{"id":46400,"date":"2026-05-14T17:00:43","date_gmt":"2026-05-14T09:00:43","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=46400"},"modified":"2026-05-14T17:08:45","modified_gmt":"2026-05-14T09:08:45","slug":"%e5%a4%9a%e8%ae%8a%e5%a4%9a%e5%b7%b4%e8%83%ba-%e7%ac%ac%e5%8d%81%e4%ba%8c%e9%83%a8%ef%bc%9a%e7%95%b6%e5%b7%a5%e4%bd%9c%e7%b4%b0%e8%83%9edan%e9%81%87%e8%a6%8b%e6%96%b0%e5%86%a0","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=46400","title":{"rendered":"\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u5341\u4e8c\u90e8\uff1a\u7576\u5de5\u4f5c\u7d30\u80deDAN\u9047\u898b\u65b0\u51a0\uff08\u4e0a\uff09\u76f4\u63a5\u653b\u64ca"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>COVID-19\u60a3\u8005\u7d93\u5e38\u8868\u73fe\u51fa\u795e\u7d93\u7cfb\u7d71\u529f\u80fd\u969c\u7919\uff0c\u8868\u660e\u4e86\u65b0\u51a0\u75c5\u6bd2(SARS-CoV-2)\u5c0d\u795e\u7d93\u7d30\u80de\u6709\u5f71\u97ff\u3002\u745e\u5178\u795e\u7d93\u751f\u7406\u79d1\u5b78\u5bb6\u751a\u81f3\u4f7f\u7528\u300c\u65b0\u51a0\u75c5\u6bd2\u5982\u4f55\u6298\u78e8\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u300d\u4f5c\u70ba\u7814\u7a76\u526f\u6a19\uff0c\u4f86\u5f37\u8abf\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff0c\u4e5f\u5c31\u662f\u6211\u5011\u6240\u8aaa\u7684\u300c\u5de5\u4f5c\u7d30\u80deDAN\u300d\uff0c\u5728\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u5f8c\u5f15\u767c\u708e\u75c7\u548c\u8870\u8001\u7684\u72c0\u614b\u3002\u5728\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u300b\u7cfb\u5217\u6587\u7ae0\u7684\u6700\u5f8c\u4e00\u90e8\uff0c\u5c31\u8b93\u6211\u5011\u4f86\u804a\u804a\u9019\u500b\u8fd1\u4e94\u5e74\u6d3b\u8e8d\u5728\u5730\u7403\u7684\u547c\u5438\u9053\u75c5\u6bd2\uff0c\u5982\u4f55\u8d85\u8d8a\u80ba\u90e8\u8207\u547c\u5438\u7cfb\u7d71\u7684\u50b7\u5bb3\uff0c\u91cd\u65b0\u601d\u8003\u9019\u7a2e\u72e1\u733e\u7684\u75c5\u6bd2\u662f\u600e\u6a23\u5c0d\u5927\u8166\u3001\u5c0d\u5de5\u4f5c\u7d30\u80deDAN\u9020\u6210\u5f71\u97ff\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5cA. H.<\/strong><\/p>\n<figure id=\"attachment_46403\" aria-describedby=\"caption-attachment-46403\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-46403\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_1-1024x576.png\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_1-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_1-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_1-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_1.png 1280w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-46403\" class=\"wp-caption-text\">\u5716\u4e00\uff1a\u65b0\u51a0\u75c5\u6bd2\u5982\u4f55\u6298\u78e8\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u793a\u610f\u5716\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b\uff0fAI\u5354\u540c\u88fd\u5716<\/figcaption><\/figure>\n<p>\u4e00\u5834\u5e2d\u6372\u5168\u7403\u7684COVID-19\u5927\u6d41\u884c\uff0c\u7559\u4e0b\u7684\u4e0d\u53ea\u662f\u54b3\u55fd\u8207\u767c\u71d2\u3002\u8a31\u591a\u5eb7\u5fa9\u8005\u56de\u5831\u4e86\u4ee4\u4eba\u4e0d\u5b89\u7684\u5f8c\u907a\u75c7\uff1a\u8166\u9727\u3001\u8a8d\u77e5\u529b\u4e0b\u964d\u3001\u904b\u52d5\u9072\u7de9\u7b49\u9019\u4e9b\u63ee\u4e4b\u4e0d\u53bb\u7684\u9670\u5f71\uff0c\u662f\u5426\u6697\u793a\u8457\u65b0\u51a0\u75c5\u6bd2\u6084\u6084\u5730\u5728\u6211\u5011\u7684\u5927\u8166\u4e2d\u57cb\u4e0b\u4e86\u65b0\u7684\u5a01\u8105\uff1f\u9019\u5834\u98a8\u66b4\uff0c\u8207\u6211\u5011\u5927\u8166\u4e2d\u52e4\u596e\u7684\u300c\u5de5\u4f5c\u7d30\u80deDAN\u300d\uff08\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff09\u4e4b\u9593\uff0c\u7a76\u7adf\u4e0a\u6f14\u4e86\u4f55\u7a2e\u9a5a\u5fc3\u52d5\u9b44\u7684\u4ea4\u92d2\uff1f<\/p>\n<p>\u65e9\u5728\u75ab\u60c5\u521d\u671f\uff0c\u79d1\u5b78\u5bb6\u5c31\u61f7\u7591\u65b0\u51a0\u75c5\u6bd2\u7684\u9b54\u722a\u53ef\u80fd\u4f38\u5411\u4e86\u6211\u5011\u795e\u7d93\u7cfb\u7d71\u7684\u6df1\u8655\u3002\u6709\u7406\u8ad6\u63a8\u6e2c\uff0c\u591a\u5df4\u80fa\u5408\u6210\u9014\u5f91\u7684\u6539\u8b8a\u53ef\u80fd\u53c3\u8207\u65b0\u51a0\u80ba\u708e\u7684\u75c5\u7406\u751f\u7406\u5b78\uff0c\u75c5\u6bd2\u86cb\u767d\u53ef\u80fd\u6703\u6a21\u4eff\u795e\u7d93\u5143\u6e9d\u901a\u7684\u95dc\u9375\u89d2\u8272\uff08\u65b0\u51a0\u75c5\u6bd2\u86cb\u767d\u4e5f\u985e\u4f3c\u7a81\u89f8\u56ca\u6ce1\u8ff4\u5708\u7684\u91cd\u8981\u86cb\u767d\u8cea\uff09\uff0c\u751a\u81f3\u76f4\u63a5\u5165\u4fb5\u4e14\u7e41\u6b96\u3002\u5982\u4eca\uff0c\u65b0\u8208\u7814\u7a76\u4e0d\u518d\u53ea\u662f\u731c\u6e2c\uff0c\u800c\u662f\u660e\u78ba\u6307\u51fa\uff1a\u65b0\u51a0\u75c5\u6bd2\u6b63\u626e\u6f14\u8457\u4e00\u500b\u52a0\u901f\u5e15\u91d1\u68ee\u6c0f\u75c7 (Parkinson\u2019s Disease, PD) \u75c5\u7a0b\u7684\u6f5b\u4f0f\u89d2\u8272\u3002\u5b83\u767c\u52d5\u4e86\u4e00\u5834\u591a\u7ba1\u9f4a\u4e0b\u7684\u731b\u653b\uff0c\u5c0d\u672c\u5c31\u8106\u5f31\u7684\u591a\u5df4\u80fa\u7cfb\u7d71\u9020\u6210\u4e86\u5be6\u8cea\u640d\u5bb3\u3002<\/p>\n<p>\u7136\u800c\uff0c\u75c5\u6bd2\u7a76\u7adf\u80fd\u5426\u300c\u76f4\u63a5\u300d\u611f\u67d3\u8166\u7d30\u80de\uff1f\u9019\u500b\u554f\u984c\u4e00\u76f4\u662f\u79d1\u5b78\u754c\u722d\u8ad6\u7684\u7126\u9ede\u3002\u70ba\u4e86\u627e\u51fa\u78ba\u5207\u7b54\u6848\uff0c Yang\u7b49\u4eba (2024) \u6240\u767c\u8868\u7684\u7814\u7a76\u5229\u7528\u4e00\u9805\u5f37\u5927\u7684\u751f\u7269\u6280\u8853\uff0c\u7d66\u51fa\u4e86\u6c7a\u5b9a\u6027\u7684\u8b49\u64da\u3002\u4ed6\u5011\u4f7f\u7528\u7684\u7955\u5bc6\u6b66\u5668\u662f\u4eba\u985e\u591a\u529f\u80fd\u5e79\u7d30\u80de (human pluripotent stem cell, hPSC)\uff0c\u6210\u529f\u5728\u5be6\u9a57\u5ba4\u4e2d\u57f9\u990a\u51fa\u4eba\u985e\u7684\u4e2d\u8166\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff0c\u4e0a\u6f14\u4e86\u4e00\u5834\u300c\u75c5\u6bd2\u8207\u795e\u7d93\u5143\u300d\u7684\u6b63\u9762\u5c0d\u6c7a\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #ffcc00;\"><strong>\u89e3\u5bc6\u5de5\u5177\uff1ahPSC\u8b8a\u8eab\u70ba\u4efb\u4f55\u7d30\u80de\u7684\u300c\u5927\u5e2b\u300d<\/strong><\/span><\/h6>\n<p>\u5728\u6df1\u5165\u63a2\u8a0e\u9019\u5834\u5c0d\u6c7a\u524d\uff0c\u6211\u5011\u5148\u4f86\u8a8d\u8b58\u4e00\u4e0b\u9019\u500b\u95dc\u9375\u7684\u7814\u7a76\u5de5\u5177\uff1a\u4eba\u985e\u591a\u529f\u80fd\u5e79\u7d30\u80de (hPSC)\u3002hPSC\u5c31\u50cf\u7d30\u80de\u754c\u7684\u300c\u842c\u7528\u7a4d\u6728\u300d\u6216\u300c\u5927\u5e2b\u7d1a\u5e79\u7d30\u80de\u300d\uff0c\u5b83\u64c1\u6709\u8fd1\u4e4e\u7121\u9650\u7684\u300c\u81ea\u6211\u66f4\u65b0\u300d\u80fd\u529b\uff0c\u53ef\u4ee5\u5206\u5316\u3001\u8b8a\u8eab\u70ba\u4eba\u9ad4\u4e2d\u5e7e\u4e4e\u4efb\u4f55\u4e00\u7a2e\u7d30\u80de\uff0c\u5176\u4e2d\u7576\u7136\u4e5f\u5305\u62ec\u6211\u5011\u9019\u6b21\u7684\u4e3b\u89d2\u2014\u2014\u5de5\u4f5c\u7d30\u80deDAN\u3002\u9019\u9805\u6280\u8853\u61c9\u7528\u5728\u591a\u5df4\u80fa\u7814\u7a76\u7684\u50f9\u503c\u5728\u65bc\uff1a<\/p>\n<ul>\n<li><strong>\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u751f\u6210\uff1a<\/strong>hPSC\u53ef\u5206\u5316\u7522\u751f\u591a\u5df4\u80fa\u7684\u795e\u7d93\u5143\uff0c\u9019\u5c0d\u65bc\u7814\u7a76\u548c\u53ef\u80fd\u6cbb\u7642\u5e15\u91d1\u68ee\u6c0f\u75c7 (PD) \u7b49\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u81f3\u95dc\u91cd\u8981\u3002\u76ee\u524d\u5df2\u6210\u529f\u5730\u5f9ehPSC\u4e2d\u57f9\u80b2\u4e86\u4e2d\u8166\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff0c\u9019\u4e9b\u795e\u7d93\u5143\u53ef\u8868\u73fe\u51fa\u591a\u5df4\u80fa\u5408\u6210\u3001\u91cb\u653e\u548c\u518d\u651d\u53d6\u7b49\u529f\u80fd\u3002<\/li>\n<li><strong>\u75be\u75c5\u5efa\u6a21\uff1a<\/strong>\u901a\u904e\u5f9ehPSC\u5275\u5efa\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff0c\u79d1\u5b78\u5bb6\u53ef\u5728\u9ad4\u5916\u5c0dPD\u7b49\u75be\u75c5\u9032\u884c\u5efa\u6a21\uff0c\u56e0\u6b64\u6709\u52a9\u65bc\u79d1\u5b78\u5bb6\u66f4\u597d\u5730\u77ad\u89e3\u75be\u75c5\u6a5f\u5236\u548c\u958b\u767c\u65b0\u7684\u6cbb\u7642\u7b56\u7565\u3002<\/li>\n<li><strong>\u518d\u751f\u91ab\u5b78\uff1a<\/strong>hPSC\u884d\u751f\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u6709\u671b\u5728\u7522\u751f\u591a\u5df4\u80fa\u7684\u795e\u7d93\u5143\u4e1f\u5931\u60c5\u6cc1\u4e0b\uff08\u5982PD\u7b49\u75be\u75c5\uff09\u9032\u884c\u7d30\u80de\u66ff\u4ee3\u7642\u6cd5\uff0c\u5c07\u9019\u4e9b\u795e\u7d93\u5143\u79fb\u690d\u5230\u60a3\u8005\u9ad4\u5167\uff0c\u6062\u5fa9\u591a\u5df4\u80fa\u6c34\u5e73\u4e26\u7de9\u89e3\u75c7\u72c0\u3002<\/li>\n<li><strong>\u591a\u5df4\u80fa\u8a0a\u865f\u50b3\u5c0e\u7814\u7a76\uff1a<\/strong>\u7814\u7a76\u8868\u660e\uff0c\u591a\u5df4\u80fa\u8a0a\u865f\u50b3\u5c0e\u5728\u8abf\u7bc0\u5404\u7a2e\u5e79\u7d30\u80de\uff08\u5305\u62echPSC\uff09\u7684\u529f\u80fd\u4e2d\u767c\u63ee\u4f5c\u7528\uff0c\u77ad\u89e3\u9019\u4e9b\u76f8\u4e92\u4f5c\u7528\u6709\u52a9\u65bc\u958b\u767c\u708e\u75c7\u548c\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u65b0\u7642\u6cd5\u3002<\/li>\n<\/ul>\n<p>\u6b63\u662f\u56e0\u70bahPSC\u64c1\u6709\u9019\u4e9b\u5f37\u5927\u7684\u7279\u6027\uff0cYang\u5718\u968a\u624d\u5f97\u4ee5\u5728\u5be6\u9a57\u5ba4\u4e2d\uff0c\u7cbe\u6e96\u5730\u89c0\u5bdf\u65b0\u51a0\u75c5\u6bd2\u5c0d\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u76f4\u63a5\u5f71\u97ff\u3002\u82e5\u6839\u64da\u5fb7\u570b\u5e03\u502b\u745e\u514b\u5de5\u696d\u5927\u5b78\u751f\u7269\u8cc7\u8a0a\u8207\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u7814\u7a76\u4eba\u54e1\u5275\u5efa\u7684BRENDA\u7d44\u7e54\u672c\u9ad4 (The BRENDA Tissue Ontology, BTO)\uff0chPSC\u5305\u62ec\u4eba\u985e\u80da\u80ce\u5e79\u7d30\u80de (human embryonic stem cell, hESC) \u548c\u4eba\u985e\u8a98\u5c0e\u578b\u591a\u529f\u80fd\u5e79\u7d30\u80de (human induced pluripotent stem cell, hiPSC)\u3002\u5b83\u53ef\u4ee5\u5728\u57f9\u990a\u7269\u4e2d\u7121\u9650\u5730\u81ea\u6211\u66f4\u65b0\uff0c\u540c\u6642\u4fdd\u6301\u80fd\u5920\u5206\u5316\u6210\u4eba\u9ad4\u4e2d\u5e7e\u4e4e\u4efb\u4f55\u7d30\u80de\u985e\u578b\u7684\u529f\u80fd\u3002\u7531\u5716\u4e8c\u53ef\u77e5\uff0chPSC\u662f\u591a\u529f\u80fd\u5e79\u7d30\u80de\u7684\u5b50\u985e\uff0c\u548c\u6210\u9ad4\u5e79\u7d30\u80de\u8207\u80da\u80ce\u5e79\u7d30\u80de\u662f\u5144\u5f1f\u59ca\u59b9\u3002<\/p>\n<figure id=\"attachment_46401\" aria-describedby=\"caption-attachment-46401\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-46401\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_2-1024x576.png\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_2-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_2-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_2-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_2.png 1280w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-46401\" class=\"wp-caption-text\">\u5716\u4e8c\uff1aBRENDA\u7d44\u7e54\u672c\u9ad4\u4e2dhPSC\u77e5\u8b58\u6a39\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #ffcc00;\"><strong>\u5be6\u9a57\u5ba4\u76f4\u64ca\uff1a\u65b0\u51a0\u5c0d\u5de5\u4f5c\u7d30\u80deDAN\u7684\u300c\u7cbe\u6e96\u6253\u64ca\u300d<\/strong><\/span><\/h6>\n<p>Yang\u5718\u968a\u7684\u5be6\u9a57\u8a2d\u8a08\u76f8\u7576\u5de7\u5999\u3002\u4ed6\u5011\u5c07\u5be6\u9a57\u5ba4\u57f9\u990a\u51fa\u7684\u300c\u5de5\u4f5c\u7d30\u80deDAN\u300d\u66b4\u9732\u5728\u65b0\u51a0\u75c5\u6bd2\u7684\u74b0\u5883\u4e2d\u3002\u7d50\u679c\u5982\u4f55\uff1f\u900f\u904e\u5148\u9032\u7684\u55ae\u7d30\u80deRNA\u5b9a\u5e8f (scRNAseq) \u6280\u8853\uff0c\u4ed6\u5011\u767c\u73fe\u65b0\u51a0\u4e0d\u50c5\u6210\u529f\u611f\u67d3\u4e86\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff0c\u9084\u5728\u5176\u4e2d\u5927\u91cf\u8907\u88fd\uff0c\u7522\u751f\u4e86\u65b0\u75c5\u6bd2\u3002\u96fb\u5b50\u986f\u5fae\u93e1\u751a\u81f3\u6355\u6349\u5230\u4e86\u75c5\u6bd2\u9846\u7c92\u585e\u6eff\u795e\u7d93\u5143\u5167\u90e8\u7684\u72c0\u6cc1\u3002\u66f4\u95dc\u9375\u7684\u662f\uff0c\u9019\u5834\u653b\u64ca\u5177\u6709\u9ad8\u5ea6\u9078\u64c7\u6027\u3002\u5728\u540c\u6a23\u7684\u689d\u4ef6\u4e0b\uff0c\u5927\u8166\u76ae\u8cea\u795e\u7d93\u5143 (cortex neuron) \u537b\u80fd\u5b89\u7136\u7121\u6059\uff0c\u9019\u529b\u8b49\u4e86\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u5b58\u5728\u8457\u7279\u5b9a\u7684\u300c\u8106\u5f31\u6027\u300d\u3002\u7814\u7a76\u9032\u4e00\u6b65\u9396\u5b9a\uff0c\u5927\u8166\u9ed1\u8cea\u5340\u57df\u6700\u5bb9\u6613\u53d7\u5230\u611f\u67d3\u7684\u7d30\u80de\u7a2e\u985e\u70ba\u300cA9\u578b\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u300d(A9-DA neuron)\uff0c\u9019\u8207\u5e15\u91d1\u68ee\u6c0f\u75c7\u60a3\u8005\u8166\u4e2d\u53d7\u640d\u6700\u56b4\u91cd\u7684\u7d30\u80de\u985e\u578b\u4e0d\u8b00\u800c\u5408\uff0c\u985e\u4f3c\u65bcPD\u60a3\u8005\u4e2d\u53d7\u5f71\u97ff\u6700\u56b4\u91cd\u7684\u9ed1\u8ceaA9\u795e\u7d93\u5143\u7684\u8106\u5f31\u6027\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #ffcc00;\"><strong>\u771f\u5be6\u4e16\u754c\u7684\u8b49\u64da\uff1a\u4f86\u81ea\u901d\u8005\u5927\u8166\u7684\u8b66\u8a0a<\/strong><\/span><\/h6>\n<p>\u5be6\u9a57\u5ba4\u7684\u767c\u73fe\u56fa\u7136\u9a5a\u4eba\uff0c\u4f46\u771f\u5be6\u4eba\u9ad4\u5167\u4e5f\u662f\u5982\u6b64\u55ce\uff1f\u7814\u7a76\u5718\u968a\u5206\u6790\u4e866\u540d\u65b0\u51a0\u901d\u8005\u82073\u540d\u5c0d\u7167\u7d44\u7684\u5927\u8166\u9ed1\u8cea\u6a23\u672c\uff0c\u7d50\u679c\u767c\u73fe\u5728\u65b0\u51a0\u901d\u8005\u7684\u5927\u8166\u6a23\u672c\u4e2d\uff0c\u4e0d\u50c5\u6aa2\u6e2c\u5230\u4e86\u75c5\u6bd2\u7684RNA\uff0c\u5176\u57fa\u56e0\u6d3b\u52d5\u7279\u5fb5\u4e5f\u8207\u5be6\u9a57\u5ba4\u4e2d\u88ab\u611f\u67d3\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u9ad8\u5ea6\u4e00\u81f4\u3002\u9032\u884c\u514d\u75ab\u67d3\u8272\u6cd5\u6a19\u5b9a\u5f8c\u66f4\u986f\u793a\uff0c\u65b0\u51a0\u75c5\u6bd2\u8207\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u6a19\u8a18\u7269\u7dca\u5bc6\u5730\u300c\u5171\u5b58\u300d\u65bc\u540c\u4e00\u4f4d\u7f6e\u3002<\/p>\n<p>\u6700\u5f15\u4eba\u6ce8\u76ee\u7684\u4e00\u9805\u767c\u73fe\u662f\uff0c\u65b0\u51a0\u901d\u8005\u9ed1\u8cea\u5340\u57df\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u5bc6\u5ea6\uff0c\u7adf\u7136\u5448\u73fe\u51fa\u8207\u5e15\u91d1\u68ee\u6c0f\u75c7\u60a3\u8005\u76f8\u4f3c\u7684\u986f\u8457\u6e1b\u5c11\u3002\u5118\u7ba1\u6709\u5176\u4ed6\u7814\u7a76\u8005\uff08\u5982Eidhof\u7b49\u4eba, 2024\uff09\u63d0\u9192\uff0c\u76ee\u524d\u5c1a\u96e3\u5b8c\u5168\u65b7\u5b9a\u9019\u5c31\u662f\u65b0\u51a0\u611f\u67d3\u7684\u76f4\u63a5\u5f8c\u679c\uff0c\u4f46\u9019\u9805\u767c\u73fe\u7121\u7591\u6572\u97ff\u4e86\u4e00\u8a18\u8b66\u9418\u3002<\/p>\n<figure id=\"attachment_46402\" aria-describedby=\"caption-attachment-46402\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-46402 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_3-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_3-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_3-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_3-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_3.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-46402\" class=\"wp-caption-text\">\u5716\u4e09\uff1a\u9a57\u8b49\u65b0\u51a0\u75c5\u6bd2\u76f4\u63a5\u611f\u67d3\u5de5\u4f5c\u7d30\u80deDAN\u793a\u610f\u5716\uff5c\u4f86\u6e90\uff1a\u6574\u5408Yang\u7b49\u4eba (2024) \u8207Fidbof\u7b49\u4eba (2024) \u5716\u5f62\u6458\u8981<\/figcaption><\/figure>\n<p>\u5f9e\u6700\u521d\u81e8\u5e8a\u89c0\u5bdf\u7684\u86db\u7d72\u99ac\u8de1\uff0c\u5230\u5982\u4eca\u5be6\u9a57\u5ba4\u88e1\u9ad4\u5916\u9ad4\u5167\u6240\u9a57\u8b49\uff0c\u7121\u53ef\u8faf\u99c1\u7684\u7d30\u80de\u8b49\u64da\uff08\u5716\u4e09\uff09\uff0c\u79d1\u5b78\u754c\u7d42\u65bc\u8b49\u5be6\u4e86\u9577\u4e45\u4ee5\u4f86\u7684\u61f7\u7591\uff1a\u65b0\u51a0\u75c5\u6bd2\u78ba\u5be6\u53ef\u4ee5\u76f4\u63a5\u611f\u67d3\u4e26\u6467\u6bc0\u5927\u8166\u4e2d\u8106\u5f31\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u3002\u6211\u5011\u4e0d\u5f97\u4e0d\u627f\u8a8d\uff0cCOVID-19\u75ab\u60c5\u70ba\u7814\u7a76\u300c\u75c5\u6bd2\u8207\u5e15\u91d1\u68ee\u6c0f\u75c7\u300d\u9019\u500b\u5145\u6eff\u722d\u8b70\u7684\u53e4\u8001\u554f\u984c\u63d0\u4f9b\u4e86\u4e00\u500b\u7368\u7279\u800c\u7dca\u8feb\u7684\u6a5f\u6703\u3002\u73fe\u5728\uff0c\u6211\u5011\u63e1\u6709\u4e86\u65b0\u51a0\u76f4\u63a5\u653b\u64ca\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u78ba\u947f\u8b49\u64da\uff0c\u4f46\u9019\u4e5f\u5f15\u767c\u4e86\u66f4\u6df1\u5c64\u7684\u554f\u984c\uff1a\u9019\u7a2e\u653b\u64ca\u7684\u9577\u671f\u5f71\u97ff\u662f\u4ec0\u9ebc\uff1f\u80cc\u5f8c\u6240\u6f5b\u85cf\u7684\u75c5\u7406\u6a5f\u5236\uff0c\u53c8\u5c07\u70ba\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u7814\u7a76\u8207\u6cbb\u7642\u5e36\u4f86\u54ea\u4e9b\u65b0\u7684\u555f\u793a\u8207\u6311\u6230\uff1f\uff08\u5f85\u7e8c\uff09<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u8a3b\u91cb<\/strong><\/p>\n<p>\u8a3b\u4e00\uff1a\u591a\u529f\u80fd\u5e79\u7d30\u80de\u65bc1961\u5e74\u9996\u6b21\u88ab\u767c\u73fe\uff0c\u4ee3\u8868\u4e86\u5e79\u7d30\u80de\u548c\u518d\u751f\u91ab\u5b78\u7684\u521d\u6b65\u7a81\u7834\u3002\u7dbf\u7f8a\u591a\u8389\u65bc 1997\u5e74\u88ab\u514b\u9686\uff0c\u5f9e\u57fa\u790e\u7814\u7a76\u5230\u81e8\u5e8a\u524d\u7814\u7a76\uff0c\u6700\u5f8c\u5230\u81e8\u5e8a\u8a66\u9a57\u7684\u904e\u6e21\u662f\u7531\u8a31\u591a\u767c\u73fe\u548c\u91cc\u7a0b\u7891\u63a8\u52d5\u7684\u3002hPSC\u5728\u7814\u7a76\u548c\u91ab\u5b78\u4e2d\u5177\u6709\u6975\u9ad8\u7684\u50f9\u503c\uff0c\u56e0\u70ba\u5b83\u5011\u5177\u6709\u518d\u751f\u53d7\u640d\u7d44\u7e54\u548c\u6cbb\u7642\u5404\u7a2e\u75be\u75c5\u7684\u6f5b\u529b\uff0c\u5b83\u5011\u53ef\u7528\u65bc\u7814\u7a76\u75be\u75c5\u6a5f\u5236\u3001\u6e2c\u8a66\u65b0\u85e5\uff0c\u751a\u81f3\u958b\u767c\u57fa\u65bc\u7d30\u80de\u7684\u7642\u6cd5\u7b49\u3002hPSC\u6280\u8853\u7684\u9032\u6b65\u5141\u8a31\u7814\u7a76\u4eba\u985e\u75be\u75c5\u76f8\u95dc\u7d30\u80de\u4e2d\u7684\u300c\u5bbf\u4e3b-\u75c5\u6bd2\u300d\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p>\u8a3b\u4e8c\uff1aBRENDA \u7d44\u7e54\u672c\u9ad4\u8ad6(BTO)\uff0c\u8a72\u5c08\u6848\u59cb\u65bc2003\u5e74\uff0c\u65e8\u5728\u9176\u8cc7\u6599\u5eab\u7684\u9176\u8cc7\u6599\u6536\u96c6\u8207\u7d44\u7e54\u548c\u7d30\u80de\u985e\u578b\u7d50\u69cb\u5316\u9593\u5efa\u7acb\u806f\u7e6b\uff0c\u4e26\u958b\u767c\u4f86\u81ea\u6bcf\u500b\u5206\u985e\u7d44\uff08\u5305\u62ec\u52d5\u7269\u3001\u690d\u7269\u3001\u771f\u83cc\u548c\u539f\u6838\u751f\u7269\uff09\u7684\u6240\u6709\u7d44\u7e54\u8853\u8a9e\u7684\u6a19\u6e96\u5316\u8868\u793a\u3002\u6b64\u672c\u9ad4\u88ab\u5be6\u9a57\u5ba4\u79d1\u5b78\u5bb6\u3001\u57fa\u56e0\u7d44\u548c\u751f\u5316\u8cc7\u6599\u5eab\u7684\u7ba1\u7406\u8005\u4ee5\u53ca\u751f\u7269\u8cc7\u8a0a\u5b78\u5bb6\u5ee3\u6cdb\u4f7f\u7528\u3002<a href=\"http:\/\/purl.obolibrary.org\/obo\/BTO_0006079\">BTO:0006079<\/a>: \u5b9a\u7fa9\u300c\u4eba\u985e\u591a\u80fd\u5e79\u7d30\u80de\u3002\u5305\u62ec\u4eba\u985e\u80da\u80ce\u5e79\u7d30\u80de\u548c\u4eba\u985e\u8a98\u5c0e\u6027\u591a\u80fd\u5e79\u7d30\u80de\u3002\u5b83\u80fd\u5920\u5728\u57f9\u990a\u689d\u4ef6\u4e0b\u7121\u9650\u671f\u5730\u81ea\u6211\u66f4\u65b0\uff0c\u540c\u6642\u4fdd\u6301\u5206\u5316\u6210\u4eba\u9ad4\u5e7e\u4e4e\u4efb\u4f55\u7d30\u80de\u985e\u578b\u7684\u80fd\u529b\u3002\u300d<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7228370\/\" target=\"_blank\" rel=\"noopener\">Nataf, S. (2020). An alteration of the dopamine synthetic pathway is possibly involved in the pathophysiology of COVID\u201019. Journal of medical virology, 92(10), 1743.<\/a><\/li>\n<li><a href=\"https:\/\/www.frontiersin.org\/journals\/human-neuroscience\/articles\/10.3389\/fnhum.2021.656313\/full\" target=\"_blank\" rel=\"noopener\">Yapici-Eser, H., Koroglu, Y. E., Oztop-Cakmak, O., Keskin, O., Gursoy, A., &amp; Gursoy-Ozdemir, Y. (2021). Neuropsychiatric symptoms of COVID-19 explained by SARS-CoV-2 proteins\u2019 mimicry of human protein interactions. Frontiers in Human Neuroscience, 15, 656313.<\/a><\/li>\n<li><a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(23)00442-3\" target=\"_blank\" rel=\"noopener\">Yang, L., Kim, T. W., Han, Y., Nair, M. S., Harschnitz, O., Zhu, J., ... &amp; Chen, S. (2024). SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell Stem Cell, 31(2), 196-211.<\/a><\/li>\n<li><a href=\"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1366\" target=\"_blank\" rel=\"noopener\">Fiorenzano, A., Sozzi, E., Parmar, M., &amp; Storm, P. (2021). Dopamine neuron diversity: Recent advances and current challenges in human stem cell models and single cell sequencing. Cells, 10(6), 1366.<\/a><\/li>\n<li><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12015-019-09935-x\" target=\"_blank\" rel=\"noopener\">Liu, G., David, B. T., Trawczynski, M., &amp; Fessler, R. G. (2020). Advances in pluripotent stem cells: history, mechanisms, technologies, and applications. Stem cell reviews and reports, 16(1), 3-32.<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3013802\/\" target=\"_blank\" rel=\"noopener\">Gremse, M., Chang, A., Schomburg, I., Grote, A., Scheer, M., Ebeling, C., &amp; Schomburg, D. (2010). The BRENDA Tissue Ontology (BTO): the first all-integrating ontology of all organisms for enzyme sources. Nucleic acids research, 39(suppl_1), D507-D513.<\/a><\/li>\n<li><a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(24)00002-X\" target=\"_blank\" rel=\"noopener\">Eidhof, I., Twohig, D., &amp; Falk, A. (2024). Unraveling the brain\u2019s response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons. Cell Stem Cell, 31(2), 152-154.<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>COVID-19\u60a3\u8005\u7d93\u5e38\u8868\u73fe\u51fa\u795e\u7d93\u7cfb\u7d71\u529f\u80fd\u969c\u7919\uff0c\u8868\u660e\u4e86\u65b0\u51a0\u75c5\u6bd2(SARS-CoV-2)\u5c0d\u795e\u7d93\u7d30\u80de\u6709\u5f71\u97ff\u3002\u745e\u5178\u795e\u7d93\u751f\u7406\u79d1\u5b78\u5bb6\u751a\u81f3\u4f7f\u7528\u300c\u65b0\u51a0\u75c5\u6bd2\u5982\u4f55\u6298\u78e8\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u300d\u4f5c\u70ba\u7814\u7a76\u526f\u6a19\uff0c\u4f86\u5f37\u8abf\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff0c\u4e5f\u5c31\u662f\u6211\u5011\u6240\u8aaa\u7684\u300c\u5de5\u4f5c\u7d30\u80deDAN\u300d\uff0c\u5728\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u5f8c\u5f15\u767c\u708e\u75c7\u548c\u8870\u8001\u7684\u72c0\u614b\u3002\u5728\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u300b\u7cfb\u5217\u6587\u7ae0\u7684\u6700\u5f8c\u4e00\u90e8\uff0c\u5c31\u8b93\u6211\u5011\u4f86\u804a\u804a\u9019\u500b\u8fd1\u4e94\u5e74\u6d3b\u8e8d\u5728\u5730\u7403\u7684\u547c\u5438\u9053\u75c5\u6bd2\uff0c\u5982\u4f55\u8d85\u8d8a\u80ba\u90e8\u8207\u547c\u5438\u7cfb\u7d71\u7684\u50b7\u5bb3\uff0c\u91cd\u65b0\u601d\u8003\u9019\u7a2e\u72e1\u733e\u7684\u75c5\u6bd2\u662f\u600e\u6a23\u5c0d\u5927\u8166\u3001\u5c0d\u5de5\u4f5c\u7d30\u80deDAN\u9020\u6210\u5f71\u97ff\u3002<\/p>\n","protected":false},"author":20,"featured_media":46403,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7498,257,3293,3005,1025],"tags":[7556,2412,4694,1172],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/05\/SARS_DA_1.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46400"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46400"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46400\/revisions"}],"predecessor-version":[{"id":46409,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46400\/revisions\/46409"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/46403"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}