{"id":5493,"date":"2010-10-08T14:12:49","date_gmt":"2010-10-08T06:12:49","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=5493"},"modified":"2017-03-31T23:21:16","modified_gmt":"2017-03-31T15:21:16","slug":"%e3%80%902010%e8%ab%be%e8%b2%9d%e7%88%be%e3%80%91%e5%8c%96%e5%ad%b8%e7%8d%8e%ef%bc%9a%e9%88%80%e5%82%ac%e5%8c%96%e4%ba%a4%e5%8f%89%e5%81%b6%e5%90%88%e5%8f%8d%e6%87%89%ef%bc%88richard-f-heck%e6%a0%b9","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=5493","title":{"rendered":"\u30102010\u8afe\u8c9d\u723e\u3011\u5316\u5b78\u734e\uff1a\u9200\u50ac\u5316\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\uff08Richard F. Heck,\u6839\u5cb8\u82f1\u4e00 & \u9234\u6728\u7ae0 \uff09"},"content":{"rendered":"

\u25a0 \u4eca\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u662f\u6211\u5011\u5f9e\u5b57\u9762\u4e0a\u6700\u96e3\u7406\u89e3\u7684\u734e\u9805\u3002\u4f46\u9019\u9805\u6709\u6a5f\u5316\u5b78\u7684\u8ca2\u737b\u8b93\u88fd\u85e5\u3001\u96fb\u5b50\u7b49\u88fd\u7a0b\u8b8a\u5f97\u7cbe\u7cb9\uff0c\u662f\u73fe\u4ee3\u751f\u6d3b\u7684\u5e55\u5f8c\u529f\u81e3\u3002<\/span><\/strong><\/p>\n

\"Palladium_1\"
\u7a00\u6709\u91d1\u5c6c\u9200\uff08Palladium\uff09\uff0c\u4e0d\u50c5\u984f\u8272\u7f8e\u9e97\u4e5f\u5f88\u5be6\u7528\u3002\uff08\u5716\uff0f\u65e5\u6587\u7dad\u57fa\uff09<\/figcaption><\/figure>\n

\u7ffb\u8b6f<\/strong> \u2223 \u8521\u860a\u660e\uff08\u53f0\u5927\u5316\u5b78\u7cfb\u9000\u4f11\u6559\u6388\uff09<\/p>\n

\u3000\u3000\u5c0d\u7d50\u69cb\u8907\u96dc\u7684\u5316\u5b78\u54c1\u9700\u6c42\u8d8a\u4f86\u8d8a\u9ad8\uff0c\u4eba\u985e\u9700\u8981\u65b0\u7684\u85e5\u7269\u4f86\u6cbb\u7642\u764c\u75c7\u6216\u963b\u6b62\u81f4\u547d\u75c5\u6bd2\u5728\u4eba\u9ad4\u5167\u7684\u6bc0\u6ec5\u6027\u7834\u58de\u3002\u96fb\u5b50\u7522\u696d\u5c0b\u627e\u80fd\u767c\u5149\u7684\u7269\u8cea\uff0c\u8fb2\u696d\u5247\u6709\u4fdd\u8b77\u4f5c\u7269\u7684\u9700\u6c42\u30022010\u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u734e\uff0c\u9812\u7d66\u4e86\u4e00\u9805\u5de5\u5177\uff0c\u5b83\u4ee5\u975e\u5e38\u6709\u6548\u7387\u7684\u65b9\u5f0f\u589e\u9032\u4e86\u5316\u5b78\u5bb6\u7684\u80fd\u529b\uff0c\u4f86\u6eff\u8db3\u4e0a\u8ff0\u7684\u9700\u6c42\uff0c\u5c31\u662f---\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\u3002<\/p>\n

\u3000\u3000\u57281980\u5e74\u4ee3\u672b\u671f\uff0c\u5728\u52a0\u52d2\u6bd4\u6d77\u7684\u6f5b\u6c34\u592b\u53d6\u5f97\u4e86\u4e00\u7a2e\u540d\u70baDiscodermia dissoluta\u7684\u6d77\u7dbf\uff0c\u90a3\u662f\u4e00\u7a2e\u572833\u516c\u5c3a\u7684\u6df1\u8655\u6240\u627e\u5230\u7684\u4e00\u7a2e\u6c92\u6709\u773c\u775b\u3001\u5634\u5df4\u3001\u80c3\u548c\u9aa8\u982d\u7684\u5c0f\u751f\u7269\u3002\u4e4d\u770b\u4e4b\u4e0b\uff0c\u7260\u5f88\u539f\u59cb\uff0c\u4f46\u7531\u65bc\u7121\u6cd5\u8eb2\u907f\u6575\u4eba\uff0c\u4f7f\u5f97 Discodermia dissoluta\u4ee5\u53ca\u5176\u4ed6\u7684\u6d77\u7dbf\u7cbe\u901a\u4e86\u5316\u5b78\uff0c\u5177\u6709\u4ee4\u4eba\u9a5a\u8a1d\u7684\u80fd\u529b\uff0c\u53ef\u4ee5\u88fd\u9020\u5de8\u5927\u4e14\u8907\u96dc\u7684\u5316\u5b78\u5206\u5b50\uff0c\u9019\u4e9b\u5206\u5b50\u5177\u6709\u6bd2\u6027\u800c\u80fd\u8b93\u5b83\u5011\u907f\u514d\u5176\u5b83\u7684\u751f\u7269\u63a0\u98df\u3002<\/p>\n

\u3000\u3000\u7814\u7a76\u8005\u767c\u73fe\u8a31\u591a\u9019\u985e\u7684\u6bd2\u7269\u5177\u6709\u91ab\u7642\u6548\u679c\uff0c\u53ef\u4f5c\u70ba\u6297\u751f\u7d20\u3001\u6297\u75c5\u6bd2\u6216\u6d88\u708e\u7684\u85e5\u7269\u3002\u4f8b\u5982\u521d\u671f\u7684\u4e00\u4e9b\u6e2c\u8a66\u986f\u793a\uff0c\u7531Discodermia dissoluta\u5206\u96e2\u51fa\u7684\u7269\u8cea\u300cdiscodermolide\u300d\u6709\u6a5f\u6703\u5728\u672a\u4f86\u6210\u70ba\u5316\u7642\u65b0\u85e5\uff0c\u5b83\u5177\u6709\u591a\u7a2e\u7279\u8cea\uff0c\u5305\u62ec\u53ef\u5728\u8a66\u7ba1\u4e2d\u963b\u6b62\u764c\u7d30\u80de\u589e\u751f\u3002<\/p>\n

\u79fb\u9664\u91cd\u8981\u7684\u969c\u7919\u5411\u524d\u63a8\u9032<\/strong><\/p>\n

\u3000\u3000\u7d93\u904e\u8a31\u591a\u6df1\u5165\u7684\u7814\u7a76\uff0c\u79d1\u5b78\u5bb6\u5df2\u7d93\u8b49\u5be6\u4e86discodermolide\u5982\u4f55\u4ee5\u985e\u4f3c\u65bc\u7d2b\u6749\u9187\uff08Taxol\uff0c\u4e00\u500b\u73fe\u5728\u5168\u7403\u6700\u5e38\u4f7f\u7528\u7684\u6297\u764c\u85e5\u7269\uff09\u7684\u65b9\u5f0f\u64ca\u6f70\u764c\u7d30\u80de\u3002\u767c\u73fe\u5982\u6b64\u5177\u6709\u6f5b\u529b\u7684\u5316\u5b78\u7269\u8cea\u7684\u78ba\u975e\u5e38\u4ee4\u4eba\u96c0\u8e8d\uff0c\u4f46\u5982\u679c\u6c92\u67092010\u5e74\u8afe\u8c9d\u723e\u734e\u6240\u63a8\u5d07\u7684\u767c\u73fe\uff0cdiscodermolide\u7684\u6545\u4e8b\u53ef\u80fd\u5f9e\u6b64\u6c92\u6709\u4e0b\u6587 \uff08\u898b\u5716\u4e00\uff09\uff0c\u56e0\u70ba\u7121\u6cd5\u5f9e\u52a0\u52d2\u6bd4\u6d77\u7684\u6df1\u6d77\u4e2d\u53d6\u5f97\u7684\u5fae\u91cf\u7269\u8cea\uff0c\u767c\u5c55\u51fa\u6709\u6548\u7684\u85e5\u7269\u3002\u6240\u5e78\uff0c\u7406\u5bdf\u6d77\u514b\uff08Richard F. Heck\uff09\u3001\u6839\u5cb8\u82f1\u4e00\uff08Ei-ichi Negishi\uff09\u4ee5\u53ca\u9234\u6728\u7ae0\uff08Akira Suzuki\uff09\u7b49\u4eba\uff0c\u5728\u5316\u5b78\u5bb6\u7684\u5de5\u5177\u7bb1\u4e2d\u52a0\u5165\u4e86\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\uff0c\u5316\u5b78\u5bb6\u73fe\u5728\u80fd\u4ee5\u4eba\u5de5\u65b9\u5f0f\u88fd\u9020discodermolide\uff0c\u6839\u5cb8\u767c\u5c55\u7684\u53cd\u61c9\u70ba\u5176\u5408\u6210\u7684\u95dc\u9375\u6b65\u9a5f\u4e4b\u4e00\u3002\u5176\u4ed6\u7684\u79d1\u5b78\u5bb6\u5011\u9032\u4e00\u6b65\u63d0\u9ad8\u6574\u9ad4\u88fd\u7a0b\u7684\u6548\u7387\uff0c\u7d42\u65bc\u80fd\u5f97\u5230\u8db3\u91cf\u7684discodermolide\uff0c\u5c0d\u7f79\u764c\u7684\u75c5\u4eba\u9032\u884c\u81e8\u5e8a\u6e2c\u8a66\u3002<\/p>\n

<\/p>\n

?<\/p>\n

\"image001\"<\/a>
\u5716\u4e00\uff1a\u9200\u662f\u78b3\u539f\u5b50\u7d04\u6703\u7684\u597d\u5730\u9ede\u3002\uff08\u9ede\u9078\u53ef\u770b\u5927\u5716\uff09<\/figcaption><\/figure>\n

\u3000\u3000\u96d6\u7136discodermolide\u662f\u5426\u80fd\u6210\u70ba\u6551\u547d\u7684\u85e5\u7269\u4ecd\u5728\u672a\u5b9a\u4e4b\u5929\uff0c\u4f46\u4e0d\u8ad6\u5982\u4f55\uff0c\u8a31\u591a\u7684\u4f8b\u5b50\u986f\u793a\u5929\u7136\u5316\u5b78\u7269\u8cea\u555f\u767c\u4e86\u5316\u5b78\u5bb6\u7684\u7814\u7a76\u3002\u5728\u6709\u6a5f\u751f\u7269\u9ad4\u4e2d\u5b58\u5728\u7684\u8a31\u591a\u5316\u5b78\u5206\u5b50\u5e38\u88ab\u7a31\u70ba\u6709\u6a5f\u5316\u5408\u7269\uff0c\u5b83\u5011\u7531\u78b3\u539f\u5b50\u7d44\u6210\u5176\u57fa\u672c\u7684\u7d50\u69cb\u9aa8\u5e79\uff0c\u56e0\u6b64\u78b3\u8207\u78b3\u4e4b\u9593\u7684\u9375\u7d50\u53ef\u8aaa\u662f\u751f\u547d\u7684\u6839\u672c\u3002\u622a\u81f3\u76ee\u524d\u70ba\u6b62\uff0c\u9019\u500b\u9818\u57df\u5171\u7372\u5f97\u4e86\u4e94\u6b21\u8afe\u8c9d\u723e\u734e\uff0c\u5c0d\u65bc\u5316\u5b78\u5bb6\u7684\u91cd\u8981\u6027\u53ef\u898b\u4e00\u6591\u3002\u4e4b\u524d\u7684\u56db\u6b21\u5305\u62ec\u4e861912\u5e74\u7684\u683c\u6797\u7d0d\u53cd\u61c9\uff08Grignard reaction\uff09\u30011950\u5e74\u7684\u72c4\u8033\u58eb-\u963f\u723e\u5fb7\u53cd\u61c9\uff08Diels-Alder reaction\uff09\u30011979\u5e74\u7684\u8cbb\u66ff\u53cd\u61c9\uff08Wittig reaction\uff09\u3001\u4ee5\u53ca2005\u5e74\u7684\u70ef\u70f4\u8907\u5206\u89e3\u53cd\u61c9\uff08olefin metathesis\uff09\u3002<\/p>\n

\u9200 \u2500 \u78b3\u539f\u5b50\u7684\u7d04\u6703\u5730\u9ede<\/strong><\/p>\n

\u3000\u3000\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\u662f\u975e\u5e38\u7368\u7279\u7684\uff0c\u56e0\u70ba\u5b83\u53ef\u4ee5\u975e\u5e38\u7cbe\u6e96\u7684\u5728\u6eab\u548c\u7684\u689d\u4ef6\u4e0b\u9032\u884c\u3002\u904e\u53bb\u5316\u5b78\u5bb6\u5fc5\u9700\u4f7f\u7528\u6d3b\u6027\u5f88\u9ad8\u7684\u7269\u8cea\u4f86\u9a45\u52d5\u5169\u500b\u78b3\u539f\u5b50\u9593\u7684\u53cd\u61c9\uff0c\u9019\u985e\u5316\u5b78\u7269\u8cea\u96d6\u53ef\u9054\u6210\u4efb\u52d9\uff0c\u4f46\u662f\u5176\u78b3\u539f\u5b50\u4e5f\u6703\u8207\u5176\u5b83\u7684\u78b3\u539f\u5b50\u4f5c\u7528\u800c\u5f97\u5230\u7121\u7528\u7684\u526f\u7522\u7269\u3002\u7576\u5316\u5b78\u5bb6\u8981\u88fd\u9020\u5982\u540cdiscodermolide\u822c\u7684\u5de8\u5927\u5206\u5b50\u6642\uff0c\u9700\u8981\u7d93\u904e\u8a31\u591a\u7684\u6b65\u9a5f\u4f86\u9054\u6210\uff0c\u5982\u679c\u90a3\u4e9b\u6d6a\u8cbb\u6389\u7684\u526f\u7522\u7269\u904e\u591a\uff0c\u6700\u5f8c\u5c07\u7121\u6cd5\u5f97\u5230\u8db3\u91cf\u7684\u6700\u7d42\u7522\u7269\u3002<\/p>\n

\u3000\u3000\u5728\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\u4e2d\uff0c\u79d1\u5b78\u5bb6\u7528\u9200\u9019\u500b\u5143\u7d20\u4f86\u4f5c\u70ba\u78b3\u539f\u5b50\u7684\u7d04\u6703\u5730\u9ede\uff0c\u78b3\u539f\u5b50\u9023\u63a5\u5728\u9200\u539f\u5b50\u4e0a\uff0c\u4f7f\u5f97\u78b3\u539f\u5b50\u76f8\u4e92\u9760\u8fd1\u800c\u5bb9\u6613\u53cd\u61c9\uff0c\u9200\u539f\u5b50\u626e\u6f14\u4e86\u50ac\u5316\u7684\u89d2\u8272\uff0c\u4f46\u672c\u8eab\u537b\u4e0d\u6703\u6d88\u8017\u3002<\/p>\n

\u7531\u5de5\u696d\u88fd\u7a0b\u5f97\u5230\u7684\u9748\u611f<\/strong><\/p>\n

\u3000\u3000\u904b\u7528\u9200\u4f5c\u70ba\u50ac\u5316\u5291\u7684\u53ef\u80fd\u6027\uff0c\u57281950\u5e74\u4ee3\u5f15\u8d77\u5927\u5bb6\u7684\u8208\u8da3\uff0c\u7576\u6642\u5fb7\u570b\u7684\u74e6\u514b\u5316\u5b78\u80a1\u4efd\u6709\u9650\u516c\u53f8 \uff08Wacker Chemie AG\uff09\u958b\u59cb\u5229\u7528\u9200\u4f86\u5c07\u4e59\u70ef\u8f49\u63db\u6210\u70ba\u4e59\u919b\u3002\u4e59\u919b\u662f\u88fd\u9020\u6cb9\u6f06\u4e2d\u7684\u9ecf\u5408\u5291\uff0c\u5851\u81a0\u8edf\u5316\u5291\uff0c\u4ee5\u53ca\u918b\u9178\u4e4b\u91cd\u8981\u539f\u6599\u3002<\/p>\n

\u3000\u3000\u7406\u5bdf\u6d77\u514b\u7576\u6642\u5728\u7f8e\u570b\u9054\u62c9\u5a01\u723e\u7684\u4e00\u9593\u5316\u5b78\u516c\u53f8\u4efb\u8077\uff0c\u7531\u65bc\u5316\u5de5\u754c\u5c0d\u65bc\u975e\u5e38\u6210\u529f\u7684\u74e6\u514b\u88fd\u7a0b\uff08Wacker-process\uff09\u8d8a\u4f86\u8d8a\u597d\u5947\uff0c\u4ed6\u958b\u59cb\u7528\u9200\u4f5c\u70ba\u50ac\u5316\u5291\u4f86\u9032\u884c\u5be6\u9a57\u3002\u57281968\u5e74\u4ed6\u958b\u59cb\u767c\u8868\u4e00\u7cfb\u5217\u6210\u529f\u7684\u8ad6\u6587\uff0c\u5176\u4e2d\u4ed6\u5c55\u793a\u4e86\uff08\u5716\u4e8c\uff09\u5982\u4f55\u5c07\u78b3\u539f\u5b50\u7684\u74b0\u72c0\u7269\u9023\u63a5\u5230\u4e00\u500b\u8f03\u77ed\u7684\u78b3\u93c8\u4e0a\u800c\u5f97\u5230\u82ef\u4e59\u70ef\uff08styrene\uff09\uff0c\u4e5f\u5c31\u662f\u805a\u82ef\u4e59\u70ef\u5851\u81a0\u7684\u4e3b\u8981\u539f\u6599\u3002\u56db\u5e74\u4e4b\u5f8c\u4ed6\u9032\u4e00\u6b65\u767c\u5c55\u4e86\u9019\u500b\u53cd\u61c9\uff0c\u5982\u4eca\u7a31\u70ba\u6d77\u514b\u53cd\u61c9\uff08Heck reaction\uff09\uff0c\u5df2\u662f\u5efa\u7acb\u78b3\u539f\u5b50\u9593\u7684\u55ae\u9375\u65b9\u6cd5\u4e2d\u6700\u91cd\u8981\u53cd\u61c9\u4e4b\u4e00\u3002\u4f8b\u5982\u88ab\u904b\u7528\u5728\u5927\u91cf\u88fd\u5099\u6d88\u708e\u6b62\u75db\u85e5\u62ff\u767e\u75bc \uff08naproxen\uff09\uff0c\u9084\u6709\u6c23\u5598\u6cbb\u7642\u85e5\u7269montelukast\uff08\u4e2d\u6587\u85e5\u540d\uff1a\u6b23\u6d41\u5480\u56bc\u9320\uff09\uff0c\u4ee5\u53ca\u4e00\u7a2e\u7528\u65bc\u96fb\u5b50\u696d\u7684\u5316\u5b78\u7269\u8cea\u3002<\/p>\n

\"image002\"<\/p>\n

8 \u2500 \u6709\u6a5f\u5316\u5b78\u7684\u795e\u5947\u6578\u5b57<\/strong><\/p>\n

\u3000\u3000\u70ba\u4e86\u77ad\u89e3\u7406\u5bdf\u6d77\u514b\u9019\u9805\u767c\u73fe\u7684\u91cd\u8981\u6027\uff0c\u6211\u5011\u9700\u8981\u8df3\u5165\u539f\u5b50\u7684\u4e16\u754c\uff0c\u9032\u5165\u570d\u7e5e\u5728\u539f\u5b50\u6838\u5468\u570d\u7684\u96fb\u5b50\u96f2\u4e2d\u3002\u96fb\u5b50\u5e38\u88ab\u5716\u793a\u70ba\u7e5e\u5728\u539f\u5b50\u6838\u5916\u65cb\u8f49\u7684\u4e00\u4e9b\u5c0f\u7c92\u5b50\uff0c\u5be6\u969b\u4e0a\u8f03\u6b63\u78ba\u7684\u770b\u6cd5\u662f\u4e00\u500b\u5e36\u8ca0\u96fb\u7684\u96f2\u5c64\uff0c\u5305\u8986\u8457\u5e36\u6b63\u96fb\u7684\u6838\u3002<\/p>\n

\u3000\u3000\u5728\u6838\u7684\u5468\u570d\u6709\u4e00\u4e9b\u4e0d\u540c\u5c64\u6b21\u7684\u96fb\u5b50\u96f2\uff0c\u8f03\u5927\u7684\u539f\u5b50\u5177\u6709\u8f03\u591a\u7684\u96f2\u5c64\uff0c\u5316\u5b78\u5bb6\u5c0d\u65bc\u5728\u6700\u5916\u9762\u7684\u96f2\u5c64\u6700\u6709\u8208\u8da3\uff0c\u56e0\u70ba\u6240\u6709\u7684\u5316\u5b78\u53cd\u61c9\u57fa\u672c\u4e0a\u90fd\u5728\u4f01\u5716\u8b93\u9019\u500b\u96f2\u5c64\u5b8c\u6574\u3002\u5728\u6709\u6a5f\u5316\u5b78\u4e2d\u6700\u91cd\u8981\u7684\u5e7e\u500b\u539f\u5b50\uff1a\u78b3\u3001\u6c27\u548c\u6c2e\u90fd\u8f03\u5c0f\uff0c\u5b83\u5011\u5728\u6700\u5916\u7684\u4e00\u5c64\u90fd\u9700\u8981\u6709\u516b\u500b\u96fb\u5b50\uff0c\u56e0\u6b64\u516b\u53ef\u8996\u70ba\u6709\u6a5f\u5316\u5b78\u7684\u795e\u5947\u6578\u5b57\u3002<\/p>\n

\u3000\u3000\u78b3\u539f\u5b50\u7684\u57fa\u672c\u5f62\u614b\u4e2d\u6700\u5916\u5c64\u53ea\u6709\u56db\u500b\u96fb\u5b50\uff0c\u56e0\u6b64\u5b83\u6975\u529b\u4f01\u5716\u8207\u5176\u5b83\u539f\u5b50\u9023\u63a5\uff0c\u900f\u904e\u5316\u5b78\u9375\u9054\u5230\u96fb\u5b50\u7684\u5171\u4eab\u3002\u4f8b\u5982\u5728\u6700\u7c21\u55ae\u7684\u6709\u6a5f\u5206\u5b50\u7532\u70f7\uff08methane\uff09\u4e2d\uff0c\u78b3\u539f\u5b50\u8207\u56db\u500b\u6c2b\u539f\u5b50\u5171\u4eab\u96fb\u5b50\uff0c\u5982\u6b64\u5176\u6700\u5916\u9762\u7684\u96fb\u5b50\u96f2\u5c64\u53ef\u4ee5\u5b8c\u6574\u800c\u6eff\u8db3\u3002<\/p>\n

\u611a\u5f04\u4e00\u500b\u6eff\u8db3\u7684\u539f\u5b50<\/strong><\/p>\n

\u3000\u3000\u7576\u5316\u5b78\u5bb6\u88fd\u9020\u4e00\u500b\u5982discodermolide\u822c\u8907\u96dc\u7684\u5206\u5b50\u6642\uff0c\u4ed6\u5011\u6703\u63a1\u53d6\u6377\u5f91\uff0c\u5229\u7528\u5df2\u5b58\u5728\u7684\u5c0f\u5206\u5b50\u4f5c\u70ba\u5408\u6210\u7684\u584a\u6750\uff0c\u4e0d\u904e\u8981\u5c07\u9019\u4e9b\u5c0f\u5206\u5b50\u9023\u63a5\u8d77\u4f86\u662f\u8aaa\u6bd4\u505a\u5bb9\u6613\u3002\u5728\u9019\u4e9b\u5c0f\u5206\u5b50\u4e2d\u7684\u78b3\u539f\u5b50\uff0c\u5df2\u7d93\u8207\u5176\u5b83\u7684\u539f\u5b50\u5171\u4eab\u96fb\u5b50\uff0c\u5b83\u5011\u6700\u5916\u5c64\u5df2\u7d93\u6709\u4e86\u516b\u500b\u96fb\u5b50\uff0c\u56e0\u6b64\u5f88\u7a69\u5b9a\uff0c\u6c92\u6709\u7406\u7531\u8207\u5176\u5b83\u5206\u5b50\u4e2d\u7684\u78b3\u539f\u5b50\u53cd\u61c9\u3002<\/p>\n

\u3000\u3000\u5316\u5b78\u5bb6\u7684\u4efb\u52d9\u5c31\u662f\u53bb\u5f04\u9192\u78b3\u539f\u5b50\uff0c\u4f7f\u5b83\u9858\u610f\u8207\u53e6\u4e00\u500b\u78b3\u539f\u5b50\u53cd\u61c9\u30021912\u5e74\u7684\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u7dad\u591a\u683c\u6797\u7d0d\uff08Victor Grignard\uff09 \u627e\u5230\u4e00\u500b\u89e3\u6c7a\u65b9\u6cd5\uff0c\u904b\u7528\u5404\u7a2e\u5316\u5b78\u4f0e\u5006\uff0c\u4ed6\u5c07\u4e00\u500b\u9382\u539f\u5b50\u63a5\u5728\u4e00\u500b\u4ed6\u5e0c\u671b\u4f7f\u4e4b\u6d3b\u6027\u589e\u9ad8\u7684\u78b3\u539f\u5b50\u4e0a\uff0c\u9382\u5728\u5b83\u7684\u6700\u5916\u5c64\u5177\u6709\u5169\u500b\u96fb\u5b50\uff0c\u800c\u4e14\u5e0c\u671b\u628a\u5b83\u5011\u90fd\u4e1f\u68c4\uff0c\u56e0\u6b64\u5728\u9019\u500b\u88ab\u7a31\u70ba\u683c\u6797\u7d0d\u8a66\u5291\uff08Grignard reagent\uff09\u7684\u5206\u5b50\u4e2d\uff0c\u9382\u539f\u5b50\u6700\u5916\u5c64\u7684\u5169\u500b\u96fb\u5b50\u6703\u5e7e\u4e4e\u5b8c\u5168\u504f\u5411\u78b3\u539f\u5b50\u4e00\u65b9\uff0c\u5c31\u597d\u50cf\u78b3\u539f\u5b50\u6700\u5916\u5c64\u591a\u52a0\u4e86\u96fb\u5b50\u4e00\u822c\uff0c\u4f7f\u5f97\u78b3\u539f\u5b50\u6838\u7684\u6b63\u96fb\u8377\u8207\u6838\u5916\u96fb\u5b50\u96f2\u7684\u8ca0\u96fb\u8377\u6578\u4e0d\u5747\uff0c\u78b3\u539f\u5b50\u8b8a\u5f97\u4e0d\u7a69\u5b9a\uff0c\u56e0\u6b64\u6703\u5c0b\u627e\u53e6\u4e00\u500b\u539f\u5b50\u5f62\u6210\u9375\u7d50\u3002<\/p>\n

\u7cbe\u6e96\u5ea6 \u2500 \u67b6\u69cb\u5de8\u5927\u5206\u5b50\u7684\u95dc\u9375<\/strong><\/p>\n

\u3000\u3000\u683c\u6797\u7d0d\u5076\u5408\u78b3\u539f\u5b50\u7684\u65b9\u6cd5\u5728\u5316\u5b78\u4e0a\u6975\u70ba\u91cd\u8981\uff0c\u4f46\u662f\u7576\u9700\u8981\u5408\u6210\u5de8\u5927\u800c\u4e14\u7d50\u69cb\u8907\u96dc\u7684\u5206\u5b50\u6642\uff0c\u9019\u500b\u65b9\u6cd5\u6709\u5176\u9650\u5236\uff0c\u9019\u500b\u683c\u6797\u7d0d\u8a66\u5291\u4e2d\u7684\u78b3\u539f\u5b50\u4e4b\u884c\u70ba\u4e0d\u6613\u9810\u6e2c\uff0c\u7576\u5b83\u78b0\u5230\u6578\u500b\u539f\u5b50\u7686\u53ef\u8207\u4e4b\u53cd\u61c9\u6642\uff0c\u5c07\u6703\u7522\u751f\u592a\u591a\u7121\u7528\u7684\u526f\u7522\u7269\u3002<\/p>\n

\u3000\u3000\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\uff0c\u900f\u904e\u5176\u7cbe\u6e96\u5ea6\u89e3\u6c7a\u4e86\u9019\u500b\u554f\u984c\u3002\u7576\u78b3\u539f\u5b50\u5011\u5728\u9200\u539f\u5b50\u4e0a\u76f8\u9047\uff0c\u5316\u5b78\u5bb6\u4e0d\u9700\u8981\u5c07\u78b3\u539f\u5b50\u6d3b\u5316\u5230\u683c\u6797\u7d0d\u8a66\u5291\u7684\u7a0b\u5ea6\uff0c\u9019\u4f7f\u5f97\u526f\u7522\u7269\u8f03\u5c11\u800c\u53cd\u61c9\u66f4\u6709\u6548\u7387\u3002<\/p>\n

\u3000\u3000\u4e0d\u50cf\u683c\u6797\u7d0d\u8a66\u5291\u90a3\u6a23\uff0c\u7406\u5bdf\u6d77\u514b\u958b\u4f7f\u904b\u7528\u4e00\u7a2e\u7a31\u70ba\u70ef\u985e\u7684\u5316\u5408\u7269\uff0c\u5728\u70ef\u985e\u5316\u5408\u7269\u4e2d\u7684\u78b3\u539f\u5b50\u672c\u4f86\u5c31\u6709\u4e00\u4e9b\u6d3b\u6027\uff0c\u7576\u5b83\u63a5\u8457\u5728\u9200\u539f\u5b50\u4e0a\u6642\u8b8a\u5f97\u66f4\u5bb9\u6613\u8207\u5176\u5b83\u7684\u78b3\u539f\u5b50\u7d50\u5408\u3002<\/p>\n

\u3000\u3000\u57281977\u5e74\u6839\u5cb8\u82f1\u4e00\u767c\u5c55\u4e86\u4e00\u500b\u683c\u6797\u7d0d\u8a66\u5291\u7684\u8b8a\u5316\u5f62\u5f0f\uff0c\u5c07\u5176\u4e2d\u7684\u9382\u6539\u70ba\u92c5\uff0c\u92c5\u4e0a\u7684\u78b3\u539f\u5b50\u6d3b\u6027\u8b8a\u5f97\u8f03\u4f4e\uff0c\u4f46\u662f\u92c5\u539f\u5b50\u5c07\u78b3\u539f\u5b50\u50b3\u9001\u5230\u9200\u539f\u5b50\u4e0a\uff0c\u7576\u78b3\u539f\u5b50\u5728\u9200\u539f\u5b50\u4e0a\u9047\u5230\u53e6\u4e00\u500b\u78b3\u539f\u5b50\u6642\uff0c\u4e8c\u8005\u8f03\u6613\u5076\u5408 \uff08\u898b\u5716\u4e00\uff09\u3002<\/p>\n

\u3000\u3000\u5169\u5e74\u5f8c\uff0c\u9234\u6728\u7ae0\u904b\u7528\u787c\u9019\u500b\u5143\u7d20\uff0c\u5b83\u662f\u76ee\u524d\u6700\u6eab\u548c\u7684\u6d3b\u5316\u8005\uff0c\u800c\u4e14\u6bd4\u92c5\u7684\u6bd2\u6027\u9084\u8981\u4f4e\uff0c\u9019\u5728\u904b\u7528\u5230\u5927\u91cf\u7684\u88fd\u7a0b\u6642\u6703\u662f\u4e00\u9805\u512a\u9ede\uff0c\u4f8b\u5982\u9234\u6728\u53cd\u61c9\u88ab\u904b\u7528\u5728\u4e00\u7a2e\u4fdd\u8b77\u8fb2\u4f5c\u7269\u4e0d\u88ab\u83cc\u985e\u4fb5\u5bb3\u7684\u5316\u5b78\u7269\u8cea\u7684\u5de5\u696d\u5408\u6210\u4e0a\uff0c\u53ef\u88fd\u9020\u4e0a\u5343\u5678\u7522\u54c1\u3002<\/p>\n

\"image003\"?<\/p>\n

\u3000\u3000\u5982\u4eca\u6d77\u514b\u53cd\u61c9\u3001\u6839\u5cb8\u53cd\u61c9\u8207\u9234\u6728\u53cd\u61c9\u5c0d\u5316\u5b78\u5bb6\u76f8\u7576\u91cd\u8981\uff0c\u4e00\u500b\u6700\u4ee4\u4eba\u5606\u70ba\u89c0\u6b62\u7684\u4f8b\u5b50\uff0c\u662f\u5c07\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\u904b\u7528\u5728\u8a66\u7ba1\u4e2d\u5408\u6210\u83df\u8475\u6bd2\u7d20\uff08palytoxin\uff09---\u5316\u5b78\u4e16\u754c\u7684\u6050\u9f8d \uff08\u5716\u4e09\uff09\uff0c\u5b83\u662f\u4e00\u7a2e\u5929\u7136\u5b58\u5728\u7684\u6bd2\u7269\uff0c\u65bc1971\u5e74\u5f9e\u590f\u5a01\u5937\u7684\u4e00\u7a2e\u73ca\u745a\u4e2d\u9996\u5ea6\u5206\u96e2\u51fa\u4f86\u3002\u83df\u8475\u6bd2\u7d20\u662f\u7531129\u500b\u78b3\u539f\u5b50\uff0c223\u500b\u6c2b\u539f\u5b50\uff0c3\u500b\u6c2e\u539f\u5b50\uff0c\u53ca54\u500b\u6c27\u539f\u5b50\u7d44\u6210\u7684\u3002\u57281994\u5e74\uff0c\u79d1\u5b78\u5bb6\u8a2d\u6cd5\u5728\u8a66\u7ba1\u4e2d\u5c07\u5b83\u88fd\u9020\u51fa\u4f86\uff0c\u6709\u8cf4\u65bc\u9234\u6728\u53cd\u61c9\u7684\u5e6b\u52a9\u3002<\/p>\n

\u3000\u3000\u985e\u4f3c\u83df\u8475\u6bd2\u7d20\u9019\u9ebc\u5177\u6709\u6311\u6230\u6027\u7684\u88fd\u7a0b\uff0c\u8feb\u4f7f\u5316\u5b78\u5bb6\u5fae\u8abf\u4ed6\u5011\u7684\u5de5\u5177\u3002\u518d\u8005\uff0c\u70ba\u4e86\u7814\u7a76\u7684\u76ee\u7684\uff0c\u80fd\u5728\u8a66\u7ba1\u4e2d\u91cd\u65b0\u88fd\u9020\u51fa\u5929\u7136\u7269\u662f\u5f88\u91cd\u8981\u7684\u3002\u7576\u79d1\u5b78\u5bb6\u627e\u5230\u4e00\u500b\u65b0\u7684\u5206\u5b50\u6642\uff0c\u4ed6\u5011\u904b\u7528\u4e0d\u540c\u7684\u5316\u5b78\u65b9\u6cd5\u4f86\u9451\u5b9a\u539f\u5b50\u9593\u76f8\u4e92\u7684\u4f4d\u7f6e\u95dc\u4fc2\uff0c\u4e0d\u904e\u552f\u4e00\u8b49\u5be6\u5176\u7d50\u69cb\u7684\u65b9\u6cd5\u662f\u4ee5\u4eba\u5de5\u7684\u65b9\u5f0f\u91cd\u65b0\u88fd\u9020\u5b83\uff0c\u7136\u5f8c\u8207\u5929\u7136\u7269\u76f8\u4e92\u6bd4\u5c0d\u3002<\/p>\n

\u4e00\u500b\u641c\u5c0b\u65b0\u85e5\u7684\u5de5\u5177\u2026<\/strong><\/p>\n

\u3000\u3000\u5f9e\u672c\u6587\u4e00\u958b\u59cb\u4ecb\u7d39\u7684\u6709\u95dc\u6d77\u7dbf\u7684\u6545\u4e8b\uff0c\u5f88\u660e\u986f\u53ef\u4ee5\u770b\u51fa\uff0c\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\u662f\u5728\u641c\u5c0b\u65b0\u85e5\u4e0a\u7684\u4e00\u9805\u5229\u5668\u3002\u7576\u4eca\u5168\u4e16\u754c\u7684\u79d1\u5b78\u5bb6\u5c07\u6d77\u6d0b\u7576\u6210\u4e00\u500b\u5927\u85e5\u8216\uff0c\u4ed6\u5011\u5f9e\u6d77\u6d0b\u7684\u751f\u7269\u4e2d\u5206\u96e2\u51fa\u4e86\u4e0a\u5343\u7684\u5316\u5b78\u7269\u8cea\uff0c\u800c\u9019\u4e9b\u7269\u8cea\u555f\u767c\u4e86\u66f4\u591a\u7684\u79d1\u5b78\u9032\u5c55\u3002\u9664\u4e86discodermolide\uff0c\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\u4e5f\u5e6b\u52a9\u5316\u5b78\u5bb6\u4eba\u5de5\u5408\u6210\u4e86diazonamide A\uff0c\u4e00\u7a2e\u6e90\u81ea\u65bc\u83f2\u5f8b\u8cd3\u7684\u6d77\u9798\u985e\u52d5\u7269\u3002\u5728\u5be6\u9a57\u5ba4\u7684\u6e2c\u8a66\u4e2d\uff0cdiazonamide A\u88ab\u8b49\u5be6\u53ef\u5c0d\u6297\u5927\u8178\u764c\u7d30\u80de\u3002\u53e6\u4e00\u500b\u4f8b\u5b50\u662fdragmacidin F\uff0c\u90a3\u662f\u4e00\u500b\u5f9e\u7fa9\u5927\u5229\u6d77\u5cb8\u908a\u751f\u9577\u7684\u6d77\u7dbf\u4e2d\u5206\u96e2\u51fa\u4f86\u7684\u3002\u521d\u6b65\u5be6\u9a57\u986f\u793a\uff0cdragmacidin F\u5c0d\u76b0\u75b9\u75c5\u6bd2\u548c\u611b\u6ecb\u75c5\u6bd2\u6709\u6548\u7528\u3002<\/p>\n

\u3000\u3000\u5316\u5b78\u5bb6\u4e5f\u904b\u7528\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\u4f86\u4fee\u98fe\u5929\u7136\u85e5\u7269\u7684\u7d50\u69cb\uff0c\u4ee5\u589e\u9032\u5176\u85e5\u6548\u3002\u4e00\u500b\u4f8b\u5b50\u662f\u842c\u53e4\u9ef4\u7d20\uff08vancomycin\uff09\uff0c\u5b83\u662f\u57281950\u5e74\u4ee3\u9996\u6b21\u5f9e\u5a46\u7f85\u6d32\u53e2\u6797\u7684\u571f\u58e4\u6a23\u54c1\u4e2d\u5206\u96e2\u51fa\u4f86\u7684\u3002\u73fe\u5728\u842c\u53e4\u9ef4\u7d20\u88ab\u7528\u5728\u5c0d\u6297MRSA \uff08\u8d85\u7d1a\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\uff09 \u4ee5\u53ca\u8178\u7403\u83cc \uff08enterococci\uff09\uff0c\u9019\u4e9b\u7d30\u83cc\u5c0d\u6211\u5011\u5e38\u7528\u7684\u6297\u751f\u7d20\u5df2\u7d93\u7522\u751f\u4e86\u6297\u85e5\u6027\u3002\u9019\u5169\u7a2e\u7d30\u83cc\u901a\u5e38\u662f\u7121\u5bb3\u7684\uff0c\u4f46\u662f\u5b83\u5011\u6703\u611f\u67d3\u50b7\u53e3\uff0c\u4e26\u6703\u9020\u6210\u79fb\u690d\u624b\u8853\u7684\u554f\u984c\u3002\u7531\u65bc\u9019\u4e9b\u4ee4\u4eba\u6182\u5fc3\u7684\u767c\u5c55\uff0c\u79d1\u5b78\u5bb6\u4f01\u5716\u4fee\u98fe\u842c\u53e4\u9ef4\u7d20\u7684\u7d50\u69cb\uff0c\u8b93\u5b83\u5c0d\u65bc\u6297\u842c\u53e4\u9ef4\u7d20\u7684\u83cc\u682a\u4e5f\u6709\u6548\u3002\u904b\u7528\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\uff0c\u79d1\u5b78\u5bb6\u5275\u9020\u4e86\u842c\u53e4\u9ef4\u7d20\u7684\u8b8a\u9ad4\uff0c\u80fd\u5c0d\u4ed8\u5177\u6709\u6297\u85e5\u6027\u7684\u7d30\u83cc\u3002<\/p>\n

\u2026\u9084\u6709\u66f4\u8584\u7684\u96fb\u8166\u87a2\u5e55<\/strong><\/p>\n

\u3000\u3000\u96fb\u5b50\u696d\u4e5f\u5728\u904b\u7528\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\uff0c\u4f8b\u5982\u7528\u5728\u9700\u8981\u5c0b\u627e\u4e8c\u6975\u9ad4 \uff08diodes\uff09\u7684\u66f4\u4f73\u5149\u6e90\u3002\u6709\u6a5f\u96fb\u81f4\u767c\u5149\u4e8c\u6975\u9ad4 \uff08OLED\uff09\uff0c\u5305\u542b\u4e86\u6703\u653e\u5149\u7684\u6709\u6a5f\u5206\u5b50\uff0c\u5728\u96fb\u5b50\u5de5\u696d\u4e2d\u5b83\u5011\u88ab\u7528\u5728\u88fd\u9020\u975e\u5e38\u8584\u7684\u96fb\u8166\u87a2\u5e55\uff0c\u53ea\u6709\u5e7e\u6beb\u7c73\u539a\u3002\u79d1\u5b78\u5bb6\u904b\u7528\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\uff0c\u4f86\u6700\u4f73\u5316OLED\u7684\u85cd\u5149\u6750\u6599\u3002<\/p>\n

\u6c38\u4e0d\u505c\u6b47\u7684\u9032\u5c55<\/strong><\/p>\n

\u3000\u3000\u5728\u6d77\u514b\u53cd\u61c9\u3001\u6839\u5cb8\u53cd\u61c9\u8207\u9234\u6728\u53cd\u61c9\u5c0d\u88fd\u9020\u66f4\u8907\u96dc\u7684\u5316\u5b78\u54c1\u6975\u70ba\u91cd\u8981\u7684\u540c\u6642\uff0c\u5176\u4ed6\u7684\u5316\u5b78\u5bb6\u5011\u9032\u4e00\u6b65\u5730\u8abf\u6574\u548c\u6539\u9032\u9019\u4e9b\u65b9\u6cd5\uff0c\u5176\u4e2d\u7684\u4e00\u500b\u6539\u9032\u8207\u4eca\u5e74\u8afe\u8c9d\u723e\u7269\u7406\u734e\u6709\u95dc\u3002\u57282010\u5e74\u7684\u6625\u5929\uff0c\u6709\u5e7e\u4f4d\u79d1\u5b78\u5bb6\u5ba3\u5e03\u4ed6\u5011\u6210\u529f\u7684\u5c07\u9200\u539f\u5b50\u92ea\u5728\u77f3\u58a8\u70ef\uff08graphene\uff09\u4e0a\uff0c\u5f97\u5230\u7684\u56fa\u9ad4\u7269\u8cea\u53ef\u4ee5\u7528\u4f86\u5728\u6c34\u4e2d\u9032\u884c\u9234\u6728\u53cd\u61c9\u3002<\/p>\n

\u3000\u3000\u9200\u50ac\u5316\u7684\u4ea4\u53c9\u5076\u5408\u53cd\u61c9\u9084\u5728\u767c\u5c55\u4e4b\u4e2d\uff0c\u96d6\u7136\u96e2\u7406\u5bdf\u6d77\u514b\u5728\u9054\u62c9\u5a01\u723e\u7684\u5316\u5b78\u5be6\u9a57\u5ba4\u4e2d\u958b\u59cb\u5176\u5be6\u9a57\u5df2\u670940\u591a\u5e74\uff0c\u4e14\u7406\u5bdf\u6d77\u514b\uff0c\u6839\u5cb8\u82f1\u4e00\uff0c\u9234\u6728\u7ae0\u4e09\u4eba\u7684\u767c\u73fe\u5df2\u5c0d\u4eba\u985e\u6709\u91cd\u8981\u7684\u8ca2\u737b\uff0c\u4f46\u5f9e\u73fe\u4eca\u5168\u4e16\u754c\u5404\u5be6\u9a57\u5ba4\u4e2d\u9032\u884c\u7684\u7814\u7a76\u767c\u5c55\u4f86\u770b\uff0c\u4ed6\u5011\u7684\u53cd\u61c9\u5728\u672a\u4f86\u9084\u6703\u8b8a\u5f97\u66f4\u91cd\u8981\u3002?<\/p>\n

?<\/p>\n

\u7372\u734e\u8005\u7c21\u4ecb<\/strong><\/p>\n

\"nobel_chemistry\"
\u5f9e\u5de6\u5230\u53f3\uff1a\u6d77\u514b\u3001\u6839\u5cb8\u3001\u9234\u6728<\/figcaption><\/figure>\n

Richard F. Heck<\/strong>---\u7f8e\u570b\u4eba\u30021931\u5e74\u751f\u65bc\u6625\u7530\u5e02\u3002\u52a0\u5dde\u5927\u5b78\u6d1b\u6749\u78ef\u5206\u6821\u535a\u58eb\uff0c\u65bc\u5fb7\u62c9\u74e6\u5dde\u5927\u5b78\u4efb\u6559\u76f4\u5230\u9000\u4f11\u3002<\/p>\n

\u6839\u5cb8\u82f1\u4e00<\/strong>---\u65e5\u672c\u4eba\u30021935\u5e74\u751f\u65bc\u6eff\u5dde\u570b\u3002\u7f8e\u570b\u8cd3\u5915\u6cd5\u5c3c\u4e9e\u5927\u5b78\u535a\u58eb\u3002\u73fe\u70ba\u7f8e\u570b\u666e\u6e21\u5927\u5b78\u7279\u8058\u6559\u6388\u3002<\/p>\n

\u9234\u6728\u7ae0<\/strong>---\u65e5\u672c\u4eba\u30021930\u5e74\u51fa\u751f\u65bc\u65e5\u672c\u5317\u6d77\u9053\u9d61\u5ddd\u753a\u3002\u65e5\u672c\u5317\u6d77\u9053\u5927\u5b78\u535a\u58eb\u30021994\u5e74\u4ee5\u69ae\u8b7d\u6559\u6388\u982d\u929c\u81ea\u6bcd\u6821\u9000\u4f11\u3002\u8207\u6839\u5cb8\u7686\u66fe\u5e2b\u4e8b1979\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u4e3b\u5e03\u6717\u6559\u6388\uff08Herbert Charles Brown\uff09\u3002<\/p>\n

?<\/p>\n

\u7279\u5225\u611f\u8b1d\u8521\u860a\u660e\u6559\u6388\u63d0\u4f9b\u6b64<\/span>\u8b6f\u7a3f<\/span><\/a>\uff08\u9023\u7d50\u5167\u6709\u4ed6\u7684\u8b6f\u5f8c\u8a18\uff0c\u63a8\u85a6\u95b1\u8b80\uff09\u3002\u904e\u53bb\u5341\u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u8b6f\u7a3f\u53ef\u898b\u65bc<\/span>\u8521\u860a\u660e\u6559\u6388\u500b\u4eba\u7db2\u7ad9<\/span><\/a>??<\/span><\/pre>\n
\u5ef6\u4f38\u95b1\u8b80\uff1a<\/span>2010\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5b98\u65b9\u82f1\u6587\u65b0\u805e\u7a3f\u539f\u6587<\/span><\/a>\u3001<\/span>2010\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u79d1\u5b78\u80cc\u666f\u8cc7\u6599\u539f\u6587<\/span><\/a><\/pre>\n
\u8cac\u4efb\u7de8\u8f2f\uff1aMissZoe<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"
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