{"id":36461,"date":"2009-11-21T12:12:19","date_gmt":"2009-11-21T04:12:19","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=36461"},"modified":"2021-10-06T16:38:24","modified_gmt":"2021-10-06T08:38:24","slug":"%e8%b6%85%e7%b4%9a%e8%80%90%e5%8a%9b%e7%9a%84%e7%a5%9e%e7%a7%98%e8%82%8c%e8%82%89","status":"publish","type":"post","link":"http:\/\/localhost\/%e8%b6%85%e7%b4%9a%e8%80%90%e5%8a%9b%e7%9a%84%e7%a5%9e%e7%a7%98%e8%82%8c%e8%82%89\/","title":{"rendered":"\u8d85\u7d1a\u8010\u529b\u7684\u795e\u79d8\u808c\u8089"},"content":{"rendered":"

\u8d85\u7d1a\u8010\u529b\u7684\u795e\u79d8\u808c\u8089<\/span>
\n\u77e5\u8b58\u901a\u8a0a\u8a55\u8ad6\u7b2c52\u671f<\/span><\/strong><\/p>\n

\u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u5229\u7528\u57fa\u56e0\u6539\u9020\u53ef\u4f7f\u8001\u9f20\u589e\u52a0\u67d0\u7a2e\u808c\u8089\u7e96\u7dad\uff0c\u800c\u9019\u7a2e\u7279\u6b8a\u808c\u8089\u7e96\u7dad\u53ef\u4ee5\u63d0\u5347\u4eba\u9ad4\u904b\u52d5\u80fd\u529b\u3002<\/strong><\/p>\n

\"\"<\/a>\u900f\u904e\u57fa\u56e0\u5fae\u8abf\uff08genetic tweak\uff09\u4f7f\u8001\u9f20\u9ad4\u5167\u67d0\u7a2e\u5c11\u898b\u7684\u808c\u8089\u7e96\u7dad\u589e\u52a0\uff0c\u6703\u628a\u5b83\u8b8a\u6210\u9577\u8dd1\u5065\u5c07\u3002\u9019\u500b\u65b0\u767c\u73fe\u53ef\u80fd\u6709\u52a9\u65bc\u589e\u52a0\u4eba\u9ad4\u7684\u904b\u52d5\u80fd\u529b\uff0c\u751a\u81f3\u6e1b\u7de9\u808c\u8089\u840e\u7e2e\u3002<\/p>\n

\u4eba\u9ad4\u808c\u8089\u7531\u56db\u7a2e\u7e96\u7dad\u7d44\u6210\uff0c\u5176\u4e2d\u5305\u62ec\u5169\u7a2e\u8010\u4e45\u6d3b\u52d5\u9069\u7528\u7684\u6162\u7e2e\uff08slow-twitch\uff09\u7e96\u7dad\u3001\u4e00\u7a2e\u885d\u523a\u6d3b\u52d5\u9069\u7528\u7684\u5feb\u7e2e\uff08fast-twitch\uff09\u7e96\u7dad\u3002\u4f46\u662f\u6211\u5011\u5c0d\u65bc\u7b2c\u56db\u7a2e IIX\u578b\u7e96\u7dad\u77ad\u89e3\u975e\u5e38\u6709\u9650\uff0c\u56e0\u70ba\u5b83\u6563\u4f48\u5728\u8a31\u591a\u4e0d\u540c\u7a2e\u985e\u7684\u808c\u8089\u4e4b\u9593\u3002<\/p>\n

\u6700\u8fd1\u7f8e\u570b\u6ce2\u58eb\u9813\u7684\u4e00\u500b\u7814\u7a76\u5718\u968a\u767c\u73fe\u4e86\u67d0\u7a2e\u57fa\u56e0\u958b\u95dc\uff0c\u5e7e\u4e4e\u53ef\u4ee5\u628a\u8001\u9f20\u9ad4\u5167\u6240\u6709\u808c\u8089\u7e96\u7dad\u8b8a\u6210IIX\u578b\u7e96\u7dad\u3002\u5be6\u9a57\u6210\u679c\u4ee4\u4eba\u5403\u9a5a\u3002<\/p>\n

\u7814\u7a76\u8a08\u756b\u4e3b\u6301\u4eba\u3001\u54c8\u4f5b\u91ab\u5b78\u9662\u7684\u53f2\u8c9d\u66fc\uff08Bruce Spiegelman\uff09\u8aaa\uff1a\u300c\u5b83\u5011\u9084\u771f\u662f\u512a\u79c0\u7684\u904b\u52d5\u54e1\u3002\u300d\u9019\u4e9b\u63a5\u53d7\u57fa\u56e0\u5fae\u8abf\u7684\u8001\u9f20\u5728\u8dd1\u6b65\u6a5f\u9023\u7e8c\u5feb\u8dd1\u76f4\u5230\u9ad4\u529b\u8017\u76e1\u7684\u6642\u9593\uff0c\u6bd4\u666e\u901a\u8001\u9f20\u591a\u4e86\u767e\u5206\u4e4b\u4e8c\u5341\u4e94\u3002<\/p>\n

\u9019\u500b\u767c\u73fe\u4e5f\u986f\u793a\uff0cIIX\u578b\u808c\u8089\u7e96\u7dad\u5c0d\u65bc\u904b\u52d5\u80fd\u529b\u7684\u63d0\u5347\u6709\u5f88\u5927\u8ca2\u737b\uff0c\u4f46\u662f\u9bae\u70ba\u4eba\u77e5\u3002\u5b78\u8005\u8a8d\u70ba\uff0c\u5728\u4e16\u754c\u7d1a\u904b\u52d5\u54e1\u7684\u9ad4\u5167\uff0c\u9019\u7a2e\u7e96\u7dad\u5f88\u53ef\u80fd\u6bd4\u4e00\u822c\u4eba\u591a\uff0c\u61c9\u662f\u5929\u8ce6\u6240\u81f4\uff0c\u7136\u800c\u56b4\u683c\u8a13\u7df4\u4e5f\u53ef\u80fd\u589e\u52a0\u9019\u7a2e\u7e96\u7dad\u3002<\/p>\n

\u7814\u7a76\u8a08\u756b\u6210\u54e1\u4e4b\u4e00\u3001\u54c8\u4f5b\u91ab\u5b78\u9662\u7684\u963f\u96f7\u5c3c\uff08Zoltan Arany\uff09\u8868\u793a\uff0c\u679c\u771f\u5982\u6b64\uff0c\u5c07\u4f86\u7684\u904b\u52d5\u54e1\u5c31\u53ef\u4ee5\u5229\u7528\u9019\u9805\u65b0\u767c\u73fe\u7684\u6210\u679c\u3002\u4ed6\u8aaa\uff0c\u672a\u4f86\u5f88\u6709\u53ef\u80fd\u51fa\u73fe\u80fd\u5920\u4fc3\u9032\u7279\u6b8a\u7e96\u7dad\u589e\u9577\u7684\u85e5\u7269\uff0c\u904b\u52d5\u54e1\u4e5f\u53ef\u80fd\u6feb\u7528\u9019\u985e\u85e5\u7269\u3002<\/p>\n

\u5148\u524d\u7684\u7814\u7a76\u8b49\u5be6\uff0c\u589e\u52a0\u67d0\u7a2e\u808c\u8089\u7e96\u7dad\uff0c\u6709\u52a9\u65bc\u6e1b\u7de9\u808c\u8089\u8870\u9000\u3002\u963f\u96f7\u5c3c\u8aaa\uff0c\u672a\u4f86\u7684\u76f8\u95dc\u7814\u7a76\uff0c\u4e5f\u8a31\u80fd\u5e6b\u52a9\u7f79\u60a3\u300c\u808c\u840e\u7e2e\u6027\u810a\u9ad3\u5074\u7d22\u786c\u5316\u75c7\u300d\uff08amyotrophic lateral sclerosis\uff09\u7b49\u75be\u75c5\u7684\u4eba\u6e1b\u7de9\u808c\u8089\u840e\u7e2e\u75c7\u72c0\u3002<\/p>\n

\u7e96\u7dad\u8f49\u8b8a<\/strong><\/p>\n

\u4e0d\u540c\u7684\u808c\u8089\u7e96\u7dad\u6709\u4e0d\u540c\u7684\u7279\u6027\uff0c\u4e5f\u9069\u7528\u65bc\u4e0d\u540c\u7684\u9ad4\u80fd\u6d3b\u52d5\u3002<\/p>\n

I\u578b\u8207IIA\u578b\u9019\u5169\u7a2e\u6162\u7e2e\u7e96\u7dad\u5145\u6eff\u4e86\u6703\u7522\u751f\u80fd\u91cf\u7684\u7c92\u7dda\u9ad4\uff0c\u9069\u7528\u65bc\u8d70\u8def\u9019\u7a2e\u9023\u7e8c\u4e0d\u65b7\u3001\u6d88\u8017\u5927\u91cf\u6c27\u6c23\u7684\u8010\u4e45\u9ad4\u80fd\u904b\u52d5\u3002\u8209\u4f8b\u4f86\u8aaa\uff0c\u5c0f\u817f\u7684\u6bd4\u76ee\u9b5a\u808c\uff08soleus muscle\uff09\u5c31\u5145\u6eff\u4e86\u9019\u7a2e\u7e96\u7dad\u3002<\/p>\n

IIB\u578b\u7e96\u7dad\u662f\u5feb\u7e2e\u7e96\u7dad\uff0c\u80fd\u5728\u77ed\u6642\u9593\u5167\u8fc5\u901f\u6536\u7e2e\uff0c\u4e5f\u4e0d\u592a\u9700\u8981\u6c27\u6c23\u3002\u4eba\u9ad4\u9700\u8981\u5b83\u5011\u9032\u884c\u4e00\u4e9b\u5feb\u901f\u4f46\u8cbb\u529b\u7684\u6d3b\u52d5\u3002\u5c0d\u77ed\u8dd1\u885d\u523a\u800c\u8a00\u76f8\u7576\u91cd\u8981\u7684\u56db\u982d\u808c\uff0c\u5c31\u542b\u6709\u8a31\u591aIIB\u578b\u7e96\u7dad\u3002<\/p>\n

IIX\u578b\u7e96\u7dad\u5247\u4ecb\u65bc\u5169\u8005\u4e4b\u9593\uff0c\u5b83\u5011\u5bcc\u542b\u7c92\u7dda\u9ad4\uff0c\u4f46\u662f\u4e5f\u80fd\u5feb\u901f\u6536\u7e2e\u3002\u6709\u5b78\u8005\u8a8d\u70ba\uff0cIIX\u578b\u7e96\u7dad\u662f\u5feb\u7e2e\u7e96\u7dad\u8f49\u8b8a\u6210\u6162\u7e2e\u7e96\u7dad\u7684\u904e\u6e21\u968e\u6bb5\uff0c\u67d0\u4e9b\u808c\u529b\u8a13\u7df4\u4e5f\u80fd\u4fc3\u6210\u9019\u7a2e\u8f49\u8b8a\uff0c\u4f46\u662f\u5b83\u5011\u7a76\u7adf\u6709\u4f55\u529f\u7528\uff0c\u4ecd\u5c6c\u672a\u77e5\u3002<\/p>\n

\u70ba\u8dd1\u800c\u751f<\/strong><\/p>\n

\u56db\u5e74\u524d\uff0c\u53f2\u8c9d\u66fc\u9818\u929c\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u523a\u6fc0\u4e00\u7a2ePGC-1\u578b\u57fa\u56e0\uff0c\u6703\u628a\u5305\u542b\u5404\u7a2e\u4e0d\u540c\u7e96\u7dad\u7684\u808c\u8089\uff0c\u8f49\u8b8a\u6210\u4ee5\u6162\u7e2e\u7e96\u7dad\u70ba\u4e3b\u7684\u808c\u8089\u7d44\u7e54\u3002<\/p>\n

\u8a72\u5718\u968a\u5c07\u6700\u65b0\u7684\u7814\u7a76\u6210\u679c\u767c\u8868\u5728\u300a\u7d30\u80de\u4ee3\u8b1d\u300b\uff08Cell Metabolism\uff09\u671f\u520a\u4e2d\u3002\u4ed6\u5011\u5229\u7528\u907a\u50b3\u5de5\u7a0b\u6280\u8853\uff0c\u628aPGC-1\u57fa\u56e0\u7684\u4e00\u500b\u540c\u985e\u57fa\u56e0\u300c\u6253\u958b\u300d\uff08switch on\uff09\uff0c\u9019\u4e5f\u4f7f\u539f\u672c\u5305\u542b\u767e\u5206\u4e4b\u5341\u4e94\u5230\u767e\u5206\u4e4b\u4e8c\u5341IIX\u578b\u7e96\u7dad\u7684\u808c\u8089\uff0c\u8b8a\u6210IIX\u578b\u7e96\u7dad\u4f54\u5168\u90e8\u7d44\u7e54\u8fd1\u767e\u5206\u4e4b\u767e\u7684\u808c\u8089\u3002<\/p>\n

\u5b78\u8005\u8a8d\u70ba\uff0cPGC-1\u7b49\u5169\u7a2e\u57fa\u56e0\u53ef\u4ee5\u300c\u6253\u958b\u300d\u4e00\u9023\u4e32\u7684\u76f8\u95dc\u57fa\u56e0\uff0c\u4fc3\u4f7f\u67d0\u7a2e\u808c\u8089\u7e96\u7dad\u8f49\u8b8a\u6210\u53e6\u4e00\u7a2e\u7e96\u7dad\u3002<\/p>\n

\u63a2\u7d22\u808c\u8089\u7e96\u7dad\u7684\u8f49\u8b8a\u904e\u7a0b\uff0c\u4f7f\u5b78\u8005\u6709\u6a5f\u6703\u4ed4\u7d30\u6aa2\u8996\u4e0d\u540c\u7684\u808c\u8089\u7e96\u7dad\u5982\u4f55\u904b\u4f5c\u767c\u5c55\uff0c\u9019\u4e9b\u7e96\u7dad\u53c8\u600e\u6a23\u5f71\u97ff\u8eab\u9ad4\u7684\u6d3b\u52d5\u80fd\u529b\u3002\"\"<\/a><\/p>\n

\u79d1\u5b78\u5bb6\u9084\u7121\u6cd5\u78ba\u5b9a\u70ba\u4f55\u5c11\u6578\u4eba\u80fd\u5920\u5728\u8d85\u7d1a\u99ac\u62c9\u677e\u7b49\u8010\u529b\u7af6\u8cfd\u4e2d\u5c62\u5c62\u7372\u52dd\u3002\u54c8\u4f5b\u91ab\u5b78\u9662\u7684\u53f2\u8c9d\u66fc\u8aaa\uff0c\u4ed6\u60f3\u77e5\u9053\uff0c\u90a3\u4e9b\u8010\u529b\u8cfd\u9ad8\u624b\u7684PGC\u57fa\u56e0\u662f\u5426\u8207\u773e\u4e0d\u540c\uff0c\u6216\u8005\u4ed6\u5011\u9ad4\u5167\u7684IIX\u578b\u808c\u8089\u7e96\u7dad\u6bd4\u5e38\u4eba\u591a\u3002<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u8d85\u7d1a\u8010\u529b\u7684\u795e\u79d8\u808c\u8089 \u77e5\u8b58\u901a\u8a0a\u8a55\u8ad6\u7b2c52\u671f \u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u5229\u7528\u57fa\u56e0\u6539\u9020\u53ef\u4f7f\u8001\u9f20\u589e\u52a0\u67d0\u7a2e\u808c\u8089\u7e96\u7dad\uff0c\u800c\u9019\u7a2e\u7279\u6b8a\u808c\u8089\u7e96\u7dad…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[170,165,5930],"tags":[3973,3972,3974],"class_list":["post-36461","post","type-post","status-publish","format-standard","hentry","category-kreview05","category-kreview00","category-5930","tag-genetic-tweak","tag-3972","tag-3974","avhec_catgroup-all","loop-entry","cat-170","cat-165","cat-5930","no-thumbnail"],"views":2981,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/36461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=36461"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/36461\/revisions"}],"predecessor-version":[{"id":90149,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/36461\/revisions\/90149"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=36461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=36461"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=36461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}