{"id":26617,"date":"2011-05-03T11:10:38","date_gmt":"2011-05-03T03:10:38","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=26617"},"modified":"2021-10-06T16:27:04","modified_gmt":"2021-10-06T08:27:04","slug":"%e5%85%92%e7%ab%a5%e5%a4%9a%e7%99%bc%e6%80%a7%e7%a1%ac%e5%8c%96%e7%97%87%ef%bc%88multiple-sclerosis%ef%bc%89%e7%9a%84%e9%81%ba%e5%82%b3%e9%a2%a8%e9%9a%aa%e5%9b%a0%e5%ad%90","status":"publish","type":"post","link":"http:\/\/localhost\/%e5%85%92%e7%ab%a5%e5%a4%9a%e7%99%bc%e6%80%a7%e7%a1%ac%e5%8c%96%e7%97%87%ef%bc%88multiple-sclerosis%ef%bc%89%e7%9a%84%e9%81%ba%e5%82%b3%e9%a2%a8%e9%9a%aa%e5%9b%a0%e5%ad%90\/","title":{"rendered":"\u5152\u7ae5\u591a\u767c\u6027\u786c\u5316\u75c7\uff08Multiple Sclerosis\uff09\u7684\u907a\u50b3\u98a8\u96aa\u56e0\u5b50"},"content":{"rendered":"

\u5152\u7ae5\u591a\u767c\u6027\u786c\u5316\u75c7\uff08Multiple Sclerosis\uff09\u7684\u907a\u50b3\u98a8\u96aa\u56e0\u5b50
\n<\/span>\u53f0\u5317\u5e02\u7acb\u6210\u529f\u9ad8\u7d1a\u4e2d\u5b78\u751f\u7269\u79d1\u5f35\u6625\u6885\u8001\u5e2b\/\u570b\u7acb\u53f0\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u674e\u51a0\u7fa4\u52a9\u7406\u6559\u6388\u8cac\u4efb\u7de8\u8f2f
\n<\/span><\/strong><\/p>\n

\u591a\u767c\u6027\u786c\u5316\u75c7 (Multiple Sclerosis , MS) \u662f\u4e00\u7a2e\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u9ad3\u9798\uff08myelin sheath\uff09\u7834\u58de\u7684\u6162\u6027\u75be\u75c5\u3002\u9019\u4e9b\u9ad3\u9798\u7834\u58de\u800c\u812b\u5931\uff08\u812b\u9ad3\u9798\u4f5c\u7528\uff0cdemyelination\uff09\u7684\u5340\u57df\uff0c\u56e0\u70ba\u7d44\u7e54\u4fee\u5fa9\u7684\u904e\u7a0b\u4e2d\u7522\u751f\u75a4\u75d5\u7d44\u7e54\u800c\u51fa\u73fe\u5927\u5c0f\u4e0d\u4e00\u7684\u786c\u584a\uff0c\u800c\u4e14\u65b0\u7684\u786c\u584a\u53ef\u80fd\u96a8\u8457\u6642\u9593\u800c\u9678\u7e8c\u51fa\u73fe\uff0c\u6240\u4ee5\u7a31\u70ba\u300c\u591a\u767c\u6027\u786c\u5316\u75c7\u300d\u3002MS\u6703\u9020\u6210\u795e\u7d93\u8a0a\u865f\u7684\u50b3\u5c0e\u8b8a\u6162\uff0c\u751a\u81f3\u505c\u6b62\uff0c\u5c0e\u81f4\u963b\u585e\u6216\u5ef6\u9072\u795e\u7d93\u8a0a\u865f\u7684\u767c\u51fa\u548c\u63a5\u6536\uff0c\u800c\u5f71\u97ff\u808c\u8089\u5354\u8abf\u80fd\u529b\u3002\u591a\u767c\u6027\u786c\u5316\u767c\u751f\u7684\u90e8\u4f4d\u4e0d\u540c\uff0c\u51fa\u73fe\u7684\u75c7\u72c0\u4e5f\u6709\u5dee\u7570\uff0c\u5982\u767c\u751f\u5728\u5927\u8166\u904b\u52d5\u5340\uff0c\u53ef\u80fd\u51fa\u73fe\u985e\u4f3c\u4e2d\u98a8\u75c7\u72c0\uff1b\u767c\u751f\u5728\u5927\u8166\u524d\u984d\u8449\uff0c\u53ef\u80fd\u51fa\u73fe\u985e\u4f3c\u6182\u9b31\u7684\u75c7\u72c0\uff1b\u767c\u751f\u5728\u8996\u795e\u7d93\u6642\uff0c\u53ef\u80fd\u9020\u6210\u8996\u529b\u6e1b\u5f31\uff1b\u767c\u751f\u5728\u810a\u9ad3\u8655\uff0c\u5247\u4f7f\u80a2\u9ad4\u884c\u52d5\u7121\u529b\uff0c\u56b4\u91cd\u8005\u6703\u7671\u7613\uff0c\u751a\u81f3\u6b7b\u4ea1\u3002\u5f15\u8d77MS\u7684\u771f\u6b63\u75c5\u56e0\u4ecd\u4e0d\u6e05\u695a\uff0c\u4e00\u822c\u8a8d\u662f\u81ea\u9ad4\u514d\u75ab\u6240\u5c0e\u81f4\uff0c\u4e5f\u5c31\u662f\u8aaa\u514d\u75ab\u7cfb\u7d71\u5c07\u81ea\u8eab\u7684\u9ad3\u9798\u7576\u6210\u5916\u4f86\u7269\u8cea\u800c\u52a0\u4ee5\u7834\u58de\u3002\u500b\u4eba\u9ad4\u8cea\u6216\u75c5\u6bd2\u90fd\u6709\u53ef\u80fd\u4fc3\u6210\u9019\u7a2e\u514d\u75ab\u53cd\u61c9\u3002<\/span><\/span><\/p>\n

<\/p>\n

\u5927\u591a\u6578\u51fa\u73fe\u6025\u6027\u812b\u9ad3\u9798\uff08acute demyelination\uff09\u75c7\u72c0\u7684\u6210\u4eba\uff0c\u96a8\u5f8c\u90fd\u88ab\u8a3a\u65b7\u51fa\u60a3\u6709MS\uff1b\u4f46\u662f\uff0c\u5152\u7ae5\u6642\u767c\u751f\u7684\u812b\u9ad3\u9798\u4f5c\u7528\uff0c\u5373\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u5f8c\u5929\u6027\u812b\u9ad3\u9798\u7d9c\u5408\u75c7\uff08acquired demyelinating syndrome, ADS\uff09\uff0c\u96d6\u7136\u5c0d20\uff05\u4ee5\u4e0a\u7684\u5152\u7ae5\u800c\u8a00\uff0c\u5c31\u4ee3\u8868\u4e86\u7b2c\u4e00\u6b21MS\u7684\u767c\u4f5c\uff0c\u4f46\u4e0d\u4e00\u5b9a\u90fd\u662fMS\u3002\u52a0\u62ff\u5927\u5c0f\u5152\u812b\u9ad3\u9798\u75be\u75c5\u7db2\uff08Canadian Pediatric Demyelinating Diseases Network, CPDDN\uff09\u7684\u91ab\u751f\u53ca\u79d1\u5b78\u5bb6\u7d44\u6210\u7684\u8de8\u6821\u8de8\u9818\u57df\u5718\u968a\u767c\u73fe\u6709\u8d8a\u4f86\u8d8a\u591a\u5152\u7ae5\u88ab\u8a3a\u65b7\u70baMS\uff0c\u56e0\u6b64\u63a1\u53d6\u6578\u767e\u4f4d16\u6b72\u4ee5\u4e0b\u5152\u7ae5\uff08266\u540d\u5152\u7ae5\u60a3\u8005\uff1b196\u540d\u5065\u5eb7\u7684\u63a7\u5236\u7d44\uff09\u7684\u8840\u6db2\u6a23\u672c\u9032\u884c\u5206\u6790\uff0c\u627e\u5230\u4e00\u500b\u53c3\u8207\u4e86\u514d\u75ab\u53cd\u61c9\u7684\u7279\u5b9a\u57fa\u56e0\uff0c\u53ef\u80fd\u589e\u52a0\u4e86\u67d0\u4e9b\u5152\u7ae5\u7f79\u60a3MS\u7684\u98a8\u96aa\u3002\u5176\u7814\u7a76\u6210\u679c\u767c\u8868\u65bc2011\u5e743\u6708\u7684\u300a\u795e\u7d93\u5b78\u671f\u520a\uff08Neurology\uff09\u300b\u3002CPDDN\u8a08\u756b\u4e3b\u6301\u4ebaAmit Bar-Or\u535a\u58eb\u8868\u793a\uff0c\u5152\u7ae5MS\u8a3a\u65b7\u7684\u4e0d\u78ba\u5b9a\u6027\u9020\u6210\u8a31\u591a\u5152\u7ae5\u548c\u5bb6\u4eba\u7684\u7126\u616e\uff0c\u56e0\u6b64\u958b\u767c\u80fd\u8fa8\u5225ADS\u548cMS\u7684\u5de5\u5177\u5f88\u91cd\u8981\u3002<\/p>\n

\u5728\u6210\u4eba\u4e2d\uff0c\u907a\u50b3\u548c\u74b0\u5883\u56e0\u7d20\u7684\u8907\u96dc\u4ea4\u4e92\u4f5c\u7528\u5747\u6703\u69cb\u6210MS\u7684\u98a8\u96aa\uff0c\u800c\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u6027\u8907\u5408\u9ad4\uff08major histocompatability complex, MHC\uff09\uff0c\u6216\u7a31\u70ba\u4eba\u985e\u767d\u8840\u7403\u6297\u539f\uff08human leukocyte antigen, HLA\uff09\u7684\u7b49\u4f4d\u57fa\u56e0\uff08allele\uff09\u5247\u662fMS\u6613\u611f\u6027\uff08MS susceptibility\uff09\u4e3b\u8981\u7684\u907a\u50b3\u56e0\u7d20\u3002\u7814\u7a76\u5718\u968a\u61f7\u7591MS\u7684\u907a\u50b3\u98a8\u96aa\u56e0\u5b50\u4f4d\u65bcHLA-DRB1\u7b49\u4f4d\u57fa\u56e0\u4e0a\uff0c\u56e0\u6b64\u5e0c\u671b\u80fd\u9a57\u8b49\u9019\u7a2e\u7b49\u4f4d\u57fa\u56e0\u662f\u5426\u80fd\u9810\u6e2cADS\u5152\u7ae5\u60a3\u8005\u7f79\u60a3MS\u7684\u98a8\u96aa\u3002\u7d50\u679c\u5982\u7814\u7a76\u4eba\u54e1\u8868\u793a\uff1a\u300c\u6211\u5011\u767c\u73fe\u5f8c\u4f86\u88ab\u8a3a\u65b7\u70baMS\u7684\u5152\u7ae5\u4e2d\uff0cHLA – DRB1\u57fa\u56e0\u51fa\u73fe\u7684\u983b\u7387\u8f03\u9ad8\uff0c\u800c\u55ae\u7d14ADS\u5152\u7ae5\u60a3\u8005\u4e2d\u5247\u6c92\u6709\u9019\u7a2e\u73fe\u8c61\u3002\u9019\u986f\u793a\u9019\u7a2e\u57fa\u56e0\u662f\u9810\u6e2cMS\u767c\u4f5c\u7684\u98a8\u96aa\u56e0\u5b50\u3002\u6c92\u6709\u767c\u5c55\u6210MS\u7684ADS\u5152\u7ae5\u60a3\u8005\u5176HLA\u57fa\u56e0\u8868\u73fe\u8207\u63a7\u5236\u7d44\u6c92\u6709\u5340\u5225\uff0c\u9019\u4ee3\u8868\u9019\u7a2e\u57fa\u56e0\u4f7f\u5152\u7ae5MS\u767c\u4f5c\u7684\u98a8\u96aa\u589e\u52a0\uff0c\u4f46\u4e00\u822c\u800c\u8a00\u4e0d\u5f71\u97ffADS\u3002\u300d<\/p>\n

\u7531\u65bcMS\u5728\u5152\u7ae5\u53ca\u6210\u4eba\u767c\u75c5\u7684\u907a\u50b3\u57fa\u790e\u76f8\u4f3c\uff0c\u5152\u7ae5MS\u60a3\u8005\u66f4\u8cbc\u8fd1\u65bc\u75be\u75c5\u751f\u7269\u5b78\u548c\u521d\u671f\u767c\u75c5\u6a5f\u5236\uff0c\u6240\u4ee5\u7814\u7a76\u5718\u968a\u5f37\u8abf\u77ad\u89e3\u5152\u7ae5MS\u75c5\u56e0\u5c0d\u65bc\u63a2\u7d22MS\u75be\u75c5\u6210\u56e0\u975e\u5e38\u91cd\u8981\u3002HLA – DRB1\u57fa\u56e0\u8207\u5152\u7ae5\u7f79\u60a3MS\u7684\u76f8\u95dc\u6027\uff0c\u53ef\u63d0\u4f9b\u65e9\u671f\u8a3a\u65b7\u53ca\u4ecb\u5165\u7684\u53ef\u80fd\u6027\uff0c\u4e26\u671f\u671b\u80fd\u958b\u767c\u65b0\u7684\u6cbb\u7642\u6cd5\u3002<\/p>\n

<\/span><\/span>\u00a0<\/span><\/span><\/p>\n

\u8cc7\u6599\u4f86\u6e90\uff1a<\/strong>
\n1. \u694a\u667a\u8d85\uff0c\u8a8d\u8b58\u591a\u767c\u6027\u786c\u5316\u75c7\uff0c<\/span>http:\/\/web2.cc.nctu.edu.tw\/~hcsci\/hospital\/sci\/other\/ms1.htm<\/span><\/a>\u3002
\n2. G. Disanto, MD, et al., 2011, HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination, Neurology , vol.76: 781-786\u3002<\/span><\/span><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u5152\u7ae5\u591a\u767c\u6027\u786c\u5316\u75c7\uff08Multiple Sclerosis\uff09\u7684\u907a\u50b3\u98a8\u96aa\u56e0\u5b50 \u53f0\u5317\u5e02\u7acb\u6210\u529f\u9ad8\u7d1a\u4e2d\u5b78\u751f\u7269\u79d1\u5f35\u6625\u6885\u8001\u5e2b\/…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[110,122,4834],"tags":[2973,2970,2972,2971],"class_list":["post-26617","post","type-post","status-publish","format-standard","hentry","category-lifesciecne00","category-lifescience004","category-lifesciecne004-03","tag-2973","tag-2970","tag-2972","tag-2971","loop-entry","cat-110","cat-122","cat-4834","no-thumbnail"],"views":4567,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/26617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=26617"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/26617\/revisions"}],"predecessor-version":[{"id":88540,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/26617\/revisions\/88540"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=26617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=26617"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=26617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}