{"id":71882,"date":"2016-06-12T07:17:38","date_gmt":"2016-06-11T23:17:38","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=71882"},"modified":"2021-10-06T16:09:27","modified_gmt":"2021-10-06T08:09:27","slug":"%e7%94%9f%e7%89%a9%e5%82%b3%e6%84%9f%e5%99%a8","status":"publish","type":"post","link":"http:\/\/localhost\/%e7%94%9f%e7%89%a9%e5%82%b3%e6%84%9f%e5%99%a8\/","title":{"rendered":"\u751f\u7269\u50b3\u611f\u5668"},"content":{"rendered":"

\u751f\u7269\u50b3\u611f\u5668(Biosensor)<\/strong><\/span>
\n\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb \u9ec3\u4ef2\u6977<\/strong><\/span><\/p>\n

\u4ec0\u9ebc\u662f\u751f\u7269\u50b3\u611f\u5668<\/strong><\/span><\/p>\n

\u7c21\u55ae\u4f86\u8aaa\uff0c\u751f\u7269\u50b3\u611f\u5668 (biosensor) \u5c31\u662f\u4e00\u500b\u7d50\u5408\u4e86\u751f\u7269\u53ca\u7269\u7406\u3001\u5316\u5b78\u7b49\u8981\u7d20\uff0c\u4f86\u5075\u6e2c\u751f\u7269\u9ad4\u5167\u6216\u9ad4\u5916\u74b0\u5883\u5316\u5b78\u7269\u8cea\u7684\u5206\u6790\u88dd\u7f6e\u3002<\/p>\n

\u4e3b\u8981\u53ef\u4ee5\u5206\u6210\u4e09\u500b\u90e8\u5206\uff0c\u7b2c\u4e00\u90e8\u5206\u662f\u654f\u611f\u7684\u751f\u7269\u8b58\u5225\u5143\u4ef6\uff0c\u53ef\u4ee5\u662f\u751f\u7269\u6216\u4eff\u751f\u6750\u6599\uff0c\u4e00\u822c\u53ef\u4ee5\u900f\u904e\u751f\u7269\u5de5\u7a0b\u88fd\u9020\uff0c\u751f\u7269\u50b3\u611f\u5668\u4e5f\u88ab\u7a31\u70ba\u751f\u7269\u53d7\u9ad4 (bioreceptor)\uff0c\u5e38\u88ab\u8a2d\u8a08\u6210\u80fd\u8207\u611f\u8208\u8da3\u7684\u7279\u5b9a\u5206\u6790\u7269\u4f5c\u7528\u4ee5\u7522\u751f\u80fd\u88ab\u63db\u80fd\u5668\u6e2c\u91cf\u7684\u8b8a\u5316\u30021<\/sup><\/p>\n

\u6297\u9ad4\u3001\u9176\u3001\u591a\u80bd\u3001\u86cb\u767d\u8cea\u3001\u6838\u9178\u3001\u9069\u914d\u9ad4 (aptamer)\u3001\u591a\u80bd\u6838\u9178 (peptide nucleic acids, PNA)\u3001\u91a3\u86cb\u767d\u3001\u91a3\u916f\u3001\u805a\u91a3\u3001\u7d30\u80de\u3001\u566c\u83cc\u9ad4\u3001\u8102\u8cea\u9ad4 (liposome)\u3001\u5206\u5b50\u62bc\u5370\u805a\u5408\u7269 (molecularly imprinted polymers, MIPs)\u3001\u4eff\u751f\u927b\u819c (biomimetic chromic membranes)\u2026\u2026\u90fd\u80fd\u7576\u4f5c\u8b58\u5225\u5143\u4ef6\u30022<\/sup><\/p>\n

\u7b2c\u4e8c\u90e8\u5206\u662f\u63db\u80fd\u5668\uff0c\u5c07\u751f\u7269\u5c64\u611f\u61c9\u7684\u8b8a\u5316\u8f49\u70ba\u66f4\u6613\u6e2c\u91cf\u3001\u91cf\u5316\u7684\u8a0a\u865f\uff0c\u5305\u542b\u96fb\u5316\u5b78\u3001\u96fb\u5b50\u3001\u58d3\u96fb\u3001\u5149\u5b78\u3001\u91cd\u91cf\u5206\u6790\u3001\u6eab\u5ea6\u7b49\u6a5f\u5236\u30021<\/sup>\u7b2c\u4e09\u90e8\u5206\u70ba\u6aa2\u6e2c\u5143\u4ef6\uff0c\u8f49\u63db\u7684\u8a0a\u865f\u80fd\u88ab\u653e\u5927\u4e26\u8655\u7406\u6210\u6709\u610f\u7fa9\u7684\u53c3\u6578\uff0c\u518d\u986f\u793a\u51fa\u4f86\u30023<\/sup>\u5716\u4e00\u6240\u793a\u5373\u70ba\u5178\u578b\u7684\u751f\u7269\u50b3\u611f\u5668\uff0c\u5b83\u6240\u4f7f\u7528\u7684\u6aa2\u6e2c\u5143\u4ef6\u70ba\u96fb\u5b50\u7cfb\u7d71\u30023<\/sup><\/p>\n

\"71882_p1\"<\/a>

\u5716\u4e00\u3001\u5178\u578b\u7684\u751f\u7269\u50b3\u611f\u5668\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1a\u53c3\u8003\u8cc7\u65993\uff09<\/p><\/div>\n

\u751f\u7269\u50b3\u611f\u5668\u7684\u985e\u578b<\/strong><\/span><\/p>\n

\u751f\u7269\u50b3\u611f\u5668\u9664\u4e86\u53ef\u6839\u64da\u63db\u80fd\u6a5f\u5236\u3001\u751f\u7269\u53d7\u9ad4\u9032\u884c\u5206\u985e\u4e4b\u5916\uff0c\u9084\u53ef\u4ee5\u7528\u50b3\u611f\u5668\u7684\u5075\u6e2c\u65b9\u5f0f\u4f86\u5206\uff1a\u89aa\u548c\u50b3\u611f\u5668 (affinity sensor) \u5075\u6e2c\u7684\u662f\u751f\u7269\u53d7\u9ad4\u8207\u5206\u6790\u7269\u7684\u7d50\u5408\uff0c\u4ee3\u8b1d\u50b3\u611f\u5668 (metabolism sensor) \u5075\u6e2c\u57fa\u8cea\u6216\u7522\u7269\u7684\u6fc3\u5ea6\u8b8a\u5316\uff0c\u50ac\u5316\u50b3\u611f\u5668 (catalytic sensor) \u7684\u751f\u7269\u53d7\u9ad4\u9664\u4e86\u8207\u5206\u6790\u7269\u7d50\u5408\u4e4b\u5916\u4e5f\u50ac\u5316\u7522\u7269\u751f\u6210\u30023<\/sup><\/p>\n

\u751f\u6d3b\u61c9\u7528<\/strong><\/span><\/p>\n

\u751f\u7269\u50b3\u611f\u5668\u9019\u500b\u7814\u7a76\u9818\u57df\u8d77\u59cb\u65bc\u514b\u62c9\u514b (Clark) \u8207\u4f86\u6602\u65af (Lyons) \u65bc 1962 \u5e74\u5171\u540c\u7814\u767c\u51fa\u54c1\u7684\u8461\u8404\u7cd6\u6c27\u5316\u9176 (glucose oxidase, GOx) \u751f\u7269\u50b3\u611f\u5668\u3002\u81ea\u90a3\u6642\u4ee5\u4f86\uff0c\u751f\u7269\u50b3\u611f\u5668\u6709\u4e86\u66f4\u6df1\u5165\u7684\u7814\u7a76\u4e5f\u61c9\u7528\u5230\u66f4\u591a\u7684\u9762\u5411\uff0c\u5f9e\u516c\u5171\u885b\u751f\u5230\u74b0\u5883\u76e3\u63a7\u5230\u570b\u5bb6\u3001\u98df\u54c1\u5b89\u5168\u7686\u6709\u5b83\u7684\u8e64\u8de1\u3002<\/p>\n

\u73fe\u5728\u5247\u9010\u6f38\u5411\u7b2c\u4e00\u7dda\u3001\u66f4\u6613\u5546\u696d\u53d6\u5f97\u70ba\u76ee\u6a19\u7814\u7a76\uff0c\u4f7f\u4e4b\u91cf\u7522\u8b93\u666e\u7f85\u5927\u773e\u90fd\u80fd\u4f7f\u7528\u3002\u4f8b\u5982\u4e73\u88fd\u54c1\u3001\u91c0\u9152\u5ee0\u7684\u5373\u6642\u76e3\u63a7\uff0c\u53ef\u4ee5\u5e6b\u52a9\u696d\u8005\u71df\u9020\u4e00\u500b\u66f4\u4e7e\u6de8\u3001\u885b\u751f\u7684\u74b0\u5883\uff0c\u6216\u662f\u61c9\u7528\u5728\u958b\u767c\u65b0\u7522\u54c1\u4e0a\uff0c\u8a66\u9a57\u6dfb\u52a0\u4e0d\u540c\u7684\u5fae\u751f\u7269\u5728\u4e0d\u540c\u7684\u689d\u4ef6\u4e0b\u80fd\u6709\u4ec0\u9ebc\u7368\u7279\u7684\u98a8\u5473\u30023<\/sup><\/p>\n

\u7cd6\u5c3f\u75c5\u4eba\u7684\u8840\u7cd6\u76e3\u6e2c\uff0c\u7531\u65bc\u91ab\u7642\u3001\u5e02\u5834\u7684\u9700\u6c42\u800c\u6210\u70ba\u76ee\u524d\u6700\u5ee3\u6cdb\u4f7f\u7528\u7684\u751f\u7269\u50b3\u611f\u5668\u30021 <\/sup>\u6578\u4ee5\u767e\u842c\u8a08\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u6bcf\u5929\u90fd\u8981\u6e2c\u8a66\u4ed6\u5011\u7684\u8840\u7cd6\u6fc3\u5ea6\uff0c\u9019\u4e5f\u4f7f\u5f97\u8461\u8404\u7cd6\u6210\u70ba\u751f\u7269\u50b3\u611f\u5668\u6700\u5e38\u6e2c\u8a66\u7684\u5206\u6790\u7269\u30023 <\/sup>\u5728\u5206\u985e\u4e0a\uff0c\u5927\u90e8\u4efd\u7684\u8840\u7cd6\u76e3\u6e2c\u5100\u662f\u5c6c\u65bc\u5229\u7528\u96fb\u5316\u5b78\u7684\u50ac\u5316\u50b3\u611f\u5668\uff0c\u96fb\u6975\u662f\u63db\u80fd\u5668\uff0c\u9176\u5247\u662f\u751f\u7269\u8b58\u5225\u5143\u4ef6\u30021<\/sup><\/p>\n

\u7b2c\u4e00\u500b\u767c\u5c55\u7684\u8461\u8404\u7cd6\u9176\u96fb\u6975\u662f\u6e2c\u91cf\u9176\u50ac\u5316\u53cd\u61c9\u4e2d\u6c27\u7684\u6d88\u8017\u91cf\uff1a<\/p>\n

\"71882_eq1\"<\/a><\/p>\n

\u63a5\u8457\u5728 1973 \u5e74\u6642\u5409\u723e\u535a (Guilbault)\u3001\u9b6f\u5e03\u96f7\u8afe (Lubrano) \u63d0\u51fa\u4e86\u7528\u5b89\u57f9\u6cd5 (amperometric) \u70ba\u57fa\u790e\u7684\u9176\u96fb\u6975\u76e3\u6e2c\u904e\u6c27\u5316\u6c2b\u7684\u7522\u7269\uff0c\u7531\u6b64\u7522\u751f\u7684\u751f\u7269\u50b3\u611f\u5668\u5728\u9023\u63a5 100 \u5fae\u5347\u7684\u8840\u6db2\u6a23\u54c1\u6642\u6709\u826f\u597d\u7684\u6e96\u78ba\u5ea6\u548c\u7cbe\u5bc6\u5ea6\uff1a<\/p>\n

\"71882_eq2\"<\/a><\/p>\n

\u7d93\u904e\u4e86\u591a\u5e74\u7684\u7814\u7a76\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\u8461\u8404\u7cd6\u6aa2\u6e2c\u6700\u5408\u9069\u7684\u65b9\u6cd5\u662f\u5c07\u4e0a\u8ff0\u5169\u8005\u878d\u5408\uff0c\u4e26\u4e14\u5c07\u8461\u8404\u7cd6\u6c27\u5316\u9176\u63a5\u4e0a\u9ec3\u7d20\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (flavin adenine dinucleotide, FAD) \u7684\u57fa\u5718\uff0c\u4f5c\u70ba\u6c27\u5316\u5291\u53c3\u8207\u53cd\u61c9\uff0c\u4f7f\u7528\u5169\u500b\u96fb\u5b50\u9084\u539f\u751f\u6210 FADH2<\/sub>\uff0c\u518d\u7d93\u7531\u6c27\u5206\u5b50\u6c27\u5316\u56de FAD\uff0c\u7531\u6b64\u518d\u6c27\u5316\u7522\u751f\u7684\u96fb\u6d41\u6703\u6b63\u6bd4\u65bc\u8461\u8404\u7cd6\u6fc3\u5ea6\uff1a3<\/sup><\/p>\n

\"71882_eq3\"<\/a><\/p>\n

\u5716\u4e8c\u662f\u5e02\u9762\u4e0a\u8ca9\u552e\u7684\u8840\u7cd6\u5100\uff0c\u5176\u4f7f\u7528\u65b9\u5f0f\u901a\u5e38\u662f\u5c07\u624b\u6307\u4e0a\u7a7f\u523a\u5f8c\u6240\u6d41\u7684\u8840\u4ee5\u5373\u68c4\u7684\u8a66\u7d19\u76db\u8f09\uff0c\u7136\u5f8c\u9001\u9032\u5100\u5668\u4e2d\u9032\u884c\u6aa2\u6e2c\u3002\u5927\u591a\u6578\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u7684\u75c5\u60a3\u9700\u8981\u6bcf\u5929\u6e2c\u4e00\u6b21\uff0c\u800c\u7b2c\u4e00\u578b\u7684\u75c5\u60a3\u5247\u9700\u4e00\u5929\u6e2c\u4e09\u81f3\u5341\u6b21\uff0c\u4ee5\u8a55\u4f30\u80f0\u5cf6\u7d20\u5291\u5291\u91cf\u7684\u6709\u6548\u6027\u30024<\/sup><\/p>\n

\"71882_p2\"<\/a>

\u5716\u4e8c\u3001\u8840\u7cd6\u5100\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1a\u53c3\u8003\u8cc7\u65994\uff09<\/p><\/div>\n

\n

\u53c3\u8003\u6587\u737b<\/strong><\/p>\n

    \n
  1. Biosensor \u2014 Wikipedia. https:\/\/en.wikipedia.org\/wiki\/Biosensor<\/a><\/li>\n
  2. Armstrong, R. E., Drapeau, M. D., Loeb, C. A., Valdes, J. J. (2010). Bio-Inspired Innovation and National Security<\/em>. National Defense University. pp. 77\u201398.<\/li>\n
  3. Touhami, A. (2014). Biosensors and Nanobiosensors: Design and Applications. In A. Seifalian, A. de Mel, D. M. Kalaskar (Eds.), Nanomedicine<\/em> (pp. 374-403). One Central Press.<\/li>\n
  4. Blood glucose monitoring \u2014 wikipedia. https:\/\/en.wikipedia.org\/wiki\/Blood_glucose_monitoring<\/a><\/li>\n<\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"

    \u751f\u7269\u50b3\u611f\u5668(Biosensor) \u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb \u9ec3\u4ef2\u6977 \u4ec0\u9ebc\u662f\u751f\u7269\u50b3\u611f\u5668 \u7c21\u55ae\u4f86\u8aaa\uff0c\u751f\u7269\u50b3\u611f\u5668 (b…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8600,6214,108,78,77,110,4815,4843],"tags":[10173,10171,10169,10168,10170,10172],"class_list":["post-71882","post","type-post","status-publish","format-standard","hentry","category-8600","category-6214","category-chemistry00","category-chemistry08-01","category-chemistry08","category-lifesciecne00","category-lifesciecne006","category-lifesciecne006-06","tag-blood-glucose","tag-glucose-oxidase","tag-sensor","tag-10168","tag-10170","tag-10172","loop-entry","cat-8600","cat-6214","cat-108","cat-78","cat-77","cat-110","cat-4815","cat-4843","no-thumbnail"],"views":8851,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/71882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=71882"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/71882\/revisions"}],"predecessor-version":[{"id":86315,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/71882\/revisions\/86315"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=71882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=71882"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=71882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}