{"id":4753,"date":"2010-08-27T15:36:45","date_gmt":"2010-08-27T07:36:45","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=4753"},"modified":"2017-03-31T23:21:18","modified_gmt":"2017-03-31T15:21:18","slug":"%e3%80%90%e9%ab%94%e8%82%b2%e8%88%87dna%e3%80%91%e8%82%8c%e8%82%89%e8%a8%98%e5%be%97%e5%be%80%e6%97%a5%e6%a6%ae%e5%85%89","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=4753","title":{"rendered":"\u3010\u9ad4\u80b2\u8207DNA\u3011\u808c\u8089\u8a18\u5f97\u5f80\u65e5\u69ae\u5149"},"content":{"rendered":"<p><strong><span style=\"color: #800000;\">\u25a0 \u91cd\u91cf\u8a13\u7df4\u53ef\u4ee5\u8b93\u7dda\u689d\u7dca\u5be6\uff0c\u4e0d\u904e\u5fc5\u9808\u6301\u4e4b\u4ee5\u6046\u3002\u4f46\u6700\u8fd1\u6709\u79d1\u5b78\u5bb6\u6307\u51fa\uff0c\u300c\u5065\u7f8e\u7684\u8a18\u61b6\u300d\u6703\u5132\u5b58\u5728\u7d30\u80de\u6838\u4e2d\uff0c\u73fe\u5728\u505a\u7684\u808c\u8089\u8a13\u7df4\u4e0d\u6703\u767d\u8cbb\u3002\u9019\u500b\u767c\u73fe\u4f3c\u4e4e\u8ddf\u67d0\u4e9b\u5065\u8eab\u611b\u597d\u8005\u7684\u5e38\u8b58\u4e0d\u8b00\u800c\u5408\uff0c\u7d66\u4e86\u6211\u5011\u66f4\u597d\u7684\u7406\u7531\u4e0a\u5065\u8eab\u623f\u935b\u934a\u3002<\/span><\/strong><\/p>\n<figure id=\"attachment_4754\" aria-describedby=\"caption-attachment-4754\" style=\"width: 512px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-4754   \" title=\"d_vdm@flickr\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/08\/d_vdm@flickr.jpg\" alt=\"d_vdm@flickr\" width=\"512\" height=\"392\" \/><figcaption id=\"caption-attachment-4754\" class=\"wp-caption-text\">\u963f\u8afe\u53f2\u74e6\u8f9b\u683c\u8207\u6cd5\u862d\u79d1\uff0c\u5065\u7f8e\u5148\u751f\u4e8c\u4eba\u7d44\u3002<\/figcaption><\/figure>\n<p><strong><br \/>\n\u7de8\u8b6f<\/strong> \u2223 \u6c6a\u8283<\/p>\n<p>\u3000\u3000\u4ee5\u524d\u7df4\u904e\u8eab\u9ad4\u7684\u4eba\u8981\u518d\u5065\u8eab\u901a\u5e38\u6bd4\u8f03\u5bb9\u6613\uff0c\u9019\u9ede\u73fe\u5728\u79d1\u5b78\u5bb6\u5df2\u609f\u51fa\u7b87\u4e2d\u9053\u7406\u2500\u2500\u5967\u5999\u5728\u65bc\u808c\u8089\u5c31\u7b97\u758f\u65bc\u4f7f\u7528\u800c\u7e2e\u5c0f\u8b8a\u5f31\u4e86\uff0c\u4ecd\u6703\u8a18\u61b6\u5148\u524d\u7684\u5065\u7f8e\u72c0\u614b\u3002<\/p>\n<p>\u3000\u3000\u808c\u8089\u904b\u52d5\u6642\uff0c\u7d30\u80de\u6838\u4fbf\u6703\u8fc5\u901f\u589e\u751f\uff0c\u800c\u808c\u8089\u8a18\u61b6\u5c31\u5132\u5b58\u5728\u9019\u4e9b\u627f\u8f09DNA\uff08\u53bb\u6c27\u6838\u7cd6\u6838\u9178\uff09\u7684\u7d30\u80de\u6838\u4e2d\u3002\u9019\u4e9b\u7d30\u80de\u6838\u8207\u5148\u524d\u7684\u666e\u904d\u8a8d\u77e5\u4e0d\u540c\uff1b\u300a\u7f8e\u570b\u570b\u5bb6\u79d1\u5b78\u9662\u9662\u520a\u300b\uff08<em>Proceedings of the National Academy of Sciences<\/em>\uff098\u670816\u65e5\u65bc\u7dda\u4e0a\u767c\u8868\u4e00\u4efd\u7814\u7a76\u6307\u51fa\uff0c\u5373\u4fbf\u808c\u8089\u840e\u7e2e\uff0c\u9019\u4e9b\u7d30\u80de\u6838\u4e5f\u4e0d\u6703\u6d88\u5931\u3002\u589e\u751f\u7684\u7d30\u80de\u6838\u6703\u5f62\u6210\u808c\u8089\u8a18\u61b6\uff0c\u5728\u808c\u8089\u904b\u52d5\u518d\u5ea6\u6d3b\u8e8d\u6642\uff0c\u5354\u52a9\u808c\u8089\u6062\u5fa9\u5065\u7f8e\u3002<\/p>\n<p>\u3000\u3000\u4e3b\u5c0e\u6b64\u7814\u7a76\u7684\u662f\u4efb\u8077\u65bc\u632a\u5a01\u5967\u65af\u9678\u5927\u5b78\uff08University of Oslo\uff09\u7684\u751f\u7406\u5b78\u5bb6\u5ca1\u5fb7\u68ee\uff08Kristian Gundersen\uff09\uff0c\u4ed6\u8868\u793a\uff0c\u9019\u4efd\u7814\u7a76\u6210\u679c\u6b63\u610f\u5473\uff0c\u82e5\u4eba\u5e74\u8f15\u6642\u80fd\u591a\u904b\u52d5\uff0c\u5c07\u53ef\u907f\u514d\u5e74\u8001\u9ad4\u8870\uff1b\u6b64\u5916\uff0c\u9019\u4efd\u7814\u7a76\u7684\u7d50\u8ad6\u4e5f\u6538\u95dc\u670d\u7981\u85e5\u7684\u904b\u52d5\u9078\u624b\u7a76\u7adf\u8a72\u7981\u8cfd\u591a\u4e45\u3002<\/p>\n<p><!--more--><\/p>\n<p><strong>?<\/strong><\/p>\n<p><strong>\u808c\u8089\u8a18\u61b6<\/strong><\/p>\n<p>\u3000\u3000\u5ca1\u5fb7\u68ee\u89e3\u91cb\uff0c\u808c\u8089\u7d30\u80de\u5f88\u5927\uff0c\u56e0\u6b64\u808c\u8089\u8981\u8b8a\u58ef\uff0c\u9700\u8981\u4e0d\u53ea\u4e00\u500b\u7d30\u80de\u6838\uff0c\u624d\u80fd\u63d0\u4f9b\u8db3\u5920\u7684DNA\u6a21\u7d44\u4f86\u88fd\u9020\u5927\u91cf\u86cb\u767d\u8cea\u3002\u5148\u524d\u5df2\u6709\u7814\u7a76\u986f\u793a\uff0c\u96a8\u8457\u904b\u52d5\uff0c\u808c\u8089\u7d30\u80de\u6703\u8207\u885b\u661f\u7d30\u80de\u7d50\u5408\uff0c\u9032\u800c\u8b8a\u5927\uff1b\u885b\u661f\u7d30\u80de\u5c31\u662f\u808c\u8089\u7684\u5e79\u7d30\u80de\uff0c\u4f4d\u65bc\u808c\u7e96\u7dad\u7d30\u80de\u4e4b\u9593\u3002\u904e\u53bb\u5b78\u8005\u4e00\u76f4\u8a8d\u70ba\uff0c\u808c\u8089\u9000\u5316\u5f8c\uff0c\u591a\u9918\u7684\u7d30\u80de\u6838\u6703\u56e0\u300c\u7d30\u80de\u51cb\u4ea1\u300d\uff08apoptosis\uff09\u800c\u6d88\u4ea1\uff0c\u4ea6\u5373\u767c\u751f\u8a08\u756b\u6027\u7684\u7d30\u80de\u6b7b\u4ea1\u3002<\/p>\n<p>\u3000\u3000\u5728\u5ca1\u5fb7\u68ee\u9019\u4efd\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u54e1\u8b93\u8001\u9f20\u62ac\u8d77\u8173\u8dbe\u7684\u808c\u8089\u65bd\u529b\u8b8a\u56f0\u96e3\uff0c\u4f86\u6a21\u64ec\u904b\u52d5\u5065\u8eab\u7684\u6548\u679c\u3002\u7814\u7a76\u5c0f\u7d44\u767c\u73fe\uff0c\u9019\u6839\u808c\u8089\u958b\u59cb\u935b\u934a\u5f8c\u7b2c6\u5929\uff0c\u7d30\u80de\u6838\u7684\u6578\u91cf\u589e\u52a0\u4e86\u3002\u5be6\u9a57\u768421\u5929\u671f\u9593\uff0c\u9019\u6839\u51fa\u529b\u7684\u808c\u8089\uff0c\u808c\u7e96\u7dad\u7d30\u80de\u5167\u7684\u7d30\u80de\u6838\u6578\u91cf\u589e\u52a0\u4e86\u7d0454%\u3002\u5be6\u9a57\u7b2c9\u5929\u8d77\uff0c\u808c\u8089\u7d30\u80de\u4e5f\u958b\u59cb\u8b8a\u5927\uff0c\u53c8\u4f7f\u808c\u8089\u9ad4\u7a4d\u589e\u52a035%\u3002\u7531\u5be6\u9a57\u6210\u679c\u53ef\u77e5\uff0c\u808c\u8089\u7d30\u80de\u6838\u7684\u589e\u751f\u5728\u5148\uff0c\u800c\u808c\u8089\u8b8a\u5927\u5728\u5f8c\u3002<\/p>\n<figure id=\"attachment_4763\" aria-describedby=\"caption-attachment-4763\" style=\"width: 445px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-full wp-image-4763 \" title=\"musc_memory\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/08\/musc_memory.png\" alt=\"musc_memory\" width=\"445\" height=\"166\" \/><figcaption id=\"caption-attachment-4763\" class=\"wp-caption-text\">\u808c\u8089\u7d30\u80de\u7684\u7d30\u80de\u6838\uff08\u5373\u5716\u4e2d\u808c\u7e96\u7dad\u4e0a\u7684\u7da0\u9ede\uff09\u6703\u8a18\u61b6\u5148\u524d\u7684\u5f37\u5065\u72c0\u614b\uff1b\u808c\u8089\u758f\u65bc\u6d3b\u52d5\u4e00\u6bb5\u6642\u9593\u5f8c\uff0c\u82e5\u91cd\u65b0\u8a13\u7df4\uff0c\u808c\u8089\u8a18\u61b6\u4ecd\u80fd\u5e6b\u52a9\u808c\u8089\u6062\u5fa9\u5065\u7f8e\u3002\uff08\u5716\u7247\uff1a\u5e03\u9b6f\u65af\u8cc8\u5fb7\/\u5967\u65af\u9678\u5927\u5b78\uff09<\/figcaption><\/figure>\n<p>\u3000\u3000\u7814\u7a76\u5c0f\u7d44\u4e5f\u9032\u884c\u53e6\u4e00\u7d44\u5be6\u9a57\uff0c\u5148\u935b\u934a\u8001\u9f20\u7684\u808c\u80892\u9031\uff0c\u7136\u5f8c\u5207\u65b7\u808c\u8089\u795e\u7d93\uff0c\u4f7f\u808c\u8089\u7d44\u7e54\u840e\u7e2e\u3002\u7d50\u679c\uff0c\u808c\u8089\u9000\u5316\u5f8c\uff0c\u7d30\u80de\u6bd4\u8d77\u5148\u524d\u935b\u934a\u6642\u81a8\u5927\u7684\u9ad4\u7a4d\uff0c\u7e2e\u5c0f\u4e86\u7d0440%\uff0c\u4f46\u7d30\u80de\u5167\u7d30\u80de\u6838\u7684\u6578\u91cf\u537b\u672a\u6e1b\u5c11\u3002<\/p>\n<p>\u3000\u3000\u5148\u524d\u5176\u4ed6\u7814\u7a76\u4e2d\uff0c\u808c\u8089\u7d30\u80de\u5728\u808c\u8089\u840e\u7e2e\u5f8c\u5747\u6709\u5927\u91cf\u6b7b\u4ea1\u73fe\u8c61\uff1b\u6b64\u4efd\u65b0\u7814\u7a76\u7684\u7d50\u679c\u986f\u7136\u5927\u76f8\u9015\u5ead\u3002\u5ca1\u5fb7\u68ee\u7684\u7814\u7a76\u5718\u968a\u6aa2\u6e2c\u9000\u5316\u6d88\u7626\u7684\u808c\u8089\u5167\u7684\u5404\u7a2e\u7d30\u80de\uff0c\u767c\u73fe\u4e5f\u6709\u7d30\u80de\u51cb\u4ea1\u73fe\u8c61\uff0c\u4f46\u6b7b\u4ea1\u7684\u662f\u5176\u4ed6\u7d30\u80de\uff0c\u808c\u7e96\u7dad\u7d30\u80de\u53ca\u5176\u589e\u751f\u7684\u7d30\u80de\u6838\u5247\u5b89\u7136\u7121\u6059\u3002\u589e\u751f\u7684\u7d30\u80de\u6838\u5728\u808c\u8089\u672a\u904b\u52d5\u7684\u60c5\u6cc1\u4e0b\uff0c\u9084\u80fd\u6490\u4e0a\u81f3\u5c113\u500b\u6708\uff0c\u5ca1\u5fb7\u68ee\u8868\u793a\uff0c\u9019\u5c0d\u8001\u9f20\u4f86\u8aaa\u5df2\u662f\u5341\u5206\u9577\u7684\u6642\u9593\uff0c\u56e0\u70ba\u8001\u9f20\u5e73\u5747\u58fd\u547d\u4e0d\u904e\u5169\u4e09\u5e74\u3002<\/p>\n<p>\u3000\u3000\u5ca1\u5fb7\u68ee\u8aaa\uff1a\u300c\u6211\u4e0d\u78ba\u5b9a\u9019\u500b\u6548\u679c\u662f\u4e0d\u662f\u6c38\u4e45\u7684\uff0c\u4f46\u81f3\u5c11\u4f3c\u4e4e\u9817\u70ba\u6301\u4e45\u3002\u300d\u4ed6\u8aaa\u660e\uff0c\u589e\u751f\u7684\u7d30\u80de\u6838\u65e2\u7136\u4e0d\u6703\u6b7b\u4ea1\uff0c\u4fbf\u53ef\u84c4\u52e2\u5f85\u767c\uff0c\u96a8\u6642\u6e96\u5099\u597d\u88fd\u9020\u65b0\u7684\u808c\u86cb\u767d\uff0c\u56e0\u800c\u5f62\u6210\u6240\u8b02\u7684\u300c\u808c\u8089\u8a18\u61b6\u300d\u3002<\/p>\n<p>\u3000\u3000\u4efb\u8077\u65bc\u4e39\u9ea5\u54e5\u672c\u54c8\u6839\u5927\u5b78\uff08University of Copenhagen\uff09\u7684\u808c\u8089\u751f\u7406\u5b78\u5bb6\u8cfd\u723e\u6c40\uff08Bengt Saltin\uff09\u8a55\u8ad6\uff1a\u300c\u9019\u500b\u89c0\u9ede\u5f88\u5438\u5f15\u4eba\uff0c\u800c\u4e14\u9019\u7bc7\u8ad6\u6587\u4e2d\u4e5f\u6709\u8db3\u5920\u7684\u8b49\u660e\u4f86\u652f\u6301\u9019\u500b\u8aaa\u6cd5\u3002\u9019\u500b\u8ad6\u9ede\u5341\u5206\u65b0\u9bae\uff0c\u4e5f\u80fd\u8aaa\u660e\u70ba\u4f55\u5e73\u5e38\u81e8\u5e8a\u89c0\u5bdf\u4e2d\uff0c\u91cd\u8907\u935b\u934a\u7684\u808c\u8089\u901a\u5e38\u6703\u8f03\u5feb\u6709\u53cd\u61c9\u3002\u300d<\/p>\n<p><strong>\u5206\u5b50\u5c64\u6b21<\/strong><\/p>\n<p>\u3000\u3000\u5118\u7ba1\u5982\u6b64\uff0c\u7f8e\u570b\u9ebb\u585e\u8af8\u585e\u5927\u5b78\u963f\u9ed8\u65af\u7279\u6821\u5340\uff08University of Massachusetts Amherst\uff09\u7684\u7d30\u80de\u751f\u7269\u5b78\u5bb6\u65bd\u74e6\u8332\uff08Lawrence Schwartz\uff09\u8868\u793a\uff0c\u9019\u9805\u7814\u7a76\u7d50\u8ad6\u61c9\u6703\u5f15\u8d77\u4e00\u4e9b\u5b78\u8005\u5f37\u70c8\u53cd\u5f48\u3002<\/p>\n<p>\u3000\u3000\u300c\u9019\u4efd\u7814\u7a76\u8ddf\u5f88\u591a\u5df2\u767c\u8868\u4e14\u7d93\u5b78\u754c\u8a8d\u53ef\u7684\u6578\u64da\u5531\u53cd\u8abf\u3002\u300d\u65bd\u74e6\u8332\u76f4\u8a00\u3002\u7136\u800c\uff0c\u808c\u8089\u7d30\u80de\u4e2d\u53ea\u6709\u7279\u5b9a\u7a2e\u985e\u7684\u7d30\u80de\u6838\u6b7b\u4ea1\uff0c\u4ee3\u8868\u808c\u8089\u7d30\u80de\u6b77\u7d93\u7684\u78ba\u5be6\u662f\u4e00\u7a2e\u7279\u6b8a\u7684\u7d30\u80de\u51cb\u4ea1\u3002\u300c\u5230\u7d30\u80de\u53ca\u5206\u5b50\u7684\u9019\u500b\u5c64\u9762\uff0c\u5b78\u754c\u65e2\u6709\u7684\u7406\u8ad6\u78ba\u5be6\u5df2\u7121\u6cd5\u8aaa\u660e\u3002\u300d\u4ed6\u8a8d\u70ba\uff0c\u5ca1\u5fb7\u68ee\u7684\u7814\u7a76\u5718\u968a\u63d0\u4f9b\u4e86\u53ef\u4fe1\u5ea6\u8f03\u9ad8\u7684\u8aaa\u6cd5\uff0c\u300c\u4ed6\u5011\u7684\u6578\u64da\u611f\u89ba\u78ba\u5be6\u883b\u53ef\u4fe1\u7684\u3002\u300d<\/p>\n<p>\u3000\u3000\u5982\u679c\u935b\u934a\u808c\u8089\u7684\u6548\u679c\u771f\u7684\u53ef\u7dad\u6301\uff0c\u8a31\u591a\u9ad4\u80b2\u59d4\u54e1\u6703\u78ba\u5be6\u9808\u91cd\u65b0\u8a55\u4f30\u670d\u985e\u56fa\u9187\u9078\u624b\u7684\u7981\u8cfd\u6642\u9593\u3002\u5148\u524d\u7814\u7a76\u6307\u51fa\uff0c\u777e\u56fa\u916e\u53ef\u8b93\u808c\u8089\u7d30\u80de\u4e2d\u7d30\u80de\u6838\u6578\u91cf\u6fc0\u589e\uff0c\u9060\u8d85\u904e\u4e00\u822c\u6b63\u5e38\u5065\u8eab\u7684\u6548\u679c\u3002\u300c\u5982\u679c\u589e\u751f\u7684\u7d30\u80de\u6838\u771f\u7684\u6703\u6c38\u9060\u5b58\u5728\uff0c\u4e0d\u6703\u51cb\u4ea1\uff0c\u90a3\u4ee3\u8868\u9078\u624b\u670d\u7981\u85e5\u4f54\u7684\u512a\u52e2\u53ef\u6c38\u9060\u7dad\u6301\u3002\u300d\u5ca1\u5fb7\u68ee\u8868\u793a\u3002<\/p>\n<p>\u3000\u3000\u597d\u5427\uff0c\u6216\u8a31\u4e0d\u662f\u6c38\u9060\uff0c\u56e0\u70ba\u96a8\u8457\u4eba\u8001\u5316\uff0c\u808c\u8089\u751f\u6210\u7684\u80fd\u529b\u4e5f\u6703\u5927\u4e0d\u5982\u524d\u3002\u9019\u9805\u65b0\u7684\u7814\u7a76\u8aaa\u660e\u7684\u662f\uff0c\u5e74\u8f15\u6642\u591a\u751f\u6210\u4e00\u4e9b\u808c\u8089\u7d30\u80de\u6838\uff0c\u5c31\u80fd\u5ef6\u7de9\u808c\u8089\u96a8\u8457\u8001\u5316\u800c\u6d41\u5931\u7684\u904e\u7a0b\u3002\u300c\u9019\u5c0d\u652f\u6301\u5f37\u5236\u5b78\u751f\u4e0a\u9ad4\u80b2\u8ab2\u7684\u4eba\uff0c\u53ef\u80fd\u6703\u662f\u500b\u4e0d\u932f\u7684\u8ad6\u64da\u3002\u300d\u8cfd\u723e\u6c40\u8aaa\u3002<\/p>\n<p>?<\/p>\n<pre><span style=\"color: #333333;\">\u539f\u6587\u51fa\u8655\uff1a<\/span><a href=\"http:\/\/www.pnas.org\/content\/107\/34\/15111.abstract?sid=5c8be98d-cf59-4348-96b7-87783baa83b5\" target=\"_blank\"><span style=\"color: #333333;\">Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining<\/span><\/a><span style=\"color: #333333;\">\uff08PNAS\uff09<\/span><\/pre>\n<p><span style=\"color: #333333;\"><strong><span style=\"color: #003366;\">\u8cac\u4efb\u7de8\u8f2f\uff1aMissZoe<\/span><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0 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