{"id":3137,"date":"2009-06-05T14:03:06","date_gmt":"2009-06-05T06:03:06","guid":{"rendered":"http:\/\/highscope.ch.ntu.edu.tw\/wordpress\/?p=3137"},"modified":"2021-10-06T16:49:51","modified_gmt":"2021-10-06T08:49:51","slug":"%e6%a8%99%e9%9d%b6%e6%b2%bb%e7%99%82%ef%bc%88target-therapy%ef%bc%89","status":"publish","type":"post","link":"http:\/\/localhost\/%e6%a8%99%e9%9d%b6%e6%b2%bb%e7%99%82%ef%bc%88target-therapy%ef%bc%89\/","title":{"rendered":"\u6a19\u9776\u6cbb\u7642"},"content":{"rendered":"

\u6a19\u9776\u6cbb\u7642 (Target Therapy)<\/span>
\n\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u856d\u5168\u4f51\u78a9\u58eb\u751f\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u8449\u540d\u5009\u6559\u6388\u8cac\u4efb\u7de8\u8f2f<\/span><\/strong><\/p>\n

\u4e00\u822c\u4f86\u8aaa\u764c\u75c7\u7684\u6cbb\u7642\u6709\u4e09\u7a2e\u65b9\u5f0f\uff0c\u816b\u7624\u5207\u9664\u3001\u653e\u5c04\u7dda\u6cbb\u7642\u3001\u5316\u5b78\u6cbb\u7642\u7b49\u3002\u5316\u5b78\u6cbb\u7642\u666e\u904d\u88ab\u8a8d\u70ba\u662f\u6700\u6709\u6548\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u5f0f\uff0c\u4fc2\u5229\u7528\u4e00\u7a2e\u6216\u591a\u7a2e\u7684\u85e5\u7269\u4f86\u5408\u4f75\u4f7f\u7528\uff08\u53c8\u7a31\u70ba\u5408\u4f75\u6027\u5316\u5b78\u6cbb\u7642\uff09\u3002\u5316\u5b78\u6cbb\u7642\u662f\u5168\u8eab\u6027\u7684\u6cbb\u7642\u65b9\u5f0f\uff0c\u4e00\u500b\u597d\u7684\u5316\u5b78\u6cbb\u7642\u904e\u7a0b\u5fc5\u9808\u6839\u64da\u764c\u75c7\u7684\u985e\u578b\u3001\u90e8\u4f4d\uff0c\u914d\u5408\u9069\u7576\u7684\u6297\u764c\u85e5\u7269\u6216\u5408\u4f75\u85e5\u7269\u53bb\u6cbb\u7642\u764c\u75c7\u3002<\/p>\n

\u7136\u800c\uff0c\u50b3\u7d71\u7684\u5316\u5b78\u6cbb\u7642\u9664\u4e86\u6467\u6bc0\u764c\u7d30\u80de\u5916\uff0c\u4e5f\u5c0d\u6b63\u5e38\u7684\u7d44\u7e54\u7522\u751f\u76f8\u7576\u5927\u7684\u50b7\u5bb3\uff0c\u4e0d\u5177\u9078\u64c7\u6027\u7684\u653b\u64ca\uff0c\u56e0\u6b64\u526f\u4f5c\u7528\u8f03\u5927\u3002\u6a19\u9776\u6cbb\u7642\uff08target therapy\uff09\u7684\u539f\u7406\u5247\u662f\u5728\u4e00\u958b\u59cb\u5c31\u5df2\u9078\u64c7\u597d\u76ee\u6a19\uff0c\u5229\u7528\u764c\u7d30\u80de\u67d0\u4e9b\u7279\u6b8a\u69cb\u9020\u5728\u6b63\u5e38\u7d30\u80de\u88e1\u7f3a\u4e4f\u7684\u7279\u6027\uff0c\u4f7f\u7528\u5c08\u4e00\u6027\u7684\u85e5\u7269\u653b\u64ca\u764c\u7d30\u80de\uff0c\u800c\u53ef\u6bba\u6b7b\u764c\u7d30\u80de\u4f46\u5c0d\u6b63\u5e38\u7d30\u80de\u4e0d\u9020\u6210\u50b7\u5bb3\u3002<\/p>\n

\u76ee\u524d\u81e8\u5e8a\u4e0a\u4f7f\u7528\u7684\u6a19\u9776\u6cbb\u7642\u85e5\u7269\u4f9d\u4f5c\u7528\u6a5f\u5236\u5927\u7d04\u53ef\u5206\u62103\u5927\u985e\uff1a<\/p>\n

\u25ce \u7b2c1\u985e\uff1a\u6291\u5236\u8840\u7ba1\u65b0\u751f\uff08Anti-angiogenesis\uff09\uff1a\u5373\u6240\u8b02\u300c\u9913\u6b7b\u764c\u7d30\u80de\u300d\u7684\u6a19\u9776\u6cbb\u7642\uff0c\u4f8b\u5982\u7528\u65bc\u7d50\u8178\u764c\u7684\u85e5\u7269Avastin\u3001\u7528\u65bc\u6cbb\u7642\u665a\u671f\u814e\u7d30\u80de\u764c\u53ca\u60e1\u6027\u80c3\u8178\u9053\u57fa\u8cea\u7624\u7684\u85e5\u7269Sutent\uff0c\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u814e\u764c\u53ca\u53ef\u80fd\u7528\u65bc\u6cbb\u7642\u809d\u764c\u7684\u85e5\u7269Nexavar\u3002<\/p>\n

\u25ce \u7b2c2\u985e\uff1a\u963b\u65b7\u764c\u7d30\u80de\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u7684\u6a19\u9776\u6cbb\u7642\uff0c\u5305\u62ec\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684Iressa\u548cTarceva\u3001\u6cbb\u7642\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u7684Glivec\u548cSprycel\u4ee5\u53ca\u6cbb\u7642\u4e73\u764c\u7684Tykerb\u3002<\/p>\n

\u25ce \u7b2c3\u985e\uff1a\u91dd\u5c0d\u7d30\u80de\u8868\u9762\u6297\u539f\u7684\u6a19\u9776\u6cbb\u7642\uff0c\u4f8b\u5982\u6cbb\u7642\u60e1\u6027\u6dcb\u5df4\u7624\u7684MabThera\u3001\u4e73\u764c\u7684Herceptin\uff0c\u4ee5\u53ca\u7d50\u8178\u764c\u7684Erbitux\u548cVectibix\u3002<\/p>\n

\u82e5\u4f9d\u64da\u5206\u5b50\u5927\u5c0f\u7d04\u7565\u53ef\u5206\u70ba\u5169\u5927\u985e\uff1a\u5c0f\u5206\u5b50\uff08Small molecules\uff09\u53ca\u55ae\u682a\u6297\u9ad4\uff08Monoclonal antibodies\uff09\u3002\u5c0f\u5206\u5b50\u5982Imatinib mesylate\uff0cGefitinib\uff0cErlotinib\u7b49\u85e5\u7269\u3002\u800c\u55ae\u682a\u6297\u9ad4\u5982Rituximab\uff0cTrastuzumab\uff0cBevacizumab\u7b49\u85e5\u7269\u3002<\/p>\n

\u55ae\u682a\u6297\u9ad4\u4fc2\u5229\u7528\u6297\u9ad4\u8207\u6297\u539f\u9593\u9ad8\u5ea6\u5c08\u4e00\u6027\uff0c\u9054\u5230\u6a19\u9776\u6cbb\u7642\u7684\u6548\u679c\u3002\u800c\u5c0f\u5206\u5b50\u7684\u53cd\u61c9\u6a5f\u5236\u4ee5Imatinib mesylate\u70ba\u4f8b\uff0c\u5982\u4e0b\u5716\u6240\u793a\u3002\u7531\u65bc\u7d30\u80de\u5167\u7684\u8a0a\u606f\u662f\u85c9\u7531\u86cb\u767d\u8cea\u7684\u78f7\u9178\u5316\u4f86\u50b3\u905e\u3002\u5f15\u8d77\u86cb\u767d\u8cea\u78f7\u9178\u5316\u7684\u9175\u7d20\u7a31\u70ba\u6fc0\u9176\uff08kinase\uff09\uff0c\u53bb\u78f7\u9178\u5316\u7684\u9175\u7d20\u5247\u70ba\u78f7\u9178\u9e7d\u9176\uff08phosphatase\uff09\u3002\u800c\u8a0a\u606f\u5373\u85c9\u7531\u6fc0\u9176\u53ca\u78f7\u9178\u9e7d\u9176\u7684\u6d3b\u5316 \/ \u53bb\u6d3b\u5316\u4f5c\u7528\u800c\u9054\u5230\u50b3\u905e\u6548\u679c\u3002\u5728\u8a31\u591a\u81f4\u764c\u57fa\u56e0\u7684\u86cb\u767d\u8cea\u7522\u7269\u4e2d\uff0c\u591a\u5e36\u6709\u916a\u80fa\u9178\u6fc0\u9176\u529f\u80fd\uff0c\u56e0\u6b64\u5176\u88ab\u8a8d\u70ba\u548c\u764c\u7d30\u80de\u7684\u589e\u751f\u6709\u95dc\u3002Imatinib mesylate\u53ef\u5c08\u4e00\u6291\u5236\u916a\u80fa\u9178\u6fc0\u9176\uff08tyrosine kinase\uff09\uff0c\u4f7f\u916a\u80fa\u9178\u6fc0\u9176\u5c07ATP\u7684\u78f7\u9178\u9e7d\u7121\u6cd5\u79fb\u8f49\u5230\u57fa\u8cea\uff08substrate\uff09\uff0c\u5982\u6b64\u5c31\u6291\u5236\u4e86\u8a0a\u606f\u7684\u50b3\u905e\uff0c\u9054\u5230\u6a19\u9776\u6cbb\u7642\u3002Imatinib mesylate\u53ef\u7528\u4f86\u5c0d\u6297BCR-ABL\u3001c-KIT\u3001PDGF-R\u7b49\u6a19\u9776\uff0c\u56e0\u6b64\u88ab\u8a8d\u70ba\u662f\u4e00\u7a2e\u591a\u91cd\u6a19\u9776\u85e5\u7269\uff08multitargeting agent\uff09\u3002\u8a3b\u4e00\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u81e8\u5e8a\u4e0a\u5e38\u898b\u7684\u6a19\u9776\u6cbb\u7642\u85e5\u7269<\/strong><\/p>\n

1. Herceptin\uff08\u8cc0\u764c\u5e73\uff0c\u5225\u540d\uff1aTrastuzumab\uff09\uff1a\u6cbb\u7642\u8f49\u79fb\u6027\u4e73\u764c\u3002
\n2. MabThera\uff08\u83ab\u9808\u764c\uff0c\u5225\u540d\uff1aRituximab\uff09\uff1a\u6cbb\u7642\u5fa9\u767c\u6216\u5c0d\u5316\u7642\u6709\u6297\u85e5\u6027\u7684\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624\u3002
\n3. Avastin\uff08\u764c\u601d\u505c\uff0c\u5225\u540dBevacizumab\uff09\uff1a\u6cbb\u7642\u8f49\u79fb\u6027\u5927\u8178\u76f4\u8178\u764c\u3002
\n4. Erbitux\uff08\u723e\u5fc5\u5f97\u8212\uff0c\u5225\u540d\uff1aCetuximab\uff09\uff1a\u6cbb\u7642\u8f49\u79fb\u6027\u5927\u8178\u76f4\u8178\u764c \/ \u5c40\u90e8\u665a\u671f\u982d\u9838\u764c\u3002
\n5. Iressa\uff08\u827e\u745e\u838e\uff0c\u5225\u540d\uff1aGefitinib\uff09\uff1a\u6cbb\u7642\u80ba\u817a\u764c\u3002
\n6. Tarceva\uff08\u5f97\u8212\u7de9\uff0c\u5225\u540d\uff1aErlotinib\uff09\uff1a\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3002
\n7. Nexavar\uff08\u857e\u838e\u74e6\uff09\uff1a\u6cbb\u7642\u665a\u671f\u809d\u764c\u3001\u814e\u764c\u3002
\n8. Sutent\uff08\u7d13\u764c\u7279\uff09\uff1a\u6cbb\u7642\u665a\u671f\u814e\u7d30\u80de\u764c \/ \u60e1\u6027\u8178\u80c3\u9053\u57fa\u8cea\u7624\u3002
\n9. Mylotarg\uff08\u6ec5\u9ad3\u7624\uff09\uff1a\u6cbb\u7642\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u3002<\/p>\n

\u6a19\u9776\u85e5\u7269\u6cbb\u7642\u5c07\u9010\u6f38\u8d70\u5411\u4f4e\u6bd2\u6027\u3001\u4f4e\u526f\u4f5c\u7528\u4ee5\u53ca\u9577\u671f\u670d\u7528\u4e4b\u6cbb\u7642\u8da8\u52e2\u3002\u6108\u4f86\u6108\u591a\u7684\u7814\u7a76\u5831\u544a\u986f\u793a\uff0c\u6a19\u9776\u85e5\u7269\u53ef\u8207\u50b3\u7d71\u5316\u5b78\u6cbb\u7642\u85e5\u7269\u5728\u7b2c\u4e00\u7dda\u5171\u540c\u4f7f\u7528\uff0c\u751a\u81f3\u5728\u7b2c\u4e00\u7dda\u55ae\u7368\u4f7f\u7528\uff0c\u5982\u8fd1\u5e74\u4f86\u5728\u80ba\u7dda\u764c\u4e0aIressa\u7684\u5ee3\u6cdb\u4f7f\u7528\uff0c\u4f46\u7f3a\u9ede\u662f\u50f9\u683c\u904e\u65bc\u6602\u8cb4\uff0c\u4e00\u5e74\u7684\u85e5\u8cbb\u52d5\u8f12\u65b0\u53f0\u5e63\u6578\u5341\u842c\u6216\u4e0a\u767e\u842c\u5143\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u9078\u7528\u6a19\u9776\u85e5\u7269\u6cbb\u7642\u6642\u61c9\u6709\u4ee5\u4e0b\u5e7e\u500b\u89c0\u5ff5\uff1a<\/strong><\/p>\n

1. \u75c5\u4eba\u7684\u75c5\u6cc1\u662f\u5426\u9069\u5408\u4ee5\u6a19\u9776\u85e5\u7269\u6cbb\u7642\uff0c\u61c9\u7531\u5c08\u79d1\u91ab\u5e2b\u4f5c\u5c08\u696d\u4e4b\u8a55\u4f30\u3002
\n2. \u6a19\u9776\u85e5\u7269\u4ecd\u6709\u5176\u500b\u5225\u7684\u526f\u4f5c\u7528\uff0c\u6709\u4e9b\u85e5\u7269\u53ef\u80fd\u526f\u4f5c\u7528\u6975\u4f4e\uff0c\u6709\u4e9b\u5247\u4ecd\u5f88\u986f\u8457\u3002
\n3. \u6a19\u9776\u85e5\u7269\u56e0\u70ba\u90fd\u662f\u65b0\u4e00\u4ee3\u7684\u7814\u767c\u85e5\u54c1\uff0c\u76ee\u524d\u9020\u50f9\u4ecd\u5f88\u9ad8\u3002\u61c9\u7531\u75c5\u60a3\u53ca\u5bb6\u5c6c\u8a55\u4f30\u7d93\u6fdf\u72c0\u6cc1\uff0c\u8207\u5c08\u79d1\u91ab\u5e2b\u4f5c\u5c08\u696d\u4e4b\u8a55\u4f30\u3002<\/p>\n

\u8a3b\u4e00\uff1a\u4eba\u985e\u57fa\u56e0\u4e2d\u7b2c9\u53ca\u7b2c22\u689d\u67d3\u8272\u9ad4\u56e0\u76f8\u4e92\u6613\u4f4d(chromosome translocation)\u800c\u51fa\u73fe\u4e0d\u6b63\u5e38\u7684\u300c\u8cbb\u57ce\u67d3\u8272\u9ad4\u300d(Philadelphia chromosome), \u9019\u7a2e\u67d3\u8272\u9ad4\u8f49\u4f4d\u6703\u9020\u6210\u539f\u4f86\u4f4d\u5728\u7b2c9\u5c0d\u67d3\u8272\u9ad4\u7684Abelson (ABL) proto-oncogene\u63a5\u5230\u7b2c22\u5c0d\u67d3\u8272\u9ad4\u7684breakpoint cluster region (BCR) \u57fa\u56e0\u4e0a\uff0c\u5f62\u6210BCR-ABL chimeric\u57fa\u56e0\u3002\u6b63\u5e38\u7684ABL \u57fa\u56e0\u5728\u8f49\u9304\u8f49\u8b6f\u5f8c\u7522\u751f\u7684\u916a\u80fa\u9178\u6fc0\u9176\u6703\u53d7\u5230\u56b4\u5bc6\u7684\u8abf\u63a7\uff1b\u4f46\u767c\u751f\u8cbb\u57ce\u67d3\u8272\u9ad4\u6240\u5f62\u6210\u7684BCR-ABL\u878d\u5408\u57fa\u56e0\u5247\u5931\u53bb\u6b63\u5e38\u7684\u8abf\u63a7\u6a5f\u8f49\uff0c\u5176\u6240\u5f62\u6210\u7684\u878d\u5408\u86cb\u767dp210BCR-ABL\u6709\u6975\u5f37\u7684\u916a\u80fa\u9178\u6fc0\u9176\u6d3b\u6027\uff0c\u662f\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u7684\u4e3b\u8981\u6a5f\u8f49\u3002<\/p>\n

\n

\u53c3\u8003\u8cc7\u6599<\/strong>
\n1. \u82b1\u84ee\u6148\u6fdf\u91ab\u9662\u764c\u75c7\u91ab\u5b78\u4e2d\u5fc3\u3002http:\/\/0rz.tw\/Mug6A<\/a>
\n2. Targeted therapy. http:\/\/0rz.tw\/M74kA<\/a>
\n3. \u764c\u75c7\u6cbb\u7642\u7684\u65b9\u6cd5\u3002http:\/\/0rz.tw\/dfHnB<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u6a19\u9776\u6cbb\u7642 (Target Therapy) \u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u856d\u5168\u4f51\u78a9\u58eb\u751f\/\u570b\u7acb\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u8449\u540d\u5009\u6559…<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108,78,77],"tags":[8415,1260,1253],"class_list":["post-3137","post","type-post","status-publish","format-standard","hentry","category-chemistry00","category-chemistry08-01","category-chemistry08","tag-target-therapy","tag-1260","tag-1253","loop-entry","cat-108","cat-78","cat-77","no-thumbnail"],"views":35224,"_links":{"self":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/3137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/comments?post=3137"}],"version-history":[{"count":1,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/3137\/revisions"}],"predecessor-version":[{"id":91081,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/posts\/3137\/revisions\/91081"}],"wp:attachment":[{"href":"http:\/\/localhost\/wp-json\/wp\/v2\/media?parent=3137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/categories?post=3137"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/localhost\/wp-json\/wp\/v2\/tags?post=3137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}