{"id":62702,"date":"2015-04-16T14:37:06","date_gmt":"2015-04-16T06:37:06","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=62702"},"modified":"2021-10-06T16:11:41","modified_gmt":"2021-10-06T08:11:41","slug":"%e7%b4%b0%e8%83%9e%e5%85%a7%e6%b8%ac%e9%87%8f%e9%95%b7%e5%ba%a6%e7%9a%84%e8%9b%8b%e7%99%bd%e8%b3%aa","status":"publish","type":"post","link":"http:\/\/localhost\/%e7%b4%b0%e8%83%9e%e5%85%a7%e6%b8%ac%e9%87%8f%e9%95%b7%e5%ba%a6%e7%9a%84%e8%9b%8b%e7%99%bd%e8%b3%aa\/","title":{"rendered":"\u7d30\u80de\u5167\u6e2c\u91cf\u9577\u5ea6\u7684\u86cb\u767d\u8cea"},"content":{"rendered":"

\u7d30\u80de\u5167\u6e2c\u91cf\u9577\u5ea6\u7684\u86cb\u767d\u8cea(A nanometer ruler determines the repeat length)<\/strong><\/span>
\n\u570b\u7acb\u81fa\u7063\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u8303\u59dc\u6587\u69ae\u7de8\u8b6f\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u674e\u51a0\u7fa4\u526f\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/strong><\/span><\/p>\n

\u7de8\u8b6f\u4f86\u6e90\uff1a\u7d30\u80de\u5185\u3067\u9577\u3055\u3092\u6e2c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u898b<\/a>\u3001A molecular ruler determines the repeat length in eukaryotic cilia and flagella<\/a><\/strong><\/span><\/p>\n

\u4f60\u662f\u5426\u80fd\u6e2c\u91cf\u5948\u7c73\u5927\u5c0f\u7684\u9577\u5ea6\u5462?\u5948\u7c73\u662f\u6beb\u7c73\u7684\u767e\u842c\u5206\u4e4b\u4e00\uff0c\u6bd4\u982d\u9aee\u5c16\u7aef\u66f4\u5fae\u7d30\uff0c\u7121\u6cd5\u5f92\u624b\u6e2c\u91cf\u3002\u5728\u4eba\u985e\u7d30\u80de\u5167\uff0c\u5177\u6709\u7121\u6578\u56fa\u5b9a\u9577\u5ea6\u6216\u5927\u5c0f\u7684\u69cb\u9020\uff0c\u7d30\u80de\u5408\u6210\u9019\u4e9b\u69cb\u9020\u6642\uff0c\u7a76\u7adf\u662f\u5982\u4f55\u6e2c\u91cf\u5b83\u5011\u7684\u9577\u5ea6\u5462? \u6709\u7814\u7a76\u8005\u63d0\u51fa\u300c\u5948\u7c73\u5206\u5b50\u5c3a\u898f\u300d\u5047\u8aaa\uff0c\u8a8d\u70ba\u5b58\u5728\u56fa\u5b9a\u9577\u5ea6\u7684\u86cb\u767d\u8cea\u4f5c\u70ba\u5948\u7c73\u5206\u5b50\u5c3a\u898f(\u7c21\u7a31\u5948\u7c73\u5c3a)\uff0c\u4f86\u8abf\u63a7\u9019\u4e9b\u69cb\u9020\u7684\u9577\u5ea6\u3002\u96d6\u904e\u53bb\u7814\u7a76\u6307\u51fa\u8f03\u70ba\u539f\u59cb\u7684\u539f\u6838\u751f\u7269\u5982\u7d30\u83cc\u6216\u75c5\u6bd2\u7b49\u5177\u6709\u5948\u7c73\u5c3a\uff0c\u4f46\u4ecd\u4e0d\u77e5\u9ad8\u7b49\u751f\u7269\u5982\u4eba\u985e\u662f\u5426\u4e5f\u6709\u5948\u7c73\u5c3a\u3002<\/p>\n

\u65e5\u672c\u6771\u4eac\u5927\u5b78\u91ab\u5b78\u7814\u7a76\u6240\u7684\u7814\u7a76\u5718\u968a\uff0c\u4f7f\u7528\u8d85\u4f4e\u6eab\u96fb\u5b50\u986f\u5fae\u93e1(cryo-electron tomography)\u9996\u6b21\u8b49\u5be6\u9ad8\u7b49\u751f\u7269\u4e5f\u6709\u5948\u7c73\u5c3a\uff0c\u5206\u4f48\u65bc\u4eba\u9ad4\u6c23\u7ba1\u3001\u7cbe\u5b50\u3001\u8f38\u5375\u7ba1\u3001\u53ca\u8166\u5ba4\u7d30\u80de\u7684\u7d72\u72c0\u7d50\u69cb\u300c\u7e96\u6bdb(cilla)\u300d\u6216\u300c\u97ad\u6bdb(flagella)\u300d\u4e2d\u4ee5\u7dad\u6301\u6a5f\u80fd\u904b\u4f5c\uff0c\u7814\u7a76\u7d50\u679c2014\u5e7411\u6708\u520a\u8f09\u65bc\u79d1\u5b78\u671f\u520a\u300cScience\u300d\u3002<\/p>\n

\"11111\"<\/a>

\uff08\u5716\u7247\u7de8\u8b6f\u4f86\u6e90\uff1a\u6771\u4eac\u5927\u5b78\u7814\u7a76\u5831\u5c0ehttp:\/\/www.u-tokyo.ac.jp\/ja\/utokyo-research\/research-news\/a-molecular-ruler-in-eukaryotic-cells\/\uff09<\/p><\/div>\n

\u7e96\u6bdb\u8207\u97ad\u6bdb\u7684\u7d50\u69cb\u5e7e\u4e4e\u76f8\u540c\uff0c\u5176\u9577\u5ea6\u6578\u5fae\u7c73\u81f3\u6578\u5341\u5fae\u7c73\uff0c\u7c97\u7d30200\u5948\u7c73\u5de6\u53f3\uff0c\u662f\u4e00\u7a2e\u975e\u5e38\u5fae\u7d30\u7684\u7d30\u80de\u7a81\u51fa\u7d72\u72c0\u69cb\u9020\uff0c\u80fd\u85c9\u5f62\u6210\u6c34\u6ce2\u5f15\u767c\u6db2\u9ad4\u6d41\u52d5\u3002\u4f8b\u5982\uff1a\u7cbe\u5b50\u64fa\u52d5\u5c3e\u90e8\u7684\u97ad\u6bdb\u4ee5\u5411\u524d\u79fb\u52d5\uff1b\u7e96\u6bdb\u64fa\u52d5\u53ef\u6392\u51fa\u9032\u5165\u6c23\u7ba1\u5167\u7684\u7570\u7269\u3001\u5354\u52a9\u5375\u5b50\u5728\u8f38\u5375\u7ba1\u5167\u524d\u9032\u3001\u5f15\u767c\u5927\u8166\u5167\u8166\u810a\u9ad3\u6db2\u7684\u6d41\u52d5\u7b49\u3002\u7e96\u6bdb\u904b\u52d5\u662f\u7531\u52d5\u529b\u86cb\u767ddynein\u9a45\u52d5\uff0cdynein\u4ee596\u5948\u7c73\u70ba\u55ae\u4f4d\uff0c\u4ee5\u76f8\u540c\u91cd\u8907\u7d50\u69cb\u6574\u9f4a\u6392\u5217\u3002\u8a72\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u544a\u77e5\u7d30\u80de96\u5948\u7c73\u9577\u5ea6\u7684\u7269\u8cea\u662fFAP59\u53caFAP172\u86cb\u767d\u8907\u5408\u9ad4-\u5948\u7c73\u5c3a\u3002<\/p>\n

Kartagener\u75c5\u60a3\u7684\u7e96\u6bdb\u7121\u6cd5\u6b63\u5e38\u64fa\u52d5\u3002\u5df2\u77e5FAP59\u53caFAP172\u86cb\u767d\u8907\u5408\u9ad4\u8b8a\u7570\u7f3a\u5c11\uff0c\u662fKartagener\u75c5\u7665(Kartagener’s syndrome)\u7684\u4e3b\u8981\u81f4\u75c5\u539f\u56e0\uff0c\u4f46\u4e0d\u77e5\u70ba\u4f55\u7f3a\u5c11\u6b64\u86cb\u767d\u8907\u5408\u9ad4\uff0c\u7e96\u6bdb\u64fa\u52d5\u5c31\u51fa\u73fe\u7570\u5e38\u3002\u70ba\u89e3\u958b\u5176\u6a5f\u5236\uff0c\u7814\u7a76\u5718\u968a\u4f7f\u7528\u8d85\u4f4e\u6eab\u96fb\u5b50\u986f\u5fae\u93e1\uff0c\u89c0\u5bdf\u8a72\u86cb\u767d\u8907\u5408\u9ad4\u7f3a\u640d\u7684\u7e96\u6bdb\u69cb\u9020\uff0c\u767c\u73fe\u4e0a\u8ff096\u5948\u7c73\u70ba\u55ae\u4f4d\uff0c\u76f8\u540c\u7684\u91cd\u8907\u7d50\u69cb\u5b8c\u5168\u6d88\u5931\u3002\u6545\u8a8d\u70baFAP59\u53caFAP172\u86cb\u767d\u8907\u5408\u9ad4\uff0c\u53ef\u80fd\u4f5c\u70ba96\u5948\u7c73\u5c3a\uff0c\u7dad\u6301\u6a5f\u80fd\u904b\u4f5c\u3002<\/p>\n

\u82e5FAP59\u53caFAP172\u86cb\u767d\u8907\u5408\u9ad4\u771f\u7684\u4f5c\u70ba\u5948\u7c73\u5c3a\uff0c\u7576\u5b83\u7684\u9577\u5ea6\u6539\u8b8a\uff0c\u7d30\u80de\u5167\u7684\u7d50\u69cb\u4e5f\u61c9\u6703\u7522\u751f\u8b8a\u5316\u3002\u679c\u7136\uff0c\u85c9\u7531\u57fa\u56e0\u64cd\u63a7\uff0c\u5c07FAP59\u53caFAP172\u86cb\u767d\u8907\u5408\u9ad4\u9577\u5ea6\u8b8a\u9577\uff0c\u6210\u529f\u88fd\u9020\u51fa\u81ea\u7136\u754c\u4e0d\u5b58\u5728\u3001120\u6216128\u5948\u7c73\u70ba\u55ae\u4f4d\u7684\u91cd\u8907\u7d50\u69cb\u3002\u4e5f\u767c\u73fe\u5b83\u4e0d\u50c5\u626e\u6f14\u5948\u7c73\u5c3a\u7684\u89d2\u8272\uff0c\u4e5f\u6c7a\u5b9a\u52d5\u529b\u86cb\u767ddynein\u7684\u6392\u5217\u9806\u5e8f\u3002\u901a\u5e38\uff0c96\u5948\u7c73\u7684\u91cd\u8907\u7d50\u69cb\uff0c A\u81f3G\u51717\u7a2e\u52d5\u529b\u86cb\u767ddynein\uff0c\u4ee5A-B-C-E-G-D-F\u7684\u9806\u5e8f\u6392\u5217\uff0c\u4f46\u82e5\u64cd\u63a7\u5948\u7c73\u5c3a\u57fa\u56e0\uff0c\u5247\u80fd\u88fd\u9020\u51faA-B-C-E-C-E-G-D-F\u6216A-A-B-C-E-G-D-F-F\u7684\u4eba\u5de5\u86cb\u767d\u8cea\u5e8f\u5217\u3002\u5229\u7528\u5948\u7c73\u5c3a\u7279\u6027\uff0c\u6709\u5e0c\u671b\u80fd\u4efb\u610f\u914d\u7f6e\u52d5\u529b\u86cb\u767d\u7684\u6392\u5217\u9806\u5e8f\uff0c\u88fd\u9020\u51fa\u4eba\u5de5\u7684\u5948\u7c73\u6a5f\u5668\u3002<\/p>\n

\u7e96\u6bdb\u904b\u52d5\u4e0d\u5168\u6240\u9020\u6210\u7684Kartagener\u75c5\u7665\uff0c\u662f\u76f8\u7576\u56b4\u91cd\u7684\u75be\u75c5\u3002\u82e5\u7e96\u6bdb\u7121\u6cd5\u64fa\u52d5\uff0c\u6c23\u7ba1\u7121\u6cd5\u6392\u51fa\u7570\u7269\u800c\u6613\u5c0e\u81f4\u80ba\u708e\uff1b\u7cbe\u5b50\u7121\u6cd5\u904b\u52d5\u6703\u5c0e\u81f4\u4e0d\u5b55\uff1b\u8166\u810a\u9ad3\u6db2\u6eef\u7559\u5728\u8166\u5ba4\u6703\u5c0e\u81f4\u8166\u6c34\u816b(hydrocephalus)\uff1b\u6216\u5fc3\u81df\u8207\u809d\u81df\u7684\u4f4d\u7f6e\u76f8\u53cd\uff0c\u9020\u6210\u5167\u81df\u7570\u4f4d\uff0c\u5c0e\u81f4\u7578\u578b\u3002\u8a72\u7814\u7a76\u767c\u73fe\u9019\u4e9bKartagener\u75c5\u7665\uff0c\u90fd\u662f\u56e0\u7e96\u6bdb\u7684\u5948\u7c73\u5c3a\u7f3a\u640d\u5c0e\u81f4dynein\u86cb\u767d\u8cea\u6a5f\u80fd\u7570\u5e38\u3002<\/p>\n

\n

\u540d\u8a5e\u89e3\u91cb<\/strong><\/p>\n

1.\u52d5\u529b\u86cb\u767d<\/strong> : motor protein\uff0c\u7d30\u80de\u4e2d\u672c\u8eab\u53ef\u4ee5\u904b\u52d5\u7684\u86cb\u767d\u8cea\u3002\u4f8b\u5982\u4f7f\u7e96\u6bdb\u64fa\u52d5\u7684dynein\uff0c\u8166\u6216\u795e\u7d93\u4e2d\u8abf\u63a7\u7269\u8cea\u642c\u904b\u7684kinesin\uff0c\u4f7f\u808c\u8089\u904b\u52d5\u7684myosin\u3002<\/p>\n

2.\u8d85\u4f4e\u6eab\u96fb\u5b50\u986f\u5fae\u93e1<\/strong> : \u5c07\u7d30\u80de\u6216\u751f\u7269\u9ad4\u5167\u5206\u5b50\u77ac\u9593\u51cd\u7d50\uff0c\u4f7f\u7528\u9ad8\u89e3\u6790\u96fb\u5b50\u986f\u5fae\u93e1\u76f4\u63a5\u89c0\u5bdf\u7684\u65b9\u6cd5\u3002<\/p>\n

3.\u5167\u81df\u7570\u4f4d<\/strong> : \u5c0f\u9f20\u5167\u81df\u7684\u5de6\u53f3\u4f4d\u7f6e\uff0c\u53d7\u5230\u80da\u80ce\u767c\u80b2\u521d\u671f\u7684\u539f\u7d50(primitive knot)\u6d3b\u52d5\u6240\u6c7a\u5b9a\u3002\u5f8c\u4f86\u900f\u904e\u96fb\u5b50\u986f\u5fae\u93e1\u53ca\u9ad8\u901f\u8996\u8a0a\u986f\u5fae\u93e1\u89c0\u5bdf\u6578\u7a2e\u810a\u690e\u52d5\u7269\u80da\u80ce\uff0c\u767c\u73fe\u539f\u7d50\u9031\u908a\u7684\u7e96\u6bdb\uff0c\u9ad8\u901f\u65cb\u8f49\u6240\u7522\u751f\u6c34\u6d41\uff0c\u6703\u6c7a\u5b9a\u5167\u81df\u7684\u5de6\u53f3\u4f4d\u7f6e\u3002Kartagener\u75c5\u60a3\u56e0\u7e96\u6bdb\u7570\u5e38\uff0c\u6613\u7522\u751f\u5167\u81df\u7570\u4f4d\uff0c\u5c0e\u81f4\u7578\u578b\u3002<\/p>\n

 <\/p>\n

\u5ef6\u4f38\u95b1\u8b80\u00a0<\/strong><\/p>\n

1.\u5361\u5854\u683c\u6c0f\u75c7\u5019\u7fa4\uff08Kartagener syndrome\uff09\u4e4b\u5f71\u50cf\uff0d\u75c5\u4f8b\u5831\u544a\u00a0http:\/\/w3.tyh.com.tw\/Radiology\/teach\/paper1.html<\/a><\/p>\n

2.\u7e96\u6bdb\u00a0http:\/\/zh.wikipedia.org\/zh-tw\/%E7%BA%96%E6%AF%9B<\/a><\/p>\n

 <\/p>\n

\n

\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n

Yasushi Okada, Sen Takeda, Yosuke Tanaka, Juan-Carlos Izpis\u00faa Belmonte and Nobutaka Hirokawa,<\/p>\n

“Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis<\/p>\n

Determination”,\u00a0Cell\u00a0121, 633-644 (2005).<\/p>\n

http:\/\/www.cell.com\/abstract\/S0092-8674%2805%2900349-1<\/a><\/p>\n

 <\/p>\n

 <\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u7d30\u80de\u5167\u6e2c\u91cf\u9577\u5ea6\u7684\u86cb\u767d\u8cea(A nanometer ruler determines the repeat len…<\/p>\n","protected":false},"author":50,"featured_media":62714,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4810,4674,110,5930,4817],"tags":[8397,8395,8399,8401,8396,8400,8394,8398],"class_list":["post-62702","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifesciecne001","category-4674","category-lifesciecne00","category-5930","category-lifesciecne001-01","tag-cilla","tag-cryo-electron-tomography","tag-flagella","tag-hydrocephalus","tag-8396","tag-8400","tag-8394","tag-8398","loop-entry","cat-4810","cat-4674","cat-110","cat-5930","cat-4817"],"views":6849,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/62702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=62702"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/62702\/revisions"}],"predecessor-version":[{"id":86569,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/62702\/revisions\/86569"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media\/62714"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=62702"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=62702"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=62702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}