{"id":42974,"date":"2013-08-27T14:01:02","date_gmt":"2013-08-27T06:01:02","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=42974"},"modified":"2021-10-06T16:21:00","modified_gmt":"2021-10-06T08:21:00","slug":"%e6%b4%bb%e6%80%a7%e6%b0%a7%e7%89%a9%e7%a8%ae%ef%bc%88reactive-oxygen-species%ef%bc%89","status":"publish","type":"post","link":"http:\/\/localhost\/%e6%b4%bb%e6%80%a7%e6%b0%a7%e7%89%a9%e7%a8%ae%ef%bc%88reactive-oxygen-species%ef%bc%89\/","title":{"rendered":"\u6d3b\u6027\u6c27\u7269\u7a2e\uff08Reactive oxygen species\uff09"},"content":{"rendered":"

\u6d3b\u6027\u6c27\u7269\u7a2e\uff08Reactive oxygen species\uff09<\/span>
\n<\/strong>\u570b\u7acb\u65b0\u838a\u9ad8\u7d1a\u4e2d\u5b78\u9673\u5049\u6c11\u9000\u4f11\u6559\u5e2b<\/span><\/strong><\/p>\n

\u6d3b\u6027\u6c27\u7269\u7a2e\uff08\u7e2e\u5beb\u70baROS\uff09\u662f\u6307\u542b\u6c27\u4e4b\u5316\u5b78\u6d3b\u6027\u5206\u5b50\uff0c\u5176\u4e2d\u5305\u62ec\u904e\u6c27\u5316\u6c2b\uff08H2<\/sub>O2<\/sub>\uff09\u3001\u6b21\u6c2f\u9178\uff08HClO\uff09\u3001\u7fa5\u57fa\u81ea\u7531\u57fa\uff08HO\u009f\uff09\u3001\u55ae\u7dda\u614b\u6c27\uff081<\/sup>O2<\/sub>\uff09\u7b49\u3002ROS\u662f\u5728\u6b63\u5e38\u65b0\u9673\u4ee3\u8b1d\u5f8c\uff0c\u7531\u6c27\u5f62\u6210\u7684\u5929\u7136\u526f\u7522\u54c1\uff0c\u5728\u7d30\u80de\u8a0a\u606f\u50b3\u905e\uff08cell signaling\uff09\u53ca\u9ad4\u5167\u5e73\u8861\uff08homeostasis\uff09\u65b9\u9762\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002\u7136\u800c\u5728\u5916\u754c\u74b0\u5883\u5c6c\u65bc\u9006\u5883\u6642\uff08\u5982\u66b4\u9732\u5728\u7d2b\u5916\u7dda\u53ca\u9ad8\u6eab\u4e0b\uff09\uff0cROS\u7684\u6fc3\u5ea6\u6703\u6025\u5287\u5347\u9ad8\u3002\u9019\u7a2e\u73fe\u8c61\u6703\u5c0d\u7d30\u80de\u7d50\u69cb\u9020\u6210\u660e\u986f\u640d\u5bb3\uff0c\u9577\u671f\u7d2f\u7a4d\u4e0b\u4f86\uff0c\u5c31\u5f62\u6210\u6c27\u5316\u640d\u50b7\uff08oxidative stress\uff09\u3002ROS\u4e5f\u53ef\u80fd\u6e90\u81ea\u5916\u4f86\u56e0\u7d20\uff0c\u5982\u96fb\u96e2\u8f3b\u5c04\uff08ionizing radiation\uff09\u3002<\/p>\n

\u8a0a\u606f\u50b3\u905e\u8207\u640d\u5bb3\u4e4b\u6548\u61c9<\/strong> <\/strong><\/p>\n

\u5728\u6b63\u5e38\u7684\u60c5\u6cc1\u4e0b\uff0c\u7d30\u80de\u6703\u7528\u4e00\u4e9b\u9176\u5c0d\u6297ROS\u4e4b\u640d\u5bb3\uff0c\u5982\u03b1-1-\u5fae\u7403\u86cb\u767d\uff08alpha-1-microglobulin\uff09\u3001\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff08superoxide dismutases\uff09\u3001\u904e\u6c27\u5316\u6c2b\u9176\uff08catalases\uff09\u3001\u4e73\u904e\u6c27\u5316\u7269\u9176\uff08lactoperoxidases\uff09\u3001\u9ea9\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\uff08glutathione peroxidases\uff09\u4ee5\u53ca\u904e\u6c27\u6c27\u5316\u9084\u539f\u86cb\u767d\uff08peroxiredoxins\uff09\u3002\u5c0f\u5206\u5b50\u7684\u6297\u6c27\u5316\u5291\u5982\u6297\u58de\u8840\u9178\uff08\u7dad\u751f\u7d20C\uff09\u3001\u751f\u80b2\u915a\uff08\u7dad\u751f\u7d20E\uff09\u3001\u5c3f\u9178\u53ca\u7a40\u80f1\u7518\u80bd\uff08glutathione\uff09\u5728\u4f5c\u70ba\u7d30\u80de\u6297\u6c27\u5316\u5291\u65b9\u9762\uff0c\u4e5f\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002\u591a\u915a\u6297\u6c27\u5316\u5291\u4e5f\u6709\u985e\u4f3c\u529f\u80fd\uff0c\u53ef\u7d93\u7531\u6e05\u9664\u81ea\u7531\u57fa\u800c\u9632\u6b62ROS\u9020\u6210\u50b7\u5bb3\u3002\u6bd4\u8f03\u8d77\u4f86\uff0c\u7d30\u80de\u5916\u7684\u6297\u6c27\u5316\u5291\u529f\u80fd\u8f03\u5c0f\uff0c\u4f8b\u5982\u4eba\u9ad4\u6700\u91cd\u8981\u7684\u8840\u6f3f\u6297\u6c27\u5316\u5291\u662f\u5c3f\u9178\u3002<\/p>\n

\u6709\u8a31\u591a\u7a2eROS\u5c0d\u7d30\u80de\u65b0\u9673\u4ee3\u8b1d\u9020\u6210\u7684\u6548\u61c9\uff0c\u5df2\u7d93\u5145\u5206\u88ab\u7814\u7a76\u3002\u9019\u4e9b\u6548\u61c9\u4e0d\u4f46\u5305\u542bROS\u5728\u7d30\u80de\u51cb\u4ea1\uff08apoptosis\uff09\u4e2d\u7684\u89d2\u8272\uff0c\u4e5f\u6709\u4e9b\u6b63\u9762\u7684\u6548\u61c9\uff0c\u5982\u5f15\u767c\u57fa\u56e0\u7684\u4e3b\u9ad4\u9632\u79a6\uff0c\u4ee5\u53ca\u555f\u52d5\u96e2\u5b50\u904b\u8f38\u7cfb\u7d71\u3002\u9019\u4e5f\u4ee3\u8868ROS\u53ef\u4f5c\u70ba\u751f\u7269\u9ad4\u7684\u50b3\u8a0a\u8005\uff0c\u9019\u7a2e\u73fe\u8c61\u7a31\u70ba\u6c27\u5316\u9084\u539f\u8a0a\u606f\u50b3\u905e\uff08redox signaling\uff09\u3002\u7279\u5225\u7684\u662f\uff1a\u8840\u5c0f\u677f\u5728\u53c3\u8207\u50b7\u53e3\u7684\u4fee\u5fa9\u53ca\u8abf\u6574\u9ad4\u5167\u8840\u6db2\u5e73\u8861\u6642\uff0c\u6703\u91cb\u653eROS\uff0c\u53ec\u96c6\u66f4\u591a\u8840\u5c0f\u677f\u5230\u53d7\u50b7\u7684\u90e8\u4f4d\u3002\u6b64\u6642\u4e5f\u6703\u7d93\u7531\u53ec\u96c6\u767d\u8840\u7403\uff0c\u8abf\u6574\u514d\u75ab\u7cfb\u7d71\u3002<\/p>\n

\u70ba\u56de\u61c9\u8a31\u591a\u767c\u708e\u73fe\u8c61\uff0c\u5305\u62ec\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u6d3b\u6027\u6c27\u7269\u7a2e\u6703\u53c3\u8207\u7d30\u80de\u6d3b\u52d5\u3002\u52d5\u7269\u8207\u4eba\u9ad4\u5404\u5f0f\u5404\u6a23\u7684\u807d\u529b\u969c\u7919\uff0c\u7121\u8ad6\u662f\u9ad8\u97f3\u91cf\u5f15\u767c\u7684\u8033\u8778\u53d7\u640d\u3001\u9806\u9251\u7b49\u85e5\u7269\u7684\u8033\u6bd2\u6027\uff0c\u6216\u5148\u5929\u8033\u807e\uff0c\u90fd\u8207\u6d3b\u6027\u6c27\u7269\u7a2e\u6709\u95dc\u3002\u7d30\u80de\u51cb\u4ea1\u53ca\u7f3a\u8840\u6027\u640d\u50b7\uff0c\u5982\u4e2d\u98a8\u53ca\u5fc3\u808c\u6897\u585e\uff0c\u4e5f\u8207\u6d3b\u6027\u6c27\u7269\u7a2e\u7684\u6c27\u5316\u9084\u539f\u8a0a\u606f\u50b3\u905e\u6709\u95dc\u3002<\/p>\n

\u4e00\u822c\u800c\u8a00\uff0c\u6d3b\u6027\u6c27\u7269\u7a2e\u6240\u9020\u6210\u7684\u50b7\u5bb3\u4e2d\uff0c\u6700\u5e38\u898b\u7684\u6709\uff1a<\/p>\n

1. DNA\u7684\u640d\u5bb3\u3002<\/p>\n

2. \u8102\u8cea\u4e2d\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u7684\u6c27\u5316\uff08\u8102\u8cea\u904e\u6c27\u5316\u53cd\u61c9\uff09\u3002<\/p>\n

3. \u86cb\u767d\u8cea\u4e2d\u80fa\u57fa\u9178\u7684\u6c27\u5316\u3002<\/p>\n

4. \u8f14\u56e0\u5b50\u7684\u6c27\u5316\u53cd\u61c9\u800c\u9020\u6210\u7279\u5b9a\u9176\u7684\u6c27\u5316\u6027\u920d\u5316\u4f5c\u7528\u3002<\/p>\n

\u7d30\u80de\u5167\u7684\u7522\u751f\u65b9\u5f0f<\/strong><\/strong><\/p>\n

\u81ea\u7531\u57fa\u4e3b\u8981\u662f\u5728\u80de\u5668\uff08organelle\uff09\u2500\u2500\u4f8b\u5982\u7c92\u7dda\u9ad4\u2500\u2500\u5167\u7522\u751f\uff0c\u4e26\u91cb\u653e\u5230\u80de\u8cea\u6db2\u4e2d\u3002\u7c92\u7dda\u9ad4\u5e6b\u7d30\u80de\u628a\u80fd\u91cf\u8f49\u5316\u6210\u6709\u7528\u7684\u5f62\u5f0f\uff0c\u817a\u82f7\u4e09\u78f7\u9178\uff08ATP\uff09\u3002\u7522\u751fATP\u7684\u904e\u7a0b\u7a31\u70ba\u6c27\u5316\u78f7\u9178\u5316\uff08oxidative phosphorylation\uff09\uff0c\u5176\u4e2d\u6d89\u53ca\u5229\u7528\u96fb\u5b50\u50b3\u905e\u93c8\uff08electron transport chain\uff09\u904b\u8f38\u8cea\u5b50\uff08\u6c2b\u96e2\u5b50\uff09\uff0c\u4f7f\u8cea\u5b50\u7a7f\u904e\u7c92\u7dda\u9ad4\u5167\u819c\u3002\u5728\u96fb\u5b50\u50b3\u905e\u93c8\u4e2d\uff0c\u7d93\u7531\u4e00\u7cfb\u5217\u86cb\u767d\u8cea\u7684\u6c27\u5316\u9084\u539f\u53cd\u61c9\u50b3\u905e\u96fb\u5b50\uff0c\u93c8\u4e0a\u7684\u6bcf\u4e00\u500b\u53d7\u9ad4\u86cb\u767d\u8cea\u4e4b\u9084\u539f\u96fb\u4f4d\uff0c\u90fd\u6bd4\u524d\u4e00\u500b\u53d7\u9ad4\u86cb\u767d\u8cea\u7684\u9084\u539f\u96fb\u4f4d\u9ad8\u3002\u96fb\u5b50\u6cbf\u8457\u9019\u689d\u93c8\u50b3\u9001\u7684\u7d42\u9ede\uff0c\u662f\u4e00\u500b\u6c27\u5206\u5b50\u3002\u5728\u6b63\u5e38\u689d\u4ef6\u4e0b\uff0c\u6c27\u5206\u5b50\u88ab\u9084\u539f\uff0c\u800c\u7522\u751f\u6c34\uff0c\u7136\u800c\u6cbf\u8457\u9019\u689d\u93c8\u50b3\u905e\u7684\u96fb\u5b50\u4e2d\uff0c\u67090.1~2 %\u4f7f\u6c27\u904e\u65e9\u4e14\u4e0d\u5b8c\u5168\u9084\u539f\uff08\u9019\u500b\u6578\u64da\u662f\u5c0d\u9694\u96e2\u7684\u7c92\u7dda\u9ad4\u7814\u7a76\u800c\u5f97\u4f86\u7684\uff0c\u5728\u6d3b\u9ad4\u4e2d\u6e96\u78ba\u7684\u6bd4\u7387\u4ecd\u672a\u7372\u79d1\u5b78\u754c\u7684\u5171\u8b58\uff09\uff0c\u800c\u7522\u751f\u8d85\u6c27\u81ea\u7531\u57fa\uff08\u00b7O2<\/sub>–<\/sup>\uff09\u3002\u8d85\u6c27\u5316\u7269\u672c\u8eab\u7684\u6d3b\u6027\u4e26\u975e\u7279\u5225\u5927\uff0c\u4f46\u5b83\u53ef\u4ee5\u4f7f\u7279\u5b9a\u7684\u9176\u920d\u5316\uff0c\u6216\u8005\u5b83\u7684\u8cea\u5b50\u5316\u5f62\u5f0f\u2500\u2500\u904e\u6c27\u5316\u6c2b\u57fa\uff08HO2<\/sub>\u00b7\uff09\u2500\u2500\u555f\u52d5\u8102\u8cea\u904e\u6c27\u5316\u53cd\u61c9\u3002<\/p>\n

.<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/span><\/p>\n

1. \u6d3b\u6027\u6c27\u7269\u7a2ehttp:\/\/en.wikipedia.org\/wiki\/Reactive_oxygen_species<\/span><\/p>\n

2. B. Rada,\u00a0T. Leto,\u00a0Contrib Microbiol<\/em>. 2008<\/strong>, 15<\/em>, 164-187<\/span><\/p>\n

3. G. E. Conner, M. Salathe, R. Forteza, Am J Respir Crit Care Med.<\/em> 2002<\/strong>,166<\/em>, 57-61<\/span><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u6d3b\u6027\u6c27\u7269\u7a2e\uff08Reactive oxygen species\uff09 \u570b\u7acb\u65b0\u838a\u9ad8\u7d1a\u4e2d\u5b78\u9673\u5049\u6c11\u9000\u4f11\u6559\u5e2b \u6d3b\u6027\u6c27\u7269\u7a2e\uff08\u7e2e\u5beb…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1098,108,48],"tags":[4772,4773],"class_list":["post-42974","post","type-post","status-publish","format-standard","hentry","category-1098","category-chemistry00","category-chemistry01","tag-ros","tag-4773","loop-entry","cat-1098","cat-108","cat-48","no-thumbnail"],"views":31227,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=42974"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42974\/revisions"}],"predecessor-version":[{"id":87568,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42974\/revisions\/87568"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=42974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=42974"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=42974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}