{"id":42784,"date":"2013-08-14T16:52:53","date_gmt":"2013-08-14T08:52:53","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=42784"},"modified":"2021-10-06T16:21:02","modified_gmt":"2021-10-06T08:21:02","slug":"%e6%bf%be%e6%b3%a1%ef%bc%88%e5%9b%8a%e6%b3%a1%ef%bc%89%e6%a8%b9%e7%aa%81%e7%b4%b0%e8%83%9e%ef%bc%88follicular-dendritic-cell%ef%bc%89-2","status":"publish","type":"post","link":"http:\/\/localhost\/%e6%bf%be%e6%b3%a1%ef%bc%88%e5%9b%8a%e6%b3%a1%ef%bc%89%e6%a8%b9%e7%aa%81%e7%b4%b0%e8%83%9e%ef%bc%88follicular-dendritic-cell%ef%bc%89-2\/","title":{"rendered":"\u6ffe\u6ce1\uff08\u56ca\u6ce1\uff09\u6a39\u7a81\u7d30\u80de"},"content":{"rendered":"

\u6ffe\u6ce1\uff08\u56ca\u6ce1\uff09\u6a39\u7a81\u7d30\u80de (Follicular dendritic cell)<\/span>
\n<\/strong>\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u7814\u7a76\u52a9\u7406\u9676\u97fb\u5a77<\/span><\/strong><\/p>\n

\u591a\u6578\u7684\u6a39\u7a81\u7d30\u80de\uff08dendritic cell\uff09\u7531\u9aa8\u9ad3\u4e2d\u7684\u9020\u8840\u5e79\u7d30\u80de\uff08hematopoietic stem cell\uff09\u5206\u5316\u800c\u4f86\uff0c\u53ef\u4f9d\u7167\u4ed6\u5011\u6240\u8655\u4f4d\u7f6e\u5206\u985e\uff0c\u5982\uff1a\u8868\u76ae\u7684\u862d\u683c\u6f22\u6c0f\u7d30\u80de\uff08Langerhans cell\uff09\u3001\u5fc3\u80ba\u7b49\u81df\u5668\u7684\u9593\u8cea\u6a39\u7a81\u7d30\u80de\uff08interstitial dendritic cell\uff09\u3001\u4e8c\u7d1a\u6dcb\u5df4\u7d44\u7e54\uff08second lymphoid tissue\uff09\u8207\u80f8\u817a\u9ad3\u8cea\uff08thymic medulla\uff09\u7684\u4ea4\u932f\u6a39\u7a81\u7d30\u80de\uff08interdigitating dendritic cell\uff09\u3001\u8840\u6db2\u4e2d\u7684\u5916\u5468\u8840\u6a39\u7a81\u7d30\u80de\uff08circulating dendritic cell\uff09\u3002<\/p>\n

\u9019\u4e9b\u6a39\u7a81\u7d30\u80de\u6703\u6301\u7e8c\u4e14\u5927\u91cf\u7684\u8868\u73fe\u7b2c\u4e8c\u578b\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u8907\u5408\u9ad4\uff08class II MHC\uff09\uff0c\u4ee5\u53caB7\u5bb6\u65cf\uff08B7 family\uff09\u5354\u540c\u523a\u6fc0\u5206\u5b50\uff08co-stimulatory factor\uff09\uff0c\u5177\u6709\u6297\u539f\u5448\u73fe\u7d30\u80de\uff08antigen-presenting cells, APC\uff09\u7684\u80fd\u529b\u3002<\/p>\n

\u4eba\u985e\u7684MHC\u4e5f\u7a31\u70ba\u4eba\u985e\u767d\u8840\u7403\u6297\u539f \uff08human leukocyte antigen, HLA\uff09\u3002\u53ef\u5206\u70ba class I\u53caclass II\uff0c\u662f\u7d50\u69cb\u76f8\u4f3c\u7684\u91a3\u86cb\u767d\uff0c\u7528\u65bc\u7d30\u80de\u5448\u73fe\u6297\u539f\u7684\u4f5c\u7528\u3002\u4eba\u985e\u767d\u8840\u7403\u6297\u539fclass I\u6703\u8868\u73fe\u5728\u6240\u6709\u7684\u9ad4\u7d30\u80de\u8868\u9762\uff0c\u800c\u4eba\u985e\u767d\u8840\u7403\u6297\u539fclass II \u53ea\u5728\u5de8\u566c\u7d30\u80de\u3001B \u7d30\u80de\u53ca\u6a39\u7a81\u72c0\u7d30\u80de\u7b49\u514d\u75ab\u7d30\u80de\u7684\u8868\u9762\u5448\u73fe\u6297\u539f\uff0c\u7576\u4ed6\u5011\u541e\u566c\u6297\u539f\u5f8c\uff0c\u6703\u7528\u86cb\u767d\u9175\u7d20\u628a\u6297\u539f\u5206\u89e3\u70ba\u7247\u6bb5\uff0c\u518d\u628a\u5177\u6709\u6297\u539f\u6027\u7684\u80dc\u80bd\uff08peptide\uff09\u8207\u7b2c\u4e8c\u578b\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u8907\u5408\u7269\u7d50\u5408\u5448\u73fe\u7d30\u80de\u819c\u4e0a\uff0c\u8b93\u8f14\u52a9\u8005T\u7d30\u80de\uff08T-helper cell\uff09\u8fa8\u8b58\uff0c\u4ee5\u555f\u52d5\u5f8c\u7e8c\u7684\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n

\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u662f\u6a39\u7a81\u7d30\u80de\u4e2d\u7684\u4e00\u7a2e\uff0c\u8207\u5176\u4ed6\u6a39\u7a81\u7d30\u80de\u6709\u76f8\u540c\u7684\u5916\u578b\uff0c\u90fd\u5177\u6709\u9577\u689d\u6709\u7bc0\u9ede\u7684\u6a39\u7a81\u3002\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u4f4d\u65bc\u6dcb\u5df4\u7d50\u7684\u6dcb\u5df4\u6ffe\u6ce1\uff0c\u6dcb\u5df4\u6ffe\u6ce1\u5167\u901a\u5e38\u5177\u6709\u5927\u91cf\u7684B\u7d30\u80de\u3002<\/p>\n

\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u8207\u5176\u4ed6\u6a39\u7a81\u7d30\u80de\u4e0d\u540c\u9ede\u6709\u4e8c\uff1a<\/p>\n

\u4e00\u3001\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u662f\u7531\u9aa8\u9ad3\u4e2d\u7684\u9593\u8cea\u5e79\u7d30\u80de\uff08mesenchymal stem cell, MSC\uff09\u5206\u5316\u800c\u4f86\uff1b<\/p>\n

\u4e8c\u3001\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u7121\u6cd5\u8868\u73feclass II MHC\u5206\u5b50\uff0c\u6240\u4ee5\u4e0d\u662f\u6297\u539f\u5448\u73fe\u7d30\u80de\u3002<\/p>\n

\u7136\u800c\uff0c\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u5728\u5176\u7d30\u80de\u819c\u4e0a\u80fd\u8868\u73fe\u5927\u91cf\u7684\u6297\u9ad4\uff08antibody\uff09\u8207\u88dc\u9ad4\uff08complement\uff09\u63a5\u53d7\u5668\uff08receptor\uff09\uff0c\u85c9\u7531\u63a5\u53d7\u5668\u8207\u6297\u9ad4\uff0d\u6297\u539f\u8907\u5408\u7269\uff08antibody-antigen complexes\uff09\u7d50\u5408\uff0c\u6709\u5229\u65bcB\u7d30\u80de\u7684\u6d3b\u5316\u3002\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u53ef\u4ee5\u5448\u73fe\u6297\u9ad4\uff0d\u6297\u539f\u8907\u5408\u7269\u5728\u7d30\u80de\u819c\u4e0a\u6578\u5468\u3001\u6578\u6708\u751a\u81f3\u66f4\u4e45\uff0c\u88ab\u8a8d\u70ba\u5728\u5354\u52a9\u767c\u5c55\u6dcb\u5df4\u6ffe\u6ce1\u4e2d\u7684\u8a18\u61b6B\u7d30\u80de\uff08memory B cell\uff09\u4e0a\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002<\/p>\n

\u503c\u5f97\u4e00\u63d0\u7684\u662f\u79d1\u5b78\u5bb6\u57282000\u5e74\u767c\u73fe\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u5c0d\u65bcprion\u86cb\u767d\u7684\u8f49\u8b8a\u7d2f\u7a4d\u76f8\u7576\u91cd\u8981\uff0c\u79d1\u5b78\u5bb6\u4ee5\u85e5\u7269\u4f7f\u5c0f\u9f20\u813e\u81df\u7684\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u55aa\u5931\u529f\u80fd\uff0c\u767c\u73fe\u611f\u67d3prion\u86cb\u767d\u7684\u5c0f\u9f20\u813e\u81df\u4e2d\uff0cprion\u86cb\u767d\u7684\u8f49\u8b8a\u7d2f\u7a4d\u88ab\u524a\u5f31\u3002\u57282011\u5e74\u79d1\u5b78\u5bb6\u7814\u7a76\u767c\u73fe\u5982\u679c\u4f7f\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u505c\u6b62\u8868\u73fe\u4e00\u822c\u7d30\u80deprion\u86cb\u767d\uff08cellular prion protein\uff09\uff0c\u5c07\u6291\u5236prion\u86cb\u767d\u5728\u5c0f\u9f20\u813e\u81df\u7d2f\u7a4d\uff0c\u4e14\u4e0d\u6703\u5c0d\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de\u7684\u72c0\u614b\u529f\u80fd\u7522\u751f\u660e\u986f\u7684\u6539\u8b8a\uff0c\u6210\u70ba\u6cbb\u7642\u72c2\u725b\u75c7\u7684\u65b0\u5951\u6a5f\u3002<\/p>\n

 <\/p>\n

\n

\u53c3\u8003\u6587\u737b<\/strong><\/p>\n

    \n
  1. Goldsby, R.A. et al. (2000). Kuby Immunology, 4th ed. W.H. freeman Co., Ch2 p46-47.<\/li>\n
  2. McCulloch, L, Brown, KL, Bradford, BM, Hopkins, J, Bailey, M, et al. (2011) Follicular Dendritic Cell-Specific Prion Protein (PrPc) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen. PLoSPathog 7(12): e1002402.<\/li>\n
  3. Montrasio, C, Frigg, R, Glatzel, M, Klein,M A, et al. (2000). Impaired Prion Replication in Spleens of Mice Lacking Functional Follicular Dendritic. Science\u00a0 288 (5469), 1257-1259.<\/li>\n<\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"

    \u6ffe\u6ce1\uff08\u56ca\u6ce1\uff09\u6a39\u7a81\u7d30\u80de (Follicular dendritic cell) \u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u7814\u7a76\u52a9…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4822,110,4811],"tags":[4714,1153,8004,4713],"class_list":["post-42784","post","type-post","status-publish","format-standard","hentry","category-lifesciecne002-01","category-lifesciecne00","category-lifesciecne002","tag-follicular-dendritic-cell","tag-1153","tag-8004","tag-4713","loop-entry","cat-4822","cat-110","cat-4811","no-thumbnail"],"views":8315,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=42784"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42784\/revisions"}],"predecessor-version":[{"id":87593,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42784\/revisions\/87593"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=42784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=42784"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=42784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}