{"id":43114,"date":"2013-08-29T14:33:30","date_gmt":"2013-08-29T06:33:30","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=43114"},"modified":"2021-10-06T16:20:44","modified_gmt":"2021-10-06T08:20:44","slug":"%e8%8d%89%e9%85%b8%e9%89%91%ef%bc%88oxaliplatin%ef%bc%89","status":"publish","type":"post","link":"http:\/\/localhost\/%e8%8d%89%e9%85%b8%e9%89%91%ef%bc%88oxaliplatin%ef%bc%89\/","title":{"rendered":"\u8349\u9178\u9251\uff08Oxaliplatin\uff09"},"content":{"rendered":"<div class=\"pf-content\"><p><strong><span style=\"color: #ff6600;\">\u8349\u9178\u9251\uff08Oxaliplatin\uff09<\/span><br \/>\n<\/strong><strong><span style=\"color: #008000;\">\u570b\u7acb\u65b0\u838a\u9ad8\u7d1a\u4e2d\u5b78\u9673\u5049\u6c11\u9000\u4f11\u6559\u5e2b<\/span><\/strong><\/p>\n<p>\u8349\u9178\u9251\uff08\u6216\u8b6f\u70ba\u76ca\u6a02\u9251\uff09\u662f\u542b\u9251\u7684\u6297\u816b\u7624\u85e5\u5291\uff0c\u7528\u65bc\u764c\u75c7\u4e4b\u5316\u7642\u3002<\/p>\n<p><strong><span style=\"color: #800080;\">\u88fd\u5099\u8207\u7d50\u69cb<\/span><\/strong><strong> <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u8349\u9178\u9251\u662f1976\u5e74\u7531\u540d\u53e4\u5c4b\u5e02\u7acb\u5927\u5b78\u7684\u6559\u6388Yoshinori Kidani\u767c\u73fe\u7684\uff0c\u4ed6\u4e26\u4e14\u57281979\u5e74\u53d6\u5f97\u7f8e\u570b\u5c08\u5229\u3002\u63a5\u4e0b\u4f86Debiopharm\u91ab\u85e5\u96c6\u5718\u53d6\u5f97\u8349\u9178\u9251\u7684\u4f7f\u7528\u6b0a\uff0c\u66f4\u5c07\u5176\u767c\u5c55\u70ba\u672b\u671f\u7d50\u8178\u76f4\u8178\u764c\u7684\u7528\u85e5\u3002Deboo\u57281994\u5e74\u5c07\u6b64\u85e5\u6388\u6b0a\u7d66\u6cd5\u570b\u85e5\u5ee0Sanofi-Aventis\u3002\u8349\u9178\u9251\u57281996\u5e74\u7372\u5f97\u6b50\u6d32\u8a31\u53ef\uff08\u6700\u65e9\u662f\u5728\u6cd5\u570b\uff09\uff0c\u4e26\u57282002\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u8207\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u8a31\u53ef\u3002<\/p>\n<p>\u8349\u9178\u9251\u7684\u7d50\u69cb\u5982\u57161\uff0c\u4e2d\u5fc3\u7684\u9251\u539f\u5b50\u914d\u4f4d\u6578\u70ba4\uff0c\u5f62\u6210\u5e73\u9762\u56db\u908a\u5f62\u3002\u7814\u7a76\u986f\u793aR,R\u93e1\u50cf\u7570\u69cb\u7269\u7684\u85e5\u6548\u6bd4S,S\u93e1\u50cf\u7570\u69cb\u7269\u5f37\u3002\u8207\u9806\u9251\u548c\u5361\u9251\u6bd4\u8f03\uff0c\u8349\u9178\u9251\u4e0d\u662f\u7528\u5169\u500b\u6c28\uff08NH<sub>3<\/sub>\uff09\u4f5c\u70ba\u55ae\u7259\u57fa\uff0c\u800c\u662f\u4e00\u500b1,2-\u4e8c\u80fa\u57fa\u74b0\u5df1\u70f7\u4f5c\u70ba\u96d9\u7259\u57fa\u3002\u53e6\u5916\u9084\u6709\u4e00\u500b\u7531\u8349\u9178\u6839\u5f62\u6210\u7684\u96d9\u7259\u57fa\u3002<\/p>\n<div id=\"attachment_43115\" style=\"width: 307px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2013\/08\/110.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-43115\" class=\"size-full wp-image-43115\" title=\"1\" alt=\"\" src=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2013\/08\/110.png\" width=\"297\" height=\"164\" \/><\/a><p id=\"caption-attachment-43115\" class=\"wp-caption-text\">\u57161 \u8349\u9178\u9251\uff08\u5b78\u540d\u70ba(1R,2R-Diaminocyclohexane)oxalatoplatinum(II)\uff09<\/p><\/div>\n<p><strong><span style=\"color: #800080;\">\u4f5c\u7528\u6a5f\u5236<\/span><\/strong><strong> <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u6d3b\u9ad4\u5be6\u9a57\u986f\u793a\uff0c\u8349\u9178\u9251\u5728\u6cbb\u7642\u7d50\u8178\u764c\u6642\uff0c\u5176\u6297\u816b\u7624\u4e4b\u6027\u8cea\u4f86\u81ea\uff08\u975e\u6a19\u9776\uff09\u7d30\u80de\u6bd2\u6027\u3002\u4e00\u822c\u8a8d\u70ba\u542b\u9251\u5316\u5408\u7269\u4e4b\u7d30\u80de\u6bd2\u6027\uff0c\u4f86\u81ea\u5176\u80fd\u6291\u5236\u764c\u7d30\u80de\u4e4bDNA\u5408\u6210\u3002\u8349\u9178\u9251\u7d93\u7531\u8207\u540c\u80a1\u548c\u7570\u80a1DNA\u4e4b\u9593\u7684\u4ea4\u806f\u800c\u767c\u63ee\u85e5\u6548\uff0c\u5176\u4e2d\u540c\u80a1\u4ea4\u806f\u4e3b\u8981\u767c\u751f\u5728\u3000GG\u8207AG\uff08G\u6307\u9ce5\u7cde\u560c\u5464\uff0cA\u6307\u817a\u560c\u5464\uff09\u4f4d\u7f6e\uff0c\u5982\u57162\u6240\u793a\u3002DNA\u7684\u4ea4\u806f\u53ef\u9632\u6b62DNA\u8907\u88fd\u8207\u8f49\u9304\uff0c\u56e0\u800c\u9020\u6210\u7d30\u80de\u6b7b\u4ea1\u3002<!--more--><\/p>\n<div id=\"attachment_43116\" style=\"width: 463px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2013\/08\/25.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-43116\" class=\"size-full wp-image-43116\" title=\"2\" alt=\"\" src=\"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2013\/08\/25.png\" width=\"453\" height=\"147\" srcset=\"http:\/\/localhost\/wp-content\/uploads\/2013\/08\/25.png 453w, http:\/\/localhost\/wp-content\/uploads\/2013\/08\/25-300x97.png 300w\" sizes=\"auto, (max-width: 453px) 100vw, 453px\" \/><\/a><p id=\"caption-attachment-43116\" class=\"wp-caption-text\">\u57162 \u8349\u9178\u9251\u8207DNA\u767c\u751f\u540c\u80a1\u4ea4\u806f<\/p><\/div>\n<p><strong><span style=\"color: #800080;\">\u81e8\u5e8a\u4f7f\u7528\u65b9\u6cd5<\/span><\/strong><strong> <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u8349\u9178\u9251\u7684\u5178\u578b\u7528\u6cd5\u662f\u8207fluorouracil\u53caleucovorin\u5169\u7a2e\u85e5\u7269\u5408\u4f75\u4f7f\u7528\uff0c\u9019\u4e09\u7a2e\u85e5\u5291\u5408\u4f75\u5f8c\u7a31\u70baFOLFOX\uff0c\u5c08\u9580\u7528\u4f86\u6cbb\u7642\u7d50\u8178\u764c\u3002Sanofi-Aventis\u4ee5<strong>Eloxatin<\/strong>\u4f5c\u70ba\u5546\u6a19\u540d\u7a31\u8ca9\u552e\u8349\u9178\u9251\uff1bMedac GmbH \u4ee5<strong>Oxaliplatin Medac <\/strong>\u4f5c\u70ba\u5546\u6a19\u540d\u7a31\u3002\u5e02\u9762\u4e0a\u76ee\u524d\u5df2\u6709\u4e00\u4e9b\u6210\u4efd\u76f8\u540c\u7684\u5b78\u540d\u85e5\u3002\u8349\u9178\u9251\u5728\u6cbb\u7642\u672b\u671f\u764c\u75c7\uff08\u80c3\u764c\u53ca\u5375\u5de2\u764c\uff09\u7684\u6548\u679c\u66fe\u88ab\u62ff\u4f86\u8207\u5176\u4ed6\u542b\u9251\u5316\u5408\u7269\uff08\u9806\u9251\u53ca\u5361\u9251\uff09\u505a\u6bd4\u8f03\u3002<\/p>\n<p><strong><span style=\"color: #800080;\">\u672b\u671f\u7d50\u8178\u76f4\u8178\u764c<\/span><\/strong><strong> <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u5728\u81e8\u5e8a\u7814\u7a76\u4e0a\uff0c\u8349\u9178\u9251\u672c\u8eab\u5728\u6cbb\u7642\u672b\u671f\u7d50\u8178\u76f4\u8178\u764c\u6642\uff0c\u5373\u5177\u6709\u6eab\u548c\u7684\u6d3b\u6027\u3002\u8349\u9178\u9251\u8207fluorouracil\u53caleucovorin\u5169\u7a2e\u85e5\u7269\u5408\u4f75\u4f7f\u7528\uff08\u9019\u4e09\u7a2e\u85e5\u5291\u5408\u4f75\u5f8c\u7a31\u70baFOLFOX\uff09\u4e4b\u6548\u679c\uff0c\u5df2\u88ab\u5ee3\u6cdb\u7814\u7a76\u904e\u3002\u7576fluorouracil\u53caleucovorin\u5408\u4f75\u4f7f\u7528\uff0c\u7a31\u70ba\u300cDe Gramont \u7642\u6cd5\u300d\u3002\u82e5\u4ee5FOLFOX\u7642\u6cd5\u8207De Garmont\u7642\u6cd5\u6bd4\u8f03\u6642\uff0cFOLFOX\u7642\u6cd5\u4e26\u6c92\u6709\u63d0\u9ad8\u6574\u9ad4\u5b58\u6d3b\u7387\uff0c\u4f46\u6539\u5584\u4e86\u7121\u75c5\u8b8a\u5b58\u6d3b\u671f\uff08progression-free survival\uff0c\u6307\u7d93\u6cbb\u7642\u53ca\u6295\u85e5\u4e4b\u5f8c\uff0c\u75c5\u75c7\u6c92\u6709\u518d\u60e1\u5316\u7684\u6642\u9593\u9577\u77ed\uff09\u3002<\/p>\n<p><strong><span style=\"color: #800080;\">\u526f\u4f5c\u7528<\/span><\/strong><strong> <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u25cf\u795e\u7d93\u75c5\u8b8a\uff1a\u6025\u6027\u624b\u8173\u51b0\u51b7\u8207\u9ebb\u75fa\uff08\u53ef\u5fa9\u539f\uff09\u3001\u6162\u6027\u8173\u817f\u624b\u81c2\u9ebb\u75fa\uff08\u7121\u6cd5\u5fa9\u539f\uff09\uff0c\u901a\u5e38\u7f3a\u4e4f\u672c\u9ad4\u611f\u89ba\uff08proprioception\uff09\u3002<\/p>\n<p>\u25cf\u865b\u5f31\u3002<\/p>\n<p>\u25cf\u5641\u5fc3\u3001\u5614\u5410\u3000\u53ca\uff0f\u6216\u3000\u8179\u7009\u3002<\/p>\n<p>\u25cf\u55dc\u4e2d\u6027\u767d\u8840\u7403\u6e1b\u5c11\u75c7\u3002<\/p>\n<p>\u25cf\u8033\u6bd2\u6027\uff08Ototoxity\uff0c\u807d\u89ba\u55aa\u5931\uff09\u3002<\/p>\n<p>\u25cf\u5916\u6ef2\uff1a\u5982\u679c\u8349\u9178\u9251\u7531\u6ce8\u5c04\u7684\u8840\u7ba1\u4e2d\u6f0f\u51fa\uff0c\u53ef\u80fd\u6703\u9020\u6210\u9130\u8fd1\u7d44\u7e54\u7684\u640d\u58de\u3002<\/p>\n<p>\u25cf\u4f4e\u9240\u8840\u75c7\uff1a\u5973\u6027\u767c\u751f\u6b64\u7a2e\u526f\u4f5c\u7528\u8005\u6bd4\u7537\u59d3\u666e\u904d\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u67d0\u4e9b\u75c5\u4eba\u53ef\u80fd\u6703\u5c0d\u542b\u9251\u4e4b\u85e5\u7269\u904e\u654f\uff0c\u5973\u6027\u767c\u751f\u6b64\u7a2e\u73fe\u8c61\u8005\u6bd4\u7537\u59d3\u666e\u904d\u3002<\/p>\n<p>\u8349\u9178\u9251\u4e4b\u8033\u6bd2\u6027\u53ca\u814e\u6bd2\u6027\u5747\u8f03\u9806\u9251\u8207\u5361\u9251\u8f15\u5fae\u3002<\/p>\n<p>.<\/p>\n<p><strong><span style=\"font-size: small;\">\u53c3\u8003\u8cc7\u6599\uff1a<\/span><\/strong><\/p>\n<p><span style=\"font-size: small;\">1. \u8349\u9178\u9251http:\/\/en.wikipedia.org\/wiki\/Oxaliplatin<\/span><\/p>\n<p><span style=\"font-size: small;\">2. Spingler B , Whittington D. A., Lippard S. J., \u201c2.4 \u00c5 Crystal Structure of an Oxaliplatin 1,2-d(GpG) Intrastrand Cross-Link in a DNA Dodecamer Duplex\u201d, Inorg. Chem., <strong>2001<\/strong>, <em>40<\/em>(22), 5596-5602<\/span><\/p>\n<p><span style=\"font-size: small;\">3. Jeon Y. J., Kim S., Ko Y. H., Sakamoto S, Yamaguchi K., Kim K., \u201cNovel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug\u201d, <em>Org. Biomol. Chem.<\/em>, <strong>2005<\/strong>, <em>3<\/em>, 2122-2125<\/span><\/p>\n<p><span style=\"font-size: small;\">4. Vaismn A., masutani C., Hanaoka F., Chaney S. G., \u201cEfficient Translesion Replication Past Oxaliplatin and Cisplatin GpG Adducts by Human DNA Polymerase \u03b7\u201d, <em>Biochemistry<\/em>, <strong>2000<\/strong>, <em>39<\/em> (16), pp 4575\u20134580<\/span><\/p>\n<p>&nbsp;<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u8349\u9178\u9251\uff08Oxaliplatin\uff09 \u570b\u7acb\u65b0\u838a\u9ad8\u7d1a\u4e2d\u5b78\u9673\u5049\u6c11\u9000\u4f11\u6559\u5e2b \u8349\u9178\u9251\uff08\u6216\u8b6f\u70ba\u76ca\u6a02\u9251\uff09\u662f\u542b\u9251\u7684\u6297\u816b\u7624\u85e5\u5291\uff0c\u7528&hellip;<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[4635,4845],"class_list":["post-43114","post","type-post","status-publish","format-standard","hentry","category-chemistry00","tag-4635","tag-4845","loop-entry","cat-108","no-thumbnail"],"views":4672,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/43114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=43114"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/43114\/revisions"}],"predecessor-version":[{"id":87553,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/43114\/revisions\/87553"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=43114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=43114"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=43114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}