{"id":12879,"date":"2010-10-19T02:41:49","date_gmt":"2010-10-18T18:41:49","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=12879"},"modified":"2021-10-06T16:31:08","modified_gmt":"2021-10-06T08:31:08","slug":"%e7%ab%af%e7%b2%92%ef%bc%88telomere%ef%bc%89%e7%b4%b0%e8%83%9e%e7%9a%84%e7%94%9f%e5%91%bd%e6%99%82%e9%90%98-%e4%b8%8a","status":"publish","type":"post","link":"http:\/\/localhost\/%e7%ab%af%e7%b2%92%ef%bc%88telomere%ef%bc%89%e7%b4%b0%e8%83%9e%e7%9a%84%e7%94%9f%e5%91%bd%e6%99%82%e9%90%98-%e4%b8%8a\/","title":{"rendered":"\u7aef\u7c92\uff08Telomere\uff09~\u7d30\u80de\u7684\u751f\u547d\u6642\u9418-\u4e0a"},"content":{"rendered":"<div class=\"pf-content\"><p><strong><span style=\"color: #ff6600;\">\u7aef\u7c92\uff08Telomere\uff09~\u7d30\u80de\u7684\u751f\u547d\u6642\u9418-\u4e0a<br \/>\n<\/span><span style=\"color: #008000;\">\u65b0\u7af9\u5e02\u7acb\u5efa\u529f\u9ad8\u7d1a\u4e2d\u5b78\u751f\u7269\u79d1\u90b1\u9e97\u6167\u8001\u5e2b\/\u570b\u7acb\u53f0\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u674e\u51a0\u7fa4\u52a9\u7406\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/span><\/strong><\/p>\n<p><span style=\"color: #000000;\">\u7aef\u7c92\uff08telomere\uff09\u8207\u7aef\u7c92\u9176\uff08telomerase\uff09\u7684\u529f\u80fd\u5728\u65bc\u78ba\u4fdd\u67d3\u8272\u9ad4DNA\u7684\u5b8c\u6574\u8907\u88fd\uff0c\u8207\u9810\u9632\u5206\u89e3\u3002\u7aef\u7c92\u7684\u9577\u5ea6\uff0c\u67d0\u7a2e\u7a0b\u5ea6\u4e0a\u662f\u4e00\u7a2e\u751f\u7269\u5b78\u7684\u5e74\u9f61\u6a19\u8a18\uff0c\u800c\u7aef\u7c92\u9176\u53ef\u4ee5\u7a69\u5b9a\u7aef\u7c92\u7684\u9577\u5ea6\uff0c\u5176\u6d3b\u6027\u8207\u7d30\u80de\u8870\u8001\u6216\u764c\u7d30\u80de\u7684\u6291\u5236\u6709\u95dc\u3002<\/span><\/p>\n<p>\u7f8e\u570b\u4e09\u4f4d\u79d1\u5b78\u5bb6\u4f0a\u9e97\u838e\u767d\u2022\u5e03\u840a\u514b\u672c(Elizabeth\u3000Blackburn)\u3001\u5361\u863f\u723e\u2022\u683c\u96f7\u5fb7(Carol Greider)\u548c\u5091\u514b\u2022\u7d22\u65af\u5854\u514b(Jack Szostak)\u56e0\u89e3\u958b\u5176\u904b\u4f5c\u7684\u6a5f\u5236\u800c\u69ae\u73722009\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u91ab\u5b78\u734e\u3002\u672c\u7bc7\u5c07\u5c31\u5176\u767c\u73fe\u4e4b\u65c5\u4f5c\u4e00\u7c21\u55ae\u8981\u8ff0\u3002<!--more--><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #000000;\"><a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2010\/10\/6.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-12880\" title=\"6\" src=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2010\/10\/6.jpg\" alt=\"\" width=\"465\" height=\"496\" \/><\/a><\/span><\/p>\n<p><span style=\"color: #000000;\">\u65e9\u57281930\u5e74\uff0c\u7a46\u52d2\uff08Hermann Joseph Muller\uff0c1946\u5e74\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\uff09\u8207\u9ea5\u514b\u6797\u6258\u514b\uff08Barbara McClintock\uff0c1983\u5e74\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\uff09\u5c31\u767c\u73fe\u771f\u6838\u7d30\u80de\u67d3\u8272\u9ad4DNA\u7684\u672b\u7aef\u6709\u4e00\u6bb5\u91cd\u8907\u7684\u5e8f\u5217\uff0c\u7a46\u52d2\u7d50\u5408\u5e0c\u81d8\u6587\u4e2d\u7684\u300c\u5c3e\u7aef\u300dtelos\u4ee5\u53ca\u300c\u90e8\u5206\u300dmeros\u7d44\u6210telomere\u300c\u7aef\u7c92\u300d\u9019\u500b\u540d\u8a5e\u3002\u7576\u6642\u50c5\u77e5\u9053\uff1a\u7aef\u7c92\u7684\u529f\u80fd\u5728\u65bc\u4fdd\u8b77\u67d3\u8272\u9ad4\u672b\u7aef\u7d50\u69cb\u7684\u7a69\u5b9a\u6027\u3001\u907f\u514d\u67d3\u8272\u9ad4\u878d\u5408\uff08end-to-end fusion\uff09\uff0c\u5c0d\u65bc\u7dad\u6301\u7d30\u80de\u751f\u5b58\u53ca\u57fa\u56e0\u9ad4\u7684\u5b8c\u6574\u6027\u5341\u5206\u91cd\u8981\u3002<\/span><\/p>\n<p>\u4f46\u662f\u6839\u64da\u8a79\u59c6\u65af\u2022\u83ef\u751f\uff08Jamse Watson\uff09\u7b49\u4eba\u65bc1972\u5e74\u63d0\u51fa\u7684\u300c\u67d3\u8272\u9ad4\u672b\u7aef\u8907\u88fd\u554f\u984c\u300d\uff08end-replication problem\uff09\uff08\u5716\u4e00\uff09\uff0c\u7aef\u7c92\u7684\u9577\u5ea6\u6703\u96a8\u8457DNA\u4e0d\u5b8c\u6574\u7684\u8907\u88fd\u800c\u6f38\u8da8\u6e1b\u77ed\u3002<\/p>\n<p>\u5728DNA\u5408\u6210\u9176\u7684\u7814\u7a76\u4e2d\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\uff1a\u7d30\u80de\u5728\u9032\u884cDNA \u8907\u88fd\u6642\uff0cDNA\u805a\u5408\u9176\u53ea\u80fd\u5f9e5\u7aef\uff085\u2019\uff09\u5f803\u7aef\uff083\u2019\uff09\u7684\u65b9\u5411\u79fb\u52d5\uff0c\u65bc\u662f\u5206\u70ba\u9023\u7e8c\u7684\u9818\u5148\u80a1\uff08leading strand\uff09\u53ca\u4e0d\u9023\u7e8c\u7684\u5ef6\u9072\u80a1\uff08lagging strand\uff09\u3002\u9818\u5148\u80a1\u53ef\u5b8c\u6574\u7684\u8907\u88fd\u5230\u672b\u7aef\uff0c\u4f46\u5ef6\u9072\u80a1\uff08lagging strand\uff09\u5728\u8907\u88fd\u672b\u671f\u5247\u6703\u56e0\u70baRNA\u5f15\u5b50\uff08RNA primer\uff09\u7684\u79fb\u9664\uff0c\u800c\u9020\u6210 DNA 5\u7aef\u7684\u7a7a\u9699\uff08gap\uff09\uff0c\u4f7f\u5f97\u67d3\u8272\u9ad4\u672b\u7aef\u7aef\u7c92\u5e8f\u5217\u7121\u6cd5\u88ab\u8907\u88fd\u3002<\/p>\n<p style=\"text-align: center;\"><a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2010\/10\/7.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-12881\" title=\"7\" src=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2010\/10\/7.jpg\" alt=\"\" width=\"647\" height=\"425\" \/><\/a><\/p>\n<p style=\"text-align: left;\">\u65bc\u662fDNA\u6bcf\u8907\u88fd\u4e00\u8f2a\uff0c\u672b\u7aef\u90fd\u5c07\u640d\u5931\u4e00\u6bb5\u7d04100~200bp\u7684DNA\u7247\u6bb5\u3002\u5982\u679c\u6c92\u6709\u88dc\u511f\u6a5f\u5236\uff0cDNA\u5728\u7d93\u904e\u842c\u5343\u4ee3\u7684\u8907\u88fd\u5f8c\uff0c\u7d42\u5c07\u4e0d\u65b7\u7e2e\u77ed\u751a\u81f3\u6d88\u5931\u3002\u96a8\u8457\u6642\u9593\u7684\u6f14\u9032\uff0c\u4f9d\u7aef\u7c92\u7684\u9577\u5ea6\u5224\u65b7\uff0c\u8a31\u591a\u55ae\u7d30\u80de\u751f\u7269\u61c9\u8a72\u65e9\u5c31\u7d55\u7a2e\u4e86\u3002<\/p>\n<p>\u8acb\u53c3\u95b1\u00a0<a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=12887\">\u7aef\u7c92\uff08Telomere\uff09~\u7d30\u80de\u7684\u751f\u547d\u6642\u9418-\u4e2d<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u7aef\u7c92\uff08Telomere\uff09~\u7d30\u80de\u7684\u751f\u547d\u6642\u9418-\u4e0a \u65b0\u7af9\u5e02\u7acb\u5efa\u529f\u9ad8\u7d1a\u4e2d\u5b78\u751f\u7269\u79d1\u90b1\u9e97\u6167\u8001\u5e2b\/\u570b\u7acb\u53f0\u7063\u5e2b\u7bc4\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb&hellip;<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4810,110,4817,4818],"tags":[5044],"class_list":["post-12879","post","type-post","status-publish","format-standard","hentry","category-lifesciecne001","category-lifesciecne00","category-lifesciecne001-01","category-lifesciecne001-02","tag-5044","loop-entry","cat-4810","cat-110","cat-4817","cat-4818","no-thumbnail"],"views":44251,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/12879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=12879"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/12879\/revisions"}],"predecessor-version":[{"id":89434,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/12879\/revisions\/89434"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=12879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=12879"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=12879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}