{"id":52206,"date":"2014-02-27T10:23:30","date_gmt":"2014-02-27T02:23:30","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=52206"},"modified":"2021-10-06T16:18:36","modified_gmt":"2021-10-06T08:18:36","slug":"%e8%a7%a3%e9%96%8bc%e5%9e%8b%e8%82%9d%e7%82%8e%e7%ba%96%e7%b6%ad%e5%8c%96%e6%a9%9f%e5%88%b6","status":"publish","type":"post","link":"http:\/\/localhost\/%e8%a7%a3%e9%96%8bc%e5%9e%8b%e8%82%9d%e7%82%8e%e7%ba%96%e7%b6%ad%e5%8c%96%e6%a9%9f%e5%88%b6\/","title":{"rendered":"\u89e3\u958bC\u578b\u809d\u708e\u7e96\u7dad\u5316\u6a5f\u5236"},"content":{"rendered":"

\u89e3\u958bC\u578b\u809d\u708e\u7e96\u7dad\u5316\u6a5f\u5236<\/strong><\/span>
\n\u570b\u7acb\u81fa\u7063\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u8303\u59dc\u6587\u69ae\u7de8\u8b6f\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u674e\u51a0\u7fa4\u526f\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/strong><\/span><\/p>\n

\u7de8\u8b6f\u4f86\u6e90\uff1a<\/strong>\u72ec\u7acb\u884c\u653f\u6cd5\u4eba\u7406\u5316\u5b66\u7814\u7a76\u6240(RIKEN)2013\u5e7411\u670827\u65e5\u8a0a <C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff08HCV\uff09\u304c\u809d\u7dda\u7dad\u5316\u3092\u9032\u884c\u3055\u305b\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e><\/a><\/p>\n

\"HCV_EM_picture_2\"<\/a>

C\u578b\u809d\u708e (\u5716\u7247\u4f86\u6e90\uff1a\u7dad\u57fa\u767e\u79d1)<\/p><\/div>\n

\u65e5\u672c\u7406\u5316\u5b78\u7814\u7a76\u6240\u7b49\u7814\u7a76\u5718\u968a\u89e3\u6790\u51faC\u578b\u809d\u708e\u75c5\u6bd2\u7684NS3\u86cb\u767d\u91761<\/sup>\uff0c\u5b83\u80fd\u66ff\u4ee3\u809d\u7d30\u80de\u7684\u300c\u8f49\u8b8a\u751f\u9577\u56e0\u5b50TGF-\u03b2\u300d2<\/sup>\uff0c\u6d3b\u5316\u809d\u81df\u5167\u7d50\u7de0\u7d44\u7e54\u751f\u6210\u7684\u8a0a\u606f\u800c\u5c0e\u81f4\u809d\u81df\u7e96\u7dad\u5316\u3002\u8a72\u7814\u7a76\u6210\u679c2013\u5e7411\u670822\u65e5\u520a\u8f09\u65bc\u79d1\u5b78\u671f\u520a\u300cScientific Reports\u300d\u7dda\u4e0a\u7248\u3002<\/p>\n

\u4e16\u754c\u4e0a\u4f30\u8a08\u7d04\u6709\u4e00\u5104\u4e09\u5343\u842c\u5230\u4e00\u5104\u4e03\u5343\u842c\u4eba\u53d7\u5230C\u578b\u809d\u708e\u75c5\u6bd2\u7684\u611f\u67d3\uff0c\u9020\u6210\u809d\u81df\u7e96\u7dad\u5316\u3001\u786c\u5316\u3001\u4ee5\u53ca\u764c\u5316\u3002\u809d\u7e96\u7dad\u5316\u7684\u4e3b\u8981\u539f\u56e0\u5305\u62ecB\u578b\u6216C\u578b\u809d\u708e\u75c5\u6bd2\u7684\u611f\u67d3\u3001\u651d\u53d6\u904e\u91cf\u7684\u9152\u7cbe\u98f2\u54c1\uff0c\u4ee5\u53ca\u80a5\u80d6\u6240\u5c0e\u81f4\u7684\u8102\u80aa\u809d\u7b49\u3002\u5b83\u5011\u6703\u9020\u6210\u809d\u81df\u5167\u5806\u7a4d\u904e\u91cf\u7684\u81a0\u539f\u7e96\u7dad\u7b49\u7d30\u80de\u9593\u8cea\uff0c\u9019\u4e9b\u7269\u8cea\u9032\u800c\u4e92\u76f8\u7d50\u5408\u5c0e\u81f4\u7e96\u7dad\u5316\u3002\u82e5\u809d\u7e96\u7dad\u5316\u4e0d\u65b7\u9032\u884c\uff0c\u5c07\u8b8a\u6210\u809d\u786c\u5316\u6216\u809d\u764c\uff0c\u56b4\u91cd\u5247\u5c0e\u81f4\u6b7b\u4ea1\u3002<\/p>\n

\u6839\u64da\u904e\u53bb\u7684\u7814\u7a76\u5831\u544a\uff0c\u986f\u793a\u809d\u7e96\u7dad\u5316\u5927\u591a\u7531C\u578b\u809d\u708e\u75c5\u6bd2\u7684\u611f\u67d3\u6240\u5f15\u767c\uff0c\u4f46\u809d\u7e96\u7dad\u5316\u767c\u751f\u6a5f\u5236\u4e0d\u660e\u3002\u8fd1\u5e74\u5e38\u7528C\u578b\u809d\u708e\u75c5\u6bd2\u6291\u5236\u5291\u4f86\u91ab\u6cbb\u809d\u708e\u75c5\u60a3\uff0c\u96d6\u63a7\u5236\u4f4f\u75c5\u6bd2\uff0c\u4f46\u809d\u7e96\u7dad\u5316\u4ecd\u4e0d\u65b7\u767c\u751f\uff0c\u5c0e\u81f4\u809d\u764c\u767c\u75c5\u98a8\u96aa\u63d0\u9ad8\uff0c\u6545\u6709\u5fc5\u8981\u77ad\u89e3\u809d\u7e96\u7dad\u5316\u7684\u6a5f\u5236\uff0c\u4ee5\u958b\u767c\u65b0\u7684\u6cbb\u7642\u6cd5\u3002
\n<\/p>\n

\u904e\u53bb\u5df2\u77e5\u300c\u8f49\u8b8a\u751f\u9577\u56e0\u5b50TGF-\u03b2\u300d\u662f\u5c0e\u81f4\u809d\u7e96\u7dad\u5316\u7684\u539f\u56e0\u3002TGF-\u03b2 \u751f\u6210\u521d\u671f\u70ba\u975e\u6d3b\u6027\u7d50\u69cb\uff0c\u4e4b\u5f8c\u7d93\u7531\u4e00\u4e9b\u7279\u5b9a\u7684\u86cb\u767d\u8cea\u5206\u89e3\u9175\u7d20\u7b49\u4f5c\u7528\uff0c\u8f49\u8b8a\u70ba\u6709\u6d3b\u6027\u7d50\u69cb\u3002\u65e5\u672c\u7406\u5316\u5b78\u7814\u7a76\u6240\u7b49\u7814\u7a76\u5718\u968a\u63d0\u51faC\u578b\u809d\u708e\u75c5\u6bd2\u5c0e\u81f4\u809d\u7e96\u7dad\u5316\u7684\u5047\u8aaa\uff0c\u8a8d\u70baC\u578b\u809d\u708e\u75c5\u6bd2\u7684NS3\u86cb\u767d\u9176\u80fd\u5c07TGF-\u03b2\u8f49\u8b8a\u70ba\u5177\u6709\u6d3b\u6027\u7684\u7d50\u69cb\uff0c\u56e0\u6b64\u5c0e\u81f4\u809d\u7e96\u7dad\u5316\u3002\uff0c\u4f46\u7d93\u5be6\u9a57\u9a57\u8b49\u5f8c\uff0c\u5df2\u767c\u73fe\u8a72\u5047\u8aaa\u6709\u8aa4\uff1b\u7d93\u9032\u4e00\u6b65\u6aa2\u9a57\uff0c\u767c\u73feNS3\u86cb\u767d\u9176\u8207TGF-\u03b2\u5177\u6709\u975e\u5e38\u76f8\u4f3c\u7684\u6d3b\u6027\uff0c\u4e14NS3\u86cb\u767d\u9176\u8207\u809d\u7d30\u80de\u8868\u9762\u4e0a\u7684TGF-\u03b2\u2161\u53d7\u5668\uff08TGF-\u03b2 receptor\uff09\u7d50\u5408\uff0c\u6d3b\u5316\u809d\u7e96\u7dad\u5316\u8a0a\u606f\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u63a5\u8457\u767c\u73feNS3\u86cb\u767d\u9176\u7684TGF-\u03b2\u76f8\u4f3c\u6d3b\u6027\uff0c\u6703\u88abTGF-\u03b2\u2160\u578b\u53d7\u5668\u7684\u6291\u5236\u5291\u4e88\u4ee5\u6291\u5236\u3002\u7d93\u89e3\u6790NS3\u86cb\u767d\u9176\u8207TGF-\u03b2\u2160\u53d7\u5668\uff08TGF-\u03b2 type I receptor\uff0c TbRI\uff09\u9593\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u767c\u73fe\u809d\u7d30\u80de\u5728C\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u5f8c\uff0c NS3\u86cb\u767d\u9176\u6703\u8207TGF-\u03b2\u2160\u578b\u53d7\u5668\u7d50\u5408\u3002\u518d\u5c0dNS3\u86cb\u767d\u9176\u7684\u63a5\u5408\u6a23\u5f0f\u9032\u884c\u5206\u5b50\u7d50\u69cb\u6a21\u64ec\uff0c\u9810\u6e2cNS3\u86cb\u767d\u9176\u8207TGF-\u03b2\u53d7\u5668\u7684\u7d50\u5408\uff0c\u53ef\u80fd\u4f4d\u65bc\u4e09\u8655\uff0c\u6545\u91dd\u5c0d\u9810\u6e2c\u4f4d\u7f6e\uff0c\u88fd\u4f5c\u80fd\u963b\u7919NS3\u86cb\u767d\u9176\u8207TGF-\u03b2\u53d7\u5668\u7d50\u5408\u7684\u300c\u6297NS3\u6297\u9ad4\u300d\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u4e5f\u5c07\u4eba\u985e\u809d\u7d30\u80de\u79fb\u690d\u5230\u8001\u9f20\u9ad4\u5167\uff0c\u4f7f\u5176\u611f\u67d3C\u578b\u809d\u708e\u75c5\u6bd2\u4e26\u6295\u4e88\u300c\u6297NS3\u6297\u9ad4\u300d\uff0c\u89e3\u6790\u300c\u6297NS3\u6297\u9ad4\u300d\u80fd\u5426\u6291\u5236C\u578b\u809d\u708e\u75c5\u6bd2\u6240\u5f15\u8d77\u7684\u809d\u7e96\u7dad\u5316\uff0c\u7d50\u679c\u986f\u793a\u809d\u7e96\u7dad\u5316\u75c7\u72c0\u5982\u81a0\u539f\u7e96\u7dad\u7684\u904e\u91cf\u7d2f\u7a4d\uff0c\u6703\u56e0\u6295\u4e88\u300c\u6297NS3\u6297\u9ad4\u300d\u800c\u88ab\u6291\u5236\u3002<\/p>\n

\u4ee5\u4e0a\u7d50\u679c\u986f\u793aC\u578b\u809d\u708e\u75c5\u6bd2\u5728\u611f\u67d3\u809d\u7d30\u80de\u5f8c\uff0c\u56e0NS3\u86cb\u767d\u9176\u80fd\u8207TGF-\u03b2\u53d7\u5668\u7d50\u5408\uff0c\u6d3b\u5316\u7e96\u7dad\u751f\u6210\u4e4b\u8a0a\u606f\uff0c\u4f7f\u5f97\u81a0\u539f\u7e96\u7dad\u8207TGF-\u03b2\u7684\u57fa\u56e0\u8868\u73fe\u4e0a\u5347\uff0c\u9020\u6210\u809d\u7e96\u7dad\u5316\u3002\u8a72\u7814\u7a76\u6709\u52a9\u65bc\u672a\u4f86\u958b\u767c\u8a3a\u5bdfC\u578b\u809d\u708e\u4e4b\u8840\u6db2NS3\u86cb\u767d\u9176\u6fc3\u5ea6\u6aa2\u6e2c\u6cd5\uff0c\u4ee5\u53ca\u85c9\u7531\u300c\u6297NS3\u6297\u9ad4\u300d\u7684\u81e8\u5e8a\u904b\u7528\uff0c\u65e9\u671f\u767c\u73fe\u4e26\u6cbb\u7642C\u578b\u809d\u708e\u60a3\u8005\u809d\u7e96\u7dad\u5316\u7684\u75c5\u5fb5\u3002<\/p>\n

\u540d\u8a5e\u89e3\u91cb :<\/b><\/p>\n

    \n
  1. NS3\u86cb\u767d\u9176\u00a0:\u00a0non-structural protein 3 (NS3) protease\u3002\u85c9\u5207\u65b7C\u578b\u809d\u708e\u75c5\u6bd2\u7684\u86cb\u767d\u8cea\u93c8\uff0c\u4fc3\u4f7f\u75c5\u6bd2\u6210\u719f\u3002<\/li>\n
  2. \u8f49\u8b8a\u751f\u9577\u56e0\u5b50TGF-\u03b2\u00a0:\u00a0Transforming growth factor-\u03b2\uff0c\u6291\u5236\u7d30\u80de\u589e\u6b96\u6216\u5206\u5316\u7684\u4e00\u7a2e\u7d30\u80de\u4ecb\u7d20(cytokine)\uff0c\u5df2\u77e5\u80fd\u4fc3\u9032\u7d30\u80de\u5916\u9593\u8cea\u5982\u81a0\u539f\u7e96\u7dad\u6216TGF-\u03b2\u81ea\u8eab\u7684\u7522\u751f\u3002TGF-\u03b2\u7522\u751f\u7684\u521d\u671f\u70ba\u975e\u6d3b\u6027\u8907\u5408\u6027\u86cb\u767d\u8cea\uff0c\u81f3\u6a19\u7684\u7d30\u80de\u5468\u570d\u5f8c\uff0c\u7d93\u6d3b\u5316\u53cd\u61c9\u8b8a\u6210\u6709\u6d3b\u6027\u7684TGF-\u03b2\uff0c\u80fd\u8207TGF-\u03b2\u2160\u578b\u8207TGF-\u03b2\u2161\u578b\u53d7\u5668\u76f8\u7d50\u5408\uff0c\u8a98\u5c0eSmad\u8a0a\u606f\u3002<\/li>\n<\/ol>\n

    \u5ef6\u4f38\u95b1\u8b80\uff1a<\/strong>
    \n<\/a><\/p>\n

      \n
    1. B\u578b\u809d\u708e\u75c5\u6bd2\uff08Hepatitis B Virus, HBV\uff09
      \n      http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=549<\/a><\/li>\n
    2. \u4eba\u5de5\u809d\u81df\uff08Artificial Liver\uff09
      \n      http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=1055<\/a><\/li>\n<\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"

      \u89e3\u958bC\u578b\u809d\u708e\u7e96\u7dad\u5316\u6a5f\u5236 \u570b\u7acb\u81fa\u7063\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u8303\u59dc\u6587\u69ae\u7de8\u8b6f\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u674e\u51a0\u7fa4\u526f\u6559\u6388\u8cac\u4efb\u7de8\u8f2f \u7de8…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4674,110,5930],"tags":[6186,6185],"class_list":["post-52206","post","type-post","status-publish","format-standard","hentry","category-4674","category-lifesciecne00","category-5930","tag-ns3","tag-tgf-","loop-entry","cat-4674","cat-110","cat-5930","no-thumbnail"],"views":2465,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/52206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=52206"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/52206\/revisions"}],"predecessor-version":[{"id":87147,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/52206\/revisions\/87147"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=52206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=52206"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=52206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}