177\u6709\u8a31\u591a\u6297\u539f\u6c7a\u5b9a\u57fa\uff0c\u56e0\u6b64\u8001\u9f20\u9ad4\u5167\u6703\u7522\u751f\u591a\u7a2e\u5c0d\u6297\u6297\u539f\u6c7a\u5b9a\u57fa\u7684\u6297\u9ad4\u3002<\/p>\n<p>2.\u53d6\u51fa\u8001\u9f20\u7684\u813e\u81df\u7d30\u80de\uff08\u5927\u591a\u70baB\u7d30\u80de\uff09\uff0c\u8207\u9aa8\u9ad3\u7624\u7d30\u80de\u878d\u5408\uff0c\u4ee5\u5f62\u6210\u878d\u5408\u7624\u3002<\/p>\n<p>3.\u5c07\u878d\u5408\u7624\u7d30\u80de\u57f9\u990a\u5728\u57f9\u990a\u57fa\u4e0a\uff0c\u82e5\u80fd\u5b58\u6d3b\u4e0b\u4f86\u8005\uff0c\u5373\u70ba\u6210\u529f\u7684\u878d\u5408\u7624\u7d30\u80de\u3002<\/p>\n<p>4.\u5f9e\u6210\u529f\u7684\u878d\u5408\u7624\u7d30\u80de\u7be9\u9078\u51fa\u6703\u7522\u751f\u6240\u9700\u8981\u7684\u5c08\u4e00\u6027\u6297\u9ad4\u7684\u7d30\u80de\u682a\u3002<\/p>\n<p>5.\u5927\u91cf\u57f9\u990a\u8a72\u7d30\u80de\u682a\uff0c\u53ef\u5f9e\u57f9\u990a\u6db2\u4e2d\u7372\u5f97\u5927\u91cf\u7684\u55ae\u682a\u6297\u9ad4\u3002<\/p>\n<p>\u8acb\u53c3\u7167<a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=7166\">\u55ae\u682a\u6297\u9ad4\uff08Monoclonal Antibody\uff09-\u4e0b<\/a><\/p>\n<p>\u53c3\u8003\u8cc7\u6599<br \/>\n1.Ezzell C (2001) Magic Bullets Fly Again. Scientific American 285, pp28~35<br \/>\n2.Richard A. Goldsby et al (2000) Kuby Immunology (4e) <a href=\"http:\/\/www.whfreeman.com\/kuby\/\">http:\/\/www.whfreeman.com\/kuby\/<\/a><br \/>\n3.\u55ae\u682a\u6297\u9ad4\u3002<a href=\"http:\/\/juang.bst.ntu.edu.tw\/ECX\/monoclonal.htm\">http:\/\/juang.bst.ntu.edu.tw\/ECX\/monoclonal.htm<\/a>\u3002<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u55ae\u682a\u6297\u9ad4\uff08Monoclonal Antibody\uff09-\u4e0a \u570b\u7acb\u5609\u7fa9\u9ad8\u7d1a\u5546\u696d\u8077\u696d\u5b78\u6821\u751f\u7269\u79d1\u88d8\u6587\u99a5\u8001\u5e2b\/\u570b\u7acb\u53f0\u7063\u5e2b\u7bc4&hellip;<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[110,4815,1166],"tags":[1168,1169,1170],"class_list":["post-7163","post","type-post","status-publish","format-standard","hentry","category-lifesciecne00","category-lifesciecne006","category-lifesciecne006-05","tag-b","tag-1169","tag-1170","loop-entry","cat-110","cat-4815","cat-1166","no-thumbnail"],"views":25392,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/7163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=7163"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/7163\/revisions"}],"predecessor-version":[{"id":89753,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/7163\/revisions\/89753"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=7163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=7163"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=7163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}