{"id":46143,"date":"2026-02-05T18:00:26","date_gmt":"2026-02-05T10:00:26","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=46143"},"modified":"2026-02-04T15:40:45","modified_gmt":"2026-02-04T07:40:45","slug":"%e5%be%9e%e5%af%a6%e9%a9%97%e5%ae%a4%e5%88%b0%e8%87%a8%e5%ba%8a%ef%bc%9aipsc%e6%87%89%e7%94%a8%e7%9a%84%e7%84%a1%e9%99%90%e5%8f%af%e8%83%bd","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=46143","title":{"rendered":"\u5f9e\u5be6\u9a57\u5ba4\u5230\u81e8\u5e8a\uff1aiPSC\u61c9\u7528\u7684\u7121\u9650\u53ef\u80fd"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u8a98\u5c0e\u578b\u591a\u529f\u80fd\u5e79\u7d30\u80de (iPSC) \u8b93\u5df2\u5206\u5316\u7684\u9ad4\u7d30\u80de\u5f97\u4ee5\u91cd\u8fd4\u591a\u80fd\u72c0\u614b\uff0c\u70ba\u91ab\u5b78\u7814\u7a76\u5e36\u4f86\u9769\u547d\u6027\u7a81\u7834\u3002\u672c\u6587\u4ecb\u7d39iPSC\u5728\u75be\u75c5\u6a21\u578b\u3001\u85e5\u7269\u7814\u767c\u8207\u518d\u751f\u91ab\u5b78\u9818\u57df\u7684\u61c9\u7528\u3002\u900f\u904e\u60a3\u8005\u81ea\u9ad4\u7d30\u80de\u5efa\u7acb\u7684iPSC\u6a21\u578b\uff0c\u7814\u7a76\u8005\u80fd\u771f\u5be6\u91cd\u73fe\u75be\u75c5\u6a5f\u5236\u4e26\u9032\u884c\u500b\u9ad4\u5316\u85e5\u7269\u7be9\u9078\uff0c\u63d0\u5347\u7cbe\u6e96\u91ab\u7642\u7684\u53ef\u80fd\u6027\u3002\u5728\u518d\u751f\u91ab\u5b78\u4e2d\uff0ciPSC\u53ef\u5206\u5316\u70ba\u7279\u5b9a\u7d44\u7e54\u7d30\u80de\uff0c\u7528\u65bc\u4fee\u5fa9\u53d7\u640d\u5668\u5b98\uff1b\u540c\u6642\uff0c\u57fa\u56e0\u7de8\u8f2f\u8207\u7d30\u80de\u5eab\u7684\u767c\u5c55\u6b63\u63a8\u52d5\u300c\u901a\u7528\u578b\u300diPSC\u7684\u81e8\u5e8a\u61c9\u7528\u3002\u5118\u7ba1\u4ecd\u9762\u81e8\u7d30\u80de\u6210\u719f\u5ea6\u3001\u5b89\u5168\u6027\u8207\u514d\u75ab\u6392\u65a5\u7b49\u6311\u6230\uff0ciPSC\u6280\u8853\u6b63\u9010\u6b65\u8d70\u51fa\u5be6\u9a57\u5ba4\uff0c\u9081\u5411\u81e8\u5e8a\uff0c\u70ba\u518d\u751f\u91ab\u5b78\u8207\u75be\u75c5\u6cbb\u7642\u958b\u555f\u4e0b\u4e00\u6b65\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5c\u6797\u6cf3\u4ea8<\/strong><\/p>\n<p>\u5728\u4e0a\u4e00\u7bc7\u6587\u7ae0\u4e2d\uff0c\u6211\u5011\u63a2\u8a0e\u4e86\u8a98\u5c0e\u578b\u591a\u529f\u80fd\u5e79\u7d30\u80de (induced pluripotent stem cells, iPSCs) \u7684\u88fd\u5099\u65b9\u6cd5\u53ca\u5176\u8fd1\u5e74\u4f86\u7684\u6280\u8853\u6539\u826f\u3002\u672c\u6587\u5c07\u9032\u4e00\u6b65\u805a\u7126\u65bciPSC\u5728\u75be\u75c5\u6a21\u578b\u5efa\u7acb\u3001\u85e5\u7269\u7814\u767c\u8207\u518d\u751f\u91ab\u5b78\u9818\u57df\u4e2d\u7684\u61c9\u7528\u6f5b\u529b\uff0c\u4e26\u63a2\u8a0e\u5176\u76ee\u524d\u6240\u9762\u81e8\u7684\u9650\u5236\u8207\u672a\u4f86\u6311\u6230\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>iPSC\u7684\u591a\u6f5b\u80fd\u512a\u52e2\uff1a\u75be\u75c5\u6a21\u578b\u5efa\u7acb\u8207\u85e5\u7269\u958b\u767c<\/strong><\/span><\/h6>\n<p>iPSC\u5177\u6709\u8207\u80da\u80ce\u5e79\u7d30\u80de\u76f8\u4f3c\u7684\u80fd\u529b\uff1a\u5728\u9ad4\u5916\u53ef\u589e\u6b96\u4e26\u5206\u5316\u70ba\u591a\u7a2e\u9ad4\u7d30\u80de\u3002\u7279\u5225\u662f\u5229\u7528\u60a3\u8005\u81ea\u8eab\u7684\u9ad4\u7d30\u80de\u9032\u884c\u91cd\u65b0\u7de8\u7a0b\uff0c\u53ef\u751f\u6210\u5e36\u6709\u60a3\u8005\u57fa\u56e0\u7279\u5fb5\u7684iPSC\uff0c\u9032\u4e00\u6b65\u8a98\u5c0e\u5206\u5316\u6210\u75c5\u7076\u76f8\u95dc\u7684\u7d30\u80de\u985e\u578b\u3002\u7814\u7a76\u4eba\u54e1\u5f97\u4ee5\u5efa\u7acb\u5c08\u5c6c\u65bc\u75c5\u4eba\u7684\u75be\u75c5\u6a21\u578b\uff0c\u771f\u5be6\u518d\u73fe\u75c5\u4eba\u7d44\u7e54\u4e2d\u767c\u751f\u7684\u75c5\u7406\u73fe\u8c61\uff0c\u5f9e\u800c\u7cbe\u6e96\u7814\u7a76\u75be\u75c5\u6a5f\u5236\u4e26\u9032\u884c\u85e5\u7269\u7be9\u9078\u3002\u9019\u4e00\u65b9\u6cd5\u6709\u6548\u514b\u670d\u4e86\u52d5\u7269\u6a21\u578b\u7684\u5c40\u9650\u6027\uff1a\u8a31\u591a\u8907\u96dc\u7684\u4eba\u985e\u75be\u75c5\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u6709\u6240\u5dee\u7570\uff0c\u800c\u60a3\u8005\u4f86\u6e90\u7684iPSC\u6a21\u578b\u5247\u8207\u60a3\u8005\u57fa\u56e0\u80cc\u666f\u5b8c\u5168\u4e00\u81f4\uff0c\u66f4\u80fd\u771f\u5be6\u53cd\u6620\u4eba\u985e\u75be\u75c5\u75c5\u7a0b\u3002<\/p>\n<ul>\n<li>\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\uff1a\u4ee5\u5e15\u91d1\u68ee\u6c0f\u75c7\u70ba\u4f8b\uff0c\u50b3\u7d71\u4e0a\u96e3\u4ee5\u53d6\u5f97\u6d3b\u9ad4\u60a3\u8005\u7684\u5927\u8166\u591a\u5df4\u80fa\u795e\u7d93\u5143\u3002\u4f46\u5229\u7528iPSC\u6280\u8853\uff0c\u79d1\u5b78\u5bb6\u53ef\u5f9e\u5e15\u91d1\u68ee\u6c0f\u75c7\u60a3\u8005\u7684\u76ae\u819a\u7d30\u80de\u91cd\u65b0\u7de8\u7a0b\u51faiPSC\uff0c\u4e26\u9032\u4e00\u6b65\u5206\u5316\u70ba\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u3002\u5728\u9ad4\u5916\u57f9\u990a\u4e2d\uff0c\u9019\u4e9b\u795e\u7d93\u5143\u53ef\u8868\u73fe\u51fa\u5e15\u91d1\u68ee\u75c5\u7406\u7279\u5fb5\uff08\u5982\u03b1-\u7a81\u89f8\u6838\u86cb\u767d\u805a\u96c6\u5f62\u6210\u8def\u6613\u9ad4\u3001\u795e\u7d93\u5143\u529f\u80fd\u969c\u7919\u751a\u81f3\u7d30\u80de\u51cb\u4ea1\uff09\uff0c\u5f9e\u800c\u4f7f\u7814\u7a76\u8005\u6df1\u5165\u89e3\u6790\u75be\u75c5\u7684\u5206\u5b50\u6a5f\u5236\u3002<\/li>\n<\/ul>\n<p>\u57fa\u65bc\u4e0a\u8ff0\u60a3\u8005\u7279\u7570\u6027\u75be\u75c5\u6a21\u578b\uff0ciPSC\u5728\u7cbe\u6e96\u91ab\u7642\u4e2d\u767c\u63ee\u8457\u91cd\u8981\u4f5c\u7528\u3002\u50b3\u7d71\u85e5\u7269\u958b\u767c\u5f80\u5f80\u63a1\u7528\u300c\u4e00\u9ad4\u9069\u7528\u300d\u7b56\u7565\uff0c\u5ffd\u8996\u500b\u9ad4\u9593\u7684\u57fa\u56e0\u5dee\u7570\uff0c\u5c0e\u81f4\u540c\u4e00\u85e5\u7269\u5728\u4e0d\u540c\u60a3\u8005\u8eab\u4e0a\u7642\u6548\u4e0d\u540c\u3002iPSC\u6a21\u578b\u5141\u8a31\u79d1\u5b78\u5bb6\u5c0d\u591a\u4f4d\u5177\u6709\u76f8\u540c\u75be\u75c5\u4f46\u57fa\u56e0\u80cc\u666f\u4e0d\u540c\u7684\u60a3\u8005\u5206\u5225\u5efa\u7acb\u7d30\u80de\u6a21\u578b\uff0c\u5c07\u4e0d\u540c\u60a3\u8005\u7684iPSC\u5206\u5225\u66b4\u9732\u65bc\u5019\u9078\u85e5\u7269\u4e4b\u4e2d\u3002\u901a\u904e\u89c0\u5bdf\u54ea\u4e9b\u85e5\u7269\u80fd\u5920\u5728\u7279\u5b9a\u60a3\u8005\u7684\u7d30\u80de\u6a21\u578b\u4e2d\u6700\u6709\u6548\u4e14\u526f\u4f5c\u7528\u6700\u5c0f\uff0c\u5373\u53ef\u70ba\u6bcf\u4f4d\u60a3\u8005\u7be9\u9078\u51fa\u6700\u9069\u5408\u5176\u57fa\u56e0\u80cc\u666f\u7684\u7642\u6cd5\uff0c\u5be6\u73fe\u771f\u6b63\u7684\u500b\u9ad4\u5316\u6cbb\u7642\u3002\u9019\u5c0d\u65bc\u7f55\u898b\u75c5\u6216\u96e3\u6cbb\u6027\u75be\u75c5\u60a3\u8005\u800c\u8a00\uff0c\u66f4\u662f\u7121\u7591\u70ba\u4ed6\u5011\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>iPSC\u5728\u518d\u751f\u91ab\u5b78\u4e2d\u7684\u61c9\u7528\uff1a\u4fee\u5fa9\u8207\u91cd\u5851<\/strong><\/span><\/h6>\n<p>\u5728\u518d\u751f\u91ab\u5b78\u9818\u57df\uff0ciPSC\u5247\u626e\u6f14\u4e86\u300c\u4fee\u5fa9\u8005\u300d\u7684\u89d2\u8272\uff0c\u76ee\u6a19\u662f\u91cd\u5efa\u53d7\u640d\u90e8\u4f4d\u7684\u529f\u80fd\u3002\u5176\u4e2d\u4e00\u7a2e\u7b56\u7565\u662f\u81ea\u9ad4\u7d30\u80de\u6cbb\u7642\uff1a\u9996\u5148\u5f9e\u60a3\u8005\u81ea\u8eab\u53d6\u51fa\u9ad4\u7d30\u80de\uff0c\u91cd\u65b0\u7de8\u7a0b\u70baiPSC\uff0c\u518d\u8a98\u5c0e\u5206\u5316\u70ba\u6240\u9700\u7684\u529f\u80fd\u7d30\u80de\uff0c\u6700\u5f8c\u79fb\u690d\u56de\u60a3\u8005\u9ad4\u5167\u3002\u7531\u65bc\u7d30\u80de\u4f86\u81ea\u60a3\u8005\u81ea\u8eab\uff0c\u53ef\u7406\u8ad6\u4e0a\u907f\u514d\u79fb\u690d\u5f8c\u7684\u514d\u75ab\u6392\u65a5\u53cd\u61c9\uff0c\u662f\u50b3\u7d71\u7570\u9ad4\u79fb\u690d\u7121\u6cd5\u6bd4\u64ec\u7684\u512a\u52e2\u3002<\/p>\n<ul>\n<li>\u4ee5\u773c\u79d1\u75be\u75c5\u518d\u751f\u6cbb\u7642\u70ba\u4f8b\uff1a\u65e5\u672c\u5927\u5b78\u7684\u7814\u7a76\u6307\u51fa\uff0c\u4ed6\u5011\u5f9e\u9ec3\u6591\u90e8\u75c5\u8b8a\u60a3\u8005\u76ae\u819a\u7372\u53d6\u7d30\u80de\u751f\u6210iPSC\uff0c\u518d\u8a98\u5c0e\u5206\u5316\u51fa\u5065\u5eb7\u7684\u8996\u7db2\u819c\u8272\u7d20\u4e0a\u76ae (RPE) \u7d30\u80de\u7247\u5c64\uff0c\u96a8\u5f8c\u5c07\u8a72\u81ea\u9ad4RPE\u7d30\u80de\u7247\u5c64\u79fb\u690d\u5230\u60a3\u8005\u53d7\u640d\u7684\u8996\u7db2\u819c\u5340\u57df\u3002\u81e8\u5e8a\u96a8\u8a2a\u767c\u73fe\uff0c\u79fb\u690d\u5f8c\u4e00\u5e74\uff0c\u60a3\u8005\u79fb\u690d\u5340\u57df\u7684\u7d30\u80de\u5c64\u4f9d\u7136\u5b8c\u597d\uff0c\u8996\u529b\u672a\u60e1\u5316\uff0c\u986f\u793a\u51fa\u8a72\u6280\u8853\u7684\u5b89\u5168\u6027\u8207\u53ef\u884c\u6027\u3002<\/li>\n<\/ul>\n<p>\u9664\u4e86\u81ea\u9ad4\u7d30\u80de\u6cbb\u7642\uff0c\u76ee\u524d\u4e5f\u7a4d\u6975\u767c\u5c55\u7570\u9ad4\u7d30\u80de\u6cbb\u7642\u8207iPSC\u7d30\u80de\u5eab\u7b49\u65b9\u6848\u3002\u7570\u9ad4\u6cbb\u7642\u4f7f\u7528\u4f86\u81ea\u5065\u5eb7\u4f9b\u8005\u7684iPSC\uff0c\u53ef\u5be6\u73fe\u5373\u53d6\u5373\u7528\u3001\u6a19\u6e96\u5316\u751f\u7522\u7684\u9858\u666f\u3002\u7136\u800c\uff0c\u5176\u6311\u6230\u5728\u65bc\u514d\u75ab\u6392\u65a5\u3002\u70ba\u6b64\uff0c\u79d1\u5b78\u5bb6\u5011\u63a1\u7528\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\uff0c\u5982CRISPR-Cas9\uff0c\u5c0d\u4f9b\u8005iPSC\u9032\u884cMHC\/HLA\u57fa\u56e0\u6539\u9020\u3002\u6700\u65b0\u7814\u7a76\u5df2\u88fd\u9020\u51fa\u300c\u4f4e\u514d\u75ab\u539f\u6027\u300diPSC\uff1a\u901a\u904e\u6572\u9664HLA-A\u3001HLA-B\u3001HLA-DR\u7b49\u95dc\u9375\u514d\u75ab\u6a19\u8a8c\u57fa\u56e0\uff0c\u4f7fiPSC\u5728\u7570\u9ad4\u4f9b\u8005\u9593\u964d\u4f4e\u88ab\u6392\u65a5\u7684\u53ef\u80fd\u6027\u3002\u7406\u60f3\u60c5\u6cc1\u4e0b\uff0c\u900f\u904e\u9019\u4e9b\u57fa\u56e0\u5de5\u7a0b\u65b9\u6cd5\u57f9\u990a\u51fa\u901a\u7528\u578biPS\u7d30\u80de\u7cfb\u5f8c\uff0c\u4fbf\u53ef\u5927\u898f\u6a21\u751f\u7522\u4e26\u5132\u5b58\u5404\u7a2e\u6cbb\u7642\u7d30\u80de\u7522\u54c1\u3002\u5728\u81e8\u5e8a\u4e0a\uff0c\u91ab\u751f\u53ef\u6839\u64da\u9700\u8981\u76f4\u63a5\u5f9e\u7d30\u80de\u5eab\u53d6\u7528\u5408\u9069\u7684\u7d30\u80de\u9032\u884c\u79fb\u690d\uff0c\u63d0\u9ad8\u6cbb\u7642\u53ef\u53ca\u6027\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>iPSC\u6280\u8853\u9762\u81e8\u7684\u6311\u6230\u8207\u672a\u4f86\u65b9\u5411<\/strong><\/span><\/h6>\n<p>\u5118\u7ba1\u524d\u666f\u5149\u660e\uff0ciPSC\u6280\u8853\u5728\u8d70\u5411\u81e8\u5e8a\u61c9\u7528\u4e4b\u524d\u4ecd\u9700\u514b\u670d\u591a\u7a2e\u6311\u6230\u3002\u9996\u5148\u662f\u91cd\u65b0\u7de8\u7a0b\u6548\u7387\u8207\u907a\u7559\u7d30\u80de\u8a18\u61b6\u7684\u554f\u984c\uff1a\u4e00\u4e9biPSC\u5728\u91cd\u65b0\u7de8\u7a0b\u5f8c\u53ef\u80fd\u4fdd\u7559\u539f\u59cb\u9ad4\u7d30\u80de\u7684\u8868\u89c0\u907a\u50b3\u8a18\u61b6\uff0c\u5c0e\u81f4\u5176\u5206\u5316\u6f5b\u80fd\u6709\u6240\u504f\u5411\u6216\u6548\u7387\u4e0d\u9ad8\u3002\u4e0d\u540c\u4f86\u6e90\u6216\u4e0d\u540c\u6279\u6b21\u7684iPSC\u9593\uff0c\u4e5f\u53ef\u80fd\u5b58\u5728\u660e\u986f\u7684\u5dee\u7570\uff0c\u5f71\u97ff\u7d50\u679c\u7684\u4e00\u81f4\u6027\u3002\u70ba\u89e3\u6c7a\u6b64\u554f\u984c\uff0c\u7814\u7a76\u4eba\u54e1\u6b63\u5728\u63a2\u7d22\u7cbe\u7d30\u63a7\u5236\u91cd\u65b0\u7de8\u7a0b\u689d\u4ef6\u548c\u6dfb\u52a0\u7279\u5b9a\u5c0f\u5206\u5b50\u4ee5\u91cd\u5851\u67d3\u8272\u8cea\u72c0\u614b\u7b49\u65b9\u6cd5\uff0c\u529b\u6c42\u6e05\u9664\u9ad4\u7d30\u80de\u8a18\u61b6\uff0c\u63d0\u5347iPSC\u7684\u5747\u4e00\u6027\u548c\u5206\u5316\u6548\u7387\u3002<\/p>\n<p>\u5176\u6b21\uff0ciPSC\u884d\u751f\u7d30\u80de\u7684\u6210\u719f\u5ea6\u4e0d\u8db3\u4e5f\u662f\u5236\u7d04\u56e0\u7d20\u3002\u8a98\u5c0e\u5206\u5316\u51fa\u7684\u7d30\u80de\u5f80\u5f80\u505c\u7559\u5728\u985e\u4f3c\u80da\u80ce\u6642\u671f\u7684\u672a\u6210\u719f\u72c0\u614b\uff0c\u8207\u5b8c\u5168\u6210\u719f\u7684\u7d30\u80de\u4ecd\u6709\u5dee\u8ddd\u3002\u4f8b\u5982\uff0ciPSC\u884d\u751f\u7684\u5fc3\u808c\u7d30\u80de\u53ef\u4ee5\u81ea\u4e3b\u8df3\u52d5\uff0c\u4f46\u5176\u96fb\u751f\u7406\u7279\u6027\u548c\u6536\u7e2e\u529b\u901a\u5e38\u4e0d\u5982\u6210\u5e74\u5fc3\u808c\u3002\u6b64\u985e\u672a\u6210\u719f\u7d30\u80de\u5728\u75be\u75c5\u6a21\u578b\u4e2d\u53ef\u80fd\u7121\u6cd5\u6e96\u78ba\u518d\u73fe\u75c5\u7406\u7279\u5fb5\u3002\u70ba\u4fc3\u9032\u6210\u719f\u5316\uff0c\u7814\u7a76\u8005\u6b63\u5728\u5229\u7528\u4e09\u7dad\u57f9\u990a\u7cfb\u7d71\uff08\u5982\u985e\u5668\u5b98\u3001\u5668\u5b98\u6676\u7247\uff09\uff0c\u4ee5\u53ca\u6dfb\u52a0\u7d30\u80de\u5916\u57fa\u8cea\u6216\u5171\u57f9\u990a\u4e0d\u540c\u7d30\u80de\u985e\u578b\u7b49\u624b\u6bb5\u4f86\u6a21\u64ec\u9ad4\u5167\u5fae\u74b0\u5883\uff0c\u5f9e\u800c\u6539\u5584\u5206\u5316\u7d30\u80de\u7684\u529f\u80fd\u7279\u6027\u3002\u53e6\u5916\uff0c\u5c07iPSC\u884d\u751f\u7d44\u7e54\u6216\u985e\u5668\u5b98\u79fb\u690d\u5230\u751f\u7269\u9ad4\u9ad4\u5167\uff0c\u4ee5\u5229\u7528\u9ad4\u5167\u74b0\u5883\u4fc3\u9032\u8840\u7ba1\u751f\u6210\u548c\u529f\u80fd\u6210\u719f\uff0c\u4e5f\u662f\u4e00\u7a2e\u53ef\u884c\u7b56\u7565\u3002<\/p>\n<p>\u6700\u5f8c\uff0c\u5b89\u5168\u6027\u59cb\u7d42\u662f\u81e8\u5e8a\u61c9\u7528\u7684\u6838\u5fc3\u8003\u91cf\uff0c\u5305\u62ec\u816b\u7624\u5f62\u6210\u98a8\u96aa\u548c\u514d\u75ab\u539f\u6027\u3002\u7531\u65bciPSC\u672c\u8eab\u5177\u6709\u589e\u6b96\u80fd\u529b\uff0c\u4e00\u65e6\u91cd\u65b0\u7de8\u7a0b\u904e\u7a0b\u4e2d\u767c\u751f\u57fa\u56e0\u7a81\u8b8a\uff0c\u6216\u79fb\u690d\u6642\u6df7\u5165\u672a\u5206\u5316\u7684iPSC\uff0c\u90fd\u53ef\u80fd\u5728\u9ad4\u5167\u5f62\u6210\u7578\u80ce\u7624\u3002\u56e0\u6b64\uff0c\u54c1\u8cea\u63a7\u5236\u548c\u53bb\u9664\u672a\u5206\u5316\u7d30\u80de\u81f3\u95dc\u91cd\u8981\u3002\u8fd1\u671f\u7814\u7a76\u63d0\u51fa\u5c07\u300c\u5b89\u5168\u958b\u95dc\u300d\u57fa\u56e0\u5d4c\u5165iPSC\u7684\u69cb\u60f3\uff1a\u7576\u767c\u73fe\u7591\u4f3c\u816b\u7624\u5f62\u6210\u6642\uff0c\u53ef\u8a98\u5c0e\u8a72\u57fa\u56e0\u555f\u52d5\uff0c\u4f7f\u6b98\u7559\u7684\u672a\u5206\u5316\u7d30\u80de\u9078\u64c7\u6027\u51cb\u4ea1\uff0c\u5f9e\u800c\u964d\u4f4e\u816b\u7624\u98a8\u96aa\u3002<\/p>\n<figure id=\"attachment_46144\" aria-describedby=\"caption-attachment-46144\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-46144 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/02\/iPSC-3-\u5716\u4e00-1024x467.png\" alt=\"\" width=\"800\" height=\"365\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/02\/iPSC-3-\u5716\u4e00-1024x467.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/02\/iPSC-3-\u5716\u4e00-300x137.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/02\/iPSC-3-\u5716\u4e00-768x350.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/02\/iPSC-3-\u5716\u4e00-1536x700.png 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/02\/iPSC-3-\u5716\u4e00.png 1625w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-46144\" class=\"wp-caption-text\">\u5716\u4e00\uff1a\u5229\u7528iPSC\u4fee\u5fa9\u9ec3\u6591\u90e8\u75c5\u8b8a\u7684\u81e8\u5e8a\u89c0\u5bdf\u7d50\u679c\u3002\u9019\u5f35\u5716\u986f\u793a\u60a3\u8005\u5728\u63a5\u53d7iPSC\u884d\u751f\u8996\u7db2\u819c\u8272\u7d20\u4e0a\u76ae (RPE) \u7d30\u80de\u79fb\u690d\u524d\u5f8c\u7684\u773c\u90e8\u7d50\u69cb\u8b8a\u5316\u3002\u624b\u8853\u524d\uff08\u4e0a\u5716\uff09\uff0c\u9ec3\u6591\u4e0b\u65b9\u53ef\u898b\u7570\u5e38\u7684\u65b0\u751f\u8840\u7ba1\u819c\uff08\u9ec3\u8272\u865b\u7dda\u5340\uff09\uff0c\u5c0e\u81f4\u4e2d\u592e\u8996\u7db2\u819c\u9686\u8d77\u3002\u624b\u8853\u4e00\u5e74\u524d\uff08\u4e0b\u5716\uff09\uff0c\u53ef\u89c0\u5bdf\u5230\u7531\u79fb\u690d\u7d30\u80de\u5f62\u6210\u7684\u9ad8\u53cd\u5c04\u6027RPE\u7d30\u80de\u5c64\uff08\u9ec3\u8272\u7bad\u982d\uff09\uff0c\u5176\u4e0a\u65b9\u7684\u611f\u5149\u7d30\u80de\u5c64\u7d50\u69cb\u4ecd\u7136\u4fdd\u7559\uff0c\u986f\u793a\u79fb\u690d\u5f8c\u8996\u7db2\u819c\u7d50\u69cb\u7a69\u5b9a\uff0c\u8b49\u5be6\u6b64\u518d\u751f\u6cbb\u7642\u7684\u53ef\u884c\u6027\u8207\u5b89\u5168\u6027\uff5c\u4f86\u6e90\uff1a\u53c3\u8003\u6587\u737b3<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>\u7d50\u8ad6\u8207\u672a\u4f86\u5c55\u671b\uff1aiPSC\u5f15\u9818\u751f\u547d\u79d1\u5b78\u65b0\u7d00\u5143<\/strong><\/span><\/h6>\n<p>\u7d9c\u89c0iPSC\u6280\u8853\u7684\u767c\u5c55\uff0c\u5f9e\u7d04\u7ff0\uff0e\u683c\u767b\u7684\u6838\u8f49\u79fb\u8a66\u9a57\u5230\u5c71\u4e2d\u4f38\u5f4c\u7684\u91cd\u65b0\u7de8\u7a0b\uff0c\u79d1\u5b78\u5bb6\u5df2\u5be6\u73fe\u4e86\u5f9e\u9ad4\u7d30\u80de\u56de\u5230\u591a\u80fd\u72c0\u614b\u7684\u7a81\u7834\u3002\u5982\u4eca\uff0c\u85c9\u7531iPSC\u5e73\u81fa\uff0c\u6211\u5011\u80fd\u5efa\u7acb\u60a3\u8005\u7279\u7570\u7684\u75be\u75c5\u6a21\u578b\u3001\u52a0\u901f\u65b0\u85e5\u7814\u767c\uff0c\u751a\u81f3\u4fee\u5fa9\u53d7\u640d\u7d44\u7e54\u3002\u96a8\u8457\u91cd\u65b0\u7de8\u7a0b\u8207\u57f9\u990a\u6280\u8853\u7684\u9032\u6b65\uff0ciPSC\u7684\u54c1\u8cea\u63d0\u5347\u3001\u6210\u672c\u4e0b\u964d\u3002\u7d50\u5408\u6db5\u84cb\u5e38\u898bHLA\u985e\u578b\u7684\u7d30\u80de\u5eab\u8207\u57fa\u56e0\u7de8\u8f2f\u7684\u300c\u901a\u7528\u578b\u300diPSC\uff0c\u7d30\u80de\u6cbb\u7642\u5c07\u66f4\u5177\u898f\u6a21\u8207\u53ef\u53ca\u6027\u3002\u540c\u6642\uff0ciPSC\u884d\u751f\u7684\u985e\u5668\u5b98\u5c07\u5728\u85e5\u7269\u7be9\u9078\u8207\u6bd2\u6027\u6e2c\u8a66\u4e2d\u767c\u63ee\u95dc\u9375\u4f5c\u7528\uff0c\u7e2e\u77ed\u65b0\u85e5\u958b\u767c\u6642\u7a0b\u4e26\u6e1b\u5c11\u52d5\u7269\u5be6\u9a57\u3002\u5118\u7ba1\u4ecd\u6709\u6311\u6230\uff0ciPSC\u4ee5\u5176\u5f37\u5927\u7684\u591a\u80fd\u6027\uff0c\u6b63\u70ba\u518d\u751f\u91ab\u5b78\u8207\u75be\u75c5\u6cbb\u7642\u958b\u555f\u65b0\u7bc7\u7ae0\uff0c\u7167\u4eae\u91ab\u5b78\u7684\u672a\u4f86\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li>Mandai, M., Watanabe, A., Kurimoto, Y., Hirami, Y., Morinaga, C., Daimon, T., ... &amp; Takahashi, M. (2017). Autologous induced stem-cell\u2013derived retinal cells for macular degeneration.\u00a0<em>New England Journal of Medicine<\/em>,\u00a0<em>376<\/em>(11), 1038-1046.<\/li>\n<li>Cerneckis, J., Cai, H., &amp; Shi, Y. (2024). Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications.\u00a0<em>Signal Transduction and Targeted Therapy<\/em>,\u00a0<em>9<\/em>(1), 112.<\/li>\n<li>Mandai, M., Watanabe, A., Kurimoto, Y., Hirami, Y., Morinaga, C., Daimon, T., ... &amp; Takahashi, M. (2017). Autologous induced stem-cell\u2013derived retinal cells for macular degeneration.\u00a0<em>New England Journal of Medicine<\/em>,\u00a0<em>376<\/em>(11), 1038-1046.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u8a98\u5c0e\u578b\u591a\u529f\u80fd\u5e79\u7d30\u80de (iPSC) \u8b93\u5df2\u5206\u5316\u7684\u9ad4\u7d30\u80de\u5f97\u4ee5\u91cd\u8fd4\u591a\u80fd\u72c0\u614b\uff0c\u70ba\u91ab\u5b78\u7814\u7a76\u5e36\u4f86\u9769\u547d\u6027\u7a81\u7834\u3002\u672c\u6587\u4ecb\u7d39iPSC\u5728\u75be\u75c5\u6a21\u578b\u3001\u85e5\u7269\u7814\u767c\u8207\u518d\u751f\u91ab\u5b78\u9818\u57df\u7684\u61c9\u7528\u3002\u900f\u904e\u60a3\u8005\u81ea\u9ad4\u7d30\u80de\u5efa\u7acb\u7684iPSC\u6a21\u578b\uff0c\u7814\u7a76\u8005\u80fd\u771f\u5be6\u91cd\u73fe\u75be\u75c5\u6a5f\u5236\u4e26\u9032\u884c\u500b\u9ad4\u5316\u85e5\u7269\u7be9\u9078\uff0c\u63d0\u5347\u7cbe\u6e96\u91ab\u7642\u7684\u53ef\u80fd\u6027\u3002\u5728\u518d\u751f\u91ab\u5b78\u4e2d\uff0ciPSC\u53ef\u5206\u5316\u70ba\u7279\u5b9a\u7d44\u7e54\u7d30\u80de\uff0c\u7528\u65bc\u4fee\u5fa9\u53d7\u640d\u5668\u5b98\uff1b\u540c\u6642\uff0c\u57fa\u56e0\u7de8\u8f2f\u8207\u7d30\u80de\u5eab\u7684\u767c\u5c55\u6b63\u63a8\u52d5\u300c\u901a\u7528\u578b\u300diPSC\u7684\u81e8\u5e8a\u61c9\u7528\u3002\u5118\u7ba1\u4ecd\u9762\u81e8\u7d30\u80de\u6210\u719f\u5ea6\u3001\u5b89\u5168\u6027\u8207\u514d\u75ab\u6392\u65a5\u7b49\u6311\u6230\uff0ciPSC\u6280\u8853\u6b63\u9010\u6b65\u8d70\u51fa\u5be6\u9a57\u5ba4\uff0c\u9081\u5411\u81e8\u5e8a\uff0c\u70ba\u518d\u751f\u91ab\u5b78\u8207\u75be\u75c5\u6cbb\u7642\u958b\u555f\u4e0b\u4e00\u6b65\u3002<\/p>\n","protected":false},"author":20,"featured_media":46145,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,3005,6512,1025],"tags":[7444,7445,7447],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2026\/02\/\u518d\u751f\u91ab\u5b78-scaled.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46143"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46143"}],"version-history":[{"count":2,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46143\/revisions"}],"predecessor-version":[{"id":46147,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/46143\/revisions\/46147"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/46145"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}