{"id":46550,"date":"2026-07-02T17:00:22","date_gmt":"2026-07-02T09:00:22","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=46550"},"modified":"2026-07-01T16:05:40","modified_gmt":"2026-07-01T08:05:40","slug":"%e8%ae%93%e7%b4%b0%e8%83%9e%e7%95%99%e4%b8%8b%e8%a8%98%e6%86%b6%ef%bc%9atimevault%e5%a6%82%e4%bd%95%e5%b0%81%e5%ad%98%e9%81%8e%e5%8e%bb%e7%9a%84rna","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=46550","title":{"rendered":"\u8b93\u7d30\u80de\u7559\u4e0b\u8a18\u61b6\uff1aTimeVault\u5982\u4f55\u5c01\u5b58\u904e\u53bb\u7684RNA"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>RNA\u80fd\u53cd\u6620\u7d30\u80de\u7576\u4e0b\u7684\u57fa\u56e0\u8868\u73fe\u72c0\u614b\uff0c\u56e0\u6b64\u88ab\u8996\u70ba\u7814\u7a76\u7d30\u80de\u6d3b\u52d5\u7684\u91cd\u8981\u4f9d\u64da\u3002\u7136\u800c\uff0c\u7531\u65bcRNA\u5bb9\u6613\u88ab\u964d\u89e3\uff0c\u50b3\u7d71RNA\u5b9a\u5e8f\u6280\u8853\u5f80\u5f80\u53ea\u80fd\u89c0\u5bdf\u7d30\u80de\u5728\u63a1\u6a23\u77ac\u9593\u7684\u5206\u5b50\u72c0\u614b\uff0c\u800c\u96e3\u4ee5\u8ffd\u8e64\u5176\u904e\u53bb\u7d93\u6b77\u30022026\u5e74\u767c\u8868\u65bc\u300a<em>Science<\/em>\u300b\u7684TimeVault\u6280\u8853\uff0c\u5229\u7528\u5de5\u7a0b\u5316Vault\u9846\u7c92\u5c01\u5b58\u7279\u5b9a\u6642\u9593\u5340\u6bb5\u5167\u7522\u751f\u7684RNA\uff0c\u8b93\u7814\u7a76\u4eba\u54e1\u5f97\u4ee5\u56de\u6eaf\u7d30\u80de\u904e\u53bb\u7684\u8f49\u9304\u9ad4\u8cc7\u8a0a\u3002\u9019\u9805\u6280\u8853\u70ba\u7814\u7a76\u764c\u75c7\u6297\u85e5\u6027\u3001\u5e79\u7d30\u80de\u5206\u5316\u8207\u7d30\u80de\u547d\u904b\u6c7a\u5b9a\u7b49\u554f\u984c\u63d0\u4f9b\u4e86\u65b0\u7684\u89c0\u5bdf\u8996\u89d2\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5c\u6797\u6cf3\u4ea8<\/strong><\/p>\n<p>\u7d30\u80de\u7121\u6642\u7121\u523b\u90fd\u5728\u56de\u61c9\u5468\u906d\u74b0\u5883\u3002\u7576\u906d\u9047\u7f3a\u6c27\u3001\u75c5\u6bd2\u611f\u67d3\u3001\u85e5\u7269\u523a\u6fc0\uff0c\u751a\u81f3\u958b\u59cb\u764c\u5316\u6642\uff0c\u7d30\u80de\u5167\u7684\u57fa\u56e0\u8868\u73fe\u90fd\u6703\u8fc5\u901f\u6539\u8b8a\uff0c\u7522\u751f\u4e0d\u540c\u7a2e\u985e\u8207\u6578\u91cf\u7684RNA\u5206\u5b50\u3002\u7531\u65bcRNA\u6703\u96a8\u8457\u7d30\u80de\u72c0\u614b\u8b8a\u5316\u800c\u4e0d\u65b7\u66f4\u65b0\uff0c\u56e0\u6b64\u7814\u7a76\u4eba\u54e1\u7d93\u5e38\u5c07\u5176\u8996\u70ba\u53cd\u6620\u7d30\u80de\u7576\u4e0b\u6d3b\u52d5\u7684\u5206\u5b50\u7d00\u9304\u3002\u8fd1\u5e74\u4f86\uff0c\u55ae\u7d30\u80deRNA\u5b9a\u5e8f (single-cell RNA sequencing) \u7684\u5feb\u901f\u767c\u5c55\uff0c\u66f4\u8b93\u79d1\u5b78\u5bb6\u5f97\u4ee5\u7cbe\u7d30\u5730\u89c0\u5bdf\u500b\u5225\u7d30\u80de\u5728\u4e0d\u540c\u72c0\u614b\u4e0b\u7684\u8f49\u9304\u9ad4 (transcriptome) \u8b8a\u5316\uff0c\u9032\u4e00\u6b65\u4e86\u89e3\u7d30\u80de\u5982\u4f55\u505a\u51fa\u5404\u7a2e\u751f\u7406\u6c7a\u7b56\u3002<\/p>\n<p>\u7136\u800c\uff0cRNA\u6709\u4e00\u500b\u81f4\u547d\u7684\u7f3a\u9ede\uff1a\u5b83\u7121\u6cd5\u5728\u7d30\u80de\u5167\u4fdd\u5b58\u592a\u4e45\u3002\u5927\u591a\u6578mRNA\u7684\u534a\u8870\u671f\u53ea\u6709\u6578\u5c0f\u6642\u5230\u4e00\u5929\u5de6\u53f3\uff0c\u5f88\u5feb\u5c31\u6703\u88ab\u7d30\u80de\u5167\u7684\u6838\u9178\u9176\u5206\u89e3\u3002\u9019\u4f7f\u5f97\u7814\u7a76\u4eba\u54e1\u5373\u4f7f\u80fd\u5920\u7cbe\u6e96\u6e2c\u91cfRNA\uff0c\u4e5f\u5f80\u5f80\u53ea\u80fd\u77e5\u9053\u7d30\u80de\u5728\u63a1\u6a23\u7576\u4e0b\u6b63\u5728\u505a\u4ec0\u9ebc\uff0c\u800c\u96e3\u4ee5\u8ffd\u8e64\u5b83\u904e\u53bb\u66fe\u7d93\u6b77\u904e\u54ea\u4e9b\u4e8b\u4ef6\u3002<\/p>\n<p>\u9019\u9805\u9650\u5236\u5728\u764c\u75c7\u7814\u7a76\u4e2d\u5099\u53d7\u95dc\u6ce8\u3002\u4f8b\u5982\uff0c\u7576\u764c\u7d30\u80de\u63a5\u53d7\u85e5\u7269\u6cbb\u7642\u5f8c\uff0c\u50c5\u6709\u6975\u5c11\u6578\u7d30\u80de\u80fd\u5920\u5b58\u6d3b\u4e0b\u4f86\uff0c\u5f62\u6210\u6240\u8b02\u7684\u85e5\u7269\u8010\u53d7\u7d30\u80de (drug-tolerant persister cells)\u3002\u7814\u7a76\u4eba\u54e1\u5e0c\u671b\u4e86\u89e3\u9019\u4e9b\u7d30\u80de\u7a76\u7adf\u662f\u5728\u6cbb\u7642\u524d\u5c31\u5df2\u7d93\u5177\u6709\u7279\u6b8a\u7684\u57fa\u56e0\u8868\u73fe\u6a21\u5f0f\uff0c\u9084\u662f\u5728\u6cbb\u7642\u904e\u7a0b\u4e2d\u624d\u9010\u6f38\u6f14\u8b8a\u800c\u6210\uff1f\u7136\u800c\uff0c\u7576\u79d1\u5b78\u5bb6\u771f\u6b63\u5206\u6790\u9019\u4e9b\u5b58\u6d3b\u7d30\u80de\u6642\uff0c\u5b83\u5011\u7684RNA\u72c0\u614b\u901a\u5e38\u65e9\u5df2\u6539\u8b8a\uff0c\u4f7f\u5f97\u904e\u53bb\u7684\u5206\u5b50\u8cc7\u8a0a\u96e3\u4ee5\u88ab\u91cd\u5efa\u3002<\/p>\n<p>\u90a3\u9ebc\uff0c\u6709\u6c92\u6709\u8fa6\u6cd5\u66ff\u7d30\u80de\u5efa\u7acb\u4e00\u5957\u80fd\u5920\u4fdd\u5b58\u904e\u53bbRNA\u8a0a\u606f\u7684\u7cfb\u7d71\uff0c\u8b93\u7814\u7a76\u4eba\u54e1\u5728\u672a\u4f86\u4ecd\u80fd\u56de\u982d\u8b80\u53d6\u7d30\u80de\u66fe\u7d93\u6b77\u904e\u7684\u5206\u5b50\u72c0\u614b\uff1f2026\u5e741\u6708\uff0c\u4e00\u7bc7\u767c\u8868\u65bc\u300a<em>Science<\/em>\u300b\u7684\u7814\u7a76\u63d0\u51fa\u4e86\u4e00\u9805\u540d\u70baTimeVault\u7684\u65b0\u6280\u8853\u3002\u9019\u5957\u7cfb\u7d71\u7684\u6838\u5fc3\u6982\u5ff5\u662f\u5728\u7814\u7a76\u4eba\u54e1\u6307\u5b9a\u7684\u6642\u9593\u5340\u9593\u5167\uff0c\u5c07\u7576\u6642\u7522\u751f\u7684RNA\u8a0a\u606f\u5c01\u5b58\u8d77\u4f86\uff0c\u5f62\u6210\u4e00\u4efd\u53ef\u4f9b\u65e5\u5f8c\u8b80\u53d6\u7684\u5206\u5b50\u7d00\u9304\u3002\u900f\u904e\u9019\u7a2e\u65b9\u5f0f\uff0c\u5373\u4f7f\u7d30\u80de\u5f8c\u7e8c\u5df2\u7d93\u9032\u5165\u4e0d\u540c\u72c0\u614b\uff0c\u7814\u7a76\u4eba\u54e1\u4ecd\u6709\u6a5f\u6703\u56de\u6eaf\u5b83\u5728\u904e\u53bb\u67d0\u500b\u95dc\u9375\u6642\u523b\u7684\u57fa\u56e0\u8868\u73fe\u6a23\u8c8c\u3002<\/p>\n<figure id=\"attachment_46552\" aria-describedby=\"caption-attachment-46552\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-46552\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/\u5716\u4e00.png\" alt=\"\" width=\"600\" height=\"192\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/\u5716\u4e00.png 609w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/\u5716\u4e00-300x96.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-46552\" class=\"wp-caption-text\">\u5716\u4e00\uff1a\u50b3\u7d71\u55ae\u7d30\u80deRNA\u5b9a\u5e8f\u53ea\u80fd\u5206\u6790\u7d30\u80de\u5728\u63a1\u6a23\u7576\u4e0b\u7684\u8f49\u9304\u9ad4\u72c0\u614b\uff1b\u800cTimeVault\u5c07\u7279\u5b9a\u6642\u9593\u5340\u6bb5\u5167\u7522\u751f\u7684RNA\u5c01\u5b58\u8d77\u4f86\uff0c\u9032\u4e00\u6b65\u8ffd\u8e64\u7d30\u80de\u72c0\u614b\u8b8a\u5316\u3001\u767c\u80b2\u6b77\u7a0b\u8207\u85e5\u7269\u53cd\u61c9\uff5c\u4f86\u6e90\uff1a\u53c3\u8003\u6587\u737b2<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>RNA\u96e3\u4ee5\u88ab\u4fdd\u5b58\u7684\u539f\u56e0<\/strong><\/span><\/h6>\n<p>RNA\u4e4b\u6240\u4ee5\u96e3\u4ee5\u88ab\u9577\u671f\u4fdd\u5b58\uff0c\u8207\u5b83\u7684\u5316\u5b78\u7279\u6027\u6709\u95dc\u3002\u76f8\u8f03\u65bcDNA\uff0cRNA\u5206\u5b50\u4e0a\u7684\u6838\u7cd6\u591a\u4e86\u4e00\u500b2\u2032-\u7fa5\u57fa (2\u2032-hydroxyl, 2\u2032-OH) \u7d50\u69cb\uff0c\u4f7f\u5176\u66f4\u5bb9\u6613\u767c\u751f\u6c34\u89e3\u53cd\u61c9\u3002\u6b64\u5916\uff0c\u7d30\u80de\u5167\u4e5f\u5b58\u5728\u5927\u91cf\u8ca0\u8cac\u5206\u89e3RNA\u7684\u6838\u9178\u9176\uff0c\u80fd\u8fc5\u901f\u6e05\u9664\u4e0d\u518d\u9700\u8981\u7684RNA\u5206\u5b50\u3002\u9019\u7a2e\u5feb\u901f\u751f\u6210\u8207\u964d\u89e3\u7684\u7279\u6027\uff0c\u8b93\u7d30\u80de\u80fd\u5920\u9748\u6d3b\u8abf\u63a7\u57fa\u56e0\u8868\u73fe\uff0c\u4f46\u4e5f\u4f7fRNA\u96e3\u4ee5\u4f5c\u70ba\u9577\u671f\u4fdd\u5b58\u7684\u5206\u5b50\u7d00\u9304\u3002\u56e0\u6b64\uff0c\u5373\u4f7f\u662f\u76ee\u524d\u5ee3\u6cdb\u4f7f\u7528\u7684\u55ae\u7d30\u80deRNA\u5b9a\u5e8f\uff0c\u672c\u8cea\u4e0a\u4ecd\u5c6c\u65bc\u7d42\u9ede\u6e2c\u91cf (endpoint measurement)\u3002\u7814\u7a76\u4eba\u54e1\u770b\u5230\u7684\u5f80\u5f80\u53ea\u662f\u7d30\u80de\u5728\u63a1\u6a23\u7576\u4e0b\u7684\u8f49\u9304\u9ad4\u5feb\u7167\uff0c\u800c\u975e\u7d30\u80de\u904e\u53bb\u4e00\u6bb5\u6642\u9593\u5167\u7684\u5b8c\u6574\u6b77\u7a0b\u3002\u82e5\u80fd\u5c07\u904e\u53bb\u7522\u751f\u7684RNA\u8a0a\u606f\u4fdd\u5b58\u4e0b\u4f86\uff0c\u79d1\u5b78\u5bb6\u4fbf\u6709\u6a5f\u6703\u76f4\u63a5\u8ffd\u8e64\u7d30\u80de\u66fe\u7d93\u6b77\u904e\u7684\u5206\u5b50\u4e8b\u4ef6\uff0c\u800c\u4e0d\u5fc5\u53ea\u80fd\u5f9e\u6700\u7d42\u7d50\u679c\u9032\u884c\u63a8\u6e2c\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>\u5c11\u88ab\u91cd\u8996\u7684\u7d30\u80de\u7d50\u69cb\uff1aVault\u7684\u518d\u767c\u73fe<\/strong><\/span><\/h6>\n<p>\u8981\u8b93\u8106\u5f31\u7684RNA\u9577\u6642\u9593\u4fdd\u5b58\u4e0b\u4f86\uff0c\u6700\u76f4\u63a5\u7684\u65b9\u6cd5\u5c31\u662f\u66ff\u5b83\u5efa\u7acb\u4e00\u9053\u4fdd\u8b77\u5c4f\u969c\uff0c\u4f7f\u5176\u514d\u53d7\u6838\u9178\u9176\u964d\u89e3\u3002TimeVault\u7684\u7814\u7a76\u5718\u968a\u4e26\u6c92\u6709\u4f7f\u7528\u5e38\u898b\u7684\u4eba\u5de5\u5948\u7c73\u8f09\u9ad4\uff0c\u800c\u662f\u5c07\u76ee\u5149\u6295\u5411\u7d30\u80de\u5167\u539f\u672c\u5c31\u5b58\u5728\u7684\u4e00\u7a2e\u7279\u6b8a\u7d50\u69cb\u2014\u2014Vault\u3002Vault\u6700\u65e9\u65bc1980\u5e74\u4ee3\u900f\u904e\u96fb\u5b50\u986f\u5fae\u93e1\u88ab\u767c\u73fe\uff0c\u662f\u5ee3\u6cdb\u5b58\u5728\u65bc\u771f\u6838\u7d30\u80de\u4e2d\u7684\u5927\u578b\u6838\u7cd6\u6838\u86cb\u767d\u8907\u5408\u9ad4 (ribonucleoprotein complex)\u3002\u5b83\u4e3b\u8981\u7531\u6578\u5341\u500bVault\u86cb\u767d (major vault protein, MVP) \u7d44\u88dd\u800c\u6210\uff0c\u5f62\u6210\u4e00\u500b\u4e2d\u7a7a\u7d50\u69cb\uff0c\u5176\u9ad4\u7a4d\u751a\u81f3\u6bd4\u6838\u7cd6\u9ad4\u9084\u5927\u4e0a\u6578\u500d\u3002\u6709\u8da3\u7684\u662f\uff0c\u5118\u7ba1Vault\u5728\u54fa\u4e73\u985e\u7d30\u80de\u4e2d\u76f8\u7576\u8c50\u5bcc\uff0c\u55ae\u4e00\u7d30\u80de\u5167\u53ef\u5b58\u5728\u6578\u842c\u81f3\u5341\u842c\u500b\u9846\u7c92\uff0c\u4e14\u5728\u6f14\u5316\u904e\u7a0b\u4e2d\u9ad8\u5ea6\u4fdd\u5b88\uff0c\u4f46\u79d1\u5b78\u5bb6\u81f3\u4eca\u4ecd\u672a\u5b8c\u5168\u7406\u89e3\u5b83\u7684\u751f\u7406\u529f\u80fd\u3002\u904e\u53bb\u66fe\u6709\u4eba\u63a8\u6e2c\u5b83\u53ef\u80fd\u53c3\u8207\u7d30\u80de\u5167\u7269\u8cea\u904b\u8f38\u6216\u764c\u7d30\u80de\u6297\u85e5\u6027\u7b49\u904e\u7a0b\uff0c\u4f46\u76f8\u95dc\u8b49\u64da\u59cb\u7d42\u6709\u9650\u3002\u6b63\u56e0\u5982\u6b64\uff0c\u9019\u500b\u9577\u671f\u88ab\u5ffd\u8996\u7684\u7d30\u80de\u7d50\u69cb\uff0c\u53cd\u800c\u6210\u70baTimeVault\u8a95\u751f\u7684\u91cd\u8981\u9748\u611f\u4f86\u6e90\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>TimeVault\u7684\u8a2d\u8a08\u539f\u7406\uff1a\u5c07Vault\u5316\u70ba\u6642\u5149\u81a0\u56ca<\/strong><\/span><\/h6>\n<p>\u5728TimeVault\u7cfb\u7d71\u4e2d\uff0c\u7814\u7a76\u4eba\u54e1\u5c07\u5929\u7136\u7684Vault\u9846\u7c92\u91cd\u65b0\u8a2d\u8a08\u6210RNA\u7684\u5132\u5b58\u88dd\u7f6e\u3002\u6574\u5957\u7cfb\u7d71\u4e3b\u8981\u7531\u5169\u500b\u5143\u4ef6\u7d44\u6210\uff1a\u4e00\u662f\u5f62\u6210Vault\u5916\u6bbc\u7684Vault\u86cb\u767d\uff0c\u53e6\u4e00\u500b\u5247\u662f\u7d93\u904e\u5de5\u7a0b\u6539\u9020\u3001\u80fd\u5920\u7d50\u5408RNA\u7684PABP-INT\u878d\u5408\u86cb\u767d\u3002\u7576\u9019\u5169\u7a2e\u5143\u4ef6\u5728\u7d30\u80de\u5167\u5171\u540c\u8868\u73fe\u6642\uff0c\u65b0\u7522\u751f\u7684RNA\u6703\u88ab\u62db\u52df\u81f3Vault\u9846\u7c92\u4e2d\uff0c\u4e26\u53d7\u5230\u5176\u86cb\u767d\u8cea\u5916\u6bbc\u7684\u4fdd\u8b77\u3002<\/p>\n<figure id=\"attachment_46551\" aria-describedby=\"caption-attachment-46551\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-46551\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/\u5716\u4e8c-1024x274.png\" alt=\"\" width=\"600\" height=\"161\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/\u5716\u4e8c-1024x274.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/\u5716\u4e8c-300x80.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/\u5716\u4e8c-768x205.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/\u5716\u4e8c.png 1170w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-46551\" class=\"wp-caption-text\">\u5716\u4e8c\uff1aTimeVault\u7684\u8a2d\u8a08\u539f\u7406\u3002\u5de5\u7a0b\u5316\u7684MVP\u8207PABP-INT\u86cb\u767d\u7d50\u5408\u65b0\u751f\u6210\u7684RNA\uff0c\u4e26\u81ea\u7d44\u88dd\u5f62\u6210TimeVault\u9846\u7c92\uff0c\u5c07RNA\u5c01\u5b58\u65bc\u5176\u4e2d\uff5c\u4f86\u6e90\uff1a\u53c3\u8003\u6587\u737b1<\/figcaption><\/figure>\n<p>\u9019\u7a2e\u4fdd\u8b77\u4f5c\u7528\u5927\u5e45\u5ef6\u9577\u4e86RNA\u7684\u4fdd\u5b58\u6642\u9593\u3002\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u539f\u672c\u5bb9\u6613\u964d\u89e3\u7684RNA\u5728\u88ab\u5c01\u5b58\u5f8c\uff0c\u7a69\u5b9a\u6027\u986f\u8457\u63d0\u5347\uff1b\u5373\u4f7f\u5728\u9ad4\u5916\u88c2\u89e3\u6db2\u74b0\u5883\u4e2d\u653e\u7f6e\u9577\u905412\u5929\uff0c\u4ecd\u80fd\u4fdd\u7559\u76f8\u7576\u6bd4\u4f8b\u7684RNA\u8a0a\u865f\u3002\u7136\u800c\uff0cTimeVault\u6700\u91cd\u8981\u7684\u5275\u65b0\u4e26\u4e0d\u53ea\u662f\u5ef6\u9577RNA\u58fd\u547d\uff0c\u800c\u662f\u63d0\u4f9b\u4e86\u4e00\u500b\u53ef\u63a7\u5236\u7684\u6642\u9593\u8a18\u9304\u7bc4\u570d (recording window)\u3002\u7814\u7a76\u5718\u968a\u5229\u7528doxycycline\u8abf\u63a7\u7cfb\u7d71\u63a7\u5236TimeVault\u7684\u555f\u52d5\u8207\u505c\u6b62\uff0c\u4f7f\u7814\u7a76\u4eba\u54e1\u80fd\u5920\u6307\u5b9a\u67d0\u6bb5\u6642\u9593\u4f5c\u70ba\u7d00\u9304\u5340\u9593\u3002\u5728\u9019\u6bb5\u671f\u9593\u5167\u7522\u751f\u7684RNA\u6703\u88ab\u6355\u6349\u4e26\u4fdd\u5b58\uff0c\u800c\u7d00\u9304\u95dc\u9589\u5f8c\u65b0\u751f\u6210\u7684RNA\u5247\u4e0d\u6703\u88ab\u7d0d\u5165\u7d00\u9304\u3002\u900f\u904e\u9019\u5957\u6a5f\u5236\uff0c\u7576\u7d30\u80de\u7d93\u6b77\u7f3a\u6c27\u3001\u71b1\u4f11\u514b\u6216\u85e5\u7269\u523a\u6fc0\u7b49\u4e8b\u4ef6\u6642\uff0c\u7576\u4e0b\u7522\u751f\u7684RNA\u8b8a\u5316\u80fd\u5920\u88abTimeVault\u4fdd\u7559\u4e0b\u4f86\uff0c\u4f7f\u7814\u7a76\u4eba\u54e1\u5f97\u4ee5\u5206\u6790\u5b83\u904e\u53bb\u7684\u5206\u5b50\u7279\u5fb5\u3002<\/p>\n<p>\u70ba\u4e86\u8b49\u660eTimeVault\u7684\u529f\u80fd\u6027\uff0c\u7814\u7a76\u5718\u968a\u5c07\u9019\u9805\u6280\u8853\u61c9\u7528\u65bc\u80ba\u764c\u7d30\u80de\u7684\u85e5\u7269\u8010\u53d7\u7814\u7a76\u3002\u5229\u7528TimeVault\u5728\u85e5\u7269\u8655\u7406\u524d\u5148\u8a18\u9304\u7d30\u80de\u7684\u8f49\u9304\u9ad4\u72c0\u614b\uff0c\u4e26\u5728\u6cbb\u7642\u5f8c\u627e\u51fa\u6700\u7d42\u5b58\u6d3b\u4e0b\u4f86\u7684\u7d30\u80de\uff0c\u518d\u56de\u982d\u8b80\u53d6\u5b83\u5011\u5148\u524d\u88ab\u4fdd\u5b58\u7684RNA\u8a0a\u606f\u3002\u7d50\u679c\u767c\u73fe\uff0c\u672a\u4f86\u6703\u6f14\u5316\u6210\u85e5\u7269\u8010\u53d7\u7d30\u80de\u7684\u65cf\u7fa4\uff0c\u5728\u63a5\u53d7\u6cbb\u7642\u4e4b\u524d\u5c31\u5df2\u7d93\u5177\u6709\u7279\u5b9a\u7684\u57fa\u56e0\u8868\u73fe\u7279\u5fb5\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5176\u4e2d\u8a31\u591a\u8a0a\u865f\u5728\u6cbb\u7642\u5f8c\u5df2\u7d93\u6d88\u5931\uff0c\u82e5\u50c5\u5206\u6790\u6700\u7d42\u5b58\u6d3b\u7684\u7d30\u80de\uff0c\u7814\u7a76\u4eba\u54e1\u5c07\u7121\u6cd5\u5bdf\u89ba\u9019\u4e9b\u5dee\u7570\u3002\u9019\u9805\u7d50\u679c\u986f\u793a\uff0c\u7d30\u80de\u7684\u672a\u4f86\u547d\u904b\u6709\u6642\u4e26\u975e\u5b8c\u5168\u7531\u5916\u754c\u523a\u6fc0\u6240\u6c7a\u5b9a\uff0c\u800c\u53ef\u80fd\u5728\u4e8b\u4ef6\u767c\u751f\u4e4b\u524d\u5c31\u5df2\u7d93\u57cb\u4e0b\u4f0f\u7b46\u3002\u900f\u904e\u4fdd\u5b58\u904e\u53bb\u7684\u8f49\u9304\u9ad4\u8cc7\u8a0a\uff0cTimeVault\u63d0\u4f9b\u4e86\u4e00\u7a2e\u76f4\u63a5\u89c0\u5bdf\u9019\u4e9b\u524d\u671f\u5206\u5b50\u8a0a\u865f\u7684\u65b0\u65b9\u6cd5\u3002<\/p>\n<p>TimeVault\u7684\u51fa\u73fe\uff0c\u8b93RNA\u5b9a\u5e8f\u4e0d\u518d\u53ea\u80fd\u53cd\u6620\u7d30\u80de\u88ab\u63a1\u6a23\u7576\u4e0b\u7684\u72c0\u614b\uff0c\u800c\u6709\u6a5f\u6703\u4fdd\u5b58\u4e26\u8b80\u53d6\u7d30\u80de\u904e\u53bb\u67d0\u6bb5\u6642\u9593\u5167\u7684\u5206\u5b50\u8cc7\u8a0a\u3002\u672a\u4f86\uff0c\u7121\u8ad6\u662f\u60f3\u63ea\u51fa\u764c\u7d30\u80de\u5982\u4f55\u6697\u4e2d\u6f14\u5316\u51fa\u6297\u85e5\u6027\uff0c\u9084\u662f\u8ffd\u8e64\u5e79\u7d30\u80de\u6c7a\u5b9a\u547d\u904b\u7684\u95dc\u9375\u77ac\u9593\uff0c\u79d1\u5b78\u5bb6\u90fd\u4e0d\u518d\u53ea\u662f\u5c0d\u6700\u7d42\u7684\u7d50\u679c\u63a8\u6e2c\uff0c\u800c\u662f\u80fd\u76f4\u63a5\u67e5\u770b\u7d30\u80de\u7684\u8a18\u61b6\uff0c\u770b\u770b\u5b83\u7a76\u7adf\u7d93\u6b77\u904e\u4ec0\u9ebc\u3002\u9019\u4efd\u80fd\u5920\u56de\u6eaf\u904e\u53bb\u7684\u80fd\u529b\uff0c\u6216\u8a31\u6b63\u662f\u6211\u5011\u672a\u4f86\u89e3\u6c7a\u8af8\u591a\u75be\u75c5\u7684\u95dc\u9375\u9470\u5319\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li>Chao, Y. K., Wu, M., Gong, Q., &amp; Chen, F. (2026). A genetically encoded device for transcriptome storage in mammalian cells. Science, eadz9353.<\/li>\n<li>Plummer, J. T. (2026). TimeVault: A molecular time machine for single cells. Molecular Cell, 86(6), 996-997.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>RNA\u80fd\u53cd\u6620\u7d30\u80de\u7576\u4e0b\u7684\u57fa\u56e0\u8868\u73fe\u72c0\u614b\uff0c\u56e0\u6b64\u88ab\u8996\u70ba\u7814\u7a76\u7d30\u80de\u6d3b\u52d5\u7684\u91cd\u8981\u4f9d\u64da\u3002\u7136\u800c\uff0c\u7531\u65bcRNA\u5bb9\u6613\u88ab\u964d\u89e3\uff0c\u50b3\u7d71RNA\u5b9a\u5e8f\u6280\u8853\u5f80\u5f80\u53ea\u80fd\u89c0\u5bdf\u7d30\u80de\u5728\u63a1\u6a23\u77ac\u9593\u7684\u5206\u5b50\u72c0\u614b\uff0c\u800c\u96e3\u4ee5\u8ffd\u8e64\u5176\u904e\u53bb\u7d93\u6b77\u30022026\u5e74\u767c\u8868\u65bc\u300aScience\u300b\u7684TimeVault\u6280\u8853\uff0c\u5229\u7528\u5de5\u7a0b\u5316Vault\u9846\u7c92\u5c01\u5b58\u7279\u5b9a\u6642\u9593\u5340\u6bb5\u5167\u7522\u751f\u7684RNA\uff0c\u8b93\u7814\u7a76\u4eba\u54e1\u5f97\u4ee5\u56de\u6eaf\u7d30\u80de\u904e\u53bb\u7684\u8f49\u9304\u9ad4\u8cc7\u8a0a\u3002\u9019\u9805\u6280\u8853\u70ba\u7814\u7a76\u764c\u75c7\u6297\u85e5\u6027\u3001\u5e79\u7d30\u80de\u5206\u5316\u8207\u7d30\u80de\u547d\u904b\u6c7a\u5b9a\u7b49\u554f\u984c\u63d0\u4f9b\u4e86\u65b0\u7684\u89c0\u5bdf\u8996\u89d2\u3002<\/p>\n","protected":false},"author":20,"featured_media":46553,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,3005,6512,2977,1025],"tags":[3148,7584,129],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/07\/52995449_MotionElements_a-glowing-green-rna-helix-structure-with-the-text-jpeg-scaled.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46550"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46550"}],"version-history":[{"count":2,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46550\/revisions"}],"predecessor-version":[{"id":46555,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46550\/revisions\/46555"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/46553"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}