{"id":42585,"date":"2013-08-06T16:59:53","date_gmt":"2013-08-06T08:59:53","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=42585"},"modified":"2021-10-06T16:21:03","modified_gmt":"2021-10-06T08:21:03","slug":"%e5%8e%9f%e8%87%b4%e7%99%8c%e5%9f%ba%e5%9b%a0%ef%bc%88proto-oncogene%ef%bc%89-2","status":"publish","type":"post","link":"http:\/\/localhost\/%e5%8e%9f%e8%87%b4%e7%99%8c%e5%9f%ba%e5%9b%a0%ef%bc%88proto-oncogene%ef%bc%89-2\/","title":{"rendered":"\u539f\u81f4\u764c\u57fa\u56e0\uff08Proto-oncogene\uff09"},"content":{"rendered":"

\u539f\u81f4\u764c\u57fa\u56e0\uff08Proto-oncogene\uff09<\/span>
\n<\/strong>\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u7814\u7a76\u52a9\u7406\u80e1\u742c\u7433<\/span><\/strong><\/p>\n

\"\"\u539f\u81f4\u764c\u57fa\u56e0\uff08proto-oncogene\uff09\u70ba\u7d30\u80de\u5167\u4e4b\u6b63\u5e38\u57fa\u56e0\uff0c\u5176\u8868\u73fe\u7684\u86cb\u767d\u8cea\u7522\u7269\u80fd\u4fc3\u9032\u7d30\u80de\u751f\u9577\u53ca\u5206\u88c2\uff0c\u7576\u539f\u81f4\u764c\u57fa\u56e0\u5728\u8af8\u5982\u653e\u5c04\u6027\u7269\u8cea\u3001\u5316\u5b78\u7269\u8cea\u53ca\u75c5\u6bd2<\/a>\u7684\u4f5c\u7528\u5f71\u97ff\u4e0b\u800c\u7a81\u8b8a\uff08mutation\uff09\u6642\uff0c\u6703\u9020\u6210\u5176\u86cb\u767d\u8cea\u7522\u7269\u904e\u91cf\u7522\u751f\u6216\u662f\u6d3b\u6027\u589e\u52a0\uff0c\u4f7f\u7d30\u80de\u7684\u751f\u9577\u53ca\u5206\u88c2\u5927\u5e45\u589e\u52a0\u800c\u5c0e\u81f4\u764c\u75c7\uff08cancer\uff09\u3002\u6b64\u6642\u7a81\u8b8a\u5f8c\u7684\u539f\u81f4\u764c\u57fa\u56e0\u5373\u7a31\u70ba\u81f4\u764c\u57fa\u56e0\uff08oncogene\uff09\uff0c\u63db\u8a00\u4e4b\uff0c\u539f\u81f4\u764c\u57fa\u56e0\u662f\u81f4\u764c\u57fa\u56e0\u7684\u524d\u8eab\u3002<\/p>\n

\u539f\u81f4\u764c\u57fa\u56e0\u7a81\u8b8a\u70ba\u81f4\u764c\u57fa\u56e0\u7684\u65b9\u5f0f\u53ef\u5206\u70ba\u4e09\u985e\uff1a(1) \u57fa\u56e0\u65bc\u57fa\u56e0\u7d44\u4e2d\uff08genome\uff09\u7684\u79fb\u52d5\uff1b(2) \u539f\u81f4\u764c\u57fa\u56e0\u7684\u653e\u5927\uff08amplification\uff09\uff1b(3) \u539f\u81f4\u764c\u57fa\u56e0\u672c\u8eab\u6216\u5176\u8abf\u63a7\u5340\uff08control element\uff09\u767c\u751f\u9ede\u7a81\u8b8a\uff08point mutation\uff09\u3002\u5728\u7b2c\u4e00\u985e\u60c5\u5f62\u4e2d\uff0c\u539f\u81f4\u764c\u57fa\u56e0\u7d93\u8f49\u4f4d\u4f5c\u7528\uff08translocation\uff09\u79fb\u81f3\u4e0d\u540c\u7684\u57fa\u56e0\u5ea7\uff08locus\uff09\uff0c\u56e0\u53d7\u5230\u8f03\u70ba\u6d3b\u5316\u7684\u555f\u52d5\u5b50\uff08promoter\uff09\u8abf\u63a7\uff0c\u5c0e\u81f4\u5176\u8868\u73fe\u91cf\u589e\u52a0\u800c\u8f49\u8b8a\u70ba\u81f4\u764c\u57fa\u56e0\uff1b\u5728\u7b2c\u4e8c\u985e\u60c5\u5f62\u4e2d\uff0c\u56e0\u70ba\u539f\u81f4\u764c\u57fa\u56e0\u7684\u5957\u6578\uff08copy number\uff09\u589e\u52a0\uff0c\u5c0e\u81f4\u5176\u8868\u73fe\u91cf\u589e\u52a0\u800c\u8f49\u8b8a\u70ba\u81f4\u764c\u57fa\u56e0\uff1b\u5728\u7b2c\u4e09\u985e\u60c5\u5f62\u4e2d\uff0c\u56e0\u70ba\u539f\u81f4\u764c\u57fa\u56e0\u672c\u8eab\u767c\u751f\u9ede\u7a81\u8b8a\uff0c\u4f7f\u5176\u6240\u8868\u73fe\u7684\u86cb\u767d\u8cea\u6d3b\u6027\u589e\u52a0\u6216\u4e0d\u6613\u88ab\u964d\u89e3\uff08degradation\uff09\uff0c\u6216\u8005\u7576\u539f\u81f4\u764c\u57fa\u56e0\u8abf\u63a7\u5340\u767c\u751f\u9ede\u7a81\u8b8a\uff0c\u4ea6\u53ef\u5c0e\u81f4\u5176\u8868\u73fe\u91cf\u589e\u52a0\u800c\u8f49\u8b8a\u70ba\u81f4\u764c\u57fa\u56e0\u3002<\/p>\n

\u76ee\u524d\u7814\u7a76\u6240\u767c\u73fe\u7684\u539f\u81f4\u764c\u57fa\u56e0\u5927\u81f4\u53ef\u5206\u70ba\u751f\u9577\u56e0\u5b50\uff08growth factors\uff09\u3001\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\uff08receptor tyrosine kinases\uff09\u3001\u819c\u4e0a\u975e\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\uff08membrane mssociated non-neceptor tyrosine kinases\uff09\u3001G\u86cb\u767d\u5076\u806f\u53d7\u9ad4\uff08G-protein coupled receptors\uff09\u3001\u7d72\u80fa\u9178\uff0f\u8607\u80fa\u9178\u6fc0\u9176\uff08serine\/threonine kinases\uff09\u3001\u6838\u5167DNA\u7d50\u5408\/\u8f49\u9304\u56e0\u5b50\uff08nuclear DNA-binding\/transcription factors\uff09\u7b49\u57fa\u56e0\u3002<\/p>\n

\u4ee5\u4e0b\u5206\u9805\u8209\u4f8b\u4e26\u7c21\u4ecb\u5404\u539f\u81f4\u764c\u57fa\u56e0:<\/p>\n

1. \u751f\u9577\u56e0\u5b50\uff08growth factors\uff09<\/strong><\/p>\n

SIS\u57fa\u56e0 [v-sis\u57fa\u56e0\u70ba\u733f\u7334\u8089\u7624\u75c5\u6bd2\uff08simian sarcoma virus\uff09\u4e2d\u7684\u81f4\u764c\u57fa\u56e0] \u8868\u73fe\u8840\u5c0f\u677f\u884d\u751f\u6027\u751f\u9577\u56e0\u5b50B\u93c8\uff08PDGF B chain\uff09\uff0c\u6b64\u57fa\u56e0\u70ba\u6700\u5148\u88ab\u78ba\u8a8d\u8207\u5df2\u77e5\u7d30\u80de\u5167\u57fa\u56e0\u5177\u6709\u540c\u6e90\u6027\u7684\u81f4\u764c\u57fa\u56e0\u3002<\/p>\n

int-2\u57fa\u56e0\u8868\u73fe\u4e00\u7a2e\u8207\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u76f8\u95dc\u7684\u751f\u9577\u56e0\u5b50\uff08FGF-related growth factor\uff09\u3002<\/p>\n

KGF\u57fa\u56e0\u53c8\u7a31HST\u57fa\u56e0\uff0c\u4ea6\u8868\u73fe\u4e00\u7a2e\u8207\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u76f8\u95dc\u7684\u751f\u9577\u56e0\u5b50\uff0c\u800c\u4e14\u5728\u80c3\u764c\u53ca\u5361\u6ce2\u897f\u6c0f\u8089\u7624\uff08Kaposi’s sarcoma\uff09\u7d30\u80de\u4e2d\u88ab\u767c\u73fe\u3002<\/p>\n

2. \u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\uff08receptor tyrosine kinases\uff09<\/strong><\/p>\n

FMS\u57fa\u56e0\u8868\u73fe\u8840\u7403\u751f\u9577\u6fc0\u7d20-1 \u53d7\u9ad4\uff08colony stimulating factor-1 receptor\uff09\uff0c\u4e14\u88ab\u78ba\u8a8d\u70ba\u4e00\u53cd\u8f49\u9304\u75c5\u6bd2\uff08retrovirus\uff09\u7684\u81f4\u764c\u57fa\u56e0<\/p>\n

TRK\u57fa\u56e0\u8868\u73fe\u985e\u795e\u7d93\u751f\u9577\u56e0\u5b50<\/a>\u53d7\u9ad4\u86cb\u767d\uff08NGF receptor-like protein\uff09\uff0c\u7b2c\u4e00\u500b\u88ab\u767c\u73fe\u7684TRK\u57fa\u56e0\u4f4d\u65bc\u80f0\u81df\u764c\u7d30\u80de\u4e2d\u3002<\/p>\n

3. \u819c\u4e0a\u975e\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\uff08membrane associated non-receptor tyrosine kinases\uff09<\/strong><\/p>\n

SRC\u57fa\u56e0\u70ba\u7b2c\u4e00\u500b\u88ab\u767c\u73fe\u7684\u539f\u81f4\u764c\u57fa\u56e0\uff0c\u5176\u86cb\u767d\u8cea\u7522\u7269\u70ba\u86cb\u767d\u8cea\u916a\u6c28\u9178\u6fc0\u9176\uff08protein tyrosine kinase\uff09\u3002<\/p>\n

LCK\u57fa\u56e0\u5f9eT\u7d30\u80de\u816b\u7624\u682a\uff08T cell tumor line\uff09\u4e2d\u6240\u5206\u96e2\uff0c\u4e14\u88ab\u8a8d\u70ba\u8207T\u7d30\u80de\u7684CD4\u53caCD8\u6297\u539f\uff08antigen\uff09\u6709\u95dc\u3002<\/p>\n

4. G\u86cb\u767d\u5076\u806f\u53d7\u9ad4\uff08G-protein coupled receptors\uff09<\/strong><\/p>\n

MAS\u57fa\u56e0\u5728\u4e73\u764c\u7d30\u80de\uff08mammary carcinoma\uff09\u4e2d\u6240\u767c\u73fe\uff0c\u5176\u86cb\u767d\u8cea\u7522\u7269\u70ba\u8840\u7ba1\u6536\u7e2e\u7d20\uff08angiotensin\uff09\u7684\u53d7\u9ad4<\/p>\n

5. \u7d72\u80fa\u9178\uff0f\u8607\u80fa\u9178\u6fc0\u9176\uff08serine\/threonine kinases\uff09<\/strong><\/p>\n

RAF\u57fa\u56e0\u53c3\u8207\u5728\u5927\u591a\u6578\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\uff08RTK\uff09\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u3002<\/p>\n

MOS\u57fa\u56e0\u4e00\u822c\u8868\u73fe\u65bc\u751f\u6b96\u7d30\u80de\uff08germ cell\uff09\u4e14\u4f5c\u7528\u65bc\u5375\u5b50\u6210\u719f\u6642\u3002<\/p>\n

6. \u6838\u5167DNA\u7d50\u5408\/\u8f49\u9304\u56e0\u5b50\uff08nuclear DNA-binding\/transcription Factors\uff09<\/strong><\/p>\n

FOS\u57fa\u56e0\u9996\u5148\u65bc\u9aa8\u6e90\u6027\u8089\u7624\u75c5\u6bd2\uff08Finkel, Biskis, Jinkins murine osteogenic sarcoma virus\uff09\u4e2d\u88ab\u767c\u73fe\uff0c\u5176\u86cb\u767d\u8cea\u7522\u7269\u6703\u8207\u53e6\u4e00\u539f\u81f4\u764c\u57fa\u56e0JUN\u7684\u86cb\u767d\u8cea\u7522\u7269\u4ea4\u4e92\u4f5c\u7528\uff0c\u5f62\u6210\u8f49\u9304\u8abf\u7bc0\u8907\u5408\u9ad4\uff08transcriptional regulatory complex\uff09\u3002<\/p>\n

p53\u57fa\u56e0\u7684\u86cb\u767d\u8cea\u7522\u7269\u70ba\u4eba\u985e\u816b\u7624\u4e2d\u6700\u70ba\u4eba\u719f\u77e5\u7684\u7a81\u8b8a\u86cb\u767d\uff08mutant protein\uff09\uff0c\u7a81\u8b8a\u5f62\u5f0f\u7684p53\u86cb\u767d\u6703\u5e72\u64fe\u6b63\u5e38p53\u86cb\u767d\u6291\u5236\u7d30\u80de\u751f\u9577\u7684\u529f\u80fd\uff0c\u6545\u5c0e\u81f4\u764c\u75c7\u7522\u751f\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/p>\n

Jane, B. R., Lisa, A. U., Michael, L. C., Steven, A. W., Peter, V. M., & Robert, B. J. 2011. CAMPBELL BIOLOGY. Ninth Edition. San Francisco: Pearson Education, Inc.<\/p>\n

Harvey, L., Arnold, B., Chris, A. K., Monty, K., Matthew, P. S., Anthony, B., Hidde, P., & Paul, M. 2007. Molecular cell biology. Sixth Edition. W. H. Freeman and Company.<\/p>\n

The Medical Biochemistry Page. http:\/\/themedicalbiochemistrypage.org\/oncogene.php<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u539f\u81f4\u764c\u57fa\u56e0\uff08Proto-oncogene\uff09 \u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u7814\u7a76\u52a9\u7406\u80e1\u742c\u7433 \u539f\u81f4\u764c\u57fa\u56e0\uff08proto-…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[110,122,4832],"tags":[4651,2458,3529,4686],"class_list":["post-42585","post","type-post","status-publish","format-standard","hentry","category-lifesciecne00","category-lifescience004","category-lifesciecne004-01","tag-4651","tag-2458","tag-3529","tag-4686","loop-entry","cat-110","cat-122","cat-4832","no-thumbnail"],"views":28438,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=42585"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42585\/revisions"}],"predecessor-version":[{"id":87610,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/42585\/revisions\/87610"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=42585"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=42585"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=42585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}