{"id":28630,"date":"2011-06-03T17:24:54","date_gmt":"2011-06-03T09:24:54","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=28630"},"modified":"2021-10-06T16:26:31","modified_gmt":"2021-10-06T08:26:31","slug":"%e6%b5%b7%e8%97%bb%e7%b3%96%ef%bc%88trehalose%ef%bc%89%e7%9a%84%e6%ad%b7%e5%8f%b2%e8%88%87%e6%87%89%e7%94%a8-%e4%b8%8b","status":"publish","type":"post","link":"http:\/\/localhost\/%e6%b5%b7%e8%97%bb%e7%b3%96%ef%bc%88trehalose%ef%bc%89%e7%9a%84%e6%ad%b7%e5%8f%b2%e8%88%87%e6%87%89%e7%94%a8-%e4%b8%8b\/","title":{"rendered":"\u6d77\u85fb\u7cd6\uff08Trehalose\uff09\u7684\u6b77\u53f2\u8207\u61c9\u7528 \u2013 \u4e0b"},"content":{"rendered":"

\u6d77\u85fb\u7cd6\uff08Trehalose\uff09\u7684\u6b77\u53f2\u8207\u61c9\u7528 \u2013 \u4e0b
<\/font>\u570b\u7acb\u53f0\u7063\u5927\u5b78\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u675c\u6b23\u5b9c\u78a9\u58eb\u751f\/\u570b\u7acb\u53f0\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u674e\u51a0\u7fa4\u52a9\u7406\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/font><\/strong><\/p>\n

\u4e09\u3001\u6d77\u85fb\u7cd6\u7684\u6b77\u53f2 <\/p>\n

<\/font><\/strong>\u6d77\u85fb\u7cd6\u6700\u65e9\u65bc1832\u5e74\u7531H.A. Wiggers\u65bc\u9ed1\u9ea5\u7684\u9ea5\u89d2\u6c34\u6eb6\u6db2\u4e2d\u767c\u73fe\uff0c\u5c07\u9ed1\u9ea5\u7684\u9ea5\u89d2\u6c34\u6eb6\u6db2\u975c\u7f6e\u4e00\u6bb5\u6642\u9593\u5f8c\uff0c\u5728\u5bb9\u5668\u7684\u5167\u58c1\u5f62\u6210\u4e86\u7121\u8272\u3001\u4e0d\u5177\u9084\u539f\u529b\u53ca\u5fae\u751c\u7684\u7d50\u6676\uff0c\u56e0\u800c\u767c\u73fe\u4e86\u6d77\u85fb\u7cd6\u30021858\u5e74Mitscherlich\u7531\u83c7\u985e\u4e2d\u5206\u96e2\u51fa\u6d77\u85fb\u7cd6\uff0c\u4e26\u5c07\u5b83\u547d\u540d\u70ba\u300cmycose\u300d\u3002\u540c\u5e74\uff0cBerthelot\u7531\u4f86\u81ea\u4e2d\u6771\u7684\u4e00\u7a2e\u6606\u87f2\u5728\u6a39\u8449\u4e0a\u5206\u6ccc\u7684\u985e\u4f3c\u7e6d\u7684\u6bbc \uff08cocoon-like shell\uff09\uff0c\u5176\u4e7e\u71e5\u5f8c\u88ab\u7576\u4f5c\u751c\u5473\u5291\uff08\u9019\u5206\u6ccc\u7269\u88ab\u7a31\u4f5ctrehala manna\uff09\uff0cBerthelot\u5f9e\u4e2d\u8403\u53d6\u51fa\u4e00\u7a2e\u91a3\u985e\uff0c\u5c07\u5b83\u547d\u540d\u70batrehalique glucose\u6216\u300ctrehalose\u300d\u3002
<\/font><\/strong><\/p>\n

\"100\"<\/a>
\u5716\u4e00\u3001\u6d77\u85fb\u7cd6 (\u03b1,\u03b1-1,1-trehalose) \u7d50\u69cb\u5716<\/p>\n

<\/p>\n

\u56db\u3001\u6d77\u85fb\u7cd6\u7684\u61c9\u7528 <\/p>\n

<\/font><\/strong>\u7531\u65bc\u6d77\u85fb\u7cd6\u7684\u7279\u6b8a\u6027\u8cea\u53ca\u4f5c\u7528\u6a5f\u5236\uff0c\u56e0\u6b64\u53ef\u5ee3\u6cdb\u61c9\u7528\u5728\u98df\u54c1\u52a0\u5de5\u3001\u91ab\u85e5\u3001\u751f\u5316\u88fd\u54c1\u3001\u5316\u599d\u54c1\u7522\u696d\u4e2d\u3002\u4f8b\u5982\u6d77\u85fb\u7cd6\u53ef\u61c9\u7528\u5728\u4fdd\u5b58\u9175\u7d20\u3001\u4fdd\u8b77\u54fa\u4e73\u52d5\u7269\u7684\u7d30\u80de\u53ca\u7dad\u6301\u5ba4\u6eab\u4e0b\u75ab\u82d7\u4fdd\u5b58\u7684\u7a69\u5b9a\uff0c\u907f\u514d\u5728\u51b7\u51cd\u4e7e\u71e5\u7684\u904e\u7a0b\u4e2d\u53d7\u640d\uff0c\u81e8\u5e8a\u4e0a\u5c0d\u65bc\u79fb\u690d\u5668\u5b98\u7684\u4fdd\u5b58\uff0c\u53ef\u5229\u7528\u6d77\u85fb\u7cd6\u4f86\u7a69\u5b9a\u7d44\u7e54\u7d30\u80de\uff0c\u5ef6\u9577\u4fdd\u5b58\u6642\u9593\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u7814\u7a76\u4e5f\u986f\u793a\u6d77\u85fb\u7cd6\u53ef\u6e1b\u8f15\u4ea8\u4e01\u9813\u6c0f\u821e\u8e48\u75c7\uff08Huntington disease\uff09\u75c5\u75c7\u3002\u5728\u5316\u599d\u54c1\u4e0a\uff0c\u53ef\u4f5c\u70ba\u4fdd\u990a\u54c1\u7684\u4fdd\u6fd5\u5291\u6210\u5206\u3002\u5728\u98df\u54c1\u52a0\u5de5\u4e0a\uff0c\u56e0\u70ba\u6d77\u85fb\u7cd6\u5177\u6709\u751c\u5ea6\u9069\u4e2d\u3001\u6c34\u6eb6\u6027\u9ad8\u3001\u4f4e\u81f4\u9f72\u6027\u3001\u4f4e\u5438\u6fd5\u6027\u53ca\u52a0\u5de5\u5132\u5b58\u904e\u7a0b\u4e2d\u7a69\u5b9a\u7b49\u7279\u6027\uff0c\u56e0\u6b64\u53ef\u61c9\u7528\u5728\u4e7e\u71e5\u98df\u54c1\u3001\u51b7\u51cd\u98df\u54c1\u3001\u871c\u991e\u3001\u7cd6\u679c\u3001\u98f2\u6599\u3001\u767c\u9175\u98df\u54c1\u7b49\u3002<\/p>\n

\u4e94\u3001\u6d77\u85fb\u7cd6\u7684\u751f\u7522
<\/font><\/strong>
\u7531\u65bc\u6d77\u85fb\u7cd6\u6709\u4e0a\u8ff0\u7684\u61c9\u7528\u50f9\u503c\uff0c\u56e0\u6b64\u9700\u8981\u6709\u4e00\u500b\u8f03\u7d93\u6fdf\u7684\u751f\u7522\u65b9\u6cd5\u3002\u6d77\u85fb\u7cd6\u7684\u751f\u7522\u65b9\u5f0f\uff0c\u4e00\u958b\u59cb\u662f\u900f\u904e\u9175\u6bcd\u7684\u57f9\u990a\uff0c\u518d\u76f4\u63a5\u7531\u9175\u6bcd\u8403\u53d6\uff0c\u4f46\u7531\u65bc\u751f\u7522\u6210\u672c\u904e\u9ad8\uff0c\u56e0\u6b64\u50c5\u9650\u65bc\u4f7f\u7528\u5728\u67d0\u4e9b\u5316\u599d\u54c1\u548c\u5316\u5b78\u85e5\u54c1\u30021990\u5e74\u4ee3\u521d\u671f\uff0c\u5546\u696d\u4e0a\u751f\u7522\u6d77\u85fb\u7cd6\u7684\u50f9\u683c\u70ba\u6bcf\u516c\u65a4700\u7f8e\u5143\uff0c\u4e4b\u5f8c\u96a8\u8457\u65b0\u7684\u751f\u7522\u65b9\u5f0f\u88ab\u958b\u767c\u51fa\u4f86\uff0c\u5927\u5e45\u7684\u964d\u4f4e\u4e86\u751f\u7522\u6210\u672c\u30021994 \u5e74\u7531\u65e5\u672c\u6797\u539f\u5546\u4e8bHayashibara Biochemical Laboratories Inc. (Okyama, Japan\uff09\u63d0\u51fa\u4e86\u4e00\u7a2e\u975e\u9084\u539f\u7cd6\u751f\u6210\u9175\u7d20\u548c\u6d77\u85fb\u7cd6\u91cb\u653e\u9175\u7d20\uff0c\u9019\u5169\u7a2e\u9175\u7d20\u5c07\u7531\u7389\u7c73\u548c\u6728\u85af\u6240\u751f\u7522\u4e4b\u4f4e\u50f9\u7684\u6fb1\u7c89\uff0c\u8f49\u5316\u70ba\u9ad8\u50f9\u7684\u6d77\u85fb\u7cd6\uff0c\u53ef\u5927\u526f\u964d\u4f4e\u751f\u7522\u7684\u6210\u672c\u3002<\/p>\n

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\u53c3\u8003\u8cc7\u6599\uff1a
<\/strong>1. Guo N, Puhlev I, Brown DR, Mansbridge J, Levine F. 2000. Trehalose expression confers desiccation tolerance on human cells. Nat Biotechnol 18: 168-171.
2. Higashiyama T. 2002. Novel functions and applications of trehalose. Pure and Applied Chemistry 74: 1263-1269.
3. Richards AB, Krakowka S, Dexter LB, Schmid H, Wolterbeek AP, Waalkens-Berendsen DH, Shigoyuki A, Kurimoto M. 2002. Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies. Food Chem Toxicol 40: 871-898.
4. Schiraldi C, Di Lernia I, De Rosa M. 2002. Trehalose production: exploiting novel approaches. Trends Biotechnol 20: 420-425.
5. Tanaka M, Machida Y, Niu S, Ikeda T, Jana NR, Doi H, Kurosawa M, Nekooki M, Nukina N. 2004. Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat Med 10: 148-154.
6. \u7dad\u57fa\u767e\u79d1\uff1aTrehalose (http:\/\/en.wikipedia.org\/wiki\/Trehalose<\/a>)<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

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