{"id":3177,"date":"2009-07-31T14:18:55","date_gmt":"2009-07-31T06:18:55","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=3177"},"modified":"2021-10-06T16:48:23","modified_gmt":"2021-10-06T08:48:23","slug":"%e6%aa%b8%e6%aa%ac%e9%85%b8%e5%be%aa%e7%92%b0-%ef%bc%88the-citric-acid-cycle%ef%bc%89","status":"publish","type":"post","link":"http:\/\/localhost\/%e6%aa%b8%e6%aa%ac%e9%85%b8%e5%be%aa%e7%92%b0-%ef%bc%88the-citric-acid-cycle%ef%bc%89\/","title":{"rendered":"\u6ab8\u6aac\u9178\u5faa\u74b0"},"content":{"rendered":"

\u6ab8\u6aac\u9178\u5faa\u74b0 (The Citric Acid Cycle)<\/strong><\/span>
\n\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7814\u7a76\u6240\u78a9\u58eb\u751f\u6797\u6b23\u6167\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u8449\u540d\u5009\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/strong><\/span><\/p>\n

\u6ab8\u6aac\u9178\u5faa\u74b0\uff0c\u7531\u5fb7\u570b\u79d1\u5b78\u5bb6\u514b\u5229\u5e03\u65af\uff08Hans Adolf Krebs<\/span>\uff09\u6240\u63d0\u51fa\uff0c\u5f8c\u4f86\u88ab\u5be6\u9a57\u6240\u8b49\u5be6\uff0c\u6545\u53c8\u7a31\u514b\u6c0f\u5faa\u74b0\uff08The Krebs cycle<\/span>\uff09\uff1b\u88ab\u8a8d\u70ba\u662f\u751f\u7269\u9ad4\u4e2d\u4e19\u916e\u9178\u6c27\u5316\u4ee5\u53ca\u7cd6\u985e\u3001\u86cb\u767d\u8cea\u6216\u8102\u80aa\u9178\u8f49\u5316\u6210\u80fd\u91cf\u7684\u91cd\u8981\u9014\u5f91\uff0c\u53cd\u61c9\u5728\u7d30\u80de\u7684\u7c92\u7dda\u9ad4\u4e2d\u9032\u884c\uff1b\u6b64\u5faa\u74b0\u6709\u5169\u500b\u91cd\u8981\u76ee\u7684\uff1a<\/p>\n

1. <\/span>\u5c07\u4e59\u91af\u8f14\u9176A<\/span>\uff08Acetyl CoA<\/span>\uff09\u7684\u5169\u500b\u78b3\u5206\u89e3\u6210\u4e8c\u6c27\u5316\u78b3\uff0c\u7522\u751f\u80fd\u91cf\u3001\u5f62\u6210ATP<\/span>\u6216GTP<\/span>\uff0c\u4ee5\u53ca\u9084\u539f\u7684NADH<\/span>\u8207FADH2<\/sub><\/span>\uff0c\u63d0\u4f9b\u751f\u7269\u9ad4\u5167\u7684\u53cd\u61c9\u6240\u9700\u4e4b\u80fd\u91cf\u3002
\n2. <\/span>\u63d0\u4f9b\u5408\u6210\u80fa\u57fa\u9178\u3001\u7d2b\u8cea\u53ca\u6838\u82f7\u9178\u7684\u560c\u5464\u6216\u5627\u5576\u9e7c\u57fa\u7684\u524d\u9a45\u7269\u3002<\/p>\n

\u6ab8\u6aac\u9178\u5faa\u74b0\u53ef\u5206\u6210\u516b\u500b\u6b65\u9a5f\uff1a<\/p>\n

\u7b2c\u4e00\u6b65\uff1a<\/strong>
\n<\/span>\u4e59\u91af\u8f14\u9176A + <\/span>\u8349\u91af\u4e59\u9178 + <\/span>\u6c34 \u2192 <\/span>\u6ab8\u6aac\u9178 + <\/span>\u8f14\u9176A + H+<\/sup>
\n<\/span>\u7531\u7cd6\u89e3\u3001\u86cb\u767d\u8cea\u4ee3\u8b1d\u6216\u8102\u80aa\u9178\u4ee3\u8b1d\u6240\u5f97\u5230\u7684\u4e59\u91af\u8f14\u9176A<\/span>\u548c\u8349\u91af\u4e59\u9178\u4f5c\u70ba\u8d77\u59cb\u7269\u53cd\u61c9\uff0c\u7522\u751f\u516d\u78b3\u7684\u6ab8\u6aac\u9178\u5206\u5b50\uff1b\u53c3\u8207\u4f5c\u7528\u7684\u9175\u7d20\u70ba\u6ab8\u6aac\u9178\u5408\u6210\u9176\u3002<\/p>\n

\u7b2c\u4e8c\u6b65\uff1a<\/strong>
\n<\/span>\u6ab8\u6aac\u9178 \u2192 <\/span>\u9806\u5f0f–<\/span>\u70cf\u982d\u9178 \u2192 <\/span>\u7570\u6ab8\u6aac\u9178
\n<\/span>\u56e0\u70ba\u6ab8\u6aac\u9178\u4e0d\u5177\u6709\u53ef\u4ee5\u88ab\u6c27\u5316\u7684\u5b98\u80fd\u57fa\uff0c\u6240\u4ee5\u7d93\u7531\u812b\u6c34\u518d\u52a0\u6c34\u7684\u91cd\u7d44\u7570\u69cb\u53cd\u61c9\u4e2d\uff0c\u5f97\u5230\u5177\u53ef\u6c27\u5316\u5b98\u80fd\u57fa\u7684\u7570\u6ab8\u6aac\u9178\uff1b\u6b64\u904e\u7a0b\u53c3\u8207\u53cd\u61c9\u7684\u9175\u7d20\u70ba\u70cf\u982d\u9178\u9176\u3002<\/p>\n

\u7b2c\u4e09\u6b65\uff1a<\/strong>
\n<\/span>\u7570\u6ab8\u6aac\u9178 + NAD+<\/sup> \u2192 \u03b1-<\/span>\u916e\u620a\u4e8c\u9178 + CO2<\/sub> + NADH + H+<\/sup>
\n<\/span>\u7570\u6ab8\u6aac\u9178\u7684\u6c27\u5316\uff0c\u751f\u6210\u4e94\u78b3\u7684\u03b1-<\/span>\u916e\u620a\u4e8c\u9178\uff0c\u4f5c\u7528\u7684\u9175\u7d20\u70ba\u6ab8\u6aac\u9178\u53bb\u6c2b\u9176\u3002<\/p>\n

\u7b2c\u56db\u6b65\uff1a<\/strong>
\n\u03b1-<\/span>\u916e\u620a\u4e8c\u9178 + NADH + <\/span>\u8f14\u9176A \u2192 <\/span>\u7425\u73c0\u91af\u8f14\u9176A + CO2<\/sub> + NADH + H+<\/sup><\/span>\uf061
\n\u03b1-<\/span>\u916e\u620a\u4e8c\u9178\u7684\u6c27\u5316\u4f5c\u7528\uff0c\u6b64\u6b65\u8f03\u70ba\u8907\u96dc\uff0c\u9700\u8981\u4e94\u500b\u6b65\u9a5f\u3001\u4e09\u7a2e\u9176\u4f86\u53c3\u8207\u53cd\u61c9\uff1b\u6b64\u6b65\u9a5f\u7684\u76ee\u7684\u662f\u8981\u5f9e\u6c27\u5316\u7684\u904e\u7a0b\u4e2d\u7372\u5f97\u80fd\u91cf\uff0c\u5f62\u6210\u5177\u6709\u9ad8\u80fd\u91cf\u7684\u7425\u73c0\u91af\u8f14\u9176A<\/span>\u3002<\/p>\n

\u7b2c\u4e94\u6b65\uff1a<\/strong>
\n\u7425\u73c0\u91af\u8f14\u9176A + Pi + ADP<\/span>\uff08\u6216GDP<\/span>\uff09 \u2192 <\/span>\u7425\u73c0\u9178 + ATP<\/span>\uff08\u6216GTP + <\/span>\u8f14\u9176A<\/span>\uff09
\n<\/span>\u7425\u73c0\u91af\u8f14\u9176A<\/span>\u5177\u6709\u786b\u8102\u9375\uff0c\u6709\u8f03\u9ad8\u7684\u80fd\u91cf\uff0c\u53ef\u4ee5\u5c07ADP<\/span>\u6216GDP<\/span>\u9084\u539f\u6210\u5177\u6709\u80fd\u91cf\u7684ATP<\/span>\u6216GTP<\/span>\uff0c\u4ee5\u63d0\u4f9b\u751f\u7269\u9ad4\u80fd\u91cf\u3002<\/p>\n

\u7b2c\u516d\u6b65\uff1a<\/strong>
\n<\/span>\u7425\u73c0\u9178 + <\/span>\u7425\u73c0\u9178\u53bb\u6c2b\u9176 \u2192 <\/span>\u5ef6\u80e1\u7d22\u9178 + FADH2<\/sub>
\n<\/span>\u6b64\u6b65\u9a5f\u7684\u91cd\u9ede\u662f\uff1a\u5728\u6574\u500b\u5faa\u74b0\u7684\u9032\u884c\u4e2d\uff0c\u6b64\u70ba\u9996\u5148\u51fa\u73fe\u78b3–<\/span>\u78b3\u96d9\u9375\u7684\u53cd\u61c9\uff0c\u4ee5\u4fbf\u4e0b\u4e00\u6b65\u9a5f\u7684\u9032\u884c\u3002<\/p>\n

\u7b2c\u4e03\u6b65\uff1a<\/strong>
\n<\/span>\u5ef7\u80e1\u7d22\u9178 + <\/span>\u6c34 \u2192 L-<\/span>\u860b\u679c\u9178
\n<\/span>\u5e36\u6709\u78b3–<\/span>\u78b3\u96d9\u9375\u7684\u5ef6\u80e1\u7d22\u9178\uff0c\u85c9\u7531\u5ef6\u80e1\u7d22\u9178\u9176\u5c07\u6c34\u5206\u5b50\u52a0\u6210\u5728\u78b3–<\/span>\u78b3\u96d9\u9375\u4e0a\uff0c\u5f62\u6210L-<\/span>\u860b\u679c\u9178\u3002<\/p>\n

\u7b2c\u516b\u6b65\uff1a<\/strong>
\n<\/span>\u860b\u679c\u9178 + NAD+<\/sup> \u2192 <\/span>\u8349\u91af\u4e59\u9178 + NADH + H+<\/sup>
\n<\/span>\u7531\u4e0a\u4e00\u6b65\u7522\u751f\u7684L-<\/span>\u860b\u679c\u9178\uff0c\u52a0\u4e0a\u860b\u679c\u9178\u53bb\u6c2b\u9176\u6c27\u5316\u860b\u679c\u9178\u4e0a\u7684\u6c2b\u6c27\u57fa\u53ef\u5f97\u5230\u8349\u91af\u4e59\u9178\uff0c\u518d\u5f62\u6210\u7684\u8349\u91af\u4e59\u9178\u70ba\u7b2c\u4e00\u6b65\u7684\u53cd\u61c9\u7269\uff1b\u56e0\u6b64\uff0c\u514b\u6c0f\u5faa\u74b0\u53ef\u4ee5\u4e00\u76f4\u6301\u7e8c\u4e0b\u53bb\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u6ab8\u6aac\u9178\u5faa\u74b0\u7684\u8abf\u7bc0\u8207\u7279\u8272<\/strong><\/span><\/p>\n

\u5728\u751f\u7269\u9ad4\u4e2d\uff0c\u6240\u6709\u7684\u4ee3\u8b1d\u904e\u7a0b\u90fd\u662f\u53d7\u5230\u56b4\u683c\u63a7\u5236\u7684\uff0c\u7522\u7269\u7684\u6fc3\u5ea6\u592a\u9ad8\u6216\u592a\u4f4e\u6642\uff0c\u7686\u6703\u5f71\u97ff\u53cd\u61c9\u9032\u884c\u7684\u901f\u7387\u3002\u5982\u540c\u5176\u4ed6\u7684\u751f\u5316\u53cd\u61c9\u4e00\u6a23\uff0c\u6ab8\u6aac\u9178\u5faa\u74b0\u4e5f\u6709\u56de\u994b\u6291\u5236\u4f5c\u7528\uff0c\u4ee5\u6700\u7d42\u7522\u7269\u6fc3\u5ea6\u4f86\u63a7\u5236\u53cd\u61c9\u7684\u901f\u7387\uff0c\u5728\u6700\u7d42\u7522\u7269\uff08\u4e59\u91af\u8f14\u9176A\uff09\u7684\u6fc3\u5ea6\u9054\u5230\u4e00\u5b9a\u6642\uff0c\u53cd\u61c9\u901f\u7387\u6703\u4e0b\u964d\uff0c\u4ee5\u514d\u5408\u6210\u904e\u91cf\u7684\u4ee3\u8b1d\u7522\u7269\u3002<\/p>\n

\u6ab8\u6aac\u9178\u5faa\u74b0\u7684\u4e2d\u9593\u4ee3\u8b1d\u7269\u8cea\u7684\u6fc3\u5ea6\u4e5f\u5f88\u91cd\u8981\uff0c\u7576\u4e2d\u9593\u4ee3\u8b1d\u7269\u8cea\u6fc3\u5ea6\u964d\u4f4e\u6642\uff0c\u4e59\u91af\u8f14\u9176A\u7684\u6c27\u5316\u901f\u7387\u4e5f\u6703\u964d\u4f4e\uff0c\u800c\u4f7f\u5faa\u74b0\u53d7\u5230\u5f71\u97ff\uff0c\u751a\u81f3\u7121\u6cd5\u9032\u884c\u3002\u70ba\u4e86\u907f\u514d\u9019\u7a2e\u60c5\u6cc1\u767c\u751f\uff0c\u751f\u7269\u9ad4\u4e2d\u6709\u5f88\u591a\u91dd\u5c0d\u4e2d\u9593\u4ee3\u8b1d\u7269\u8cea\u6fc3\u5ea6\u63a7\u5236\u7684\u6dfb\u88dc\u53cd\u61c9\uff0c\u4ee5\u78ba\u4fdd\u53cd\u61c9\u53ef\u4ee5\u6301\u7e8c\u9032\u884c\u3002<\/p>\n

\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599<\/strong>
\nRodney Boyer\uff0cConcepts in Biochemistry<\/span>\uff0cSecond edition<\/span>\uff0c\u7b2c433 -441<\/span>\u9801\u3002<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u6ab8\u6aac\u9178\u5faa\u74b0 (The Citric Acid Cycle) \u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7814\u7a76\u6240\u78a9\u58eb\u751f\u6797\u6b23\u6167\/\u570b\u7acb\u81fa\u7063\u5e2b…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108,78,77],"tags":[1307,1306,1247],"class_list":["post-3177","post","type-post","status-publish","format-standard","hentry","category-chemistry00","category-chemistry08-01","category-chemistry08","tag-citric-acid-cycle","tag-1306","tag-1247","avhec_catgroup-all","loop-entry","cat-108","cat-78","cat-77","no-thumbnail"],"views":41763,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/3177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=3177"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/3177\/revisions"}],"predecessor-version":[{"id":90710,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/3177\/revisions\/90710"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=3177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=3177"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=3177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}