{"id":6531,"date":"2010-12-07T15:04:26","date_gmt":"2010-12-07T07:04:26","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=6531"},"modified":"2017-03-31T23:20:50","modified_gmt":"2017-03-31T15:20:50","slug":"%e3%80%90%e7%b2%be%e7%a5%9e%e9%86%ab%e5%ad%b8%e3%80%91%e6%89%be%e5%b0%8b%e7%b2%be%e7%a5%9e%e5%88%86%e8%a3%82%e7%97%87%e7%9a%84%e8%97%a5%e7%89%a9%e9%9b%a3%e5%b1%80","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=6531","title":{"rendered":"\u3010\u7cbe\u795e\u91ab\u5b78\u3011\u627e\u5c0b\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u85e5\u7269\u96e3\u5c40"},"content":{"rendered":"
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<\/p>\n

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\"\"<\/a>
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\u3000\u3000<\/strong>\u8a66\u9a57\u5f8c\u5c0d\u85e5\u7406\u6578\u64da\u7684\u91cd\u65b0\u5be9\u67e5\u986f\u793a\uff0c\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u85e5\u7269\u96d6\u7136\u90fd\u6709\u6548\u91dd\u5c0dD2\u548c5-HT2A\u53d7\u9ad4\uff0cD2\u7684\u963b\u65b7\u4f3c\u4e4e\u4e5f\u662f\u4e3b\u8981\u81e8\u5e8a\u6548\u679c\u7684\u539f\u56e0\u3002\u82f1\u570b\u79ae\u4f86\u516c\u53f8\u8a8d\u77e5\u795e\u7d93\u79d1\u5b78\u4e2d\u5fc3\u4e3b\u4efb\u7684\u884c\u70ba\u85e5\u7406\u5b78\u5bb6\u5d14\u514b\u73ed\uff08Mark Tricklebank\uff09\u8868\u793a\uff0c\u4ee5\u5f8c\u898b\u4e4b\u660e\u800c\u8a00\uff0c\u9019\u4e26\u4e0d\u4ee4\u4eba\u9a5a\u8a1d\uff0c\u56e0\u70ba\u7528\u65bc\u6e2c\u8a66\u85e5\u7269\u7684\u52d5\u7269\u6a21\u578b\u90fd\u8a2d\u8a08\u4ee5\u89c0\u6e2cD2\u53d7\u9ad4\u963b\u65b7\u3002\u300c\u9019\u5b8c\u5168\u662f\u500b\u5faa\u74b0\uff0c\u662f\u4e00\u500b\u81ea\u6211\u5be6\u73fe\u7684\u9810\u8a00\uff0c\u300d\u4ed6\u8aaa\uff0c \u300c\u7576\u6211\u5011\u771f\u6b63\u9700\u8981\u7684\u662f\u4e00\u500b\u65b0\u7684\u5f15\u64ce\u6642\uff0c\u6211\u5011\u537b\u5728\u5fae\u8abf\u5f15\u64ce\u3002\u300d<\/p>\n

\u70ba\u4e86\u64fa\u812b\u9019\u7a2e\u60e1\u6027\u5faa\u74b0\uff0c\u79d1\u5b78\u5bb6\u5011\u610f\u8b58\u5230\uff0c\u4ed6\u5011\u9700\u8981\u4e00\u4e9b\u57fa\u790e\u53ca\u61c9\u7528\u79d1\u5b78\u4e0a\u7684\u5168\u65b0\u60f3\u6cd5\u3002\u81e8\u5e8a\u8a66\u9a57\u5df2\u4e3b\u8981\u96c6\u4e2d\u65bc\u6cbb\u7642\u5e7b\u89ba\u548c\u5984\u60f3\uff0c\u4f46\u4eba\u5011\u65e5\u76ca\u8a8d\u8b58\u5230\uff0c\u8a8d\u77e5\u529f\u80fd\u969c\u7919\uff08\u5982\u8a18\u61b6\u529b\u5dee\u3001\u7121\u6cd5\u4fdd\u6301\u8db3\u5920\u7684\u6ce8\u610f\u529b\u3001\u554f\u984c\u89e3\u6c7a\u80fd\u529b\u4e0d\u8db3\u7b49\uff09\u662f\u6b64\u75be\u75c5\u7684\u4e00\u500b\u57fa\u672c\u9762\u5411\u3002<\/p>\n

\u4e8c\u25cb\u25cb\u4e94\u5e74\uff0c\u6642\u4efb\u99ac\u91cc\u862d\u5dde\u7684\u7f8e\u570b\u570b\u5bb6\u7cbe\u795e\u885b\u751f\u7814\u7a76\u6240\u4e3b\u4efb\u7684\u6d77\u66fc\uff08Steve Hyman\uff09\uff0c\u63a8\u51fa\u4e86\u300c\u6539\u9032\u6cbb\u7642\u7cbe\u795e\u5206\u88c2\u75c7\u4e4b\u6e2c\u91cf\u8207\u8a8d\u77e5\u79d1\u5b78\u7814\u7a76\u300d\uff08MATRICS\uff09\u8ad6\u58c7\u3002\u672c\u6b21\u8ad6\u58c7\u65e8\u5728\u532f\u96c6\u5b78\u8853\u754c\u3001\u7522\u696d\u754c\u548cFDA\uff0c\u4ee5\u9054\u6210\u5982\u4f55\u8a2d\u8a08\u81e8\u5e8a\u8a66\u9a57\uff0c\u4ee5\u6700\u6709\u6548\u6e2c\u8a66\u91dd\u5c0d\u9019\u4e9b\u8a8d\u77e5\u969c\u7919\u7684\u85e5\u7269\u7684\u5171\u8b58\uff08\u5f8c\u4f86\u62d3\u5c55\u5230\u300c\u9670\u6027\u75c7\u72c0\u300d\uff09\uff1b\u9019\u4e9b\u81e8\u5e8a\u8a66\u9a57\u5305\u542b\u4e00\u7fa4\u7279\u5225\u8a2d\u8a08\u7684\u6e2c\u9a57\u3002<\/p>\n

\u4f9d\u7167MATRICS\u7684\u5efa\u8b70\uff0c\u5e7e\u500b\u8a8d\u77e5\u589e\u5f37\u5291\u5df2\u7d93\u9032\u5165\u524d\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u6210\u70ba\u6297\u7cbe\u795e\u75c5\u6a19\u6e96\u85e5\u7269\u7642\u6cd5\u4e2d\uff0c\u6709\u6f5b\u529b\u7684\u52a0\u5f37\u85e5\u7269\u3002\u6b64\u5916\uff0c\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u6709\u5e7e\u500b\u4f5c\u7528\u65bc\u7a40\u6c28\u9178\uff08\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff09\u53d7\u9ad4\u7684\u5019\u9078\u85e5\u7269\u3002\u9019\u662f\u552f\u4e00\u805a\u7126\u65bc\u591a\u5df4\u80fa\u4ee5\u5916\u7269\u8cea\u7684\u65b9\u6cd5\uff1b\u4f46\u5728\u5927\u8166\u4e2d\u7684\u7a40\u6c28\u9178\u8ff4\u8def\u53ef\u80fd\u6703\u88ab\u8b49\u660e\u96e3\u4ee5\u5b89\u5168\u64cd\u7e31\u3002\u800c\u5c0d\u65bc\u79d1\u5b78\u754c\uff0c\u771f\u6b63\u7684\u6311\u6230\u5728\u65bc\u4e86\u89e3\u4ed6\u5011\u5728\u8a66\u8457\u4fee\u88dc\u7684\u7cfb\u7d71\u3002FDA\u7684\u7cbe\u795e\u79d1\u85e5\u7269\u4e3b\u4efb\u52de\u4ec1\uff08Thomas Laughren\uff09\uff0c\u8868\u9054\u4e86\u5f88\u591a\u4eba\u611f\u5230\u7684\u632b\u6298\uff1a\u300c\u6211\u5011\u751a\u81f3\u7121\u6cd5\u5728\u751f\u7269\u5b78\u5c64\u6b21\u7406\u89e3\u7cbe\u795e\u5206\u88c2\u75c7\u3002\u300d\u3002<\/p>\n

\u4e00\u500b\u6b50\u6d32\u7814\u7a76\u4eba\u54e1\u7684\u5408\u4f5c\u806f\u76df\uff0c\u540d\u70ba\u300c\u4ee5\u65b0\u65b9\u6cd5\u767c\u5c55\u6291\u9b31\u75c7\u548c\u7cbe\u795e\u5206\u88c2\u75c7\u65b0\u85e5\u300d\uff08NEWMEDS\uff09\uff0c\u4ee5\u975e\u5e38\u5c11\u898b\u7684\u516c\u79c1\u71df\u90e8\u9580\u5408\u4f5c\uff0c\u5168\u529b\u5c0d\u6b64\u8ab2\u984c\u6295\u5165\u5c16\u7aef\u6280\u8853\u3002\u6b64\u806f\u76df\u65bc\u53bb\u5e74\u555f\u52d5\uff0c\u7531\u6b50\u76df\u4e94\u5e74\u6295\u5165\u5169\u5343\u842c\u6b50\u5143\uff08\u7d04\u5408\u5169\u5343\u516b\u767e\u842c\u7f8e\u5143\uff09\uff0c\u5305\u62ec\u4e03\u500b\u5b78\u8853\u5408\u4f5c\u5925\u4f34\u3001\u4e5d\u5bb6\u88fd\u85e5\u516c\u53f8\uff08\u5305\u62ec\u963f\u65af\u5229\u5eb7\u516c\u53f8\uff09\u548c\u4e00\u4e9b\u751f\u7269\u6280\u8853\u696d\u8005\u3002\u5176\u4e2d\u4e00\u5bb6\u751f\u6280\u516c\u53f8\u662f\u51b0\u5cf6\u7684\u300c\u89e3\u78bc\u907a\u50b3\u300d\uff08deCODE genetics\uff09\uff0c\u5b83\u5728\u4e8c\u25cb\u25cb\u516b\u5e74\u4e00\u500b\u53c3\u8207\u4eba\u6578\u773e\u591a\u7684\u7814\u7a76\u4e2d\uff0c\u78ba\u5b9a\u4e86\u4e09\u500b\u7a31\u70ba\u300c\u5e8f\u5217\u91cd\u8907\u6578\u8b8a\u7570\u300d\uff08CNVs\uff09\u7684\u53ef\u8b8a\u57fa\u56e0\u5340\uff0c\u5176\u7570\u5e38\u96d6\u7136\u975e\u5e38\u7f55\u898b\uff0c\u537b\u53ef\u80fd\u5927\u5e45\u63d0\u9ad8\u7f79\u60a3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u98a8\u96aa\u3002<\/p>\n

\u7522\u696d\u754c\u7684\u79d1\u5b78\u5bb6\u8aaa\uff0c\u4e00\u958b\u59cb\u5f88\u96e3\u8aaa\u670d\u4ed6\u5011\u7684\u516c\u53f8\u5728NEWMEDS\u5171\u4eab\u8cc7\u8a0a\u7684\u50f9\u503c\u3002\u4f46\u662f\u4ed6\u5011\u6210\u529f\u4e86\uff1b\u7522\u696d\u754c\u7684\u85e5\u7406\u5b78\u5bb6\u9ad8\u8208\u7684\u662f\uff0c\u4ed6\u5011\u9996\u6b21\u80fd\uff08\u81f3\u5c11\u5728\u806f\u76df\u5167\uff09\u516c\u958b\u8a0e\u8ad6\u5404\u81ea\u5c0d\u4ed8\u7cbe\u795e\u75be\u75c5\u7684\u65b9\u6cd5\u3002\u5b78\u8853\u754c\u7684\u6210\u54e1\uff0c\u4e5f\u5f88\u958b\u5fc3\u80fd\u904b\u7528\u73fe\u5728\u5c0d\u4ed6\u5011\u958b\u653e\u7684\u7522\u696d\u754c\u8cc7\u6e90\u3002\u4ed6\u5011\u532f\u96c6\u4e86\u5927\u91cf\u8cc7\u8a0a\u548c\u6750\u6599\uff0c\u5305\u62ec\u8a31\u591a\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u6709\u6642\u9084\u9644\u5e36\u95dc\u806f\u7684\u8840\u6db2\u6a23\u672c\u3002\u4e39\u9ea5\u88fd\u85e5\u516c\u53f8\u300cH\u6717\u5fb7\u8c9d\u514b\u300d\uff08H. Lundbeck\uff09\u85e5\u7406\u5b78\u5bb6\u3001NEWMEDS\u5354\u8abf\u54e1\u5e03\u840a\u6069\u53f2\u5766\u7d72\u5821\uff08Tine Bryan Stensb\u00f8l\uff09\u8aaa\uff0c\u300c\u6211\u5011\u73fe\u5728\u6709\u9019\u7a2e\u75be\u75c5\u6709\u53f2\u4ee5\u4f86\u6700\u5927\u7684\u6578\u64da\u5eab\uff08\u8d85\u904e\u4e00\u842c\u540d\u60a3\u8005\uff09\u3002\u300d<\/p>\n

\u5728\u4e00\u500b\u7531\u89e3\u78bc\u907a\u50b3\u516c\u53f8\u907a\u50b3\u5b78\u5bb6\u53f2\u5e1d\u82ac\u68ee\uff08Hreinn Stefansson\uff09\u9818\u5c0e\u7684\u5408\u4f5c\u8a08\u756b\u4e2d\uff0c\u5fb7\u570b\u4e2d\u592e\u7cbe\u795e\u885b\u751f\u7814\u7a76\u6240\u7cbe\u795e\u75c5\u5b78\u5bb6\u7f8e\u4e9e-\u6797\u767b\u5821\uff08Andreas Meyer-Lindenberg\uff09\uff0c\u548c\u502b\u6566\u7cbe\u795e\u75c5\u7814\u7a76\u6240\u7684\u795e\u7d93\u79d1\u5b78\u5bb6\u5e03\u62c9\u9ed8\uff08Michael Brammer\uff09\uff0c\u5206\u6790\u4e86\u4e94\u767e\u540d\u5177\u6709\u9ad8\u98a8\u96aa\u5e8f\u5217\u91cd\u8907\u6578\u8b8a\u7570\u8005\uff08\u7531\u907a\u50b3\u89e3\u78bc\u516c\u53f8\u9451\u5b9a\uff09\uff0c\u4ee5\u53ca\u4e94\u767e\u540d\u5c0d\u7167\u7d44\u7684\u6838\u78c1\u5171\u632f\u6210\u50cf\u6578\u64da\u3002\u4ed6\u5011\u5e0c\u671b\uff0c\u9019\u9805\u7814\u7a76\u80fd\u8fa8\u8b58\u51fa\u7570\u5e38\u7684\u907a\u50b3\u7279\u5fb5\u5c0d\u5927\u8166\u7d50\u69cb\u7684\u5f71\u97ff\uff0c\u6700\u7d42\u4e26\u53ef\u80fd\u5f15\u51fa\u65b0\u7684\u6cbb\u7642\u76ee\u6a19\u3002\u7f8e\u4e9e-\u6797\u767b\u5821\u8aaa\uff0c\u300c\u5982\u679c\u4e0d\u662fNEWMEDS\u8d77\u982d\uff0c\u6211\u5011\u4e5f\u4e0d\u6703\u4f5c\u9019\u6a23\u7684\u7814\u7a76\u3002\u300d<\/p>\n

NEWMEDS\u4e00\u500b\u4e0d\u53ef\u6216\u7f3a\uff0c\u4f46\u4e8b\u5be6\u4e26\u975e\u90a3\u9ebc\u6709\u5438\u5f15\u529b\u7684\u4efb\u52d9\uff0c\u662f\u78ba\u5b9a\u7528\u65bc\u6e2c\u8a66\u5019\u9078\u85e5\u7269\u65b9\u6cd5\u7684\u53ef\u9760\u6027\uff1b\u7279\u5225\u662f\u52d5\u7269\u548c\u4eba\u985e\u7684\u8a18\u61b6\u529b\u3001\u6ce8\u610f\u529b\u53ca\u5176\u5b83\u65b9\u9762\u7684\u8a8d\u77e5\u8a66\u9a57\uff0c\u9019\u4e9b\u90fd\u5f88\u6e05\u695a\u5c0d\u74b0\u5883\u5fae\u5c0f\u5dee\u7570\u6709\u9ad8\u5ea6\u7684\u654f\u611f\u3002\u4e0d\u53ef\u9760\u7684\u6e2c\u8a66\u6216\u8a31\u53ef\u4ee5\u89e3\u91cb\uff0c\u70ba\u4ec0\u9ebc\u52d5\u7269\u5be6\u9a57\u4e2d\u770b\u8d77\u4f86\u6709\u5e0c\u671b\u7684\u5019\u9078\u85e5\u7269\uff0c\u537b\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5931\u6557\u3002\u73fe\u5728\uff0c\u7522\u696d\u754c\u548c\u5b78\u8853\u754c\u7684\u79d1\u5b78\u5bb6\u5728\u5404\u81ea\u7684\u5be6\u9a57\u5ba4\u4f7f\u7528\u6a19\u6e96\u5316\u7684\u7a0b\u5e8f\uff0c\u7136\u5f8c\u6bd4\u8f03\u7d50\u679c\uff0c\u4e26\u8a66\u5716\u4e86\u89e3\u70ba\u4ec0\u9ebc\u5176\u4e2d\u6709\u4e9b\u7d50\u679c\u6703\u5927\u4e0d\u76f8\u540c\u3002<\/p>\n

\u8a72\u5408\u4f5c\u7814\u7a76\u9084\u63a1\u7528\u4e86\u9f20\u985e\u89f8\u63a7\u87a2\u5e55\u6280\u8853\uff1b\u63a5\u53d7\u884c\u70ba\u6e2c\u8a66\u7684\u52d5\u7269\u4ee5\u9f3b\u5b50\u89f8\u9ede\u5c4f\u5e55\uff0c\u4ee5\u7372\u5f97\u57f7\u884c\u5be6\u9a57\u4efb\u52d9\u7684\u734e\u52f5\uff0c\u800c\u4e0d\u662f\u6309\u4e0b\u69d3\u687f\u6216\u5c07\u4ed6\u5011\u7684\u9f3b\u5b50\u4f38\u5165\u4e00\u500b\u6d1e\u4e2d\u3002\u56e0\u6b64\u5be6\u9a57\u81ea\u52d5\u5316\uff0c\u4e26\u4e0d\u9700\u8981\u4e0d\u65b7\u7684\u89c0\u5bdf\u3002\u66f4\u70ba\u95dc\u9375\u7684\u662f\uff0c\u9019\u4e9b\u5be6\u9a57\u7d50\u679c\u53ef\u80fd\u66f4\u5bb9\u6613\u8f49\u5316\u70ba\u4eba\u985e\u7684\u5fc3\u7406\u6e2c\u9a57\uff0c\u4eba\u985e\u5fc3\u7406\u6e2c\u9a57\u4e5f\u8d8a\u4f86\u8d8a\u591a\u662f\u7528\u4e86\u89f8\u63a7\u87a2\u5e55\u7684\u65b9\u5f0f\u3002<\/p>\n

\u65b0\u7684\u5354\u8abf\u4e00\u81f4\u7684\u7b56\u7565\uff0c\u53ef\u4ee5\u5ef6\u9577\u7522\u696d\u754c\u7684\u6a02\u89c0\u60c5\u7dd2\uff0c\u5373\u4f7f\u53ea\u6709\u5c11\u6578\u5177\u9ad4\u503c\u5f97\u6a02\u89c0\u7684\u8de1\u8c61\u3002\u4f30\u8a08\u9ad8\u9054\u767e\u5206\u4e4b\u4e00\u7684\u4e16\u754c\u4eba\u53e3\u53d7\u7cbe\u795e\u5206\u88c2\u75c7\u5f71\u97ff\uff1b\u5c0d\u4efb\u4f55\u80fd\u5920\u627e\u5230\u771f\u6b63\u6539\u5584\u75c7\u72c0\u65b0\u85e5\u7684\u516c\u53f8\u800c\u8a00\uff0c\u8a72\u75be\u75c5\u662f\u4e00\u500b\u5de8\u5927\u7684\u6f5b\u5728\u5e02\u5834\uff0c\u5c24\u5176\u5927\u591a\u6578\u60a3\u8005\u5728\u4e8c\u5341\u6b72\u51fa\u982d\u767c\u75c5\uff0c\u800c\u5176\u9918\u751f\u90fd\u9700\u8981\u65e5\u5e38\u5f97\u7684\u6cbb\u7642\u3002<\/p>\n

\u4e5f\u8a31\uff0c\u9019\u500b\u9818\u57df\u9700\u8981\u7684\uff0c\u7562\u7adf\u5c31\u662f\u4e00\u5834\u9707\u64bc\u3002<\/p>\n

\u5ef6\u4f38\u95b1\u8b80\uff1a\u82f1\u6587\u7dad\u57fa\u4e0a\u7684\u7cbe\u795e\u5206\u88c2\u689d\u76ee<\/span><\/a><\/span>\u3001<\/span>\u7cbe\u795e\u5206\u88c2\uff08\u5c0f\u5c0f\u795e\u7d93\u79d1\u5b78\uff09<\/span><\/a><\/pre>\n
\u539f\u8f09\u65bc\u3010<\/span>\u77e5\u8b58\u901a\u8a0a\u8a55\u8ad6\u6708\u520a\u4e5d\u5341\u516b\u671f<\/span><\/a>\u30112010.12.01??<\/span>??????? \u7db2\u8a8c\u597d\u8b80\u7248 by MissZoe<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"
\u25a0 \u7528\u85e5\u7269\u63a7\u5236\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6a02\u89c0\u671f\u5f85\uff0c\u4f4e\u4f30<\/p>\n","protected":false},"author":20,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257,3293,1025],"tags":[566,267,377],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/6531"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6531"}],"version-history":[{"count":15,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/6531\/revisions"}],"predecessor-version":[{"id":18413,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/6531\/revisions\/18413"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}