{"id":4957,"date":"2010-09-09T16:13:43","date_gmt":"2010-09-09T08:13:43","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=4957"},"modified":"2017-03-31T23:21:17","modified_gmt":"2017-03-31T15:21:17","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%99%bc%e5%b1%95%e3%80%91%e6%96%b0%e8%97%a5%e5%95%8f%e4%b8%96-%e7%9a%ae%e8%86%9a%e7%99%8c%e6%b2%bb%e7%99%82%e5%89%8d%e6%99%af%e7%9c%8b%e5%a5%bd","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=4957","title":{"rendered":"\u3010\u91ab\u5b78\u767c\u5c55\u3011\u65b0\u85e5\u554f\u4e16 \u76ae\u819a\u764c\u6cbb\u7642\u524d\u666f\u770b\u597d"},"content":{"rendered":"<p><strong><span style=\"color: #003366;\">\u25a0 \u9ed1\u8272\u7d20\u7624\u662f\u60e1\u6027\u816b\u7624\u4e2d\u6975\u5ea6\u68d8\u624b\u7684\u4e00\u7a2e\uff0c\u5b83\u662f\u76ae\u819a\u764c\u4e2d\u81f4\u6b7b\u7387\u6700\u9ad8\u7684\uff0c\u904e\u53bb\u901a\u5e38\u53ea\u80fd\u671f\u5f85\u5207\u9664\u60a3\u90e8\u8207\u5316\u7642\u594f\u6548\u3002\u4eca\u5e74\u79d1\u5b78\u5bb6\u767c\u73fe\u4e86\u4e00\u4e9b\u65b0\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u63d0\u4f9b\u60a3\u8005\u4e00\u7dda\u751f\u6a5f\u3002<\/span><\/strong><\/p>\n<figure id=\"attachment_4958\" aria-describedby=\"caption-attachment-4958\" style=\"width: 670px\" class=\"wp-caption alignnone\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-4958\" title=\"melanoma_cells\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/09\/melanoma_cells.jpg\" alt=\"melanoma_cells\" width=\"670\" height=\"381\" \/><figcaption id=\"caption-attachment-4958\" class=\"wp-caption-text\">\u9ed1\u8272\u7d20\u7624\u7d30\u80de\uff0f\u300a\u816b\u7624\u5b78\u671f\u520a\u300b\uff08Journal of Carcinogenesis\uff09<\/figcaption><\/figure>\n<p><strong>\u7de8\u8b6f<\/strong> \u2223 \u6c6a\u8283<\/p>\n<p>\u3000\u3000\u65b0\u7684\u7814\u7a76\u6307\u51fa\uff0c\u91ab\u754c\u5df2\u7814\u767c\u51fa\u4e00\u7a2e\u65b0\u85e5\uff0c\u53ef\u671b\u70ba\u9ed1\u8272\u7d20\u7624\u6cbb\u7642\u5e36\u4f86\u9577\u8db3\u9032\u6b65\uff0c\u63d0\u4f9b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e00\u500b\u65b0\u9078\u64c7\uff0c\u4e14\u7642\u6548\u512a\u65bc\u6240\u6709\u73fe\u6709\u85e5\u7269\u3002\u79d1\u5b78\u5bb68\u670826\u65e5\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u671f\u520a\u300b\uff08<em>New England Journal of Medic<\/em>ine\uff09\u767c\u8868\u4e00\u7bc7\u8ad6\u6587\u6307\u51fa\uff0c\u7814\u7a76\u4eba\u54e1\u5728\u9ed1\u8272\u7d20\u7624\u764c\u7d30\u80de\u5df2\u64f4\u6563\u7684\u75c5\u4f8b\u8eab\u4e0a\u9032\u884c\u6e2c\u8a66\uff0c\u5927\u90e8\u5206\u60a3\u8005\u670d\u7528\u65b0\u85e5\u5f8c\uff0c\u816b\u7624\u5747\u6709\u7e2e\u5c0f\u73fe\u8c61\uff0c\u6709\u5e7e\u500b\u75c5\u4f8b\u7684\u816b\u7624\u751a\u81f3\u5fb9\u5e95\u6cbb\u7652\u6d88\u5931\u3002\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u7d04\u6709\u4e00\u534a\u662f\u56e0BRAF\u57fa\u56e0\u7a81\u8b8a\u6240\u5c0e\u81f4\uff0c\u800c\u9019\u7a2e\u5316\u5408\u85e5\u7269\u9396\u5b9a\u7684\u76ee\u6a19\u6b63\u662fBRAF\u7a81\u8b8a\u7522\u751f\u7684\u86cb\u767d\u8cea\u3002<\/p>\n<p>\u3000\u3000\u300c\u9019\u9996\u5ea6\u8b49\u660e\u4e86\u9ed1\u8272\u7d20\u7624\u7528\u6a19\u9776\u6cbb\u7642\u6709\u6548\u3002\u300d\u502b\u6566\u5927\u5b78\u764c\u75c7\u7814\u7a76\u5b78\u9662\uff08Institute of Cancer Research\uff09\u7684\u5206\u5b50\u751f\u7269\u5b78\u5bb6\u99ac\u745e\uff08Richard Marais\uff09\u8868\u793a\uff0c\u300c\u9019\u662f\u9019\u500b\u9818\u57df\u7684\u4e00\u5927\u9032\u5c55\uff0c\u53ef\u8aaa\u662f\u7a7a\u524d\u7684\u7a81\u7834\u3002\u300d<\/p>\n<p>\u3000\u3000\u65e9\u671f\u76ae\u819a\u60e1\u6027\u9ed1\u8272\u7d20\u7624\u53ea\u662f\u4e00\u584a\u6591\u9ede\u5728\u76ae\u819a\u4e0a\uff0c\u624b\u8853\u5373\u53ef\u53bb\u9664\uff0c\u4e14\u5927\u90e8\u5206\u75c5\u4f8b\u7686\u53ef\u75ca\u7652\u3002\u7136\u800c\uff0c\u82e5\u764c\u7d30\u80de\u8f49\u79fb\u64f4\u6563\u5230\u76ae\u819a\u5176\u4ed6\u5730\u65b9\u6216\u5167\u90e8\u5668\u5b98\uff0c\u75c5\u6cc1\u5c31\u6703\u6025\u8f49\u76f4\u4e0b\uff0c\u8b8a\u5f97\u5341\u5206\u4e0d\u5229\uff0c\u75c5\u60a3\u4f7f\u7528\u5316\u5b78\u6cbb\u7642\u85e5\u7269\uff0c\u6cbb\u7642\u6709\u6548\u7684\u6a5f\u7387\u4e0d\u523020%\uff1b\u75c5\u4f8b\u5b58\u6d3b\u7684\u60c5\u5f62\u5404\u7570\uff0c\u8996\u764c\u7d30\u80de\u64f4\u6563\u7a0b\u5ea6\u53ca\u60a3\u8005\u5e74\u9f61\u800c\u5b9a\uff0c\u4f46\u901a\u5e38\u5b58\u6d3b\u671f\u90fd\u662f\u4ee5\u6708\u8a08\u7b97\uff0c\u6490\u4e0d\u904e\u5e7e\u5e74\u3002<\/p>\n<p>\u3000\u3000\u6b64\u6b21\u7814\u767c\u51fa\u7684\u65b0\u85e5\u547d\u540d\u70baPLX4032\uff1b\u9019\u7a2e\u85e5\u7684\u512a\u7570\u8868\u73fe\u5176\u5be6\u662f\u4eca\u590f\uff082010\u5e74\uff09\u4ee5\u4f86\u76ae\u819a\u60e1\u6027\u9ed1\u8272\u7d20\u7624\u6cbb\u7642\u7684\u7b2c\u4e8c\u5291\u5f37\u5fc3\u91dd\u30028\u670819\u65e5\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u671f\u520a\u300b\u624d\u767c\u8868\u4e00\u7bc7\u8ad6\u6587\uff0c\u5831\u5c0e\u53e6\u4e00\u7a2e\u65b0\u85e5<a href=\"http:\/\/en.wikipedia.org\/wiki\/Ipilimumab\" target=\"_blank\"><span style=\"color: #333333;\">ipilimumab<\/span><\/a>\uff0c\u9019\u7a2e\u85e5\u4f3c\u4e4e\u80fd\u5ef6\u9577\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u5b58\u6d3b\u671f\u3002\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08Food and Drug Administration\uff09\u73fe\u5df2\u52a0\u901f\u8a72\u85e5\u7269\u7684\u5be9\u6838\u6d41\u7a0b\u3002<!--more--><\/p>\n<p>\u3000\u3000\u9664\u4e86\u524d\u8ff0\u5169\u9805\u7814\u7a76\uff0c2008\u5e74\u6642\u4e5f\u6709\u4e00\u4efd\u76f8\u95dc\u7814\u7a76\u6307\u51fa\uff0c\u6cbb\u7642\u767d\u8840\u75c5\u7684\u85e5\u7269\u57fa\u7acb\u514b\uff08Gleevec\uff0c\u4ea6\u540dimatinib\uff09\uff0c\u5c0d\u4e00\u7a2e\u7f55\u898b\u7684C-kit\u57fa\u56e0\u7a81\u8b8a\u9020\u6210\u7684\u9ed1\u8272\u7d20\u7624\u9817\u6709\u7642\u6548\u3002<\/p>\n<p>\u3000\u3000\u300c\u9019\u70ba\u5f88\u591a\u76ae\u819a\u60e1\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u5e0c\u671b\u3002\u300d\u52a0\u62ff\u5927\u8499\u7279\u5a41\u9ea5\u57fa\u723e\u5927\u5b78\uff08McGill University\uff09\u7684\u75c5\u7406\u5b78\u5bb6\u53f2\u5df4\u8332\uff08Alan Spatz\uff09\u8868\u793a\uff0c\u300c\u4e00\u6b21\u51fa\u73fe\u4e09\u500b\u6210\u679c\u8c50\u78a9\u7684\u7814\u7a76\uff0c\u9019\u5728\u56db\u5341\u5e74\u4f86\u662f\u982d\u4e00\u906d\u3002\u300d<\/p>\n<figure id=\"attachment_4966\" aria-describedby=\"caption-attachment-4966\" style=\"width: 410px\" class=\"wp-caption alignright\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/09\/skincancer1.png\" target=\"_blank\"><img decoding=\"async\" class=\"size-full wp-image-4966\" title=\"skincancer\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/09\/skincancer1.png\" alt=\"skincancer\" width=\"410\" height=\"454\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/09\/skincancer1.png 684w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/09\/skincancer1-600x663.png 600w\" sizes=\"(max-width: 410px) 100vw, 410px\" \/><\/a><figcaption id=\"caption-attachment-4966\" class=\"wp-caption-text\">\u4f7f\u7528PLX4032\u4e4b\u5f8c\u7684\u6539\u5584\u60c5\u5f62\uff0f\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u671f\u520a<\/figcaption><\/figure>\n<p>\u3000\u3000\u572826\u65e5\u767c\u8868\u7684\u9019\u7bc7\u8ad6\u6587\u4e2d\uff0c\u54c8\u4f5b\u5927\u5b78\u91ab\u5b78\u9662\uff08Harvard Medical School\uff09\u816b\u7624\u79d1\u91ab\u5e2b\u5f17\u62c9\u54c8\u8fea\uff08<a href=\"http:\/\/www.dfhcc.harvard.edu\/membership\/profile\/member\/1632\/0\/\" target=\"_blank\">Keith Flaherty<\/a>\uff09\u3001\u6ce2\u58eb\u9813\u9ebb\u7701\u7e3d\u91ab\u9662\uff08Massachusetts General Hospital\uff09\u548c\u7f8e\u570b\u53ca\u6fb3\u6d32\u7814\u7a76\u4eba\u54e1\u7d44\u6210\u7684\u7814\u7a76\u5718\u968a\uff0c\u8b9348\u4f4dBRAF\u57fa\u56e0\u7570\u5e38\u7684\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4f7f\u7528PLX4032\u85e5\u7269\uff1bPLX4032\u4fc2\u7f8e\u570b\u52a0\u5dde\u67cf\u514b\u840a\u7684Plexxikon\u85e5\u5ee0\u6240\u7814\u767c\uff0c\u53ef\u6291\u5236\u7a81\u8b8a\u7684BRAF\u57fa\u56e0\u86cb\u767d\u8cea\uff0c\u4e26\u963b\u65b7\u764c\u7d30\u80de\u751f\u9577\u3002<\/p>\n<p>\u3000\u300048\u4f4d\u75c5\u60a3\u4e2d\uff0c\u670937\u4f4d\u60a3\u8005\u7684\u816b\u7624\u7e2e\u5c0f\u905430%\u4ee5\u4e0a\uff1b\u6b64\u5916\uff0c3\u4f4d\u75c5\u4f8b\u7684\u816b\u7624\u5fb9\u5e95\u6d88\u5931\u3002PLX4032\u6291\u5236\u816b\u7624\u7684\u6548\u679c\u7dad\u6301\u90543\u500b\u6708\u52302\u5e74\u4e0d\u7b49\uff0c\u6709\u4e9b\u60a3\u8005\u76ee\u524d\u4ecd\u6301\u7e8c\u7528\u85e5\u3002<\/p>\n<p>\u3000\u3000\u5f17\u62c9\u54c8\u8fea\u91ab\u5e2b\u6307\u51fa\uff0c\u63a5\u53d7\u6b64\u6cbb\u7642\u7684\u60a3\u8005\uff0c\u75c5\u60c5\u5e73\u5747\u5728\u8fd18\u500b\u6708\u5f8c\u518d\u5ea6\u60e1\u5316\u3002\u539f\u56e0\u662f\u816b\u7624\u6703\u6301\u7e8c\u767c\u5c55\uff0c\u4f7fPLX4032\u5931\u53bb\u85e5\u6548\uff1b\u9019\u500b\u8f49\u8b8a\u7684\u904e\u7a0b\u6b63\u662f\u7814\u7a76\u4eba\u54e1\u7684\u4e0b\u500b\u7814\u7a76\u76ee\u6a19\u3002<\/p>\n<p>\u3000\u3000\u5118\u7ba1\u75c5\u4f8b\u7684\u816b\u7624\u5fa9\u767c\u7387\u9817\u9ad8\uff0c\u7814\u7a76\u5718\u968a\u4e26\u672a\u56e0\u6b64\u6c23\u9912\u3002\u300c\u764c\u75c7\u75c5\u4f8b\u672c\u4f86\u5c31\u4e0d\u592a\u53ef\u80fd\u7528\u4e00\u7a2e\u85e5\u5c31\u6cbb\u7652\uff0c\u901a\u5e38\u9084\u662f\u8981\u63a1\u96de\u5c3e\u9152\u7642\u6cd5\u3002\u300d\u99ac\u745e\u8aaa\u660e\u3002<\/p>\n<p>\u3000\u3000\u7f8e\u570b\u4f5b\u5dde\u83ab\u975e\u2027\u674e\u764c\u75c7\u4e2d\u5fc3\uff08H. Lee Moffitt Cancer Center &amp; Research Institute\uff09\u5206\u5b50\u85e5\u7406\u5b78\u5bb6\u65af\u83ab\u5229\uff08Keiran Smalley\uff09\u6307\u51fa\uff0c\u7562\u7adf\u6cbb\u7642\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u672c\u4f86\u5c31\u7279\u5225\u68d8\u624b\u3002\u300c\u6211\u8a8d\u70ba\u6709\u9019\u6a23\u7684\u9032\u5c55\uff0c\u5df2\u7d93\u662f\u9019\u500b\u9818\u57df\u88e1\u7684\u4eba\u4ee5\u524d\u60f3\u90fd\u4e0d\u6562\u60f3\u7684\u4e8b\u4e86\u3002\u300d\u4ed6\u8868\u793a\u3002<\/p>\n<p>\u3000\u3000\u53e6\u5916\u5169\u7a2e\u76ae\u819a\u60e1\u6027\u9ed1\u8272\u7d20\u7624\u7684\u65b0\u7642\u6cd5\uff0c\u5229\u7528\u7684\u662f\u4e0d\u540c\u7684\u751f\u7269\u53cd\u61c9\u8def\u5f91\u3002\u5148\u524d\u85e5\u7269\u8a66\u9a57\u7d50\u679c\u986f\u793a\uff0c\u57fa\u7acb\u514b\u53ca\u985e\u4f3c\u7684\u85e5\u7269\u5982\u5c3c\u7f85\u66ff\u5c3c\uff08nilotinib\uff0c\u5e02\u5834\u4e0a\u85e5\u540d\u70baTasigna\uff0c\u4e2d\u6587\u7a31\u70ba\u6cf0\u606f\u5b89\uff09\u7b49\uff0c\u662f\u963b\u6493\u75c5\u8b8a\u7684\u86cb\u767d\u8cea\u50b3\u905e\u751f\u9577\u8a0a\u606f\u5230\u5404\u500b\u7d30\u80de\uff0c\u9032\u800c\u6291\u5236C-kit\u57fa\u56e0\u7a81\u8b8a\u6240\u5f15\u767c\u7684\u9ed1\u8272\u7d20\u7624\u751f\u9577\u3002\u4f46\u99ac\u745e\u89e3\u91cb\uff0c\u56e0\u70baC-kit\u57fa\u56e0\u7a81\u8b8a\u975e\u5e38\u5c11\u898b\uff0c\u4e14\u9019\u4e9b\u75c5\u4f8b\u901a\u5e38\u4e0d\u6703\u9023\u5e36\u6709BRAF\u57fa\u56e0\u7a81\u8b8a\uff0c\u56e0\u6b64\u5c07\u9019\u4e9b\u85e5\u7269\u8207PLX4032\u4e00\u8d77\u65bd\u7528\uff0c\u4e5f\u4e0d\u6703\u6709\u984d\u5916\u7684\u7642\u6548\u3002<\/p>\n<p>\u3000\u3000\u82e5\u60f3\u5de6\u53f3\u593e\u64ca\u764c\u7d30\u80de\uff0c\u7528ipilimumab\u6216\u8a31\u53ef\u80fd\u9054\u6210\u76ee\u6a19\uff0c\u56e0\u70ba\u9019\u7a2e\u85e5\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u6b63\u662f\u91cb\u653e\u4eba\u9ad4\u672c\u8eab\u7684\u514d\u75ab\u7a81\u64ca\u968aT\u7d30\u80de\u4f86\u653b\u64ca\u764c\u7d30\u80de\u3002\u99ac\u745e\u8868\u793a\uff0c\u540c\u6642\u4f7f\u7528ipilimumab\u53caPLX4032\uff0c\u6216\u8a31\u80fd\u7522\u751f\u52a0\u6210\u4f5c\u7528\u3002<\/p>\n<p>\u3000\u3000\u5f17\u62c9\u54c8\u8fea\u8aaa\uff0c\u76ee\u524d\u91ab\u754c\u6b63\u7814\u64ec\u4e00\u9805\u65b0\u7684\u85e5\u7269\u8a66\u9a57\uff0c\u540c\u6642\u4f7f\u7528\u9019\u5169\u7a2e\u85e5\u4f86\u6cbb\u7642BRAF\u57fa\u56e0\u7a81\u8b8a\u6240\u5f15\u767c\u7684\u9ed1\u8272\u7d20\u7624\uff1a\u4ee5PLX4032\u63a7\u5236\u65e9\u671f\u764c\u75c7\uff0c\u518d\u7528ipilimumab\u4f86\u300c\u5f37\u5316\u514d\u75ab\u7cfb\u7d71\u7684\u76e3\u7763\u6a5f\u5236\u300d\uff0c\u5c07\u9003\u904ePLX4032\u85e5\u6548\u7684\u5269\u9918\u816b\u7624\u7d30\u80de\u4e00\u6383\u800c\u76e1\u3002\u300c\u8aaa\u4e0d\u5b9a\u9019\u5169\u7a2e\u85e5\u53ef\u4ee5\u76f8\u8f14\u76f8\u6210\u3002\u300d\u5f17\u62c9\u54c8\u8fea\u8aaa\u3002<\/p>\n<p>\u3000\u3000\u9019\u4efd\u7814\u7a76\u7684\u5171\u540c\u4f5c\u8005\u67e5\u666e\u66fc\uff08Paul Chapman\uff09\u8868\u793a\uff0c\u5c0d\u65bc\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7642\uff0c\u300c\u9019\u7d55\u5c0d\u662f\u4e00\u5927\u8f49\u6369\u9ede\u3002\u300d\u67e5\u666e\u66fc\u662f\u7d10\u7d04\u65af\u9686\u51f1\u7279\u6797\u7d00\u5ff5\u764c\u75c7\u4e2d\u5fc3\uff08Memorial Sloan-Kettering Cancer Center\uff09\u7684\u816b\u7624\u79d1\u91ab\u5e2b\uff0c\u4ed6\u8868\u793a\uff1a\u300c\u9019\u662f\u816b\u7624\u7684\u6cbb\u7642\u7b2c\u4e00\u6b21\u6df1\u5165\u5230\u57fa\u56e0\u7684\u5c64\u6b21\u3002\u300d\u5728\u6b64\u4e4b\u524d\uff0c\u91ab\u751f\u5c0d\u6240\u6709\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u75c5\u4f8b\u90fd\u63a1\u53d6\u4e00\u6a23\u7684\u6cbb\u7642\u65b9\u6cd5\uff1b\u300c\u4f46\u73fe\u5728\u6211\u5011\u77ad\u89e3\u4e86\u4e0d\u540c\u9ed1\u8272\u7d20\u7624\u5728\u57fa\u56e0\u4e0a\u7684\u5dee\u7570\uff0c\u5c31\u53ef\u4ee5\u5584\u52a0\u5229\u7528\u9019\u500b\u512a\u52e2\u3002\u300d\u67e5\u666e\u66fc\u8aaa\u3002<\/p>\n<p>?<\/p>\n<pre><span style=\"color: #333333;\">\u539f\u6587\u51fa\u8655\uff1a<\/span><a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1002011\" target=\"_blank\"><span style=\"color: #333333;\">Inhibition of Mutated, Activated BRAF in Metastatic Melanoma<\/span><\/a><span style=\"color: #333333;\">\u3001<a href=\"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1003466\" target=\"_blank\"><span style=\"color: #333333;\">Ipilimumab Improves Survival in Patients With Metastatic Melanoma<\/span><\/a><span style=\"color: #333333;\">\uff08<em>New England Journal of Medicine<\/em>\uff09<\/span><\/span><\/pre>\n<p><strong><span style=\"color: #003366;\">\u8cac\u4efb\u7de8\u8f2f\uff1aMissZoe<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0 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