{"id":34077,"date":"2011-08-15T21:07:30","date_gmt":"2011-08-15T13:07:30","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=34077"},"modified":"2021-10-06T16:24:11","modified_gmt":"2021-10-06T08:24:11","slug":"%e5%aa%bd%e5%aa%bd%e9%a3%b2%e9%a3%9f%e5%8f%af%e8%83%bd%e6%94%b9%e8%ae%8a%e8%83%8e%e5%85%92%e5%9f%ba%e5%9b%a0","status":"publish","type":"post","link":"http:\/\/localhost\/%e5%aa%bd%e5%aa%bd%e9%a3%b2%e9%a3%9f%e5%8f%af%e8%83%bd%e6%94%b9%e8%ae%8a%e8%83%8e%e5%85%92%e5%9f%ba%e5%9b%a0\/","title":{"rendered":"\u5abd\u5abd\u98f2\u98df\u53ef\u80fd\u6539\u8b8a\u80ce\u5152\u57fa\u56e0"},"content":{"rendered":"<div class=\"pf-content\"><p><span style=\"color: #ff6600;\"><strong>\u5abd\u5abd\u98f2\u98df\u53ef\u80fd\u6539\u8b8a\u80ce\u5152\u57fa\u56e0<\/strong><\/span><br \/>\n<strong> <span style=\"color: #008000;\">\u77e5\u8b58\u901a\u8a0a\u8ad6\u7b2c38\u671f<\/span><\/strong><\/p>\n<p><strong>\u79d1\u5b78\u5bb6\u6700\u8fd1\u7814\u7a76\u986f\u793a\uff0c\u98f2\u98df\u88dc\u5145\u5291\u6703\u8b93\u5e7e\u4e16\u4ee3\u7684\u5c0f\u9f20\u8b8a\u5f97\u80a5\u80d6\uff0c\u9019\u7a2e\u73fe\u8c61\u5c0d\u4eba\u985e\u662f\u5426\u6709\u76f8\u540c\u5f71\u97ff\uff0c\u9084\u5f85\u89c0\u5bdf\u3002<\/strong><\/p>\n<p><a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2011\/08\/\u61f7\u5b55.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-34079\" title=\"Imacon Color Scanner\" src=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2011\/08\/\u61f7\u5b55.jpg\" alt=\"\" width=\"419\" height=\"432\" \/><\/a> \u300c\u4eba\u985e\u57fa\u56e0\u9ad4\u7d44\u7e54\u300d(the Human Genome Organisation)\u516d\u6708\u4e00\u65e5\u5728\u82ac\u862d\u9996\u90fd\u8d6b\u723e\u8f9b\u57fa\u96c6\u6703\uff0c\u6703\u4e2d\u63d0\u51fa\u7684\u4e00\u4efd\u7814\u7a76\u986f\u793a\uff0c\u5982\u679c\u5728\u61f7\u5b55\u4e2d\u6bcd\u9f20\u7684\u98f2\u98df\u6dfb\u52a0\u6771\u897f\uff0c\u5c31\u7b97\u53ea\u662f\u55ae\u7d14\u7684\u7dad\u4ed6\u547d\uff0c\u4e5f\u80fd\u53eb\u5b83\u7684\u5f8c\u4ee3\u8b8a\u80d6\u3002\u79d1\u5b78\u754c\u8a8d\u70ba\uff0c\u9019\u7a2e\u6548\u61c9\u662f\u56e0\u70ba\u6bcd\u9f20\u7684\u53bb\u6c27\u6838\u91a3\u6838\u9178\u56e0\u6b64\u7522\u751f\u5316\u5b78\u8b8a\u5316\uff0c\u5f71\u97ff\u6240\u53ca\u53ef\u9054\u597d\u5e7e\u4e16\u4ee3\u3002<\/p>\n<p>\u4eba\u985e\u6e96\u5abd\u5abd\u5728\u6bcf\u65e5\u98f2\u98df\u4e2d\uff0c\u589e\u52a0\u8449\u9178(folic acid)\u7684\u651d\u53d6\u91cf\uff0c\u800c\u964d\u4f4e\u65b0\u751f\u5152\u51fa\u73fe\u810a\u67f1\u5206\u88c2(Spina bifida)\u7684\u6848\u4f8b\uff0c\u9019\u7a2e\u60f3\u6cd5\u5230\u5e95\u597d\u4e0d\u597d\uff0c\u5411\u4f86\u6709\u722d\u8b70\uff0c\u9019\u4efd\u7814\u7a76\u582a\u7a31\u706b\u4e0a\u52a0\u6cb9\u3002<!--more--><\/p>\n<p>\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813\u5e02\u300c\u8c9d\u52d2\u91ab\u5b78\u9662\u300d(Baylor College of Medicine)\u5c08\u5bb6\u74e6\u7279\u862d(Rob Waterland)\u7387\u9818\u5718\u968a\uff0c\u7814\u7a76\u98df\u7269\u4e2d\u67d0\u4e9b\u6df7\u5408\u990a\u5206\uff0c\u5982\u8449\u9178\u53ca\u7dad\u4ed6\u547dB12\u3002\u9019\u4e9b\u6df7\u5408\u990a\u5206\u80fd\u589e\u52a0\u7a31\u505a\u7532\u57fa\u7fa4(methyl group)\u7684\u5316\u5b78\u6210\u5206\u5230\u53bb\u6c27\u6838\u91a3\u6838\u9178(DNA)\u7576\u4e2d\uff0c\u5f9e\u800c\u5f71\u97ff\u5230\u57fa\u56e0\u7684\u6d3b\u52d5\uff1b\u9019\u7a2e\u73fe\u8c61\uff0c\u90e8\u5206\u53ef\u4ee5\u7a31\u70ba\u300c\u8868\u89c0\u907a\u50b3\u5b78\u300d\uff08Epigenetics\uff09\u3002<\/p>\n<p>\u5176\u4ed6\u5b78\u8005\u5df2\u7d93\u6307\u51fa\uff0c\u6bcd\u5c0f\u9f20\u7684\u98f2\u98df\u4e2d\u6dfb\u52a0\u7532\u57fa\u5f37\u5316\u7269\uff0c\u6703\u5f71\u97ff\u5979\u5f8c\u4ee3\u7684\u57fa\u56e0\u6d3b\u52d5\u3002\u5c0f\u9f20\u7a31\u505a\u300c\u523a\u8c5a\u9f20\u300d(<em>agouti<\/em>)\u7684\u8868\u76ae\u57fa\u56e0\u80fd\u7a81\u8b8a\uff08\u9019\u7a2e\u7a81\u8b8a\u7a31\u70ba\u523a\u8c5a\u9f20\u57fa\u56e0\u8b8a\u9ec3\uff0c<em>agouti variable yellow<\/em>\uff0c\u7c21\u5beb\u70ba <em>AVY<\/em>\uff09\uff0c\u61f7\u5b55\u4e2d\u7684\u6bcd\u9f20\u98f2\u98df\u4e2d\u82e5\u52a0\u6dfb\u6771\u897f\uff0c\u90a3\u9ebc\u751f\u4e0b\u4f86\u7684\u5c0f\u9f20\uff0c\u6bdb\u76ae\u9ec3\u8272\u6703\u52a0\u6df1\u8b8a\u6210\u68d5\u8272\u3002\u74e6\u7279\u862d\u5718\u968a\u5f8c\u4f86\u986f\u793a\uff0c\u98f2\u98df\u6dfb\u52a0\u5291\u80fd\u505a\u5230\u9019\u4e00\u9ede\uff0c\u662f\u56e0\u70ba\u8abf\u7bc0\u523a\u8c5a\u9f20\u57fa\u56e0\u7684DNA\uff0c\u7532\u57fa\u591a\u4e86\u4e00\u4e9b\uff0c\u5f9e\u800c\u6709\u6548\u5730\u95dc\u9589\u7a81\u8b8a\u800c\u5c0e\u81f4\u7684\u57fa\u56e0\u7570\u5e38\u6d3b\u52d5\u3002<\/p>\n<p>AVY\u5c0f\u9f20\u5f88\u80d6\u3002\u6545\u6b64\uff0c\u74e6\u7279\u862d\u5718\u968a\u6709\u610f\u89c0\u5bdf\u9019\u4e00\u9ede\u662f\u4e0d\u662f\u4e5f\u80fd\u7528\u8868\u89c0\u907a\u50b3\u5b78\u4f86\u6539\u8b8a\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u7528\u5f37\u5316\u7532\u57fa\u7684\u5316\u5b78\u7269\u8cea\u5982\u8449\u9178\u3001\u7dad\u4ed6\u547dB12\u3001\u751c\u83dc\u9e7c( Betaine \uff0c\u53c8\u540d\u4e09\u7532\u57fa\u7518\u6c28\u9178)\u8207\u81bd\u9e7c(Choline)\u4f86\u9935\u98dfAVY\u6bcd\u9f20\uff0c\u518d\u628a\u5979\u5011\u751f\u4e0b\u4f86\u7684\u5c0f\u9f20\u79e4\u91cd\uff0c\u91cd\u8907\u9032\u884c\u9019\u9805\u5be6\u9a57\u6b65\u9a5f\u3002\u7814\u7a76\u4eba\u54e1\u539f\u672c\u4ee5\u70ba\uff0c\u5c0f\u9f20\u7684AVY\u7a81\u8b8a\u65e2\u7136\u907a\u50b3\u53c8\u53d6\u5f97\u66f4\u591a\u7684\u7532\u57fa\uff0c\u7167\u7406\u6703\u6e1b\u5f31\u523a\u8c5a\u9f20\u57fa\u56e0\u7684\u6d3b\u52d5\uff0c\u6240\u4ee5\u4ee3\u4ee3\u907a\u50b3\u4e0b\u4f86\uff0c\u5c0f\u9f20\u9ad4\u91cd\u6703\u6e1b\u8f15\u3002<\/p>\n<p>\u7d50\u679c\u9069\u8db3\u5176\u53cd\uff1a\u4ee3\u4ee3\u907a\u50b3\u4e0b\u4f86\uff0c\u5c0f\u9f20\u6108\u8b8a\u6108\u80d6\u3002\u7336\u6709\u751a\u8005\uff0c\u7814\u7a76\u4eba\u54e1\u62ff\u6c92\u6709AVY\u7684\u5c0f\u9f20\u4f86\u91cd\u8907\u9019\u9805\u5be6\u9a57\uff0c\u7d50\u679c\u985e\u4f3c\u3002<\/p>\n<p>\u7167\u7406\u4f86\u8b1b\uff0c\u7dad\u4ed6\u547d\u6dfb\u52a0\u7269\u4e0d\u6703\u5f71\u97ff\u4ed4\u9f20\u7684\u9ad4\u91cd\uff0c\u5c24\u5176\u4e0d\u8a72\u53ea\u56e0\u70ba\u6dfb\u52a0\u7269\u7684\u71df\u990a\u503c\uff0c\u5c31\u7d2f\u7a4d\u4e0b\u4f86\uff0c\u4ee3\u4ee3\u76f8\u50b3\u3002\u6240\u4ee5\uff0c\u7814\u7a76\u4eba\u54e1\u8868\u793a\uff0c\u6700\u6709\u53ef\u80fd\u662f\u67d0\u500b\u8fc4\u4eca\u4e0d\u8a73\u7684\u57fa\u56e0\u4e4b\u7532\u57fa\u4e5f\u544a\u589e\u5f37\uff0c\u5c0f\u9f20\u7684\u9ad4\u91cd\u624d\u6703\u56e0\u907a\u50b3\u800c\u589e\u52a0\u3002<\/p>\n<p>\u5357\u5b89\u666e\u9813\u5927\u5b78\u5c08\u7814\u80ce\u5152\u671f\u5c0e\u81f4\u6210\u4eba\u75be\u75c5\u7684\u5c08\u5bb6\u5df4\u723e\u514b(David Barker)\u8868\u793a\uff0c\u9019\u9805\u7814\u7a76\u7684\u6210\u679c\u8b93\u4eba\u8033\u76ee\u4e00\u65b0\uff0c\u4e86\u89e3\u6bcd\u89aa\u651d\u53d6\u7684\u990a\u5206\u53ef\u80fd\u5f71\u97ff\u80ce\u5152\u7684\u65b9\u5f0f\u3002\u4ed6\u8868\u793a\uff0c\u8868\u89c0\u907a\u50b3\u6025\u5287\u5347\u9ad8\uff0c\u5c0d\u5c08\u5bb6\u904e\u53bb\u5eff\u5e74\u81f4\u529b\u7814\u7a76\u7684\u73fe\u8c61\uff0c\u53ef\u8b02\u9952\u5bcc\u610f\u7fa9\uff1b\u5b78\u754c\u4e86\u89e3\uff0c\u4eba\u985e\u80ce\u5152\u5c0d\u71df\u990a\u74b0\u5883\uff08\u5b50\u5bae\uff09\u6975\u70ba\u654f\u611f\u3002<a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2011\/08\/\u80d6\u9f20.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-34081\" title=\"\u80d6\u9f20\" src=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2011\/08\/\u80d6\u9f20.jpg\" alt=\"\" width=\"346\" height=\"235\" \/><\/a><\/p>\n<p>\u74e6\u7279\u862d\u8868\u793a\uff0c\u4ed6\u5011\u5be6\u9a57\u4e2d\u9935\u7d66\u5c0f\u9f20\u5403\u7684\u7532\u57fa\u52a0\u5f37\u7269\u8cea\uff0c\u582a\u6bd4\u4eba\u985e\u5403\u7684\u7dad\u4ed6\u547d\u88dc\u5145\u9320\u5291\u3002\u4ed6\u5728\u5927\u6703\u4e2d\u8a62\u554f\u8868\u793a\uff0c\u9019\u4e00\u9ede\u6311\u8d77\u7591\u554f\uff0c\u7dad\u4ed6\u547d\u592a\u591a\uff0c\u6703\u4e0d\u6703\u53cd\u800c\u9020\u6210\u50b7\u5bb3\u3002<\/p>\n<p>\u6709\u4eba\u5efa\u8b70\u6253\u7b97\u61f7\u5b55\u7684\u5a66\u5973\u591a\u591a\u88dc\u5145\u8449\u9178\uff0c\u539f\u56e0\u5728\u9019\u7a2e\u71df\u990a\u54c1\u53ef\u4ee5\u5927\u5927\u964d\u4f4e\u65b0\u751f\u5152\u4e2d\u6a1e\u795e\u7d93\u7ba1\u5148\u5929\u7f3a\u9677\uff08\u6bd4\u5982\u810a\u67f1\u5206\u88c2\uff09\u7684\u6a5f\u7387\u3002\u5305\u62ec\u7f8e\u570b\u7b49\u597d\u4e9b\u570b\u5bb6\uff0c\u90fd\u5f37\u5236\u898f\u5b9a\uff0c\u6996\u985e\u53ca\u9eb5\u7c89\u7576\u4e2d\u8981\u6dfb\u52a0\u7dad\u4ed6\u547d\uff0c\u4ee5\u5168\u9762\u589e\u52a0\u5a66\u5973\u7684\u8449\u9178\u503c\u3002<\/p>\n<p>\u62dc\u9019\u7a2e\u5f37\u5236\u6dfb\u52a0\u6240\u8cdc\uff0c\u7f8e\u570b\u65b0\u751f\u5152\u4e2d\u6a1e\u795e\u7d93\u7ba1\u5148\u5929\u7f3a\u9677\u7684\u4ef6\u6578\u5927\u5e45\u6e1b\u5c11\u3002\u53ea\u662f\u5927\u5bb6\u4e5f\u71b1\u70c8\u8faf\u8ad6\u9019\u7a2e\u4f5c\u6cd5\u662f\u4e0d\u662f\u597d\u9ede\u5b50\u3002\u6bd4\u65b9\u8aaa\uff0c\u98f2\u98df\u6dfb\u52a0\u8449\u9178\uff0c\u8207\u7f79\u60a3\u67d0\u7a2e\u764c\u75c7\uff0c\u5169\u8005\u4e4b\u9593\u6709\u932f\u7d9c\u8907\u96dc\u7684\u95dc\u4fc2\u3002<\/p>\n<p>\u7814\u7a76\u63cf\u7e6a\u51fa\u7532\u57fa\u52a0\u5f37\u7269\u653e\u5230\u5c0f\u9f20\u7684\u98f2\u98df\uff0c\u80fd\u5f71\u97ff\u5979\u5f8c\u4ee3\u7684\u57fa\u56e0\u8868\u73fe\u8207\u9ad4\u91cd\uff0c\u8b93\u524d\u8ff0\u7684\u8faf\u8ad6\u6dfb\u589e\u65b0\u5c64\u9762\u3002<\/p>\n<p>\u74e6\u7279\u862d\u5f37\u8abf\uff0c\u7576\u524d\u9084\u6c92\u6709\u8b49\u64da\u8aaa\uff0c\u55ae\u55ae\u662f\u8449\u9178\u5c31\u80fd\u6709\u90a3\u4e9b\u6548\u61c9\u3002\u8fc4\u4eca\u9032\u884c\u7684\u4e00\u5207\u7814\u7a76\uff0c\u90fd\u6df7\u5408\u4f7f\u7528\u4e0d\u540c\u7684\u7532\u57fa\u52a0\u5f37\u7269\uff0c\u800c\u4e14\u53ea\u904b\u7528\u65bc\u5c0f\u9f20\u3002\u6240\u4ee5\uff0c\u8981\u4e0b\u7d50\u8ad6\u8aaa\uff0c\u8449\u9178\u5c0d\u4eba\u985e\u6709\u4ec0\u9ebc\u5f71\u97ff\uff0c\u5176\u5be6\u8a00\u4e4b\u904e\u65e9\u3002\u74e6\u7279\u862d\u5718\u968a\u5c0d\u6b64\u5c07\u505a\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u5abd\u5abd\u98f2\u98df\u53ef\u80fd\u6539\u8b8a\u80ce\u5152\u57fa\u56e0 \u77e5\u8b58\u901a\u8a0a\u8ad6\u7b2c38\u671f \u79d1\u5b78\u5bb6\u6700\u8fd1\u7814\u7a76\u986f\u793a\uff0c\u98f2\u98df\u88dc\u5145\u5291\u6703\u8b93\u5e7e\u4e16\u4ee3\u7684\u5c0f\u9f20\u8b8a\u5f97\u80a5\u80d6\uff0c\u9019\u7a2e\u73fe\u8c61&hellip;<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[170,165,5930],"tags":[],"class_list":["post-34077","post","type-post","status-publish","format-standard","hentry","category-kreview05","category-kreview00","category-5930","avhec_catgroup-all","loop-entry","cat-170","cat-165","cat-5930","no-thumbnail"],"views":5690,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/34077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=34077"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/34077\/revisions"}],"predecessor-version":[{"id":88053,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/34077\/revisions\/88053"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=34077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=34077"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=34077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}