{"id":28498,"date":"2009-09-16T21:21:22","date_gmt":"2009-09-16T13:21:22","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=28498"},"modified":"2021-10-06T16:46:58","modified_gmt":"2021-10-06T08:46:58","slug":"%e5%b9%b9%e7%b4%b0%e8%83%9e-stem-cells-%e7%a0%94%e7%a9%b6%e7%9a%84%e5%b8%8c%e6%9c%9b%e5%92%8c%e9%9a%b1%e6%86%82","status":"publish","type":"post","link":"http:\/\/localhost\/%e5%b9%b9%e7%b4%b0%e8%83%9e-stem-cells-%e7%a0%94%e7%a9%b6%e7%9a%84%e5%b8%8c%e6%9c%9b%e5%92%8c%e9%9a%b1%e6%86%82\/","title":{"rendered":"\u5e79\u7d30\u80de\uff08Stem Cells\uff09\u7814\u7a76\u7684\u5e0c\u671b\u548c\u96b1\u6182"},"content":{"rendered":"

\u5e79\u7d30\u80de (Stem Cells) \u7814\u7a76\u7684\u5e0c\u671b\u548c\u96b1\u6182<\/span>
\n\u77e5\u8b58\u901a\u8a0a\u8a55\u8ad6\u7b2c80\u671f<\/span><\/strong><\/p>\n

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<\/p>\n

\u4e8c\u25cb\u25cb\u4e03\u5e74\u6625\u5929\uff0c\u5c71\u4e2d\u4f38\u5f4c(Shinya Yamanaka)\u8a8d\u70ba\u4ed6\u5728\u4e00\u5834\u79d1\u5b78\u7af6\u8cfd\u4e2d\u7be4\u5b9a\u62d4\u5f97\u982d\u7c4c\u3002\u4e0d\u5230\u534a\u5e74\u524d\u4ed6\u5c55\u73fe\u4e86\u4e00\u7a2e\u6280\u8853\uff0c\u8b49\u660e\u80fd\u5c07\u666e\u901a\u7684\u8eab\u9ad4\u7d30\u80de\u8b8a\u6210\u985e\u4f3c\u8001\u9f20\u7684\u80da\u80ce\u5e79\u7d30\u80de\u3002\u4ed6\u7684\u7814\u7a76\u6210\u679c\u6709\u4eba\u8085\u7136\u8d77\u656c\uff0c\u6709\u4eba\u8868\u793a\u61f7\u7591\u3002\u6c92\u6709\u4eba\u76f8\u4fe1\u4e00\u500b\u7d30\u80de\u53ef\u4ee5\u9019\u9ebc\u5bb9\u6613\u8abf\u5f04\uff0c\u53ea\u690d\u5165\u56db\u500b\u80da\u80ce\u57fa\u56e0\uff0c\u5c31\u53ef\u4ee5\u4f7f\u5b83\u91cd\u8a2d\u7a0b\u5f0f\uff0c\u6210\u70ba\u4e00\u500b\u80fd\u88fd\u9020\u4efb\u4f55\u8eab\u9ad4\u7d44\u7e54\u7684\u7d30\u80de\u3002<\/p>\n

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\"\"<\/a>

\u5c71\u4e2d\u4f38\u5f4c(Shinya Yamanaka)\u5c55\u73fe\u4e86\u4e00\u7a2e\u6280\u8853\uff0c\u8b49\u660e\u80fd\u5c07\u666e\u901a\u7684\u8eab\u9ad4\u7d30\u80de\u8b8a\u6210\u985e\u4f3c\u8001\u9f20\u7684\u80da\u80ce\u5e79\u7d30\u80de\u3002<\/p><\/div>\n

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\"\"<\/a>

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\u7814\u7a76\u4eba\u54e1\u7684\u76ee\u6a19\u662f\u91cd\u8a2d\u7a0b\u5f0f\u7d30\u80de\uff0c\u4f46\u4e0d\u4f7f\u9019\u4e9b\u57fa\u56e0\u9032\u5165\u907a\u50b3\u57fa\u56e0\u7d44\uff0c\u4ee5\u514d\u9020\u6210\u7834\u58de\u3002\u4e09\u6708\u9593\u5409\u5c3c\u8a31\u9818\u5c0e\u7684\u4e00\u500b\uff0c\u66fe\u767c\u8868\u4e86\u53ef\u5c07\u5b8c\u6210\u4efb\u52d9\u7684\u91cd\u8a2d\u7a0b\u5f0f\u57fa\u56e0\u522a\u9664\u7684\u6280\u8853\u3002\u4e09\u500b\u661f\u671f\u5f8c\uff0c\u7f8e\u570b\u7dad\u65af\u5eb7\u65b0\u5927\u5b78\u7684\u6e6f\u59c6\u68ee\uff08James Thomson\uff09\u53ca\u5176\u540c\u4e8b\u5728\u300a\u79d1\u5b78\u300b\u96dc\u8a8c\u767c\u8868\u5831\u544a\uff0c\u4ed6\u5011\u53ef\u4ee5\u5b8c\u5168\u4e0d\u9700\u8981\u7f6e\u5165\u4efb\u4f55\u907a\u50b3\u57fa\u56e0\uff0c\u5c31\u80fd\u91cd\u8a2d\u7a0b\u5f0f\u88fd\u9020\u4eba\u985e\u7d30\u80de\u3002\u4ed6\u5011\u904b\u7528\u7a31\u70ba\u7d30\u80de\u8cea\u9ad4\u3001\u4e0d\u6703\u548c\u67d3\u8272\u9ad4\u6574\u5408\u7684DNA\u74b0\uff0c\u5c07\u591a\u6f5b\u80fd\u57fa\u56e0\u7f6e\u5165\u7d30\u80de\u3002<\/p>\n

\"\"<\/a>

\u91cd\u8a2d\u7a0b\u5f0f\u6280\u8853\u767c\u5c55\u5716<\/p><\/div>\n

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\n——–\u7f85\u73b2<\/p>\n

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\u7814\u7a76\u4eba\u54e1\u671f\u671b\u5e79\u7d30\u80de\u7684\u7814\u7a76\u6703\u8f49\u5411\u9019\u65b9\u9762\u8a55\u4f30\u7684\u52aa\u529b\u3002\u7f8e\u570b\u54c8\u4f5b\u5e79\u7d30\u80de\u7814\u7a76\u6240\u7684\u4faf\u5951\u9675\u683c\uff08Konrad Hochedlinger\uff09\u8aaa\uff0c\u73fe\u5728\u6700\u91cd\u8981\u7684\u662f\u6bd4\u8f03\u5404\u7a2e\u65b9\u6cd5\uff0c\u7136\u5f8c\u63a1\u884c\u904b\u4f5c\u5f97\u6700\u597d\u7684\u90a3\u4e00\u7a2e\u3002\u4ec0\u9ebc\u53eb\u300c\u6700\u597d\u7684\u300d\u53ef\u4f9d\u7528\u9014\u800c\u5b9a\u3002<\/p>\n

\u651c\u624b\u5171\u9032<\/strong><\/p>\n

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\n—–\u9054\u7acb<\/p>\n

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\u4f46\u9019\u6a23\u7684\u6e2c\u8a66\u4e0d\u53ef\u80fd\u7528\u5728\u4eba\u7684\u8eab\u4e0a\uff0c\u6240\u4ee5\u6a19\u6e96\u7684\u5316\u9a57\u6cd5\u662f\uff0c\u501f\u7528\u4eba\u985e\u80da\u80ce\u5e79\u7d30\u80de\uff0c\u6ce8\u5165\u514d\u75ab\u7cfb\u7d71\u88ab\u6291\u5236\u7684\u8001\u9f20\u9ad4\u5167\uff0c\u7b49\u5f85\u516d\u5230\u516b\u500b\u661f\u671f\uff0c\u770b\u770b\u9019\u4e9b\u7d30\u80de\u662f\u5426\u6703\u5f62\u6210\u7578\u80ce\u7624\u3002\u81ea\u7136\u767c\u751f\u7684\u7578\u80ce\u7624\u6703\u9577\u6210\u4e00\u500b\u7531\u5305\u542b\u6bdb\u9aee\u548c\u9aa8\u9abc\u7b49\u5206\u5316\u7d44\u7e54\u6240\u5f62\u6210\u7684\u816b\u584a\uff0c\u4f46\u662f\u8981\u8a8d\u5b9a\u690d\u5165\u7d30\u80de\u7684iPS\u7d30\u80de\uff0c\u7814\u7a76\u4eba\u54e1\u53ea\u8981\u770b\u770b\u5206\u5316\u7d30\u80de\u5f62\u6210\u7684\u816b\u584a\u662f\u5426\u5177\u5099\u6240\u6709\u4e3b\u8981\u7684\u7d44\u7e54\u5373\u53ef\u3002\u7814\u7a76\u4eba\u54e1\u8aaa\uff0c\u5c31\u5916\u89c0\u548c\u8868\u9762\u907a\u50b3\u6a19\u8a18\u800c\u8a00\uff0c\u770b\u4f3c\u5df2\u7d93\u5b8c\u5168\u91cd\u8a2d\u7a0b\u5f0f\u7684\u7d30\u80de\uff0c\u4f46\u9084\u662f\u6c92\u80fd\u5f62\u6210\u7578\u80ce\u7624\u7684\u60c5\u5f62\u4e26\u4e0d\u5c11\u898b\u3002<\/p>\n

\u6709\u4e9b\u7814\u7a76\u4eba\u54e1\u8a8d\u70ba\uff0c\u53ef\u4ee5\u7a31\u4e4b\u70baiPS\u7d30\u80de\uff0c\u5c31\u61c9\u8a72\u986f\u793a\u5b83\u6709\u5f62\u6210\u7578\u80ce\u7624\u7684\u80fd\u529b\u3002\u5e79\u7d30\u80de\u9818\u57df\u7684\u4e00\u4f4d\u9818\u8896\u4eba\u7269\uff0c\u6ce2\u58eb\u9813\u5152\u7ae5\u91ab\u9662\u7684\u9054\u7acb\uff08George Daley\uff09\u8aaa\uff0c\u9664\u975e\u5728\u9019\u500b\u9818\u57df\u7dad\u6301\u4e00\u500b\u6a19\u6e96\uff0c\u5426\u5247\u6587\u737b\u88e1\u7684\u754c\u7dda\u5c31\u6a21\u7cca\u4e0d\u6e05\u4e86\u3002\u7279\u5225\u662f\u9019\u500b\u9818\u57df\u9084\u521d\u8d77\u6b65\uff0c\u6280\u8853\u4ecd\u5728\u767c\u5c55\u4e4b\u4e2d\uff0c\u53ea\u56e0\u70ba\u8868\u73fe\u51fa\u80da\u80ce\u5e79\u7d30\u80de\u7684\u67d0\u7a2e\u5178\u578b\u907a\u50b3\u6a19\u8a18\uff0c\u5c31\u8aaa\u90a3\u662fiPS\u7d30\u80de\uff0c\u662f\u5f88\u300c\u5371\u96aa\u300d\u7684\u3002\u6bcf\u4e00\u500b\u5177\u6709\u4e00\u9ede\u4e3b\u5e79\u6027\u8cea\u7684\u7d30\u80de\u90fd\u53ef\u7a31\u70baiPS\u7d30\u80de\uff0c\u90a3\u9ebc\u9019\u500b\u540d\u7a31\u5c31\u6703\u55aa\u5931\u5176\u53ef\u4fe1\u5ea6\u4e86\u3002<\/p>\n

<\/strong><\/div>\n

<\/p>\n

\"\"<\/a>

\u6ce2\u58eb\u9813\u5152\u7ae5\u91ab\u9662\u7684\u9054\u7acb\uff08George Daley\uff09\u8aaa\uff0c\u9664\u975e\u5728\u5e79\u7d30\u80de\u9818\u57df\u7dad\u6301\u4e00\u500b\u6a19\u6e96\uff0c\u5426\u5247\u6587\u737b\u88e1\u7684\u754c\u7dda\u5c31\u6a21\u7cca\u4e0d\u6e05\u4e86\u3002<\/p><\/div>\n

\u5b89\u5168\u81f3\u4e0a<\/p>\n

<\/strong><\/p>\n

\u4f46\u5728\u67d0\u4e9b\u60c5\u6cc1\u4e0b\uff0c\u5982\u679c\u4e00\u500b\u7d30\u80de\u682a\u53ef\u4ee5\u9020\u6210\u5404\u7a2e\u5404\u6a23\u7684\u7d30\u80de\u985e\u578b\uff0c\u4e5f\u4e0d\u59a8\u4e8b\u3002\u4f8b\u5982\uff0c\u4e0d\u6703\u9020\u6210\u7578\u80ce\u7624\u7684iPS\u7d30\u80de\u53ef\u80fd\u5f88\u6703\u88fd\u9020\u809d\u7d30\u80de\uff0c\u800c\u66f4\u9069\u65bc\u5023\u88fd\u809d\u75c5\uff0c\u5728\u81e8\u5e8a\u4e0a\u4e5f\u8f03\u5b89\u5168\u3002\u52a0\u62ff\u5927\u5b89\u5927\u7565iPS\u7d30\u80de\u7814\u7a76\u8a2d\u65bd\u7684\u53f2\u4e39\u798f\uff08William Stanford\uff09\u8aaa\uff0c\u4f55\u6cc1\u7578\u80ce\u7624\u7684\u5316\u9a57\u4e5f\u5f88\u6602\u8cb4\u3002\u4ed6\u7684\u7814\u7a76\u5718\u968a\u6b63\u5c31\u591a\u502b\u591a\u75c5\u7ae5\u91ab\u9662\u7684\u75c5\u60a3\u53d6\u6a23\uff0c\u767c\u5c55\u7279\u5b9a\u75be\u75c5\u7684\u7d30\u80de\u682a\uff0c\u4ed6\u5011\u5df2\u6599\u5b9a\u53d6\u5f97\u53ef\u4f9b\u9032\u884c\u91cd\u8a2d\u7a0b\u5f0f\u7684\u6a23\u672c\uff0c\u6703\u6bd4\u767c\u5c55\u7d30\u80de\u682a\u9700\u8981\u7684\u8cc7\u6e90\u591a\u3002<\/p>\n

\u4ed6\u8aaa\uff0c\u4ed6\u5011\u8a0e\u8ad6\u904e\u662f\u8981\u5c11\u505a\u4e00\u4e9b\u7d30\u80de\u682a\uff0c\u7136\u5f8c\u5c0d\u6bcf\u4e00\u500b\u7d30\u80de\u682a\u90fd\u505a\u7578\u80ce\u7624\u6e2c\u8a66\uff0c\u9084\u662f\u8981\u591a\u505a\u4e00\u4e9b\u7d30\u80de\u682a\uff0c\u7d50\u679c\u4ed6\u5011\u6c7a\u5b9a\u9078\u64c7\u5f8c\u8005\u3002\u4ed6\u5011\u5c07\u4ee5\u57fa\u56e0\u6240\u986f\u73fe\u7684\u7279\u8cea\uff0c\u4ee5\u53ca\u5206\u5316\u521d\u671f\u7684\u8a66\u7ba1\u5be6\u9a57\uff0c\u8a55\u4f30\u91cd\u8a2d\u7a0b\u5f0f\u7d30\u80de\u7684\u591a\u6f5b\u80fd\u7279\u6027\uff0c\u4f46\u9032\u4e00\u6b65\u7684\u7279\u5fb5\u63cf\u8ff0\u5c07\u4ea4\u7531\u5f8c\u4f86\u4f7f\u7528\u9019\u4e9b\u7d30\u80de\u7684\u5404\u5be6\u9a57\u5ba4\u81ea\u5df1\u53bb\u505a\u3002<\/p>\n

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\u5118\u7ba1\u7d93\u904e\u9019\u4e00\u4e9b\u7684\u8a55\u9451\uff0ciPS\u7d30\u80de\u8981\u9032\u884c\u81e8\u5e8a\u4f7f\u7528\u9084\u9762\u81e8\u56b4\u683c\u7684\u5c64\u5c64\u95dc\u5361\uff0c\u8981\u8b93\u4e3b\u7ba1\u6a5f\u95dc\u76f8\u4fe1\uff0c\u5176\u98a8\u96aa\u4f4e\u5230\u53ef\u4ee5\u63a5\u53d7\u7a0b\u5ea6\uff0c\u5f15\u9032\u7684\u7d30\u80de\u771f\u7684\u80fd\u5728\u75c5\u60a3\u9ad4\u5167\u5b58\u6d3b\uff0c\u589e\u9032\u75c5\u8b8a\u8166\u90e8\u6216\u80f0\u81df\u7684\u529f\u80fd\u3002<\/p>\n

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\"\"<\/a>

\u898f\u7bc4\u8d95\u4e0d\u4e0aIPS\u7684\u7814\u767c\u7af6\u8cfd<\/p><\/div>\n

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\u79d1\u5b78\u754c\u7684\u60c5\u6cc1\u4ea6\u7136\u3002\u751f\u7269\u5b78\u8005\u4e00\u5411\u4ee5\u70ba\uff0c\u4e00\u7a2e\u7279\u5b9a\u7684\u7d30\u80de\u5f62\u614b\u4e00\u5b9a\u8981\u9084\u539f\u56de\u50cf\u80da\u80ce\u4f3c\u7684\u591a\u6f5b\u80fd\u72c0\u614b\uff0c\u624d\u53ef\u4ee5\u8f49\u8b8a\u6210\u53e6\u4e00\u7a2e\u7279\u5b9a\u7d30\u80de\u3002\u4f46\u8fd1\u4f86\u7684\u5be6\u4f5c\u986f\u793a\uff0c\u53ef\u4ee5\u7565\u904e\u591a\u6f5b\u80fd\u72c0\u614b\u968e\u6bb5\uff0c\u76f4\u63a5\u7531\u67d0\u4e00\u7a2e\u7d30\u80de\u5f62\u614b\u8df3\u5230\u53e6\u4e00\u7a2e\u5f62\u614b\u53bb\u3002\u54c8\u4f5b\u5927\u5b78\u7684\u767c\u5c55\u751f\u7269\u5b78\u8005\u6885\u723e\u9813\uff08Doug Melton\uff09\u53bb\u5e74\u5c31\u505a\u5230\u9019\u4e00\u9ede\u800c\u4ee4\u4eba\u522e\u76ee\u76f8\u770b\uff0c\u4ed6\u7684\u7814\u7a76\u986f\u793a\uff0c\u80f0\u81df\u7684\u7d30\u80de\u5982\u679c\u63d2\u5165\u984d\u5916\u7684\u80f0\u81df\u57fa\u56e0\uff0c\u5c31\u6703\u5177\u6709\u88fd\u9020\u80f0\u5cf6\u7d20\u7684\uff22\u7d30\u80de\u7684\u5916\u89c0\u548c\u529f\u80fd\u3002<\/p>\n

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\n——\u5409\u5c3c\u8a31<\/p>\n

\"\"<\/a>

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\u7c97\u7cd9\u898f\u7bc4<\/strong><\/p>\n

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\"\"<\/a>

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