{"id":43573,"date":"2012-12-15T16:28:33","date_gmt":"2012-12-15T08:28:33","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=43573"},"modified":"2021-10-06T16:22:14","modified_gmt":"2021-10-06T08:22:14","slug":"%e6%9c%89%e4%ba%86%e5%ae%83%ef%bc%8c%e9%a1%9e%e6%be%b1%e7%b2%89%e8%9b%8b%e7%99%bd%e4%b8%8d%e5%86%8d%e6%b2%89%e7%a9%8d","status":"publish","type":"post","link":"http:\/\/localhost\/%e6%9c%89%e4%ba%86%e5%ae%83%ef%bc%8c%e9%a1%9e%e6%be%b1%e7%b2%89%e8%9b%8b%e7%99%bd%e4%b8%8d%e5%86%8d%e6%b2%89%e7%a9%8d\/","title":{"rendered":"\u6709\u4e86\u5b83\uff0c\u985e\u6fb1\u7c89\u86cb\u767d\u4e0d\u518d\u6c89\u7a4d"},"content":{"rendered":"

\u6709\u4e86\u5b83\uff0c\u985e\u6fb1\u7c89\u86cb\u767d\u4e0d\u518d\u6c89\u7a4d<\/span>
\n<\/strong>\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u526f\u6559\u6388\u674e\u51a0\u7fa4<\/span>\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u526f\u6559\u6388\u674e\u51a0\u7fa4<\/span>\u8cac\u4efb\u7de8<\/span><\/span>\u8f2f<\/span><\/strong><\/strong><\/strong><\/span><\/p>\n

\"\"<\/a>\u985e\u6fb1\u7c89\u86cb\u767d(amyloids ) \u662f1\u7a2e\u4e0d\u53ef\u6eb6\u7684\u7e96\u7dad\u72c0\u86cb\u767d\u8cea\uff0c\u540d\u7a31\u7684\u7531\u4f86\u662f\u56e0\u70ba\u65e9\u671f\u7898\u67d3\u8272\uff08iodine-staining\uff09\u6280\u8853\u5c1a\u4e0d\u6210\u719f\uff0c\u4f7f\u5f97\u79d1\u5b78\u5bb6\u8aa4\u4ee5\u70ba\u5b83\u662f1\u7a2e\u6fb1\u7c89\uff08\u62c9\u4e01\u6587\u70baamylum\uff09\u3002\u7576\u6642\u79d1\u5b78\u754c\u4e00\u76f4\u5728\u722d\u8ad6\u5b83\u5230\u5e95\u662f\u5c6c\u65bc\u8102\u80aa\u6c89\u6fb1\u7269\uff0c\u6216\u662f\u78b3\u6c34\u5316\u5408\u7269\u6c88\u6fb1\u7269\uff0c\u76f4\u5230\u6700\u5f8c\uff0c\u624d\u767c\u73fe\u5b83\u5176\u5be6\u662f1\u7a2e\u86cb\u767d\u8cea\u3002\u7576\u985e\u6fb1\u7c89\u86cb\u767d\u4e0d\u6b63\u5e38\u5730\u5728\u5668\u5b98\u4e2d\u5806\u7a4d\u6642\uff0c\u6703\u9020\u6210\u985e\u6fb1\u7c89\u6c89\u7a4d\u75c7(amyloidosis)\u3002<\/p>\n

\u76ee\u524d\u5df2\u77e5\u5728\u4eba\u9ad4\u5167\u81f3\u5c11\u670918\u7a2e\u86cb\u767d\u8cea\uff0c\u6703\u56e0\u70ba\u5176\u86cb\u767d\u7d50\u69cb\u932f\u8aa4\u6298\u758a\uff0c\u5c0e\u81f4\u8a72\u86cb\u767d\u8cea\u6703\u8207\u5176\u672c\u8eab\u3001\u6216\u8207\u7d30\u80de\u5167\u5176\u4ed6\u86cb\u767d\u8cea\u767c\u751f\u7cfe\u7d50\uff0c\u5f62\u6210\u7e96\u7dad\u72c0\u7684\u985e\u6fb1\u7c89\u86cb\u767d\u6c89\u7a4d\u3002\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u548c\u5e15\u91d1\u68ee\u6c0f\u75c7\u7b49\u591a\u7a2e\u795e\u7d93\u6027\u75be\u75c5\u60a3\u8005\u7684\u795e\u7d93\u7cfb\u7d71\u4e2d\uff0c\u90fd\u53ef\u4ee5\u89c0\u5bdf\u5230\u5927\u91cf\u985e\u6fb1\u7c89\u86cb\u767d\u7684\u6c89\u7a4d\uff0c\u56e0\u6b64\uff0c\u8a31\u591a\u5b78\u8005\u76f8\u4fe1\u5b83\u53ef\u80fd\u662f\u5c0e\u81f4\u8166\u90e8\u6216\u5176\u4ed6\u5668\u5b98\u529f\u80fd\u9000\u5316\u6216\u529f\u80fd\u969c\u7919\u7684\u539f\u56e0\u3002<\/p>\n

\u7f8e\u570b\u52a0\u5dde\u5927\u5b78\u6b50\u6587\u5206\u6821\u7684\u8a79\u59c6\u65af\u2027\u8afe\u7dad\u514b\u6559\u6388\uff08James Nowick of the University of California, Irvine\uff09\u548c\u6d1b\u6749\u78ef\u5206\u6821\u7684\u5927\u885b\u2027\u827e\u68ee\u4f2f\u683c\u6559\u6388\uff08David Eisenberg of the University of California, Los Angeles\uff09\u6240\u9818\u5c0e\u7684\u7814\u7a76\u5718\u968a\uff0c\u5df2\u7d93\u5171\u540c\u7814\u88fd\u51fa1\u7a2e\u74b0\u72c0\u80dc\u80bd\u985e\u7684\u6a21\u677f\u5206\u5b50\uff0c\u5b83\u53ef\u8a98\u5c0e\u591a\u7a2e\u80dc\u80bd\u5f62\u6210\u03b2-\u8936\u677f\u7d50\u69cb(\u03b2-sheet structures)\u3002\u5728\u9ad4\u5916\u7684\u8a66\u9a57\u4e2d\uff0c\u9019\u4e9b\u03b2-\u8936\u677f\u7d50\u69cb\u53ef\u4ee5\u963b\u65b7\u5305\u62ecamyloid-\u03b2 (\u7c21\u7a31A\u03b2)\u3001tau\u548c\u03b1-synuclein\u7b49\u591a\u7a2e\u86cb\u767d\u7684\u6c89\u7a4d\uff0c\u4e5f\u53ef\u6e1b\u5c11A\u03b2\u5728\u7d30\u80de\u9020\u6210\u7684\u6bd2\u6027\uff0c\u800cA\u03b2\u8207tau\u6b63\u662f\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u81f4\u75c5\u86cb\u767d\u8cea\uff1b\u03b1-synuclein\u5247\u662f\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u81f4\u75c5\u86cb\u767d\u8cea\uff0c\u56e0\u6b64\uff0c\u8a72\u7a2e\u65b0\u578b\u86cb\u767d\u6c89\u7a4d\u6291\u5236\u5291\uff0c\u5f88\u53ef\u80fd\u6210\u70ba\u5ee3\u6cdb\u6cbb\u7642\u985e\u6fb1\u7c89\u86cb\u767d\u6c89\u7a4d\u75c7\u7684\u300c\u842c\u7528\u85e5\u7269\u300d\uff0c\u5728\u540c\u6642\u6cbb\u7642\u591a\u7a2e\u795e\u7d93\u6027\u75be\u75c5\u4e0a\u5177\u6709\u6975\u5927\u7684\u6f5b\u529b\u3002\u6b64\u7d50\u679c\u5df2\u767c\u8868\u57282012\u5e749\u6708\u7dda\u4e0a\u7684\u300a\u81ea\u7136\u5316\u5b78\u300b\uff08Nature Chemistry<\/em>\uff09\u671f\u520a\u3002<\/p>\n

2000\u5e74\uff0c\u8afe\u7dad\u514b\u7684\u7814\u7a76\u5718\u968a\u5408\u6210\u51fa\u5e36\u6709\u4e00\u7a2e\u7a31\u70ba\u201c\u300cHao\u300d\u201d\u7684\u4eba\u9020\u80fa\u57fa\u9178\u7684\u74b0\u72c0\u80dc\u80bd\uff0c\u767c\u73fe\u9019\u7a2e\u80dc\u80bd\u6bcf2\u500b\u5206\u5b50\u6703\u81ea\u884c\u5f62\u6210\u03b2-\u8936\u677f\u7684\u7d50\u69cb\uff0c\u4f46\u4e0d\u6703\u9032\u4e00\u6b65\u5f62\u6210\u805a\u96c6\u6c89\u7a4d\u3002\u7531\u65bc\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u548c\u524d\u984d\u8449\u7661\u5446\u75c7\uff08frontotemporal dementia\uff09\u60a3\u8005\u7b49\u7684\u8166\u5167\uff0ctau\u86cb\u767d\u6703\u5f62\u6210\u03b2-\u8936\u677f\u7d50\u69cb\uff0c\u4e26\u6703\u9032\u4e00\u6b65\u5f62\u6210\u805a\u96c6\u6c89\u7a4d\uff0c\u9020\u6210\u795e\u7d93\u7e96\u7dad\u7e8f\u7d50\uff08neurofibrillary tangles\uff09\uff0c\u4f7f\u795e\u7d93\u7d30\u80de\u6700\u7d42\u58de\u6b7b\uff0c\u65bc\u662f\u8a72\u7814\u7a76\u5718\u968a\u5617\u8a66\u5728\u74b0\u72c0\u80dc\u80bd\u5206\u5b50\u4e2d\u7d0d\u5165tau\u86cb\u767d\u7247\u6bb5\uff0c\u7d50\u679c\u767c\u73fe\u9019\u7a2e\u74b0\u72c0\u5206\u5b50\u6703\u6291\u5236tau\u86cb\u767d\u884d\u751f\u7247\u6bb5\u7684\u805a\u96c6\u3002\u7136\u800c\uff0c\u82e5\u5c07\u6b64\u6cd5\u61c9\u7528\u65bcA\u03b2\u86cb\u767d\uff0c\u5247\u963b\u6b62\u805a\u96c6\u7684\u6548\u679c\u5f88\u5fae\u5f31\uff0c\u63a8\u6e2c\u9019\u53ef\u80fd\u662f\u56e0\u70ba\u542b\u6709A\u03b2\u86cb\u767d\u7247\u6bb5\u7684\u74b0\u72c0\u5206\u5b50\u592a\u5c0f\u4e4b\u6545\u3002<\/p>\n

2012\u5e74\uff0c\u8afe\u7dad\u514b\u5be6\u9a57\u5ba4\u7684\u535a\u58eb\u73ed\u7814\u7a76\u751fPin-Nan Cheng\uff08\u4f86\u81ea\u53f0\u7063\u7684\u912d\u5f6c\u7537\uff0c\u4e5f\u662f\u8a72\u7bc7\u7814\u7a76\u8ad6\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\uff09\u548c\u827e\u68ee\u4f2f\u683c\u7814\u7a76\u5718\u968a\u7684\u6210\u54e1\uff0c\u4ee5\u542b\u6709\u201c\u300cHao\u300d\u201d\u7684\u74b0\u72c0\u80dc\u80bd\u70ba\u6a21\u677f\uff0c\u5275\u9020\u51fa\u65b0\u578b\u8f03\u5927\u7684\u74b0\u72c0\u5206\u5b50\uff0c\u8a72\u5206\u5b50\u540c\u6a23\u80fd\u5f62\u6210\u03b2-\u8936\u677f\u69cb\u9020\uff0c\u4e26\u53ef\u6709\u6548\u9632\u6b62A\u03b2\u805a\u96c6\uff0c\u4ee5\u53ca\u964d\u4f4e\u985e\u6fb1\u7c89\u86cb\u767d\u805a\u96c6\u9ad4\u7684\u6bd2\u6027\u3002\u8a72\u5718\u968a\u751a\u81f3\u5c07\u6b64\u74b0\u72c0\u5206\u5b50\u6a21\u677f\u7d0d\u5165\u5176\u4ed6\u6703\u5c0e\u81f4\u985e\u6fb1\u7c89\u6c89\u7a4d\u75c7(amyloidosis)\u7684\u86cb\u767d\u7247\u6bb5\uff0c\u4f8b\u5982tau\u3001\u03b1-synuclein\u3001\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u6709\u95dc\u7684\u80f0\u5cf6\u985e\u6fb1\u7c89\u86cb\u767d\u7b49\uff0c\u767c\u73fe\u4e5f\u6709\u6291\u5236\u805a\u96c6\u7684\u6548\u7528\u3002<\/p>\n

\u76ee\u524d\u8afe\u7dad\u514b\u7814\u7a76\u5718\u968a\u53ea\u5728\u751f\u7269\u9ad4\u5916\u6e2c\u8a66\u4e86\u9019\u4e9b\u65b0\u578b\u963b\u65b7\u5291\uff0c\u4ed6\u5011\u5c0d\u9019\u4e9b\u963b\u65b7\u5291\u5982\u4f55\u5f7c\u6b64\u4f5c\u7528\u3001\u5982\u4f55\u548c\u6b63\u5728\u805a\u96c6\u7684\u86cb\u767d\u8cea\u4f5c\u7528\uff0c\u4ee5\u53ca\u86cb\u767d\u8cea\u5982\u4f55\u5f62\u6210\u5be1\u805a\u9ad4\uff08oligomers\uff09\u6df1\u611f\u8208\u8da3\uff0c\u6700\u7d42\u5c07\u6703\u628a\u985e\u4f3c\u7684\u963b\u65b7\u5291\u5206\u5b50\u5f15\u5230\u6a21\u5f0f\u52d5\u7269\u4e2d\u9032\u884c\u6e2c\u8a66\u3002\u6b64\u7814\u7a76\u5c0d\u65bc\u5c0b\u627e\u66f4\u666e\u904d\u963b\u65b7\u4e0d\u540c\u86cb\u767d\u805a\u96c6\u7684\u65b0\u578b\u963b\u65b7\u5291\u800c\u8a00\uff0c\u662f\u9081\u51fa\u4e86\u4e00\u5927\u6b65\u3002<\/p>\n

\u81f3\u65bc\u9019\u985e\u963b\u65b7\u5291\u5206\u5b50\u662f\u5426\u80fd\u6210\u70ba\u963b\u6b62\u86cb\u767d\u805a\u96c6\u7684\u826f\u597d\u85e5\u7269\uff0c\u4ecd\u6709\u5f85\u89c0\u5bdf\u3002\u904e\u53bb\uff0c\u66fe\u6709\u7814\u7a76\u4eba\u54e1\u9032\u884c\u81e8\u5e8a\u8a66\u9a57\uff0c\u6e2c\u8a66\u67d0\u4e9bA\u03b2\u805a\u96c6\u963b\u65b7\u5291\u7684\u6548\u679c\uff0c\u7d50\u679c\u6548\u7528\u4e0d\u5927\uff0c\u4f8b\u5982Scyllo-inositol (\u53c8\u540d ELND005\uff09\u662f\u4e00\u7a2e\u53ef\u963b\u6b62A\u03b2\u805a\u96c6\u7684\u690d\u7269\u6027\u7cd6\u9187\uff0c\u5b83\u80fd\u4f7f\u963f\u8332\u6d77\u9ed8\u75c7\u8f49\u57fa\u56e0\u5c0f\u9f20\u7684\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u60c5\u5f62\u7372\u5f97\u63a7\u5236\uff0c\u4f46\u5728\u7b2c\u4e8c\u968e\u6bb5\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u5c0d\u65bc\u8f15\u5ea6\u81f3\u4e2d\u5ea6\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u4f86\u8aaa\uff0c\u4e26\u6c92\u6709\u63d0\u9ad8\u9019\u4e9b\u60a3\u8005\u7684\u8a8d\u77e5\u529f\u80fd\u3002\u53e6\u4e00\u7a2eA\u03b2\u805a\u96c6\u6291\u88fd\u5291Alzhemed\uff08\u53c8\u540dtramiprosate\uff09\uff0c\u96d6\u7136\u901a\u904e\u7b2c\u4e8c\u968e\u6bb5\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u4f46\u5728\u7b2c\u4e09\u968e\u6bb5\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u8a66\u9a57\u4e2d\uff0c\u4e26\u672a\u51fa\u73fe\u81e8\u5e8a\u7642\u6548\u3002<\/p>\n

(\u672c\u6587\u7531\u570b\u79d1\u6703\u88dc\u52a9\uff62\u65b0\u5a92\u9ad4\u79d1\u666e\u50b3\u64ad\u5be6\u4f5c\u8a08\u756b)\u57f7\u884c\u5718\u968a\u64b0\u7a3f\uff0c\u672c\u6587\u9996\u5ea6\u767c\u8868\u65bc\u79d1\u6280\u5927\u89c0\u5712<\/a>)<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u6709\u4e86\u5b83\uff0c\u985e\u6fb1\u7c89\u86cb\u767d\u4e0d\u518d\u6c89\u7a4d \u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u526f\u6559\u6388\u674e\u51a0\u7fa4\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u526f\u6559\u6388\u674e\u51a0\u7fa4\u8cac\u4efb…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4674,110,4815,5930,4843],"tags":[4895,4927,4590,4928,4926,1007,4578,4574],"class_list":["post-43573","post","type-post","status-publish","format-standard","hentry","category-4674","category-lifesciecne00","category-lifesciecne006","category-5930","category-lifesciecne006-06","tag-4895","tag-4927","tag-4590","tag-4928","tag-4926","tag-1007","tag-4578","tag-4574","loop-entry","cat-4674","cat-110","cat-4815","cat-5930","cat-4843","no-thumbnail"],"views":18132,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/43573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=43573"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/43573\/revisions"}],"predecessor-version":[{"id":87711,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/43573\/revisions\/87711"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=43573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=43573"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=43573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}