{"id":53462,"date":"2014-05-22T13:41:59","date_gmt":"2014-05-22T05:41:59","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=53462"},"modified":"2021-10-06T16:18:10","modified_gmt":"2021-10-06T08:18:10","slug":"%e7%b3%96%e7%b2%be%ef%bc%88saccharin%ef%bc%89","status":"publish","type":"post","link":"http:\/\/localhost\/%e7%b3%96%e7%b2%be%ef%bc%88saccharin%ef%bc%89\/","title":{"rendered":"\u7cd6\u7cbe\uff08Saccharin\uff09"},"content":{"rendered":"

\u7cd6\u7cbe\uff08Saccharin\uff09<\/strong><\/span>
\n\u81fa\u5317\u5e02\u7acb\u7b2c\u4e00\u5973\u5b50\u9ad8\u7d1a\u4e2d\u5b78\u4e8c\u5e74\u7d1a\u738b\u828a\u84c1\/\u81fa\u5317\u5e02\u7acb\u7b2c\u4e00\u5973\u5b50\u9ad8\u7d1a\u4e2d\u5b78\u5316\u5b78\u79d1\u5f35\u6c38\u4f76\u8001\u5e2b\u4fee\u6539<\/b><\/strong><\/span><\/p>\n

\u7cd6\u7cbe\uff08Saccharin\uff09\u5206\u5b50\u5f0f\u70ba $$\\mathrm{C_7H_5NO_3S}$$\uff0c\u767d\u8272\u7d50\u6676\u6216\u7c89\u672b\uff0c\u662f\u4e00\u7a2e\u4eba\u5de5\u751c\u5473\u5291\u3002\u751c\u5ea6\u662f\u7b49\u91cd\u91cf\u8517\u7cd6\u7684 $$300$$\uff5e$$400$$ \u500d\uff0c\u56e0\u70ba\u4eba\u9ad4\u7121\u6cd5\u4ee3\u8b1d\uff0c\u6703\u81ea\u5c3f\u6db2\u4e2d\u6392\u51fa\uff0c\u6240\u4ee5\u4e0d\u5177\u71b1\u91cf\uff1b\u4e5f\u4e0d\u6703\u5f71\u97ff\u8840\u6db2\u4e2d\u7684\u80f0\u5cf6\u7d20\uff0c\u53ef\u88ab\u7cd6\u5c3f\u75c5\u60a3\u8005\u98df\u7528\uff0c\u552f\u751c\u4e2d\u5e36\u9ede\u8f15\u5fae\u7684\u82e6\u5473\u548c\u91d1\u5c6c\u5473\uff0c\u4f46\u76f8\u5c0d\u71b1\u7a69\u5b9a\uff0c\u6545\u53ef\u7528\u65bc\u70d8\u7119\uff0c\u672c\u8eab\u96d6\u96e3\u6eb6\u65bc\u6c34\uff0c\u4f46\u5176\u9209\u9e7d\u6613\u6eb6\u65bc\u6c34\u3002<\/p>\n

\u7531\u52d5\u7269\u5be6\u9a57\u767c\u73fe\u9ad8\u5291\u91cf\u7684\u7cd6\u7cbe\u6703\u63d0\u9ad8\u8001\u9f20\u7f79\u60a3\u8180\u80f1\u764c\u7684\u6a5f\u7387\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u8b49\u5be6\u5c0d\u4eba\u9ad4\u6709\u5bb3\u3002\u6bcf\u65e5\u5141\u8a31\u651d\u53d6\u7528\u91cf\u70ba\u6bcf\u516c\u65a4\u9ad4\u91cd $$2.5$$ \u6beb\u514b\u7cd6\u7cbe\u3002<\/p>\n

1879 \u5e74\u7d04\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b78\u7684\u7814\u7a76\u751f\u6cd5\u723e\u8c9d\u91cc<\/span>\uff08Constantin Fahlberg\uff09\u5728\u6307\u5c0e\u6559\u6388\u96f7\u59c6\u68ee<\/span>\uff08Ira Remsen\uff09\u7684\u5be6\u9a57\u5ba4\uff0c\u7814\u7a76\u7164\u7126\u6cb9\u7684\u7528\u9014\u6642\uff0c\u4e0d\u5c0f\u5fc3\u628a\u4e00\u500b\u5316\u5b78\u7269\u8cea\u7051\u5728\u624b\u4e0a\u537b\u5fd8\u4e86\u6d17\u624b\u3002\u7576\u5929\u665a\u4e0a\uff0c\u6cd5\u723e\u8c9d\u91cc<\/span>\u8207\u59bb\u5b50\u5171\u9032\u665a\u9910\u6642\uff0c\u5ffd\u7136\u767c\u73fe\u4ed6\u7684\u9eb5\u5305\u6372\u751c\u751c\u7684\u3002\u554f\u53ca\u59bb\u5b50\u9eb5\u5305\u662f\u5426\u6709\u505a\u7279\u5225\u7684\u8655\u7406\uff0c\u7b54\u6848\u537b\u662f\u6c92\u6709\u3002\u4ed6\u99ac\u4e0a\u610f\u8b58\u5230\u5690\u5230\u7684\u751c\u5473\uff0c\u61c9\u8a72\u662f\u5728\u5be6\u9a57\u5ba4\u7051\u5230\u7684\u7269\u8cea\u3002<\/p>\n

\u5f8c\u4f86\u96f7\u59c6\u68ee<\/span>\u8207\u6cd5\u723e\u8c9d\u91cc<\/span>\u767c\u73fe\u8a72\u5316\u5b78\u7269\u8cea\u3002\u5e2b\u751f\u5006\u5728 1880 \u5e74\u5c07\u6b64\u7269\u8cea\u767c\u8868\u5728\u300a\u7f8e\u570b\u5316\u5b78\u671f\u520a\u300b\uff08American Chemical Journal\uff09\u3002\u56db\u5e74\u5f8c\uff0c\u6cd5\u723e\u8c9d\u91cc<\/span>\u7533\u8acb\u5c08\u5229\uff0c\u628a\u9019\u500b\u5316\u5b78\u7269\u8cea\u547d\u540d\u70ba\u7cd6\u7cbe\u3002<\/p>\n

\u7d50\u69cb\uff08Structure\uff09<\/strong><\/span><\/p>\n

\u7cd6\u7cbe\u7684\u7d50\u69cb\u4e2d\u542b\u6709\u7a20\u74b0\uff08fused ring\uff09\uff0c\u4e00\u500b\u82ef\u74b0\u548c\u4e00\u500b\u5177\u6709\u78fa\u91af\u80fa\u57fa\u7684\u74b0\uff0c\u74b0\u4e0a\u6c2e\u539f\u5b50\u4e0a\u7684\u9178\u6027\u6c2b\uff0c\u5176 $$pKa$$ \u503c\u7d04\u70ba $$2$$\u3002<\/p>\n

\"500px-Saccharin.svg\"<\/a>

\u5716\u7247\u4e00
http:\/\/en.wikipedia.org\/wiki\/File:Saccharin.svg<\/p><\/div>\n

\u5408\u6210\uff08synthesis\uff09<\/strong><\/span><\/p>\n

\u7cd6\u7cbe\u7684\u5408\u6210\u6709\u8a31\u591a\u88fd\u5099\u65b9\u6cd5\uff0c\u5176\u4e2d\u53c8\u4ee5\u96f7\u59c6\u68ee<\/span>-\u6cd5\u723e\u8c9d\u91cc<\/span>\uff08Remsen-Fahlberg\uff09\u5408\u6210\u6cd5\u6700\u5e38\u898b\uff0c\u4e00\u958b\u59cb\u5148\u5c07\u6c2f\u78fa\u9178 $$(\\mathrm{Cl_2SO_3H})$$\u00a0\u52a0\u5165\u7532\u82ef\uff0c\u5728\u7532\u82ef\u74b0\u4e0a\u5f62\u6210\u9130\u4f4d\u8207\u5c0d\u4f4d\u7684\u78fa\u91af\u6c2f\u57fa $$(\\mathrm{SO_2Cl})$$\u00a0\u7532\u82ef\u5169\u7a2e\u7522\u7269\uff0c\u5c07\u300c\u9130\u78fa\u91af\u6c2f\u7532\u82ef\u300d\u8207\u6c28\u6216\u78b3\u9178\u92a8\u53cd\u61c9\uff0c\u4f7f\u5176\u53d6\u4ee3\u5206\u5b50\u4e2d\u7684\u6c2f\uff0c\u5f62\u6210\u300c\u9130\u78fa\u91af\u80fa\u7532\u82ef\u300d\uff0c\u7cbe\u7149\u5206\u96e2\u51fa\u8a72\u5206\u5b50\u5f8c\uff0c\u7f6e\u65bc\u9ad8\u6fc3\u5ea6\u904e\u9333\u9178\u9240\u6eb6\u6db2\u6c27\u5316\uff0c\u4e26\u52a0\u71b1\u81f3\u651d\u6c0f $$150$$ \u5ea6\uff0c\u7532\u57fa\u6703\u8b8a\u6210\u7fa7\u57fa\uff0c\u9032\u4e00\u6b65\u767c\u751f\u5206\u5b50\u5167\u74b0\u5316\u53cd\u61c9\uff0c\u751f\u6210\u6c34\u548c\u7cd6\u7cbe\u3002\u5982\u679c\u9032\u4e00\u6b65\u4ee5\u91d1\u5c6c\u967d\u96e2\u5b50\u66ff\u63db\u6c2e\u539f\u5b50\u4e0a\u7684\u6c2b\uff0c\u5373\u53ef\u5f62\u6210\u6613\u6eb6\u65bc\u6c34\u7684\u7cd6\u7cbe\u9209\u9e7d\u3001\u9240\u9e7d\u7b49\u7269\u8cea\u3002<\/p>\n

\"640px-Remsen-Fahlberg_synthesis_of_saccharin\"<\/a>

\u5716\u7247\u4e8c
(\u4f86\u6e90\uff1ahttp:\/\/en.wikipedia.org\/wiki\/File:Remsen-Fahlberg_synthesis_of_saccharin.png)<\/p><\/div>\n

\u96f7\u59c6\u68ee<\/span>–<\/span>\u6cd5\u723e\u8c9d\u91cc<\/span>\u5408\u6210\u6cd5\uff0c\u5728\u6280\u8853\u4e0a\u9700\u8981\u6602\u8cb4\u7684\u8a66\u5291\uff0c\u4e14\u50c5\u6709\u7d04 $$26\\%$$ \u4e0d\u7406\u60f3\u7684\u7522\u91cf\u3002\u65bc\u662f\u5728 1950 \u5e74\u7f8e\u570b\u4fc4\u4ea5\u4fc4\u5dde<\/span>\u7684\u83ab\u7c73\u5316\u5b78\u516c\u53f8<\/span>\u6539\u826f\u4e86\u5408\u6210\u65b9\u5f0f\uff08Maumee \u5408\u6210\u6cd5\uff09\uff0c\u63d0\u51fa\u53e6\u5916\u4e00\u7a2e\u88fd\u5099\u65b9\u6cd5\uff1a\u7b2c\u4e00\u6b65\u9a5f\u5148\u884c\u5408\u6210\u300c\u9130\u80fa\u57fa\u82ef\u7532\u9178\u7532\u916f\u300d\uff0c\u518d\u8207\u4e9e\u785d\u9178\u9209\u53ca\u9e7d\u9178\u53cd\u61c9\uff0c\u5f62\u6210\u91cd\u6c2e\u5316\u7684\u9130\u82ef\u7532\u9178\u7532\u916f\u6eb6\u6db2\uff0c\u63a5\u8457\u5206\u5225\u8207\u4e8c\u6c27\u5316\u786b\u3001\u6c2f\u6c23\u548c\u6c28\u9032\u4e00\u6b65\u53cd\u61c9\u5f62\u6210\u7cd6\u7cbe\uff0c\u8a72\u53cd\u61c9\u63d0\u4f9b\u4e86\u66f4\u7c21\u55ae\u8207\u66f4\u7d93\u6fdf\u88fd\u5099\u7cd6\u7cbe\u7684\u65b9\u6cd5\u3002<\/p>\n

\"640px-Maumee_synthesis_of_saccharin\"<\/a>

\u5716\u7247\u4e09 (\u4f86\u6e90\uff1ahttp:\/\/commons.wikimedia.org\/wiki\/File:Maumee_synthesis_of_saccharin.png)<\/p><\/div>\n

\u53c3\u8003\u8cc7\u6599:<\/p>\n

    \n
  1. http:\/\/pubchem.ncbi.nlm.nih.gov\/summary\/summary.cgi?cid=5143<\/a><\/li>\n
  2. http:\/\/www.elmhurst.edu\/~chm\/vchembook\/549saccharin.html<\/a><\/li>\n
  3. http:\/\/www2.mmh.org.tw\/nutrition\/chao\/sweetner.htm<\/a><\/li>\n
  4. http:\/\/en.wikipedia.org\/wiki\/Saccharin<\/a><\/li>\n<\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"

    \u7cd6\u7cbe\uff08Saccharin\uff09 \u81fa\u5317\u5e02\u7acb\u7b2c\u4e00\u5973\u5b50\u9ad8\u7d1a\u4e2d\u5b78\u4e8c\u5e74\u7d1a\u738b\u828a\u84c1\/\u81fa\u5317\u5e02\u7acb\u7b2c\u4e00\u5973\u5b50\u9ad8\u7d1a\u4e2d\u5b78\u5316\u5b78\u79d1\u5f35\u6c38\u4f76\u8001\u5e2b\u4fee\u6539…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1098,108,48],"tags":[6514,6515],"class_list":["post-53462","post","type-post","status-publish","format-standard","hentry","category-1098","category-chemistry00","category-chemistry01","tag-6514","tag-6515","loop-entry","cat-1098","cat-108","cat-48","no-thumbnail"],"views":9434,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/53462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=53462"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/53462\/revisions"}],"predecessor-version":[{"id":87063,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/53462\/revisions\/87063"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=53462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=53462"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=53462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}