{"id":8484,"date":"2011-04-19T17:57:06","date_gmt":"2011-04-19T09:57:06","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=8484"},"modified":"2017-03-31T23:20:44","modified_gmt":"2017-03-31T15:20:44","slug":"%e3%80%90%e7%94%9f%e7%89%a9%e6%bc%94%e5%8c%96%e3%80%91%e9%99%b0%e8%8e%96%e6%80%8e%e9%ba%bc%e5%b0%91%e4%ba%86%e5%88%ba","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=8484","title":{"rendered":"\u3010\u751f\u7269\u6f14\u5316\u3011\u9670\u8396\u600e\u9ebc\u5c11\u4e86\u523a"},"content":{"rendered":"<p><span style=\"color: #800000;\"><strong>\u25a0 \u4eba\u985e\u57fa\u56e0\u812b\u5e8f\uff0c\u6f14\u5316\u51fa\u5e73\u6ed1\u7684\u9670\u8396\uff0c\u4ee5\u53ca\u6bd4\u8f03\u5927\u7684\u5927\u8166\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_8496\" aria-describedby=\"caption-attachment-8496\" style=\"width: 760px\" class=\"wp-caption alignnone\"><a href=\"http:\/\/www.flickr.com\/photos\/st-stev\/2426803954\/in\/photostream\/\" target=\"_blank\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-8496\" title=\"St-Stev@flickr\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/04\/St-Stev@flickr3.jpg\" alt=\"\" width=\"760\" height=\"653\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/04\/St-Stev@flickr3.jpg 844w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/04\/St-Stev@flickr3-800x687.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/04\/St-Stev@flickr3-600x515.jpg 600w\" sizes=\"(max-width: 760px) 100vw, 760px\" \/><\/a><figcaption id=\"caption-attachment-8496\" class=\"wp-caption-text\">\u8a31\u591a\u6587\u5316\u90fd\u9084\u7559\u8457\u967d\u5177\u5d07\u62dc\u7684\u75d5\u8de1\uff0c\u8b6c\u5982\u65e5\u672c\u5c31\u6709\u77e5\u540d\u7684\u9435\u7537\u6839\u796d\u3002<\/figcaption><\/figure>\n<p>\u3000\u3000\u5982\u679c\u7537\u4eba\u8ddf\u9ed1\u7329\u7329\u3001\u737c\u7334\u53ca\u8001\u9f20\u7b49\u52d5\u7269\u4e00\u6a23\uff0c\u64c1\u6709\u9577\u6eff\u7d30\u5c0f\u786c\u523a\u7684\u9670\u8396\uff0c\u90a3\u9ebc\u6027\u611b\u9019\u6a94\u4e8b\u53ef\u5c31\u5927\u4e0d\u76f8\u540c\u4e86\u3002\u7f8e\u570b\u53f2\u4e39\u4f5b\u5927\u5b78\u7684\u7814\u7a76\u8005\uff0c\u767c\u73fe\u4e00\u7a2e\u5206\u5b50\u6a5f\u5236\uff0c\u4f7f\u5f97\u4eba\u985e\u7684\u9670\u8396\u6f14\u5316\u6210\u4eca\u65e5\u9019\u6a23\uff0c\u8207\u773e\u4e0d\u540c\u5730\u5b8c\u5168\u7121\u523a\u3002\u4ed6\u5011\u627e\u51fa\u4eba\u985e\u57fa\u56e0\u88e1\uff0c\u907a\u5931\u4e86\u4e00\u6bb5\u7279\u5b9a\u7684\u975e\u7de8\u78bc DNA \uff0c\u5f71\u97ff\u8207\u8377\u723e\u8499\u8a0a\u606f\u6709\u95dc\u7684\u96c4\u6fc0\u7d20\u53d7\u5668\u57fa\u56e0\u8868\u5fb5\u3002<\/p>\n<p>\u3000\u3000\u8207\u540c\u4e8b\u91d1\u65af\u5229 (David Kingsley) \u5171\u540c\u9818\u5c0e\u7814\u7a76\u5de5\u4f5c\u7684\u53f2\u4e39\u4f5b\u5927\u5b78\u767c\u5c55\u751f\u7269\u5b78\u5bb6\u8c9d\u8036\u83c8\u8afe (Gill Bejerano) \u8868\u793a\uff0c\u4ee5\u4eba\u985e\u7279\u6709\u7684\u7279\u5fb5\u6f14\u5316\u6982\u8c8c\u4f86\u8aaa\uff0c\u9019\u584a\u62fc\u5716\u96d6\u5c0f\u537b\u5341\u5206\u6709\u8da3\u3002\u76f8\u95dc\u8a0e\u8ad6\u8d77\u78bc\u5ef6\u7e8c\u6709\u6578\u5341\u5e74\u4e86\uff0c\u4ed6\u5011\u70ba\u5176\u589e\u6dfb\u4e86\u4e00\u7a2e\u5206\u5b50\u89c0\u9ede\u3002<\/p>\n<p>\u3000\u3000\u9019\u9805\u4e09\u6708\u4efd\u767c\u8868\u65bc\u300a\u81ea\u7136\u300b\u96dc\u8a8c\u7684\u7814\u7a76\uff0c\u9ede\u51fa\u6211\u5011\u5982\u4f55\u6f14\u5316\u51fa\u6bd4\u9ed1\u7329\u7329\u9084\u8981\u5927\u7684\u5927\u8166\uff0c\u4ee5\u53ca\u6211\u5011\u55aa\u5931\u4e86\u4eba\u733f\u81c9\u90e8\u5c0f\u578b\u611f\u77e5\u9830\u9aed\u7684\u5206\u5b50\u6a5f\u5236\uff0c\u4eba\u733f\u8207\u4eba\u985e\u6700\u63a5\u8fd1\u7684\u7269\u7a2e\uff0c\u64da\u4f30\u8a08\u6709\u767e\u5206\u4e4b\u4e5d\u5341\u516d\u7684\u76f8\u540c DNA \u3002<!--more--><\/p>\n<p><strong>\u4e00\u592b\u4e00\u59bb\u5236<\/strong><\/p>\n<p>\u3000\u3000\u9577\u4e45\u4ee5\u4f86\uff0c\u4e00\u822c\u90fd\u8a8d\u70ba\u4eba\u985e\u6703\u6f14\u5316\u51fa\u5e73\u6ed1\u7684\u9670\u8396\uff0c\u662f\u65e9\u671f\u4eba\u985e\u5148\u7956\u6539\u63a1\u4e00\u7a2e\u504f\u5411\u4e00\u592b\u4e00\u59bb\u7684\u7e41\u884d\u7b56\u7565\u7684\u7d50\u679c\u3002\u90a3\u4e9b\u5148\u7956\u8207\u5973\u6027\u4ea4\u914d\u6642\uff0c\u53ef\u80fd\u662f\u5229\u7528\u9670\u8396\u7684\u5c16\u523a\uff0c\u79fb\u9664\u7af6\u722d\u8005\u7684\u7cbe\u6db2\u3002\u7136\u800c\u7a76\u7adf\u9019\u7a2e\u8b8a\u5316\u662f\u5982\u4f55\u7522\u751f\u7684\uff0c\u9084\u6c92\u6709\u4eba\u77e5\u9053\u3002<\/p>\n<p>\u3000\u3000\u539f\u672c\u7814\u7a76\u8005\u4e26\u4e0d\u662f\u8981\u7814\u7a76\u9670\u8396\u5c16\u523a\uff0c\u800c\u662f\u8981\u5c0b\u627e\u9084\u5b58\u5728\u9ed1\u7329\u7329\u57fa\u56e0\u7d44\u88e1\uff0c\u4f46\u662f\u5df2\u5f9e\u4eba\u985e\u57fa\u56e0\u7d44\u88e1\u55aa\u5931\u7684DNA \u6bb5\u843d\uff0c\u5982\u6b64\u4ed6\u5011\u5c31\u53ef\u4ee5\u8a66\u8457\u6b63\u78ba\u6307\u51fa\uff0c\u90a3\u4e9b\u6bb5\u843d\u662f\u505a\u4ec0\u9ebc\u7528\u7684\u3002<\/p>\n<p>\u3000\u3000\u8c9d\u8036\u83c8\u8afe\u8207\u91d1\u65af\u5229\u89e3\u91cb\u8aaa\uff0c\u8ddf\u5927\u591a\u6578\u7684\u7814\u7a76\u4e0d\u540c\u4e4b\u8655\uff0c\u662f\u5728\u4ed6\u5011\u8981\u627e\u7684\u662f\u4eba\u985e\u57fa\u56e0\u7d44\u88e1\u88ab\u522a\u9664\u7684\u90e8\u5206\uff0c\u800c\u4e0d\u662f\u51fa\u73fe\u7684\u90e8\u5206\u3002\u8c9d\u8036\u83c8\u8afe\u8aaa\uff0c\u5982\u679c\u4f60\u5f9e\u4eba\u985e\u57fa\u56e0\u7d44\u958b\u59cb\u8457\u624b\uff0c\u5728\u4ed6\u5011\u9019\u4efd\u7814\u7a76\u88e1\uff0c\u6839\u672c\u6c92\u5565\u597d\u770b\u7684\u3002<\/p>\n<p>\u3000\u3000\u4ed6\u5011\u9996\u5148\u7cfb\u7d71\u5730\u8fa8\u8b58\u51fa\u4e94\u767e\u4e00\u5341\u7d44\u4eba\u985e\u6c92\u6709\uff0c\u7136\u800c\u537b\u51fa\u73fe\u5728\u9ed1\u7329\u7329\u57fa\u56e0\u7d44\u88e1\u7684 DNA \u5e8f\u5217\uff0c\u767c\u73fe\u90a3\u4e9b\u5e8f\u5217\u5e7e\u4e4e\u90fd\u4f86\u81ea\u57fa\u56e0\u4e4b\u9593\u7684\u975e\u7de8\u78bc\u57fa\u56e0\u7d44\u5340\u57df\u3002\u63a5\u8457\u4ed6\u5011\u6df1\u5165\u7814\u7a76\u5169\u6bb5\u4eba\u985e\u6c92\u6709\uff0c\u4f46\u662f\u4ed6\u5011\u89ba\u5f97\u6709\u610f\u601d\u7684\u5e8f\u5217\uff1a\u4e00\u6bb5\u63a5\u8fd1\u96c4\u6fc0\u7d20\u53d7\u5668 (<em>AR<\/em>) \u57fa\u56e0\uff0c\u53e6\u4e00\u6bb5\u5247\u63a5\u8fd1\u8207\u816b\u7624\u6291\u5236\u6709\u95dc\u7684\u57fa\u56e0 (<em>GADD45G<\/em>) \u3002<\/p>\n<p>\u3000\u3000\u628a\u9ed1\u7329\u7329\u7684\u57fa\u56e0\u5e8f\u5217\uff0c\u690d\u5165\u8001\u9f20\u80da\u80ce\u5f8c\uff0c\u986f\u793a\u524d\u4e00\u6bb5\u5e8f\u5217\u4e0d\u4f46\u6703\u88fd\u9020\u786c\u7684\u9670\u8396\u5c16\u523a\uff0c\u4e5f\u6703\u8b93\u67d0\u4e9b\u52d5\u7269\u9577\u51fa\u611f\u77e5\u9830\u9aed\u3002\u5f8c\u4e00\u6bb5\u5e8f\u5217\u5247\u662f\u50cf\u67d0\u7a2e\u715e\u8eca\u4e00\u6a23\uff0c\u6703\u6291\u5236\u7279\u5b9a\u8166\u90e8\u5340\u57df\u7684\u6210\u9577\uff0c\u79fb\u9664\u5176\u529f\u80fd\u4e4b\u5f8c\uff0c\u4f3c\u4e4e\u5c31\u6703\u4fc3\u4f7f\u4eba\u985e\u6f14\u5316\u51fa\u6bd4\u8f03\u5927\u7684\u5927\u8166\u3002<\/p>\n<p>\u3000\u3000\u91d1\u65af\u5229\u8868\u793a\uff0c\u9019\u500b\u7814\u7a76\u8a08\u756b\u7684\u76ee\u7684\uff0c\u662f\u8981\u4ee5\u63cf\u7e6a\u6b64\u4e00\u539f\u7406\u5404\u500b\u5c64\u9762\u7684\u7bc4\u4f8b\uff0c\u4f86\u627e\u51fa\u85cf\u5728\u4eba\u985e\u6f14\u5316\u7279\u5fb5\u4e4b\u4e0b\u7684\u5206\u5b50\u640d\u5bb3\u3002\u8c9d\u8036\u83c8\u8afe\u88dc\u5145\u8aaa\uff0c\u9664\u975e\u6211\u5011\u63a2\u7a76 DNA \u8868\u5fb5\u4e4b\u8655\uff0c\u4e0d\u7136\u6211\u5011\u5c0d\u65bc\u5b83\u5011\u5be6\u969b\u4e0a\u63a7\u5236\u4ec0\u9ebc\u6771\u897f\uff08\u5982\u679c\u6709\u7684\u8a71\uff09\uff0c\u5c31\u6beb\u7121\u6982\u5ff5\u3002<\/p>\n<p>\u3000\u3000\u5176\u4ed6\u7684\u5206\u5b50\u751f\u7269\u5b78\u5bb6\u8b9a\u8cde\u9019\u4efd\u7814\u7a76\uff0c\u8a8d\u70ba\u5176\u7814\u7a76\u65b9\u6cd5\u5f88\u8070\u660e\uff0c\u4e26\u8868\u793a\u9019\u6703\u70ba\u63a2\u7a76\u4e4b\u8def\u53e6\u95e2\u65b0\u5f91\uff0c\u7279\u5225\u662f\u5c0d\u5c0d\u90a3\u4e9b\u5f9e\u4e8b\u4eba\u985e\u5927\u8166\u6f14\u5316\u7814\u7a76\u7684\u4eba\u4f86\u8aaa\u3002<\/p>\n<p>\u3000\u3000\u7f8e\u570b\u5a01\u65af\u5eb7\u8f9b\u5927\u5b78\u9ea5\u8fea\u905c\u5206\u6821\u52d5\u7269\u907a\u50b3\u6f14\u5316\u5c08\u5bb6\u5361\u7f85\u723e\uff08Sean Carroll\uff09 \u8868\u793a\uff0c\u9019\u662f\u4e00\u7a2e\u5075\u63a2\u5de5\u4f5c\uff0c\u4e00\u5b9a\u8981\u8a18\u5f97\u7684\u662f\uff0c\u5728\u6f14\u5316\u7684\u904e\u7a0b\u4e2d\uff0c\u4e0d\u4f46\u6703\u7372\u5f97\u8cc7\u8a0a\uff0c\u4e5f\u6703\u907a\u5931\u8cc7\u8a0a\u3002<\/p>\n<p>\u3000\u3000\u53c3\u8207\u9019\u500b\u7814\u7a76\u5718\u968a\uff0c\u6700\u8fd1\u5b8c\u6210\u5c3c\u5b89\u5fb7\u5854\u4eba\u57fa\u56e0\u7d44\u5b9a\u5e8f\u7684\u5fb7\u570b\u99ac\u514b\u65af\u84b2\u6717\u514b\u6f14\u5316\u4eba\u985e\u5b78\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u6ce2\u4f2f (Svante P\u00e4\u00e4bo) \u8868\u793a\uff0c\u5f88\u591a\u6642\u5019\u975e\u5e38\u68d2\u7684\u60f3\u6cd5\uff0c\u5c31\u5f8c\u898b\u4e4b\u660e\u770b\u4f86\u7c21\u76f4\u5c31\u662f\u660e\u986f\u5230\u4e86\u4e4f\u5473\u7684\u5730\u6b65\u3002\u7531\u65bc\u5728\u4e94\u767e\u500b\u88ab\u522a\u9664\u7684\u5e8f\u5217\u4e2d\uff0c\u4ed6\u5011\u8fa8\u8b58\u51fa\u4f86\u7684\u5176\u4e2d\u5169\u6bb5\u6b63\u597d\u76f8\u7576\u6709\u610f\u601d\uff0c\u4ed6\u78ba\u4fe1\u4ed6\u5011\u540d\u55ae\u4e0a\u9084\u6709\u7684\u5176\u4ed6\u5e7e\u6bb5\u5e8f\u5217\uff0c\u4e5f\u6703\u662f\u5f88\u6709\u610f\u601d\u7684\u3002\u76ee\u524d\u7814\u7a76\u5718\u968a\u6b63\u7e7c\u7e8c\u5206\u6790\u5269\u4e0b\u7684\u4e94\u767e\u96f6\u516b\u500b DNA \u5e8f\u5217\u3002<\/p>\n<p>\u3000\u3000\u5728\u7f8e\u570b\u52a0\u5dde\u5927\u5b78\u8056\u5854\u514b\u9b6f\u8332\u5206\u6821\u7814\u7a76\u4eba\u985e\u57fa\u56e0\u7d44\u5206\u5b50\u6f14\u5316\u7684\u90dd\u65af\u52d2 (David Haussler) \u88dc\u5145\u8aaa\uff0c\u6211\u5011\u7684\u7956\u5148\u55aa\u5931\u9670\u8396\u5c16\u523a\uff0c\u8b93\u6211\u5011\u4eca\u5929\u7372\u76ca\u826f\u591a\u3002\u4ed6\u8aaa\u4e16\u754c\u5404\u5730\u6709\u4f34\u4fb6\u7684\u4eba\uff0c\u5176\u5be6\u53ef\u4ee5\u611f\u8b1d\u9019\u6bb5\u7279\u5b9a\u7684 DNA \u88ab\u6e05\u6389\u4e86\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<pre><span style=\"color: #333333;\">\u7814\u7a76\u51fa\u8655\uff1a<\/span><a href=\"http:\/\/www.nature.com\/nature\/journal\/v471\/n7337\/full\/nature09774.html\" target=\"_blank\"><span style=\"color: #333333;\">Human-specific loss of regulatory DNA and the evolution of human-specific traits<\/span><\/a><span style=\"color: #333333;\">\uff08<em>Nature<\/em>\uff09<\/span><\/pre>\n<p><strong><span style=\"color: #800000;\">\u539f\u8f09\u65bc\u3010<\/span><a href=\"http:\/\/www.k-review.com.tw\/index\/\" target=\"_blank\"><span style=\"color: #800000;\">\u77e5\u8b58\u901a\u8a0a\u8a55\u8ad6\u6708\u520a\u4e00\u3007\u4e8c\u671f<\/span><\/a><span style=\"color: #800000;\">\u30112011.04.01 <\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0 \u4eba\u985e\u57fa\u56e0\u812b\u5e8f\uff0c\u6f14\u5316\u51fa\u5e73\u6ed1\u7684\u9670\u8396\uff0c\u4ee5\u53ca<\/p>\n","protected":false},"author":20,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1026],"tags":[57,2248,688],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/8484"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8484"}],"version-history":[{"count":19,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/8484\/revisions"}],"predecessor-version":[{"id":8507,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/8484\/revisions\/8507"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}