{"id":5061,"date":"2010-09-16T11:41:36","date_gmt":"2010-09-16T03:41:36","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=5061"},"modified":"2017-03-31T23:21:17","modified_gmt":"2017-03-31T15:21:17","slug":"%e3%80%90%e6%9c%89%e9%97%9c%e5%9c%b0%e7%90%86%e3%80%91%e5%9f%ba%e5%9b%a0%e7%84%a1%e9%97%9c%e5%9c%8b%e7%95%8c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=5061","title":{"rendered":"\u3010\u6709\u95dc\u5730\u7406\u3011\u57fa\u56e0\u7121\u95dc\u570b\u754c"},"content":{"rendered":"

\u25a0 \u96d6\u7136\u4fd7\u8a71\u5e38\u8aaa\u300c\u8840\u6fc3\u65bc\u6c34\u300d\uff0c\u4f46\u5982\u679c\u8840\u7de3\u610f\u6307\u57fa\u56e0\u7684\u8a71\uff0c\u7814\u7a76\u767c\u73fe\u4e26\u4e0d\u662f\u540c\u4e00\u500b\u653f\u6cbb\u9ad4\u88e1\u7684\u4eba\u57fa\u56e0\u5fc5\u7136\u6bd4\u8f03\u63a5\u8fd1\uff0c\u6709\u6642\u5019\u6211\u5011\u6703\u8ddf\u9130\u570b\u7684\u4eba\u8840\u7de3\u66f4\u8fd1\u3002\u6240\u8b02\u7684\u300c\u540c\u80de\u300d\u771f\u7684\u53ea\u662f\u6bd4\u55bb\u800c\u5df2\u3002<\/span><\/strong><\/p>\n

\"R
\u6b50\u6d32\u57fa\u56e0\u5730\u5716\u3002\uff08\u5716\uff0f\u7576\u4ee3\u751f\u7269\u5b78\uff09<\/figcaption><\/figure>\n

?<\/span><\/strong><\/p>\n

\u64b0\u6587<\/strong> \u2223 \u8449\u9ad8\u83ef<\/p>\n

\u3000\u3000\u4f86\u81ea\u6b50\u6d32 13 \u500b\u570b\u5bb6\u7684 33 \u540d\u79d1\u5b78\u5bb6\u806f\u624b\u767c\u8868\u6b50\u6d32\u4eba\u7684\u57fa\u56e0\u5730\u5716\u65bc\u79d1\u5b78\u671f\u520a\u300aCurrent Biology<\/em>\u300b\u4e0a [1]\u3002\u6839\u64da\u4ed6\u5011\u7684\u6210\u679c\uff0c\u9664\u4e86\u82ac\u862d\u4eba\u7684\u57fa\u56e0\u81ea\u6210\u4e00\u570b\u4ee5\u5916\uff0c\u6b50\u6d32\u5404\u570b\u5c45\u6c11\u7684\u57fa\u56e0\u57fa\u672c\u4e0a\u8207\u570b\u754c\u7121\u95dc\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u9130\u8fd1\u5169\u570b\u5c45\u6c11\u7684\u57fa\u56e0\uff0c\u5f80\u5f80\u6bd4\u540c\u4e00\u570b\u5bb6\u4e0d\u540c\u5340\u57df\u5c45\u6c11\u7684\u57fa\u56e0\u66f4\u70ba\u76f8\u4f3c\u3002<\/p>\n

\u3000\u3000\u4ee5\u5fb7\u570b\u70ba\u4f8b\uff0c\u5317\u5fb7\u4eba (DE1) \u8207\u4e39\u9ea5\u4eba (DK) \u7684\u76f8\u4f3c\u5ea6\u9ad8\u65bc\u5317\u5fb7\u4eba\u8207\u5357\u5fb7\u4eba (DE2) \u4e4b\u9593\u3002\u53cd\u4e4b\uff0c\u5357\u5fb7\u4eba\u8207\u5967\u5730\u5229\u4eba (AT) \u7684\u76f8\u4f3c\u5ea6\u9ad8\u65bc\u5357\u5fb7\u4eba\u8207\u5317\u5fb7\u4eba\u4e4b\u9593\u3002\u5047\u8a2d\u6211\u5011\u6b66\u65b7\u5730\u4ee5\u5317\u5fb7\u4eba\u7684\u57fa\u56e0\u4f86\u5b9a\u7fa9\u5fb7\u570b\u4eba\uff0c\u5c07\u7121\u6cd5\u56de\u7b54\u9019\u6a23\u7684\u554f\u984c\uff1a\u70ba\u4f55\u4e39\u9ea5\u4eba\u53ca\u90e8\u5206\u8377\u862d\u4eba\u3001\u745e\u5178\u4eba\u3001\u632a\u5a01\u4eba\u4e0d\u662f\u5fb7\u570b\u4eba\uff1f\u53c8\u70ba\u4f55\u5357\u5fb7\u4eba\u662f\u5fb7\u570b\u4eba\uff1f<\/p>\n

<\/p>\n

\u3000\u3000\u7121\u7368\u6709\u5076\uff0c\u5317\u6f22\u4eba\u8207\u5357\u6f22\u4eba\u7684\u57fa\u56e0\u4e5f\u6709\u660e\u986f\u5dee\u7570\u3002\u5317\u6f22\u4eba\u8207\u8499\u53e4\u4eba\u3001\u671d\u9bae\u4eba\u7b49\u6771\u5317\u4e9e\u6c11\u65cf\u76f8\u4f3c\uff0c\u5357\u6f22\u4eba\u8207\u58ef\u65cf\u3001\u4f97\u65cf\u7b49\u6771\u5357\u4e9e\u6c11\u65cf\u76f8\u4f3c [2]\u3002\u5047\u8a2d\u6211\u5011\u6b66\u65b7\u5730\u4ee5\u5317\u6f22\u4eba\u7684\u57fa\u56e0\u4f86\u5b9a\u7fa9\u6f22\u4eba\uff0c\u4e5f\u7121\u6cd5\u56de\u7b54\u9019\u6a23\u7684\u554f\u984c\uff1a\u70ba\u4f55\u8499\u53e4\u4eba\u3001\u671d\u9bae\u4eba\u4e0d\u662f\u6f22\u4eba\uff1f\u53c8\u70ba\u4f55\u5357\u6f22\u4eba\u81ea\u8a8d\u70ba\u662f\u6f22\u4eba\uff1f<\/p>\n

\u3000\u3000\u986f\u800c\u6613\u898b\u5730\uff0c\u57fa\u56e0\u7121\u95dc\u6c11\u65cf\uff0c\u66f4\u7121\u95dc\u570b\u5bb6\u3002\u60f3\u4ee5\u57fa\u56e0\u4f86\u8ffd\u6c42\u653f\u6cbb\u4e0a\u7684\u7d71\u4e00\u6216\u7368\u7acb\uff0c\u6beb\u7121\u79d1\u5b78\u6839\u64da\u3002<\/p>\n

\u3000\u3000\u76ee\u524d\uff0c\u5927\u91cf\u7814\u7a76\u986f\u793a\u81fa\u7063\u6f22\u4eba\u7684\u57fa\u56e0\u8207\u5317\u6f22\u4eba\u5dee\u7570\u9817\u5927\u3002\u65bc\u662f\u67d0\u4e9b\u4eba\u8208\u596e\u5730\u5ba3\u5e03\uff1a\u81fa\u7063\u4eba\u4e0d\u662f\u6f22\u4eba\u3002\u7136\u800c\uff0c\u5927\u91cf\u7814\u7a76\u4e5f\u986f\u793a\u81fa\u7063\u6f22\u4eba\u7684\u57fa\u56e0\u8207\u798f\u5efa\u4eba\u3001\u5ee3\u6771\u4eba\u975e\u5e38\u76f8\u4f3c [3]\u3002\u67d0\u4e9b\u4eba\u53ea\u597d\u65b7\u8a00\u798f\u5efa\u4eba\u3001\u5ee3\u6771\u4eba\u4e5f\u4e0d\u662f\u6f22\u4eba\uff0c\u662f\u8d8a\u65cf\u3002\u5982\u6b64\u4e00\u4f86\uff0c\u81fa\u7063\u6f22\u4eba\u5c31\u4e0d\u6703\u662f\u6f22\u4eba\u4e86\u3002\u6211\u5011\u66ab\u4e14\u4e0d\u8ad6\u9019\u6a23\u7684\u8ad6\u65b7\u662f\u5426\u7b26\u5408\u5b78\u7406\u3002\u5c31\u7b97\u798f\u5efa\u4eba\u3001\u5ee3\u6771\u4eba\u771f\u7684\u4e0d\u662f\u6f22\u4eba\uff0c\u53c8\u600e\u6a23\uff1f\u76ee\u524d\u7684\u4ed6\u5011\uff0c\u4e26\u4e0d\u61f7\u7591\u4ed6\u5011\u662f\u4e2d\u570b\u4eba\u3002\u96e3\u9053\u81fa\u7063\u6f22\u4eba\u56e0\u70ba\u57fa\u56e0\u8ddf\u4ed6\u5011\u76f8\u4f3c\uff0c\u5c31\u5fc5\u9808\u8ddf\u4ed6\u5011\u4e00\u8d77\u5efa\u7acb\u570b\u5bb6\uff1f\u9019\u6050\u6015\u53c8\u4e0d\u662f\u8d8a\u65cf\u8ad6\u8005\u9858\u610f\u770b\u5230\u7684\u3002<\/p>\n

\u3000\u3000\u628a\u76f8\u540c\u7684\u908f\u8f2f\u5957\u5230\u5967\u5730\u5229\uff0c\u5c31\u6703\u6ed1\u5929\u4e0b\u4e4b\u5927\u7a3d\u3002\u5967\u5730\u5229\u662f\u500b\u5fb7\u8a9e\u570b\u5bb6\uff0c\u70ba\u4f55\u4e0d\u8ddf\u5fb7\u570b\u7d71\u4e00\u5462\uff1f\u6309\u7167\u8840\u7d71\u7368\u7acb\u8ad6\u7684\u908f\u8f2f\uff0c\u5967\u5730\u5229\u4eba\u7684\u57fa\u56e0\u8ddf\u5317\u5fb7\u4eba\u4e0d\u4e00\u6a23\uff0c\u6240\u4ee5\u4e0d\u80fd\u7d71\u4e00\u3002\u554f\u984c\u662f\uff0c\u5967\u5730\u5229\u4eba\u8ddf\u5357\u5fb7\u4eba\u5f88\u76f8\u4f3c\u5440\uff0c\u600e\u9ebc\u8fa6\uff1f\u53ea\u597d\u5ba3\u7a31\u5357\u5fb7\u4eba\u4e0d\u662f\u5fb7\u570b\u4eba\u4e86\uff1f\u5e78\u597d\uff0c\u795e\u667a\u6e05\u695a\u7684\u5967\u5730\u5229\u4eba\u4e0d\u6703\u5e79\u9019\u7a2e\u50bb\u4e8b\u3002<\/p>\n

\u3000\u3000\u9084\u662f\u8b93\u57fa\u56e0\u6b78\u57fa\u56e0\uff0c\u570b\u5bb6\u6b78\u570b\u5bb6\u3002\u9019\u5169\u4ef6\u4e8b\uff0c\u672c\u4f86\u5c31\u4e0d\u76f8\u95dc\u3002<\/p>\n

?<\/p>\n

\u8a3b\u91cb\uff1a<\/strong><\/p>\n

[1] Oscar Lao et al., (2008) Correlation between genetic and geographic structure in Europe<\/a>, Current Biology, 18(16): 1241-1248.<\/p>\n

[2] Zhao, T, and Lee, T.D. (1989) Gm and Km allotypes in 74 Chinese populations: a hypothesis of origin of the Chinese nation, Human Genetics, 83: 101-110.<\/p>\n

[3] \u4f8b\u5982\uff1aThe HUGO Pan-Asian SNP Consortiu (2009) Mapping Human Genetic Diversity in Asia, Science, 326: 1541 - 1545.<\/p>\n

?<\/p>\n

\u4f5c\u8005\u7c21\u4ecb<\/strong><\/p>\n

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