{"id":46505,"date":"2026-06-18T17:00:51","date_gmt":"2026-06-18T09:00:51","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=46505"},"modified":"2026-06-23T09:37:17","modified_gmt":"2026-06-23T01:37:17","slug":"%e5%a4%9a%e8%ae%8a%e5%a4%9a%e5%b7%b4%e8%83%ba-%e7%ac%ac%e5%8d%81%e4%ba%8c%e9%83%a8%ef%bc%9a%e7%95%b6%e5%b7%a5%e4%bd%9c%e7%b4%b0%e8%83%9edan%e9%81%87%e8%a6%8b%e6%96%b0%e5%86%a0-2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=46505","title":{"rendered":"\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u5341\u4e8c\u90e8\uff1a\u7576\u5de5\u4f5c\u7d30\u80deDAN\u9047\u898b\u65b0\u51a0\uff08\u4e0b\uff09\u9023\u74b0\u653b\u64ca"},"content":{"rendered":"

\u4e0a\u6b21\u6211\u5011\u4e00\u6b65\u6b65\u5728\u65b0\u51a0\u5c0d\u300c\u5de5\u4f5c\u7d30\u80deDAN\u300d\u7684\u300a\u76f4\u63a5\u653b\u64ca\u300b\u7bc7\u4e2d\uff0c\u898b\u8b49\u79d1\u5b78\u5bb6\u5982\u4f55\u5229\u7528\u5c16\u7aef\u5e79\u7d30\u80de\u6280\u8853\uff0c\u6355\u6349\u5230\u75c5\u6bd2\u76f4\u63a5\u5165\u4fb5\u3001\u751a\u81f3\u6467\u6bc0\u9019\u4e9b\u95dc\u9375\u795e\u7d93\u5143\u7684\u78ba\u947f\u8b49\u64da\u3002\u9019\u6b21\uff0c\u5728\u300a\u9023\u74b0\u91cd\u64ca\u300b\u7bc7\u4e2d\uff0c\u6211\u5011\u5c07\u6df1\u5165\u63a2\u8a0e\u65b0\u51a0\u75c5\u6bd2\u66f4\u70ba\u9670\u96aa\u7684\u5f8c\u7e8c\u624b\u6bb5\u2014\u2014\u5b83\u5982\u4f55\u89f8\u767c\u300c\u5f37\u5236\u8001\u5316\u300d\u8207\u300c\u6bd2\u86cb\u767d\u5806\u7a4d\u300d\u9023\u9396\u53cd\u61c9\uff0c\u5c0d\u795e\u7d93\u7cfb\u7d71\u65bd\u4ee5\u6b98\u9177\u7684\u4e8c\u6b21\u91cd\u64ca\uff0c\u4ee5\u53ca\u63d0\u4f9b\u6700\u65b0\u7684\u65b0\u51a0\u5982\u4f55\u7cfb\u7d71\u6027\u5730\u6467\u6bc0\u795e\u7d93\u7684\u75c5\u7406\u6a5f\u5236\u5168\u666f\u8996\u89d2\u3002\u800c\u5728\u9019\u4e8c\u7bc7\u6587\u7ae0\uff0c\u6211\u5011\u4ee5\u4e09\u500b\u76f8\u95dc\u77e5\u8b58\u672c\u9ad4\u70ba\u89e3\u958b\u9019\u500b\u8b0e\u984c\uff0c\u63d0\u4f9b\u8b80\u8005\u4e00\u500b\u524d\u6240\u672a\u6709\u7684\u77e5\u8b58\u7cfb\u7d71\u67b6\u69cb\u57fa\u790e\u3002\u9019\u8d9f\u65c5\u7a0b\u4e0d\u50c5\u95dc\u4e4e\u4e00\u500b\u65b0\u8208\u75c5\u6bd2\uff0c\u66f4\u89f8\u53ca\u611f\u67d3\u3001\u767c\u708e\u8207\u5927\u8166\u9000\u5316\u4e4b\u9593\u8907\u96dc\u800c\u6df1\u523b\u7684\u806f\u7e6b\u3002\u73fe\u5728\uff0c\u5c31\u8b93\u6211\u5011\u4e00\u8d77\u8d70\u9032\u5be6\u9a57\u5ba4\uff0c\u63a2\u5c0b\u9019\u5834\u767c\u751f\u5728\u7d30\u80de\u5c64\u7d1a\u7684\u9a5a\u5fc3\u52d5\u9b44\u7684\u4ea4\u92d2\u3002<\/strong><\/span><\/p>\n

\u64b0\u6587\uff5cA. H.<\/strong><\/p>\n

\"\"
\u5716\u56db\uff1a\u65b0\u51a0\u5982\u4f55\u6298\u78e8\u5de5\u4f5c\u7d30\u80deDAN\u793a\u610f\u5716\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b\uff0fAI\u5354\u540c\u7e6a\u88fd<\/figcaption><\/figure>\n

\u4e0a\u4e00\u7bc7\u6211\u5011\u63ed\u9732\u4e86\u65b0\u51a0\u75c5\u6bd2\u80fd\u300c\u76f4\u63a5\u653b\u64ca\u300d\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff08\u5de5\u4f5c\u7d30\u80deDAN\uff09\u7684\u9a5a\u4eba\u8b49\u64da\u3002\u7136\u800c\uff0c\u9019\u5834\u5165\u4fb5\u50c5\u50c5\u662f\u707d\u96e3\u7684\u5e8f\u5e55\u3002\u75c5\u6bd2\u4e00\u65e6\u5f97\u624b\uff0c\u4fbf\u6703\u555f\u52d5\u4e00\u9023\u4e32\u6975\u5177\u7834\u58de\u6027\u7684\u9023\u9396\u53cd\u61c9\uff0c\u5c0d\u9019\u4e9b\u73cd\u8cb4\u7684\u795e\u7d93\u5143\u65bd\u4ee5\u6b98\u9177\u7684\u300c\u9023\u74b0\u91cd\u64ca\u300d\u3002\u65b0\u51a0\u75c5\u6bd2\u6703\u5f15\u767c\u6709\u5bb3\u7684\u7d1a\u806f\u53cd\u61c9\uff0c\u4f7f\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u9032\u5165\u7d30\u80de\u4e1f\u5931\u3001\u8870\u8001\u3001\u751a\u81f3\u6b7b\u4ea1\u72c0\u614b\u3002<\/p>\n

 <\/p>\n

\u7b2c\u4e00\u64ca\uff1a\u5f37\u5236\u8001\u5316\uff0c\u8b93\u5de5\u4f5c\u7d30\u80deDAN\u672a\u8001\u5148\u8870<\/strong><\/span><\/h6>\n

\u65b0\u51a0\u7684\u7b2c\u4e00\u62db\uff0c\u662f\u5c07\u5de5\u4f5c\u7d30\u80deDAN\u63a8\u5165\u300c\u7d30\u80de\u8001\u5316\u300d\u7684\u6df1\u6df5\u3002\u9019\u4e0d\u662f\u6211\u5011\u4e00\u822c\u7406\u89e3\u7684\u81ea\u7136\u8870\u8001\uff0c\u800c\u662f\u4e00\u7a2e\u300c\u904e\u65e9\u8870\u8001\u300d\u7684\u7d30\u80de\u58d3\u529b\u72c0\u614b\u3002\u5728\u9019\u7a2e\u72c0\u614b\u4e0b\uff0c\u7d30\u80de\u6703\u505c\u6b62\u5206\u88c2\uff0c\u4f46\u4e26\u4e0d\u6703\u6b7b\u53bb\uff0c\u53cd\u800c\u50cf\u4e00\u5ea7\u5931\u63a7\u7684\u5316\u5de5\u5ee0\uff0c\u4e0d\u65b7\u91cb\u653e\u51fa\u5927\u91cf\u6709\u5bb3\u7684\u767c\u708e\u4fe1\u865f\u3002\u5728\u5b78\u8853\u4e0a\u88ab\u7a31\u70ba\u300c\u8001\u5316\u76f8\u95dc\u5206\u6ccc\u8868\u578b\u300d(senescence-associated secretory phenotype, SASP)\u3002\u6839\u64da\u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928\u7684\u91ab\u5b78\u79d1\u76ee\u6a19\u984c (MeSH:D000089262<\/a>) \u5b9a\u7fa9\uff1a\u7531\u591a\u7a2e\u8001\u5316\u7d30\u80de\u4e2d\u5bcc\u542b\u767c\u708e\u3001\u86cb\u767d\u6c34\u89e3\u548c\u751f\u9577\u56e0\u5b50\u7684\u5206\u6ccc\u86cb\u767d\u7d44\u6240\u5f15\u8d77\uff0c\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\uff0c\u9019\u4e9b\u5206\u6ccc\u86cb\u767d\u7d44\u53ef\u5c0e\u81f4\u7d44\u7e54\u4fee\u5fa9\u6216\u7d44\u7e54\u548c\u5668\u5b98\u640d\u50b7\uff0c\u4e26\u5c07SASP\u8207\u5e74\u9f61\u76f8\u95dc\u75be\u75c5\u806f\u7e6b\u8d77\u4f86\uff08\u5716\u4e94\uff09\u3002<\/p>\n

\"\"
\u5716\u4e94\uff1a\u8001\u5316\u76f8\u95dc\u5206\u6ccc\u8868\u578b (SASP) \u7684MeSH\u77e5\u8b58\u6a39\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n

SASP\u5c31\u50cf\u662f\u4e00\u7fa4\u300c\u6bad\u5c4d\u7d30\u80de\u300d\u5728\u793e\u5340\u88e1\u56db\u8655\u6563\u64ad\u8ca0\u80fd\u91cf\uff0c\u4e0d\u50c5\u8b93\u81ea\u5df1\u751f\u75c5\uff0c\u9084\u6703\u62d6\u57ae\u5468\u570d\u5065\u5eb7\u7684\u9130\u5c45\u3002\u9577\u671f\u4e0b\u4f86\uff0c\u9019\u7a2e\u6301\u7e8c\u7684\u767c\u708e\u98a8\u66b4\u6703\u5c0e\u81f4\u7d44\u7e54\u640d\u50b7\uff0c\u4e26\u8207\u591a\u7a2e\u5e74\u9f61\u76f8\u95dc\u75be\u75c5\uff08\u5982\u5df4\u91d1\u68ee\u6c0f\u75c7\uff09\u7dca\u5bc6\u76f8\u9023\u3002Yang\u7b49\u4eba (2024) \u7684\u7814\u7a76\u8b49\u5be6\u4e86\u9019\u6050\u6016\u7684\u4e00\u5e55\u3002\u4ed6\u5011\u767c\u73fe\uff0c\u5be6\u9a57\u5ba4\u4e2d\u88ab\u65b0\u51a0\u611f\u67d3\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff0c\u4f9d\u64daSASP\u5206\u6790\uff0c\u7121\u4e00\u4f8b\u5916\u5730\u8868\u73fe\u51fa\u5178\u578b\u7684\u8001\u5316\u8de1\u8c61\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7576\u4ed6\u5011\u6aa2\u8996\u65b0\u51a0\u901d\u8005\u7684\u5927\u8166\u9ed1\u8cea\u7d44\u7e54\u6642\uff0c\u770b\u5230\u4e86\u5982\u51fa\u4e00\u8f4d\u7684\u666f\u8c61\uff1a\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u901d\u8005\u8166\u4e2d\u4e0d\u50c5\u5145\u6eff\u4e86\u767c\u708e\u8207\u7d30\u80de\u8001\u5316\u7684\u57fa\u56e0\u4fe1\u865f\uff0c\u5065\u5eb7\u7684\u300c\u5de5\u4f5c\u7d30\u80deDAN\u300d\u6578\u91cf\u4e5f\u986f\u8457\u6e1b\u5c11\u3002<\/p>\n

\u9019\u5834\u98a8\u66b4\u751a\u81f3\u8207\u907a\u50b3\u98a8\u96aa\u7522\u751f\u4e86\u53ef\u6015\u7684\u5354\u540c\u6548\u61c9\u3002\u7814\u7a76\u767c\u73fe\uff0c\u90a3\u4e9b\u672c\u8eab\u5c31\u5e36\u6709\u5df4\u91d1\u68ee\u6c0f\u75c7\u907a\u50b3\u98a8\u96aa\u57fa\u56e0\u7684\u795e\u7d93\u5143\uff0c\u5728\u611f\u67d3\u65b0\u51a0\u5f8c\uff0c\u8001\u5316\u7684\u8de1\u8c61\u66f4\u70ba\u56b4\u91cd\u3002\u8207\u6b64\u540c\u6642\uff0c\u8a72\u7814\u7a76\u91cf\u5316\u4e86\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u986f\u8457\u4e1f\u640d\u6578\u64da\u3002\u8207\u5e74\u9f61\u5339\u914d\u7684\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u65b0\u51a0\u60a3\u8005\u8166\u4e2d\u5065\u5eb7\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u5169\u500b\u95dc\u9375\u6307\u6a19\u5bc6\u5ea6\u5747\u964d\u4f4e\uff0c\u8868\u660e\u4e86\u65b0\u51a0\u91cd\u75c7\u75c5\u4f8b\u4e2d\uff0c\u591a\u5df4\u80fa\u7cfb\u7d71\u7522\u751f\u4e86\u660e\u986f\u7684\u9000\u5316\u5f71\u97ff\u3002\u5f77\u5f7f\u5728\u539f\u672c\u5c31\u8106\u5f31\u7684\u57fa\u790e\u4e0a\uff0c\u53c8\u6328\u4e86\u4e00\u8a18\u91cd\u62f3\uff08\u5716\u516d\uff09\u3002<\/p>\n

\"\"
\u5716\u516d\uff1a\u65b0\u51a0\u611f\u67d3\u5c0e\u81f4\u5de5\u4f5c\u7d30\u80de\u8870\u8001\u7684\u5be6\u9a57\u8b49\u660e\u793a\u610f\u5716\uff5c\u4f86\u6e90\uff1a\u6574\u5408Yang\u7b49\u4eba (2024) \u8207Eidhof\u7b49\u4eba (2024) \u5716\u5f62\u6458\u8981<\/figcaption><\/figure>\n

 <\/p>\n

\u7b2c\u4e8c\u64ca\uff1a\u6bd2\u86cb\u767d\u5806\u7a4d\uff0c\u52a0\u901f\u8d70\u5411\u7d30\u80de\u6b7b\u4ea1\u7684\u6700\u5f8c\u4e00\u6839\u7a3b\u8349<\/strong><\/span><\/h6>\n

\u5982\u679c\u8aaa\u300c\u5f37\u5236\u8001\u5316\u300d\u662f\u8b93\u5de5\u4f5c\u7d30\u80deDAN\u8b8a\u5f97\u865b\u5f31\uff0c\u90a3\u9ebc\u7b2c\u4e8c\u64ca\u5247\u662f\u5c07\u5b83\u5011\u63a8\u5411\u6b7b\u4ea1\u7684\u61f8\u5d16\u3002<\/p>\n

\u7531Lee\u7b49\u4eba (2024) \u9032\u884c\u7684\u7814\u7a76\uff0c\u805a\u7126\u65bcPD\u7684\u6a19\u8a8c\u6027\u75c5\u7406\uff1a\u03b1-\u7a81\u89f8\u6838\u86cb\u767d (alpha-synuclein) \u7684\u932f\u8aa4\u6298\u758a\u8207\u805a\u96c6\u3002\u6b63\u5e38\u60c5\u6cc1\u4e0b\uff0c\u9019\u7a2e\u86cb\u767d\u8cea\u5c0d\u795e\u7d93\u5143\u529f\u80fd\u81f3\u95dc\u91cd\u8981\uff1b\u53ef\u4e00\u65e6\u5b83\u300c\u8b8a\u58de\u300d\u3001\u932f\u8aa4\u6298\u758a\u4e26\u7d50\u6210\u5718\u584a\uff0c\u5c31\u6703\u50cf\u5783\u573e\u4e00\u6a23\u5835\u585e\u5728\u7d30\u80de\u5167\uff0c\u7522\u751f\u5287\u6bd2\uff0c\u6700\u7d42\u5c0e\u81f4\u7d30\u80de\u6b7b\u4ea1\u3002\u7814\u7a76\u5718\u968a\u900f\u904e\u4eba\u985e\u80da\u80ce\u5e79\u7d30\u80de\uff08\u5716\u4e8c\uff09\u57f9\u990a\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u53ca\u5c0f\u9f20\u6a21\u578b\u8b49\u660e\uff1a\u65b0\u51a0\u611f\u67d3\u6703\u986f\u8457\u52a0\u5287\u03b1-\u7a81\u89f8\u6838\u86cb\u767d\u7684\u78f7\u9178\u5316\u548c\u7570\u5e38\u805a\u96c6\u3002\u66f4\u7cdf\u7684\u662f\uff0c\u75c5\u6bd2\u9084\u6703\u4fc3\u4f7f\u9019\u4e9b\u300c\u6709\u6bd2\u86cb\u767d\u8cea\u300d\u5728\u795e\u7d93\u5143\u4e4b\u9593\u50b3\u905e\u3001\u64f4\u6563\uff0c\u5f15\u767c\u66f4\u5927\u7bc4\u570d\u7684\u7d30\u80de\u6b7b\u4ea1\uff0c\u5f9e\u800c\u52a0\u901f\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u75c5\u7a0b\uff0c\u5982\u5716\u4e03\u6240\u793a\u3002<\/p>\n

\"\"
\u5716\u4e03\uff1a\u611f\u67d3\u65b0\u51a0\u6703\u589e\u52a0hPFF\u8a98\u5c0e\u7684\u4eba\u985e\u591a\u5df4\u80fa\u795e\u7d93\u5143PD\u9032\u5c55\uff5c\u4f86\u6e90\uff1a\u6539\u7e6a\u81eaLee\u7b49\u4eba (2024) \u57161<\/figcaption><\/figure>\n

 <\/p>\n

\u5168\u666f\u8996\u89d2\uff1a\u65b0\u51a0\u5982\u4f55\u7cfb\u7d71\u6027\u5730\u6467\u6bc0\u795e\u7d93\uff1f<\/strong><\/span><\/h6>\n

\u7d9c\u5408\u4f86\u770b\uff0c\u65b0\u51a0\u75c5\u6bd2\u5c0d\u795e\u7d93\u7cfb\u7d71\u7684\u7834\u58de\u662f\u5168\u9762\u6027\u7684\u3002\u4e00\u7bc7\u7531Elechi\u7b49\u4eba (2025) \u767c\u8868\u7684\u7d9c\u8ff0\u7814\u7a76\uff0c\u70ba\u6211\u5011\u6b78\u7d0d\u4e86\u4e94\u5927\u6838\u5fc3\u75c5\u7406\u6a5f\u5236\uff0c\u63cf\u7e6a\u51fa\u4e00\u5e45\u5b8c\u6574\u7684\u4f5c\u6230\u5730\u5716\uff08\u8a3b1\uff09\uff1a<\/p>\n

    \n
  1. \u76f4\u63a5\u75c5\u6bd2\u6548\u61c9\uff1a<\/strong>\u65b0\u51a0\u900f\u904eACE2\u53d7\u9ad4\u76f4\u63a5\u5165\u4fb5\uff0c\u5c0d\u591a\u5df4\u80fa\u548c\u6d77\u99ac\u8ff4\u795e\u7d93\u5143\u9020\u6210\u50b7\u5bb3\u3002<\/li>\n
  2. \u795e\u7d93\u708e\u75c7\uff1a<\/strong>\u75c5\u6bd2\u6fc0\u6d3b\u5927\u8166\u4e2d\u7684\u514d\u75ab\u7d30\u80de\uff08\u5c0f\u81a0\u8cea\u7d30\u80de\u7b49\uff09\uff0c\u91cb\u653e\u5927\u91cf\u4fc3\u708e\u56e0\u5b50\uff0c\u6380\u8d77\u4e00\u5834\u300c\u795e\u7d93\u98a8\u66b4\u300d\uff0c\u52a0\u5287\u539f\u6709\u7684\u795e\u7d93\u9000\u5316\u3002<\/li>\n
  3. \u6c27\u5316\u61c9\u6fc0\uff1a<\/strong>\u75c5\u6bd2\u5c0e\u81f4\u7d30\u80de\u80fd\u91cf\u5de5\u5ee0\uff08\u7c92\u7dda\u9ad4\uff09\u529f\u80fd\u5931\u8abf\uff0c\u7522\u751f\u5927\u91cf\u6709\u5bb3\u7684\u6d3b\u6027\u6c27\uff0c\u8b93\u7d30\u80de\u5167\u90e8\u5982\u540c\u300c\u751f\u93fd\u300d\uff0c\u52a0\u901f\u86cb\u767d\u8cea\u805a\u96c6\u548c\u795e\u7d93\u5143\u640d\u5931\u3002<\/li>\n
  4. \u8840\u7ba1\u640d\u50b7\uff1a<\/strong>\u75c5\u6bd2\u653b\u64ca\u8840\u7ba1\u5167\u76ae\uff0c\u7834\u58de\u7cbe\u5bc6\u7684\u795e\u7d93\u300c\u8840\u8166\u5c4f\u969c\u300d(BBB)\uff0c\u8b93\u6709\u5bb3\u7269\u8cea\u548c\u767c\u708e\u7d30\u80de\u5f97\u4ee5\u9577\u9a45\u76f4\u5165\u3002<\/li>\n
  5. \u86cb\u767d\u8cea\u805a\u96c6\uff1a<\/strong>\u75c5\u6bd2\u5e72\u64fe\u5927\u8166\u6e05\u9664A\u03b2\u86cb\u767d\uff08\u963f\u8332\u6d77\u9ed8\u75c7\u76f8\u95dc\uff09\u548c\u03b1-\u7a81\u89f8\u6838\u86cb\u767d\uff08\u5df4\u91d1\u68ee\u6c0f\u75c7\u76f8\u95dc\uff09\u7b49\u300c\u5783\u573e\u86cb\u767d\u300d\u7684\u80fd\u529b\uff0c\u5c0e\u81f4\u6bd2\u7d20\u5806\u7a4d\uff0c\u52a0\u901f\u75c5\u60c5\u60e1\u5316\u3002<\/li>\n<\/ol>\n

    \u9019\u4e94\u5927\u6a5f\u5236\u4e92\u70ba\u56e0\u679c\u3001\u74b0\u74b0\u76f8\u6263\uff0c\u5171\u540c\u7de8\u7e54\u51fa\u4e00\u5f35\u6467\u6bc0\u795e\u7d93\u7cfb\u7d71\u7684\u6b7b\u4ea1\u4e4b\u7db2\u3002Elechi\u7b49\u4eba\u95e1\u8ff0\u65b0\u51a0\u8a98\u5c0e\u7684\u795e\u7d93\u708e\u75c7\u8207PD\u548c\u963f\u8332\u6d77\u9ed8\u75c7\u7b49\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u7684\u60e1\u5316\u6216\u767c\u4f5c\u9593\u5b58\u5728\u6f5b\u5728\u806f\u7e6b\uff0c\u540c\u6642\u5f37\u8abf\u795e\u7d93\u708e\u75c7\u75c5\u7406\u6a5f\u5236\u662f\u52a0\u5287\u795e\u7d93\u5143\u640d\u50b7\u7684\u95dc\u9375\uff0c\u5982\u5716\u516b\u3001\u5716\u4e5d\u6240\u793a\u3002\u5831\u544a\u7e3d\u7d50\u4e86\u60a3\u6709\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u7684\u65b0\u51a0\u60a3\u8005\u5728\u8a8d\u77e5\u548c\u904b\u52d5\u529f\u80fd\u969c\u7919\u7684\u81e8\u5e8a\u7814\u7a76\uff0c\u78ba\u5b9a\u4e86\u73fe\u6709\u77e5\u8b58\u7684\u5dee\u8ddd\uff0c\u4e26\u5f37\u8abf\u9032\u4e00\u6b65\u7814\u7a76\u4ee5\u95e1\u660e\u65b0\u51a0\u611f\u67d3\u5c0d\u9577\u671f\u795e\u7d93\u7cfb\u7d71\u9020\u6210\u5f8c\u679c\u7684\u5fc5\u8981\u6027\u3002<\/p>\n

     <\/p>\n

    \"\"
    \u5716\u516b\uff1a\u611f\u67d3\u65b0\u51a0\u5c0d\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u7684\u5f71\u97ff\u793a\u610f\u5716\uff5c\u4f86\u6e90\uff1a\u6574\u5408Elechi\u7b49\u4eba (2025) \u57161\u3001\u57162\u8207\u88681.\u95dc\u9375\u795e\u7d93\u708e\u75c7\u6a19\u8a8c\u7269<\/figcaption><\/figure>\n
      \n
    1. <\/li>\n<\/ol>\n
      \"\"
      \u5716\u4e5d\uff1a\u795e\u7d93\u708e\u75c7\u6a5f\u5236\u793a\u610f\u5716\uff5c\u4f86\u6e90\uff1a\u6574\u5408Elechi\u7b49\u4eba (2025) \u57161\u3001\u57162\u8207\u88681.\u95dc\u9375\u795e\u7d93\u708e\u75c7\u6a19\u8a8c\u7269<\/figcaption><\/figure>\n

       <\/p>\n

      \u7d50\u8a9e\uff1a\u5f9e\u63ed\u793a\u5a01\u8105\u5230\u5c0b\u627e\u5e0c\u671b<\/strong><\/p>\n

      \u5f9e\u300c\u76f4\u63a5\u653b\u64ca\u300d\u5230\u300c\u9023\u74b0\u91cd\u64ca\u300d\uff0c\u79d1\u5b78\u5bb6\u5011\u4e0d\u50c5\u63ed\u793a\u4e86\u65b0\u51a0\u75c5\u6bd2\u5c0d\u591a\u5df4\u80fa\u7cfb\u7d71\u7684\u6df1\u5c64\u5a01\u8105\uff0c\u4e5f\u70ba\u6211\u5011\u6307\u660e\u4e86\u6f5b\u5728\u7684\u6cbb\u7642\u65b9\u5411\u3002Yang\u5718\u968a\u5df2\u7be9\u9078\u51fa\u4e09\u7a2e\u80fd\u963b\u65b7\u65b0\u51a0\u611f\u67d3\u3001\u62ef\u6551\u795e\u7d93\u5143\u514d\u65bc\u8001\u5316\u7684\u85e5\u7269\uff1bLee\u5718\u968a\u5247\u767c\u73fe\uff0c\u6291\u5236\u7279\u5b9a\u767c\u708e\u53cd\u61c9\u7684\u85e5\u7269\u80fd\u6709\u6548\u4fdd\u8b77\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u3002\u6b63\u5982Elechi\u7b49\u4eba\u6240\u6307\u51fa\uff0c\u9019\u4e9b\u767c\u73fe\u8feb\u5207\u5730\u63d0\u9192\u6211\u5011\uff0c\u5fc5\u9808\u5c0d\u65b0\u51a0\u5eb7\u5fa9\u8005\u9032\u884c\u9577\u671f\u7684\u795e\u7d93\u7cfb\u7d71\u76e3\u6e2c\u3002\u90a3\u4e9b\u770b\u4e0d\u898b\u7684\u7d30\u80de\u640d\u50b7\uff0c\u53ef\u80fd\u5728\u591a\u5e74\u5f8c\u624d\u4ee5\u986b\u6296\u3001\u9072\u7de9\u7684\u5f62\u5f0f\u986f\u73fe\u3002<\/p>\n

      \u7576\u5927\u8166\u9ed1\u8cea\u5340\u7684\u300cGo\uff01\u300d\u8a0a\u865f\u56e0\u5de5\u4f5c\u7d30\u80deDAN\u7684\u8001\u5316\u8207\u6b7b\u4ea1\u800c\u65e5\u6f38\u5fae\u5f31\uff08\u8acb\u898b\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e5d\u90e8<\/a>\u300b\uff09\uff0c\u6211\u5011\u7684\u4e16\u754c\u4e5f\u5c07\u96a8\u4e4b\u505c\u6eef\u3002\u4eca\u65e5\uff0c\u65b0\u51a0\u5c0d\u591a\u5df4\u80fa\u5f71\u97ff\u7684\u79d1\u5b78\u4ecd\u5728\u6301\u7e8c\u63a2\u7d22\uff0c\u5982\u75c5\u6bd2\u611f\u67d3\u8207\u6182\u9b31\u75c7\u7684\u95dc\u4fc2\u3001\u9ed1\u8cea\u7d0b\u72c0\u9ad4\u591a\u5df4\u80fa\u8f49\u904b\u9ad4 (DAT) \u6d3b\u6027\u7570\u5e38\uff08\u8acb\u898b\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e03\u90e8<\/a>\u300b\uff09\uff0c\u6216COVID-19\u5c0e\u81f4PD\u76f8\u95dc\u85e5\u7269\u8207\u57fa\u56e0\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u5c0d\u591a\u5df4\u80fa\u53d7\u9ad4\u7684\u5f71\u97ff\uff08\u8acb\u898b\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u56db\u90e8<\/a>\u300b\uff09\uff0c\u6291\u6216\u662f\u9577\u65b0\u51a0 (Long COVID) \u7b49\u3002<\/p>\n

      \u56de\u9867\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u300b\u7cfb\u5217\uff0c\u6211\u5011\u59cb\u7d42\u81f4\u529b\u65bc\u300c\u4ee5\u77e5\u8b58\u672c\u9ad4\u9a45\u52d5\u79d1\u666e\u300d\u3002\u9019\u6b21\uff0c\u6211\u5011\u900f\u904ehPSC\u6280\u8853\uff08\u5716\u4e8c\u77e5\u8b58\u6a39\uff09\u63ed\u958b\u4e86\u7d30\u80de\u5c64\u9762\u7684\u7955\u5bc6\uff1b\u770b\u898b\u4e86\u8001\u5316\u76f8\u95dc\u5206\u6ccc\u8868\u578b (SASP) \u9019\u5834\u767c\u708e\u98a8\u66b4\uff08\u5716\u4e94\u77e5\u8b58\u6a39\uff09\uff1b\u6700\u5f8c\u518d\u85c9\u7531\u51a0\u72c0\u75c5\u6bd2\u50b3\u67d3\u75c5\u672c\u9ad4 (Ontology of Coronavirus Infectious Disease, CIDO)\uff0c\u4e86\u89e3\u4e86\u65b0\u51a0\u6703\u5f15\u8d77\u300c\u5668\u5b98\u7cfb\u7d71\u7279\u7570\u6027\u5f71\u97ff\u300d\u7684\u300c\u591a\u5df4\u80fa\u6d3b\u6027\u6539\u8b8a\u300d\uff08\u5716\u5341\u77e5\u8b58\u6a39\uff09\u3002\u9019\u4e09\u8005\u5171\u540c\u69cb\u6210\u4e86\u4e00\u4efd\u95dc\u9375\u7684\u77e5\u8b58\u5730\u5716\uff0c\u5c07\u65b0\u51a0\u75c5\u6bd2\u5982\u4f55\u5f15\u767c\u300c\u591a\u5df4\u80fa\u6d3b\u6027\u6539\u8b8a\u300d\u7684\u8907\u96dc\u904e\u7a0b\u7cfb\u7d71\u5316\uff0c\u70ba\u6211\u5011\u5728\u7406\u89e3\u548c\u61c9\u5c0d\u65b0\u51a0\u8207\u591a\u5df4\u80fa\u7684\u672a\u4f86\u6311\u6230\u4e2d\uff0c\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002\u79d1\u5b78\u7684\u63a2\u7d22\u4ecd\u5728\u7e7c\u7e8c\uff0c\u800c\u6bcf\u4e00\u6b21\u7684\u63ed\u793a\uff0c\u90fd\u662f\u70ba\u4e86\u5728\u9ed1\u6697\u4e2d\u9ede\u4eae\u4e00\u76de\u5e0c\u671b\u7684\u71c8\u3002<\/p>\n

      \"\"
      \u5716\u5341\uff1a\u51a0\u72c0\u75c5\u6bd2\u50b3\u67d3\u75c5\u672c\u9ad4 (CIDO) \u4e2d\uff0c\u300c\u591a\u5df4\u80fa\u6d3b\u6027\u6539\u8b8a\u300d\u77e5\u8b58\u6a39\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n

       <\/p>\n

      \n

      \u8a3b\u91cb<\/strong><\/p>\n

      \u8a3b\u4e00\uff1a\u4e3b\u8981\u540d\u8a5e\u4e2d\u82f1\u5c0d\u7167\uff1a<\/p>\n

        \n
      1. \u8840\u8166\u5c4f\u969c (blood-brain barrier, BBB)<\/li>\n
      2. \u76f4\u63a5\u75c5\u6bd2\u6548\u61c9 (direct viral effects)<\/li>\n
      3. \u795e\u7d93\u708e\u75c7 (neuroinflammation)\uff1a\u7531\u5c0f\u81a0\u8cea\u7d30\u80de\uff0f\u5c0f\u795e\u7d93\u81a0\u8cea\u7d30\u80de (microglia) \u548c\u661f\u5f62\u81a0\u8cea\u7d30\u80de (astrocytes) \u7684\u555f\u52d5\uff0c\u4ee5\u53ca\u4fc3\u708e\u7d30\u80de\u56e0\u6578\uff08\u5982IL-6\u3001TNF-\u03b1\u548cIL-1\u03b2\uff09\u7684\u91cb\u653e\u6240\u4ecb\u5c0e\u7684\u795e\u7d93\u708e\u75c7\uff0c\u65b0\u51a0\u611f\u67d3\u5f8c\u52a0\u5287\u4e86\u5148\u524d\u5b58\u5728\u7684\u795e\u7d93\u708e\u75c7\u72c0\u614b\u800c\u52a0\u901f\u795e\u7d93\u9000\u5316<\/li>\n
      4. \u6c27\u5316\u61c9\u6fc0 (oxidative stress)<\/li>\n
      5. \u7c92\u7dda\u9ad4\u529f\u80fd\u969c\u7919 (mitochondrial dysfunction)<\/li>\n
      6. \u8840\u7ba1\u640d\u50b7 (vascular damage)<\/li>\n
      7. \u8840\u8166\u5c4f\u969c\u529f\u80fd\u969c\u7919 (BBB dysfunction)\uff1a\u5167\u76ae\u640d\u50b7\u3001\u5fae\u8840\u6813\u3001BBB\u901a\u900f\u6027\u589e\u52a0\uff0c\u4fc3\u9032\u708e\u6027\u7d30\u80de\u6d78\u6f64\uff0c\u52a0\u5287\u795e\u7d93\u5143\u640d\u50b7<\/li>\n
      8. \u86cb\u767d\u8cea\u805a\u96c6(protein aggregation)<\/li>\n<\/ol>\n

         <\/p>\n

        \n

        \u53c3\u8003\u6587\u737b<\/strong><\/p>\n

          \n
        1. \u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928\u7684\u91ab\u5b78\u79d1\u76ee\u6a19\u984c\uff1a\u8001\u5316\u76f8\u95dc\u5206\u6ccc\u8868\u578b (SASP) MeSH:D000089262<\/a>\u3002<\/li>\n
        2. Lee, B., Choi, H. N., Che, Y. H., Ko, M., Seong, H. M., Jo, M. G., ... & Yun, S. P. (2024). SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson\u2019s disease in human dopaminergic neurons and a mouse model. Cell Reports Medicine, 5(5).<\/a><\/li>\n
        3. Elechi, K. W., Oyepeju Nkem, O., Timothy Chibueze, N., Elechi, U. S., & Franklin Chimaobi, K. (2025). Long-term Neurological Consequences of COVID-19 in Patients With Pre-existing Alzheimer\u2019s and Parkinson\u2019s Disease: A Comprehensive Review. Neuroscience Insights, 20, 26331055251342755.<\/a><\/li>\n
        4. Park, E. S., Shin, C. Y., Jeon, S. J., & Ham, B. J. (2024). Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine. Biomolecules & Therapeutics, 32(6), 659.<\/a><\/li>\n
        5. Nwabufo, C. K. (2025). COVID-19 Alters Inflammatory, Mitochondrial, and Protein Clearance Pathway Genes: Potential Implications for New-onset Parkinsonism in Patients. Journal of Neuroimmune Pharmacology, 20(1), 1-17.<\/a><\/li>\n
        6. Hadidchi, R., Al\u2010Ani, Y., Piskun, H., Pakan, R., Duong, K. S., Jamil, H., ... & Duong, T. Q. (2025). Impact of COVID\u201019 on long\u2010term outcomes in Parkinson's disease. European Journal of Neurology, 32(5), e70013.<\/a><\/li>\n
        7. He, Y., Yu, H., Ong, E., Wang, Y., Liu, Y., Huffman, A., ... & Smith, B. (2020). CIDO, a community-based ontology for coronavirus disease knowledge and data integration, sharing, and analysis. Scientific data, 7(1), 181.<\/a><\/li>\n<\/ol>\n

           <\/p>\n

          \u2728\u5ef6\u4f38\u95b1\u8b80\uff1a\u300a\u591a\u8b8a\u591a\u5df4\u80fa<\/a>\u300b\u5168\u7cfb\u5217\u6587\u7ae0<\/p>\n","protected":false},"excerpt":{"rendered":"

          \u4e0a\u6b21\u6211\u5011\u4e00\u6b65\u6b65\u5728\u65b0\u51a0\u5c0d\u300c\u5de5\u4f5c\u7d30\u80deDAN\u300d\u7684\u300a\u76f4\u63a5\u653b\u64ca\u300b\u7bc7\u4e2d\uff0c\u898b\u8b49\u79d1\u5b78\u5bb6\u5982\u4f55\u5229\u7528\u5c16\u7aef\u5e79\u7d30\u80de\u6280\u8853\uff0c\u6355\u6349\u5230\u75c5\u6bd2\u76f4\u63a5\u5165\u4fb5\u3001\u751a\u81f3\u6467\u6bc0\u9019\u4e9b\u95dc\u9375\u795e\u7d93\u5143\u7684\u78ba\u947f\u8b49\u64da\u3002\u9019\u6b21\uff0c\u5728\u300a\u9023\u74b0\u91cd\u64ca\u300b\u7bc7\u4e2d\uff0c\u6211\u5011\u5c07\u6df1\u5165\u63a2\u8a0e\u65b0\u51a0\u75c5\u6bd2\u66f4\u70ba\u9670\u96aa\u7684\u5f8c\u7e8c\u624b\u6bb5\u2014\u2014\u5b83\u5982\u4f55\u89f8\u767c\u300c\u5f37\u5236\u8001\u5316\u300d\u8207\u300c\u6bd2\u86cb\u767d\u5806\u7a4d\u300d\u9023\u9396\u53cd\u61c9\uff0c\u5c0d\u795e\u7d93\u7cfb\u7d71\u65bd\u4ee5\u6b98\u9177\u7684\u4e8c\u6b21\u91cd\u64ca\uff0c\u4ee5\u53ca\u63d0\u4f9b\u6700\u65b0\u7684\u65b0\u51a0\u5982\u4f55\u7cfb\u7d71\u6027\u5730\u6467\u6bc0\u795e\u7d93\u7684\u75c5\u7406\u6a5f\u5236\u5168\u666f\u8996\u89d2\u3002\u800c\u5728\u9019\u4e8c\u7bc7\u6587\u7ae0\uff0c\u6211\u5011\u4ee5\u4e09\u500b\u76f8\u95dc\u77e5\u8b58\u672c\u9ad4\u70ba\u89e3\u958b\u9019\u500b\u8b0e\u984c\uff0c\u63d0\u4f9b\u8b80\u8005\u4e00\u500b\u524d\u6240\u672a\u6709\u7684\u77e5\u8b58\u7cfb\u7d71\u67b6\u69cb\u57fa\u790e\u3002\u9019\u8d9f\u65c5\u7a0b\u4e0d\u50c5\u95dc\u4e4e\u4e00\u500b\u65b0\u8208\u75c5\u6bd2\uff0c\u66f4\u89f8\u53ca\u611f\u67d3\u3001\u767c\u708e\u8207\u5927\u8166\u9000\u5316\u4e4b\u9593\u8907\u96dc\u800c\u6df1\u523b\u7684\u806f\u7e6b\u3002\u73fe\u5728\uff0c\u5c31\u8b93\u6211\u5011\u4e00\u8d77\u8d70\u9032\u5be6\u9a57\u5ba4\uff0c\u63a2\u5c0b\u9019\u5834\u767c\u751f\u5728\u7d30\u80de\u5c64\u7d1a\u7684\u9a5a\u5fc3\u52d5\u9b44\u7684\u4ea4\u92d2\u3002<\/p>\n","protected":false},"author":20,"featured_media":46512,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7498,257,3293,3005,1025],"tags":[2412,4694,5411],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/06\/SARS_DA_4.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46505"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46505"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46505\/revisions"}],"predecessor-version":[{"id":46519,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46505\/revisions\/46519"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/46512"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46505"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46505"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}