{"id":9444,"date":"2011-07-07T14:39:51","date_gmt":"2011-07-07T06:39:51","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=9444"},"modified":"2017-03-31T23:20:40","modified_gmt":"2017-03-31T15:20:40","slug":"%e3%80%90%e9%86%ab%e8%97%a5%e5%8c%96%e5%ad%b8%e3%80%91%e5%a4%a9%e7%84%b6%e3%84%9f%e5%b0%9a%e5%a5%bd-%e9%a6%ac%e8%b9%84%e8%8a%b1%e6%ad%a2%e7%97%9b%e5%8a%91%e5%90%88%e6%88%90%e6%88%90%e5%8a%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=9444","title":{"rendered":"\u3010\u91ab\u85e5\u5316\u5b78\u3011\u5929\u7136\u311f\u5c1a\u597d \u99ac\u8e44\u82b1\u6b62\u75db\u5291\u5408\u6210\u6210\u529f"},"content":{"rendered":"<p><span style=\"color: #800000;\"><strong>\u25a0 \u300c\u6211\u5011\u6700\u559c\u6b61\u7684\u5c31\u662f\u7d50\u69cb\u76f8\u5c0d\u7c21\u55ae\u7684\u5316\u5408\u7269\uff0c\u9019\u6a23\u5408\u6210\u8d77\u4f86\u6bd4\u8f03\u5bb9\u6613\uff0c\u50cf\u9019\u6a23\u7684\u597d\u4e8b\u53ef\u4e0d\u591a\u3002\u300d<\/strong><\/span><\/p>\n<figure id=\"attachment_9451\" aria-describedby=\"caption-attachment-9451\" style=\"width: 720px\" class=\"wp-caption alignnone\"><a href=\"http:\/\/en.wikipedia.org\/wiki\/Tabernaemontana\" target=\"_blank\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-9451\" title=\"Tabernaemontana_divaricata\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/07\/Tabernaemontana_divaricata.jpg\" alt=\"\" width=\"720\" height=\"540\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/07\/Tabernaemontana_divaricata.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/07\/Tabernaemontana_divaricata-600x450.jpg 600w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><\/a><figcaption id=\"caption-attachment-9451\" class=\"wp-caption-text\">\u99ac\u8e44\u82b1\u4f5c\u70ba\u5929\u7136\u6b62\u75db\u85e5\u7269\u5df2\u6709\u60a0\u4e45\u6b77\u53f2\uff0c\u4f46\u5728\u5be6\u9a57\u5ba4\u88fd\u9020\u5012\u662f\u982d\u4e00\u906d\u3002<\/figcaption><\/figure>\n<p><strong>\u7de8\u8b6f<\/strong> \u2223 \u6c6a\u8283<\/p>\n<p>\u3000\u3000\u79d1\u5b78\u5bb6\u5728\u5be6\u9a57\u5ba4\u88e1\u5408\u6210\u51fa\u6b62\u75db\u7684conolidine\u6210\u5206\uff08\u66ab\u8b6f\u300e\u514b\u8afe\u7acb\u5b9a\u300f\uff09\uff0c\u8b93\u85e5\u7269\u7814\u7a76\u53c8\u5f80\u524d\u8de8\u4e86\u4e00\u5927\u6b65\u3002<\/p>\n<p>\u3000\u3000\u4e00\u7a2e\u5f9e\u99ac\u8e44\u82b1\u8403\u53d6\u51fa\u7684\u5316\u5408\u7269\u53ef\u671b\u6210\u70ba\u6709\u6548\u7684\u6b62\u75db\u5291\uff0c\u4e14\u79d1\u5b78\u5bb6\u5df2\u7d93\u6210\u529f\u5728\u5be6\u9a57\u5ba4\u5408\u6210\u51fa\u4f86\u3002\u6709\u4e86\u9019\u9805\u9032\u5c55\uff0c\u63a5\u4e0b\u4f86\u4fbf\u53ef\u958b\u59cb\u4e00\u9023\u4e32\u7684\u6838\u5fc3\u7814\u7a76\uff0c\u9032\u4e00\u6b65\u4e86\u89e3\u9019\u7a2e\u5316\u5408\u7269\u7684\u85e5\u6548\u3002\u64da\u4fe1\u9019\u985e\u85e5\u7269\u5c07\u4e0d\u6703\u6709\u9d09\u7247\u985e\u6b62\u75db\u85e5\u7269\u7684\u8af8\u591a\u526f\u4f5c\u7528\u3002<\/p>\n<p>\u3000\u3000\u904e\u53bb\u5df2\u7d93\u77e5\u9053conolidine\u61c9\u53ef\u4f5c\u70ba\u6709\u6548\u6b62\u75db\u7684\u85e5\u7269\uff0c\u4f46\u537b\u5f88\u96e3\u9032\u4e00\u6b65\u7814\u7a76\uff0c\u56e0\u70ba\u5f9e\u99ac\u8e44\u82b1\u7684\u6a39\u76ae\u53ea\u80fd\u5206\u96e2\u51fa\u5f88\u5c11\u7684\u91cf\uff0c\u800cconolidine\u7684\u74b0\u72c0\u7d50\u69cb\u66f4\u4f7f\u5f97\u4eba\u5de5\u5408\u6210\u5927\u4e0d\u5bb9\u6613\u3002\u4f46\u6700\u8fd1\u7814\u7a76\u4eba\u54e1\u7d42\u65bc\u514b\u670d\u74f6\u9838\uff0c\u904b\u7528\u4e00\u7a2e\u4fbf\u5b9c\u4e14\u65b9\u4fbf\u53d6\u5f97\u7684\u5316\u5b78\u7d50\u69cb\u7269\uff0c\u5728\u5be6\u9a57\u5ba4\u88e1\u5408\u6210\u51faconolidine\u3002\u7814\u7a76\u5718\u968a\u53ea\u7528\u4e5d\u500b\u6b65\u9a5f\u5c31\u5b8c\u6210\u9019\u500b\u50cf\u300c\u842c\u80fd\u5de5\u5320\u300d\u73a9\u5177\u4e00\u822c\u7684\u5206\u5b50\u7d50\u69cb\uff0c\u800c\u4e14\u53ef\u4ee5\u5927\u91cf\u751f\u7522\u3002\u9019\u4efd\u7814\u7a76\u6210\u679c\u5df2\u65bc\u4e94\u6708\u4e8c\u5341\u4e09\u65e5\u767c\u8868\u5728\u300a\u81ea\u7136\u5316\u5b78\u300b\uff08<em>Nature Chemistry<\/em>\uff09\u671f\u520a\u4e0a\u3002<\/p>\n<p><!--more--><\/p>\n<p>\u3000\u3000\u50b3\u7d71\u91ab\u7642\u904b\u7528\u99ac\u8e44\u82b1\uff08<em>Tabernaemontana divaricata<\/em>\uff0c\u4e2d\u6587\u4e5f\u53eb\u5c71\u99ac\u8336\u3001\u72d7\u7259\u82b1\uff09\u8403\u53d6\u7269\u5df2\u7d93\u6709\u60a0\u4e45\u7684\u6b77\u53f2\uff0c\u4f46\u9019\u7a2e\u5316\u5408\u7269\u7de9\u89e3\u75bc\u75db\u7684\u6a5f\u5236\u59cb\u7d42\u662f\u4e00\u500b\u8b0e\u5718\u3002\u99ac\u8e44\u82b1\u7684\u82f1\u6587\u4fd7\u540d\u53eb\u300c\u76ba\u7e54\u8309\u8389\u300d\uff08crepe jasmine\uff09\uff0c\u4f46\u9019\u7a2e\u690d\u7269\u8ddf\u8309\u8389\u4e26\u6c92\u6709\u4ec0\u9ebc\u89aa\u5c6c\u95dc\u4fc2\uff0c\u800c\u662f\u96b8\u5c6c\u4e00\u500b\u5bcc\u542b\u751f\u7269\u9e7c\u7684\u79d1\u5225\uff0c\u751f\u7269\u9e7c\u5927\u591a\u6709\u6bd2\uff0c\u4f46\u5f88\u5e38\u7528\u4f86\u6cbb\u7642\u7627\u75be\u3001\u764c\u75c7\u548c\u5176\u4ed6\u75be\u75c5\u3002<\/p>\n<p>\u3000\u3000\u7814\u7a76\u4eba\u54e1\u8a2d\u8a08\u4e86\u591a\u9805\u5be6\u9a57\uff0c\u8a66\u5716\u4e86\u89e3conolidine\u5982\u4f55\u5728\u8001\u9f20\u8eab\u4e0a\u767c\u63ee\u85e5\u6548\uff0c\u5be6\u9a57\u7d50\u679c\u767c\u73fe\uff0cconolidine\u5728\u751f\u7269\u9ad4\u5167\u9396\u5b9a\u7684\u7d30\u80de\u6a5f\u5236\uff0c\u8ddf\u50b3\u7d71\u7684\u53ef\u5f85\u56e0\uff08codeine\uff09\u548c\u55ce\u5561\u7b49\u751f\u7269\u9e7c\u4e0d\u540c\uff0c\u4f46\u78ba\u5be6\u80fd\u6709\u6548\u7de9\u89e3\u6025\u6027\u75bc\u75db\u53ca\u767c\u708e\u5f15\u8d77\u7684\u75bc\u75db\u3002\u9019\u500b\u7814\u7a76\u5718\u968a\u4f86\u81ea\u65af\u514b\u5229\u666e\u65af\u7814\u7a76\u9662\uff08Scripps Research Institute\uff09\u4f5b\u7f85\u91cc\u9054\u5dde\u5206\u90e8\uff0c\u7814\u7a76\u4e3b\u6301\u4eba\u4e4b\u4e00\u7c73\u5361\u5229\u5947\u5967\uff08Glenn Micalizio\uff09\u8868\u793a\uff0cconolidine\u53ef\u80fd\u662f\u91dd\u5c0d\u7d30\u80de\u7684\u67d0\u4e00\u500b\u6216\u591a\u500b\u69cb\u9020\u767c\u63ee\u4e86\u7642\u6548\u3002<\/p>\n<p>\u3000\u3000\u52a0\u62ff\u5927\u9ea5\u5409\u723e\u5927\u5b78\uff08McGill University\uff09\u4e00\u4f4d\u5c08\u9580\u7814\u7a76\u75bc\u75db\u7684\u795e\u7d93\u5b78\u5bb6\u53f2\u6771\uff08Laura Stone\uff09\u5247\u8868\u793a\uff0c\u60f3\u9032\u4e00\u6b65\u4e86\u89e3conolidine\u7684\u4f5c\u7528\u65b9\u5f0f\u53ef\u80fd\u9084\u5f97\u82b1\u4e00\u6bb5\u6642\u9593\u3002\u4f46\u9019\u4efd\u65b0\u7814\u7a76\u7684\u8cc7\u6599\u986f\u793a\uff0c\u4f7f\u7528conolidine\u4e0d\u6703\u6709\u4e00\u822c\u9d09\u7247\u88fd\u5291\u5e38\u898b\u7684\u526f\u4f5c\u7528\uff0c\u4f8b\u5982\u6291\u5236\u547c\u5438\u6216\u6210\u766e\u7b49\u3002<\/p>\n<p>\u3000\u3000\u53f2\u6771\u8b66\u544a\uff1a\u300c\u9019\u4e0d\u4ee3\u8868conolidine\u4e0d\u6703\u6709\u5176\u4ed6\u65b0\u7684\u526f\u4f5c\u7528\uff0c\u4f46\u9019\u7d55\u5c0d\u662f\u4e00\u500b\u5f88\u597d\u7684\u7814\u7a76\u65b9\u5411\u3002\u300d<\/p>\n<p>\u3000\u3000\u7dad\u5409\u5c3c\u4e9e\u7406\u5de5\u5927\u5b78\uff08Virginia Tech\uff09\u7684\u5929\u7136\u7522\u7269\u5316\u5b78\u5bb6\u91d1\u65af\u9813\uff08David Kingston\uff09\u8aaa\uff0c\u73fe\u5728\u65e2\u7136\u5df2\u7d93\u53ef\u4ee5\u5927\u91cf\u53d6\u5f97conolidine\uff0c\u9032\u884c\u4e0a\u8ff0\u7814\u7a76\u4e5f\u5c31\u4e0d\u6210\u554f\u984c\u4e86\u3002\u6709\u4e9b\u690d\u7269\u63d0\u7149\u7684\u5316\u5408\u7269\u7d50\u69cb\u975e\u5e38\u8907\u96dc\uff0c\u5f88\u96e3\u5929\u7136\u8403\u53d6\u4e5f\u5f88\u96e3\u4eba\u5de5\u5408\u6210\u3002\u8209\u4f8b\u4f86\u8aaa\uff0c\u6cf0\u514b\u7d22\uff08taxol\uff0c\u5373\u7d2b\u6749\u9187\uff09\u662f\u4e00\u7a2e\u5f9e\u592a\u5e73\u6d0b\u7d2b\u6749\u6a39\u76ae\u63d0\u7149\u51fa\u4f86\u7684\u6297\u764c\u85e5\u7269\uff0c\u79d1\u5b78\u5bb6\u524d\u5f8c\u5171\u82b1\u4e86\u5341\u5e7e\u5e74\u624d\u7814\u7a76\u51fa\u91cf\u7522\u9019\u7a2e\u5316\u5408\u7269\u7684\u65b9\u6cd5\u3002\u5927\u91cf\u53d6\u5f97\u6cf0\u514b\u7d22\u7684\u65b9\u6cd5\u6709\u5169\u7a2e\uff0c\u4e00\u662f\u5728\u5be6\u9a57\u5ba4\u4e2d\u4eba\u5de5\u57f9\u80b2\u8a72\u690d\u7269\u7d30\u80de\uff0c\u4e8c\u662f\u5f9e\u7d2b\u6749\u7684\u91dd\u8449\u8403\u53d6\u51fa\u53e6\u4e00\u7a2e\u5316\u5408\u7269\uff0c\u7d50\u69cb\u5f88\u76f8\u4f3c\u4f46\u7522\u91cf\u591a\u5f97\u591a\uff0c\u7136\u5f8c\u518d\u4ee5\u4eba\u5de5\u65b9\u5f0f\u52a0\u4e0a\u4e00\u652f\u5316\u5b78\u7d50\u69cb\u4f86\u9020\u51fa\u6cf0\u514b\u7d22\u3002<\/p>\n<p>\u3000\u3000\u91d1\u65af\u9813\u8aaa\uff0c\u4eba\u5de5\u5408\u6210conolidine\u53ea\u9700\u8981\u5340\u5340\u4e5d\u500b\u6b65\u9a5f\uff0c\u56e0\u6b64\u6216\u8a31\u4e0d\u9700\u8981\u7528\u5230\u4e0a\u8ff0\u9019\u5169\u7a2e\u8907\u96dc\u7684\u65b9\u6cd5\u3002<\/p>\n<p>\u3000\u3000\u4ed6\u8aaa\uff1a\u300c\u6211\u5011\u6700\u559c\u6b61\u7684\u5c31\u662f\u7d50\u69cb\u76f8\u5c0d\u7c21\u55ae\u7684\u5316\u5408\u7269\uff0c\u9019\u6a23\u5408\u6210\u8d77\u4f86\u6bd4\u8f03\u5bb9\u6613\uff0c\u50cf\u9019\u6a23\u7684\u597d\u4e8b\u53ef\u4e0d\u591a\u3002\u300d<\/p>\n<p>\u3000\u3000<\/p>\n<pre><span style=\"color: #333333;\">\u7814\u7a76\u51fa\u8655\uff1a<\/span><a href=\"http:\/\/www.nature.com\/nchem\/journal\/v3\/n6\/full\/nchem.1050.html\" target=\"_blank\"><span style=\"color: #333333;\">Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain<\/span><\/a><span style=\"color: #333333;\">\uff08<em>Nature Chemistry<\/em>\uff09<\/span><\/pre>\n<p><span style=\"color: #003366;\"><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aMissZoe<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0 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