{"id":73137,"date":"2016-07-12T09:00:08","date_gmt":"2016-07-12T01:00:08","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=73137"},"modified":"2021-10-06T16:09:23","modified_gmt":"2021-10-06T08:09:23","slug":"%e5%8b%95%e7%89%a9%e8%83%9a%e8%83%8e%e7%9a%84%e7%94%9f%e6%ae%96%e7%b4%b0%e8%83%9e%e7%99%bc%e8%82%b2%e6%a8%a1%e5%bc%8f%ef%bc%9a%e9%a0%90%e5%85%88%e5%bd%a2%e6%88%90%e8%88%87%e5%be%8c%e6%88%90%ef%bc%88","status":"publish","type":"post","link":"http:\/\/localhost\/%e5%8b%95%e7%89%a9%e8%83%9a%e8%83%8e%e7%9a%84%e7%94%9f%e6%ae%96%e7%b4%b0%e8%83%9e%e7%99%bc%e8%82%b2%e6%a8%a1%e5%bc%8f%ef%bc%9a%e9%a0%90%e5%85%88%e5%bd%a2%e6%88%90%e8%88%87%e5%be%8c%e6%88%90%ef%bc%88\/","title":{"rendered":"\u52d5\u7269\u80da\u80ce\u7684\u751f\u6b96\u7d30\u80de\u767c\u80b2\u6a21\u5f0f\uff1a\u9810\u5148\u5f62\u6210\u8207\u5f8c\u6210\uff08\u4e0b\uff09"},"content":{"rendered":"

\u52d5\u7269\u80da\u80ce\u7684\u751f\u6b96\u7d30\u80de\u767c\u80b2\u6a21\u5f0f\uff1a\u9810\u5148\u5f62\u6210\u8207\u5f8c\u6210\uff08\u4e0b\uff09(Two Main Mechanisms of Animal Primordial Germ Cell Determination: Preformation And Epigenesis (II))<\/strong><\/span>
\n\u570b\u7acb\u81fa\u7063\u5927\u52d5\u7269\u5b78\u7814\u7a76\u6240\u78a9\u58eb \u9673\u653f\u5100<\/strong><\/span><\/p>\n

\u9023\u7d50\uff1a\u52d5\u7269\u80da\u80ce\u7684\u751f\u6b96\u7d30\u80de\u767c\u80b2\u6a21\u5f0f\uff1a\u9810\u5148\u5f62\u6210\u8207\u5f8c\u6210\uff08\u4e0a\uff09<\/a><\/p>\n

\u751f\u6b96\u7d30\u80de\u9810\u5148\u5f62\u6210\u767c\u80b2\u6a5f\u5236\uff1a\u679c\u8805\u7684\u5375\u5728\u6bcd\u9ad4\u5167\u767c\u80b2\u6642\uff0c\u5375\u6bcd\u7d30\u80de\u6703\u5206\u88c2\u56db\u6b21\uff0c\u7522\u751f\u5341\u516d\u500b\u7d30\u80de\uff0c\u5305\u62ec\u5341\u4e94\u500b\u8b77\u885b\u7d30\u80de (nurse cell) \u4ee5\u53ca\u4e00\u500b\u5375\u3002\u9019\u5341\u516d\u500b\u7d30\u80de\u7684\u80de\u88c2 (cytokinesis) \u4e26\u4e0d\u5b8c\u5168\uff0c\u5f7c\u6b64\u7684\u7d30\u80de\u8cea\u4ecd\u7531\u7d30\u80de\u6a4b\u6a11\u901a\u9053 (ring canal) \u53ca\u5176\u5167\u7684\u5fae\u7ba1\u7d30\u80de\u9aa8\u67b6\u76f8\u9023\u63a5\u3002\u7d93\u7531\u9019\u4e9b\u901a\u9053\uff0c\u8b77\u885b\u7d30\u80de\u6240\u5408\u6210\u7684\u7279\u6b8a\u86cb\u767d\u8cea\u8207 mRNA \u88ab\u9001\u5f80\u5375\u96c6\u4e2d\u3002\u4e4b\u5f8c\uff0c\u5375\u5167\u7684\u7d30\u80de\u9aa8\u67b6\u8207\u52d5\u529b\u86cb\u767d\u8cea\uff08dynein \u6216 kinesin\uff09 \u518d\u9032\u4e00\u6b65\u5c07\u9019\u4e9b\u5206\u5b50\u5206\u9001\u5230\u5375\u7684\u4e0d\u540c\u4f4d\u7f6e\u3002\u5176\u4e2d oskar \u57fa\u56e0\u7684\u86cb\u767d\u8cea\u7522\u7269\u5148\u96c6\u4e2d\u5728\u5375\u7684\u5f8c\u7aef\uff0c\u63a5\u8457\u4fc3\u4f7f nanos \u57fa\u56e0\u7684 mRNA \u4e5f\u96c6\u4e2d\u5728\u5375\u5f8c\u7aef\u3002\u7531\u65bc nanos \u8f49\u8b6f\u51fa\u7684\u86cb\u767d\u8cea\u5177\u6709\u6291\u5236\u5176\u4ed6\u975e\u751f\u6b96\u7d30\u80de\u5206\u5316\u57fa\u56e0\u7684\u8f49\u8b6f\uff0c\u540c\u6642\u518d\u914d\u5408 vasa \u548c piwi \u57fa\u56e0\u7684\u7522\u7269\uff0c\u4fc3\u4f7f\u80da\u80ce\u5f8c\u7aef\u7684\u7d30\u80de\u8d70\u5411\u521d\u59cb\u751f\u6b96\u7d30\u80de\u5206\u5316\u7684\u9053\u8def\uff08\u5716\u4e8c\uff09\u3002\u884c\u9810\u5148\u5f62\u6210\u6a5f\u5236\u80da\u80ce\u88e1\u7684\u521d\u59cb\u751f\u6b96\u7d30\u80de\u5206\u5316\u56e0\u5b50\uff0c\u65bc\u5375\u7d30\u80de\u8cea\u7684\u7279\u5b9a\u4f4d\u7f6e\u96c6\u4e2d\uff0c\u9019\u4e9b\u7d30\u80de\u8cea\u7a31\u70ba\u80da\u8cea (germ plasm)\uff0c\u80da\u8cea\u5167\u5e36\u6709\u7684 mRNA \u53ca\u86cb\u767d\u8cea\u4e3b\u8981\u4fc3\u9032\u751f\u6b96\u7d30\u80de\u5206\u5316\u57fa\u56e0\u7684\u8868\u73fe\uff0c\u4e26\u6291\u5236\u975e\u751f\u6b96\u7d30\u80de\u5206\u5316\u57fa\u56e0\u3001\u521d\u59cb\u751f\u6b96\u7d30\u80de\u7684\u7d30\u80de\u9031\u671f\u53ca\u7d30\u80de\u51cb\u4ea1 (apoptosis)\uff0c\u4f7f\u521d\u59cb\u751f\u6b96\u7d30\u80de\u4fdd\u6301\u4e00\u5b9a\u7d30\u80de\u6578\u76ee\uff0c\u76f4\u5230\u767c\u80b2\u5f8c\u671f\u9032\u5165\u9ad4\u5167\u624d\u958b\u59cb\u7e7c\u7e8c\u5206\u88c2\u6210\u66f4\u591a\u7684\u751f\u6b96\u7d30\u80de\u3002<\/p>\n

\"73137_p2\"<\/a>

\u5716\u4e8c\u3001\u679c\u8805\u521d\u59cb\u751f\u6b96\u7d30\u80de\u9810\u5148\u751f\u6210\u6a5f\u5236\u3002\u4e0a\u5716\uff1a\u5375\u6210\u719f\u6642\uff0c\u8b77\u885b\u7d30\u80de\u5408\u6210\u7684\u5206\u5b50\u7d93\u904e\u7d30\u80de\u6a4b\u6a11\u901a\u9053\u9001\u81f3\u5375\uff08\u7d05\u8272\u7bad\u982d\uff09\uff0c\u96a8\u5373\u88ab\u5375\u5167\u7684\u5fae\u7ba1\u7d30\u80de\u9aa8\u67b6\u904b\u9001\u81f3\u4e0d\u540c\u7d30\u80de\u8cea\u4f4d\u7f6e\u3002oscar mRNA \u88ab\u9001\u5f80\u5375\u5f8c\u7aef\uff0c\u56fa\u5b9a nanos mRNA \u7684\u5206\u4f48\u3002\u4e0b\u5716\uff1ananos\u3001vasa\u3001piwi \u7b49\u6c7a\u5b9a\u56e0\u5b50\u7684\u57fa\u56e0\u7522\u7269\uff08\u85cd\u8272\u5340\u57df\uff09\uff0c\u4fc3\u4f7f\u5f97\u5230\u5f8c\u7aef\u5375\u7d30\u80de\u8cea\u7684\u7d30\u80de\uff08\u6975\u7d30\u80de\uff0cpole cells\uff09\u5206\u5316\u70ba\u521d\u59cb\u751f\u6b96\u7d30\u80de\u3002\uff08\u672c\u6587\u4f5c\u8005\u9673\u653f\u5100\u7e6a\uff09<\/p><\/div>\n

\u7531\u65bc\u9019\u4e9b\u5206\u5316\u56e0\u5b50\u7684\u767c\u73fe\uff0c\u79d1\u5b78\u5bb6\u5011\u7528\u539f\u4f4d\u96dc\u4ea4 (in situ<\/em> hybridization) \u53ca\u514d\u75ab\u67d3\u8272\u6cd5 (immunostaining) \u7b49\u6a19\u5b9a\u521d\u59cb\u751f\u6b96\u7d30\u80de\u5728\u80da\u80ce\u7684\u767c\u80b2\u904e\u7a0b\u3002\u7814\u7a76\u767c\u73fe\u679c\u8805\u521d\u59cb\u751f\u6b96\u7d30\u80de\u7684\u9810\u5148\u751f\u6210\u6a5f\u5236\u4e5f\u767c\u751f\u65bc\u52d5\u7269\u6f14\u5316\u6a39\u4e0a\u7684\u5176\u4ed6\u5206\u652f\uff0c\u4f8b\u5982\uff1a\u7dda\u87f2\u3001\u6d77\u81bd\u3001\u6591\u99ac\u9b5a\u3001\u975e\u6d32\u722a\u87fe\u53ca\u96de\u80da\u88e1\u3002\u7531\u65bc\u9019\u4e9b\u53c3\u8207\u8abf\u63a7\u7684\u57fa\u56e0\u5728\u6f14\u5316\u4e0a\u90fd\u5c6c\u65bc\u540c\u6e90\u57fa\u56e0 (homologues genes)\uff0c\u4e14\u529f\u80fd\u4e0a\u90fd\u6c7a\u5b9a\u521d\u59cb\u751f\u6b96\u7d30\u80de\u5206\u5316\uff0c\u56e0\u6b64\uff0c\u79d1\u5b78\u5bb6\u5011\u61f7\u7591\u9019\u7a2e\u521d\u59cb\u751f\u6b96\u7d30\u80de\u9810\u5148\u5f62\u6210\u7684\u6a5f\u5236\u662f\u5426\u5c31\u662f\u5f8c\u751f\u52d5\u7269 (metazoan) \u7956\u5148\u7684\u751f\u6b96\u7d30\u80de\u767c\u80b2\u6240\u4f7f\u7528\u7684\u6a5f\u5236\u5462\uff1f\u7136\u800c\uff0c\u8d8a\u4f86\u8d8a\u591a\u5728\u4e0d\u540c\u52d5\u7269\u7684\u7814\u7a76\u4e0a\u767c\u73fe\uff0c\u6f14\u5316\u6a39\u4e0a\u5927\u90e8\u4efd\u751f\u7269\u7684\u751f\u6b96\u7d30\u80de\u90fd\u662f\u4ee5\u5f8c\u6210\u7684\u6a5f\u5236\u6c7a\u5b9a\u767c\u80b2\u7684\u3002\u7531\u65bc\u5f8c\u751f\u52d5\u7269\u6f14\u5316\u65e9\u671f\u5206\u652f\u7684\u6d77\u7dbf\u8207\u523a\u7d72\u80de\u52d5\u7269\u80da\u80ce\u88e1\uff0c\u7686\u6c92\u6709\u767c\u73fe\u96c6\u4e2d\u5316\u7684\u521d\u59cb\u751f\u6b96\u7d30\u80de\u6c7a\u5b9a\u56e0\u5b50\uff0c\u6697\u793a\u4e86\u5f8c\u751f\u52d5\u7269\u5171\u540c\u7956\u5148\u7684\u751f\u6b96\u7d30\u80de\u53ef\u80fd\u662f\u4ee5\u5f8c\u6210\u6a5f\u5236\u767c\u80b2\u3002\u4f46\u662f\u5728\u908f\u8f2f\u4e0a\u5fc5\u9808\u6ce8\u610f\u7684\u662f\uff0c\u6c92\u6709\u767c\u73fe\u96c6\u4e2d\u5316\u7684\u521d\u59cb\u751f\u6b96\u7d30\u80de\u6c7a\u5b9a\u56e0\u5b50\uff0c\u4e26\u4e0d\u80fd\u5920\u5b8c\u5168\u8b49\u660e\u9019\u4e9b\u52d5\u7269\u7684\u751f\u6b96\u7d30\u80de\u9810\u5148\u5f62\u6210\u7684\u6a5f\u5236\u4e0d\u5b58\u5728\u3002<\/p>\n

\u7531\u65bc\u9ad4\u7d30\u80de\u53ef\u4ee5\u7d93\u7531\u53bb\u5206\u5316 (dedifferentiation) \u53ca\u8f49\u5206\u5316 (transdifferentiaion) \u6539\u8b8a\u5176\u5df2\u6c7a\u5b9a\u7684\u5206\u5316\u8def\u5f91\u800c\u6210\u70ba\u751f\u6b96\u7d30\u80de\uff0c\u4e26\u6c7a\u5b9a\u5176\u907a\u50b3\u5206\u5b50\u662f\u5426\u80fd\u5982\u540c\u751f\u6b96\u7d30\u80de\u4e00\u6a23\u50b3\u905e\u81f3\u4e0b\u4e00\u4ee3\uff0c\u6697\u793a\u4e86\u521d\u59cb\u751f\u6b96\u7d30\u80de\u7684\u7d30\u80de\u8cea\u5167\u5b58\u5728\u7684\u9810\u5148\u751f\u6210\u56e0\u5b50\uff0c\u5e7e\u4e4e\u80fd\u7531\u5176\u4ed6\u985e\u4f3c\u5f8c\u6210\u7684\u6a5f\u5236\u6240\u53d6\u4ee3\uff0c\u4f8b\u5982\u591a\u5206\u5316\u529f\u80fd\u7684 iPS \u7d30\u80de\u7684\u8a98\u5c0e\u6a5f\u5236\uff0c\u8fd1\u4f86\uff0c\u8a98\u5c0e\u5e79\u7d30\u80de\u7684\u6982\u5ff5\u4f7f\u5f97\u5df2\u5206\u5316\u7684\u9ad4\u7d30\u80de\u8207\u672a\u5206\u5316\u7684\u591a\u529f\u80fd\u751f\u6b96\u7d30\u80de\u4e4b\u9593\u7684\u754c\u7dda\u5df2\u5341\u5206\u6a21\u7cca\u3002\u5728\u679c\u8805\u7684\u7814\u7a76\u4e5f\u767c\u73fe\u4e26\u975e\u6240\u6709\u521d\u59cb\u751f\u6b96\u7d30\u80de\u6700\u5f8c\u90fd\u6703\u5206\u5316\u70ba\u751f\u6b96\u6bcd\u7d30\u80de\uff0c\u90e8\u5206\u521d\u59cb\u751f\u6b96\u7d30\u80de\u8d70\u5411\u9ad4\u7d30\u80de\u7684\u5206\u5316\u8def\u5f91\u3002\u53e6\u5916\uff0c\u7bc0\u80a2\u52d5\u7269\u7684\u7aef\u8db3\u76ee\u65e9\u671f\u80da\u80ce\u521d\u59cb\u751f\u6b96\u7d30\u80de\u5167\u5177\u6709\u9810\u5148\u751f\u6210\u7684\u6c7a\u5b9a\u56e0\u5b50\uff0c\u7136\u800c\u5728\u9019\u4e9b\u7d30\u80de\u88ab\u53bb\u9664\u5f8c\uff0c\u767c\u80b2\u6210\u719f\u7684\u500b\u9ad4\u4ecd\u5177\u6709\u5f9e\u5167\u80da\u5c64\uff08\u9ad4\u7d30\u80de\u5206\u5316\u8def\u5f91\uff09\u5f15\u5c0e\u767c\u80b2\u800c\u4f86\u7684\u751f\u6b96\u7d30\u80de\uff0c\u4e14\u80fd\u5920\u7522\u751f\u4e0b\u4e00\u4ee3\u914d\u5b50\u3002\u540c\u6642\uff0c\u4e0d\u5e36\u6709\u751f\u6b96\u7d30\u80de\u7684\u6e26\u87f2\u3001\u6c34\u8785\u53ca\u6d77\u9798\u8eab\u9ad4\u7247\u6bb5\uff0c\u90fd\u80fd\u5920\u5b8c\u5168\u518d\u751f\u51fa\u5177\u6709\u751f\u6b96\u817a\u7684\u500b\u9ad4\u3002\u9019\u4e9b\u7814\u7a76\u90fd\u986f\u793a\uff1a\u521d\u59cb\u751f\u6b96\u7d30\u80de\u7684\u9810\u5148\u751f\u6210\u8207\u5f8c\u6210\uff0c\u4e26\u4e0d\u5b8c\u5168\u6c7a\u5b9a\u6210\u9ad4\u751f\u6b96\u7d30\u80de\u7684\u4f86\u6e90\u3002\u63db\u53e5\u8a71\u8aaa\uff0c\u5373\u4f7f\u52d5\u7269\u80da\u80ce\u767c\u80b2\u6642\u671f\u7f3a\u4e4f\u521d\u59cb\u751f\u6b96\u7d30\u80de\uff0c\u53ea\u8981\u9ad4\u5167\u4ecd\u6709\u80fd\u88ab\u8a98\u5c0e\u7684\u591a\u529f\u80fd\u6027\u5e79\u7d30\u80de\u5b58\u5728\uff0c\u6210\u719f\u7684\u4e0d\u5b55\u500b\u9ad4\u4e5f\u80fd\u5920\u884c\u6709\u6027\u751f\u6b96\uff0c\u5c07\u7d30\u80de\u6838\u5167\u6240\u5e36\u6709\u76f8\u540c\u7684\u907a\u50b3\u8a0a\u606f\u50b3\u905e\u7d66\u4e0b\u4e00\u4ee3\u3002<\/p>\n

\n

\u53c3\u8003\u6587\u737b<\/strong><\/p>\n

    \n
  1. Gilbert, S. F. (2013). Developmental Biology (10 ed.). Sinauer Associates, Inc.<\/li>\n
  2. Extavour, C. G. (2007). Evolution of the bilaterian germ line: lineage origin and modulation of specification mechanisms. Integrative and comparative biology, 47(5), 770\u201385. doi:10.1093\/icb\/icm027<\/li>\n
  3. Nieuwkoop, P., & Sutasurya, L. A. (1981). Primordial germ cells in the invertebrates: from epigenesis to preformation. Cambridge University Press.<\/li>\n<\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"

    \u52d5\u7269\u80da\u80ce\u7684\u751f\u6b96\u7d30\u80de\u767c\u80b2\u6a21\u5f0f\uff1a\u9810\u5148\u5f62\u6210\u8207\u5f8c\u6210\uff08\u4e0b\uff09(Two Main Mechanisms of Animal …<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4810,4822,4826,110,4812,4818,4811],"tags":[10320,10324,10319,10322,10323,10318,7063,10321],"class_list":["post-73137","post","type-post","status-publish","format-standard","hentry","category-lifesciecne001","category-lifesciecne002-01","category-lifesciecne003-01","category-lifesciecne00","category-lifesciecne003","category-lifesciecne001-02","category-lifesciecne002","tag-embryogenesis","tag-epigenesis","tag-germ-cell","tag-preformation","tag-10323","tag-10318","tag-7063","tag-10321","loop-entry","cat-4810","cat-4822","cat-4826","cat-110","cat-4812","cat-4818","cat-4811","no-thumbnail"],"views":2881,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/73137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=73137"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/73137\/revisions"}],"predecessor-version":[{"id":86275,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/73137\/revisions\/86275"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=73137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=73137"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=73137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}