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RNA \u75c5\u6bd2\uff0c\u8f49\u9304\u56e0\u5b50\u50c5\u5b58\u5728\u65bc\u7d30\u80de\u8cea\u4e2d\uff0c\u96a8\u8457\u91cd\u7de8\u7a0b\u5b8c\u6210\u6703\u81ea\u7136\u6d88\u5931\uff0c\u56e0\u6b64\u88ab\u8996\u70ba\u76ee\u524d\u6700\u5177\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u7684\u75c5\u6bd2\u9078\u9805\u3002<\/p>\n<p>\u9664\u4e86\u75c5\u6bd2\u8f09\u9ad4\u4e4b\u5916\uff0c\u975e\u75c5\u6bd2\u8f09\u9ad4\u6280\u8853\u9010\u6f38\u53d7\u5230\u9752\u775e\u3002\u5176\u4e2d\uff0c\u9644\u52a0\u578b\u8cea\u9ad4\u662f\u4e00\u7a2e\u4e0d\u6703\u6574\u5408\u5165\u57fa\u56e0\u7d44\u7684\u74b0\u72c0DNA\uff0c\u80fd\u5728\u7d30\u80de\u4e2d\u77ed\u66ab\u5b58\u5728\uff0c\u91cd\u65b0\u7de8\u7a0b\u5b8c\u6210\u5f8c\u81ea\u7136\u88ab\u7a00\u91cb\u6216\u5206\u89e3\u3002\u9019\u985e\u8cea\u9ad4\u56e0\u5b89\u5168\u6027\u9ad8\u800c\u5ee3\u6cdb\u61c9\u7528\u65bc\u81e8\u5e8a\u7b49\u7d1a\u7684 iPS 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\u5c0e\u5165\u6cd5\u5247\u4ee5\u77ac\u6642\u8868\u9054\u65b9\u5f0f\u5be6\u73fe\u91cd\u65b0\u7de8\u7a0b\uff0c\u4e0d\u50c5\u5b8c\u5168\u4e0d\u6d89\u53ca\u57fa\u56e0\u7d44\u4fee\u6539\uff0c\u4e14\u80fd\u85c9\u7531\u91cd\u8907\u65bd\u6253\u9054\u5230\u6240\u9700\u8868\u73fe\u91cf\uff0c\u662f\u4e00\u7a2e\u9ad8\u5ea6\u5b89\u5168\u4f46\u64cd\u4f5c\u4e0a\u8f03\u7e41\u7463\u7684\u65b9\u6cd5\u3002<\/p>\n<p>\u9664\u4e86\u57fa\u56e0\u5c0e\u5165\u65b9\u6cd5\u5916\uff0c\u8fd1\u671f\u7684\u7814\u7a76\u5247\u805a\u7126\u65bc\u5c0f\u5206\u5b50\u5316\u5408\u7269\u8a98\u5c0e\u7684\u300c\u5316\u5b78\u91cd\u65b0\u7de8\u7a0b\u300d\u3002\u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u900f\u904e\u8abf\u63a7\u7d30\u80de\u5167\u8a0a\u865f\u50b3\u5c0e\u8def\u5f91\u3001\u8868\u89c0\u907a\u50b3\u9176\u6d3b\u6027\u53ca\u7d30\u80de\u4ee3\u8b1d\u72c0\u614b\uff0c\u90e8\u5206\u5c0f\u5206\u5b50\u7d44\u5408\u53ef\u53d6\u4ee3\u8f49\u9304\u56e0\u5b50\u7684\u529f\u80fd\uff0c\u5be6\u73fe\u5b8c\u5168\u4e0d\u6d89\u53ca\u57fa\u56e0\u6539\u9020\u7684 iPSC \u88fd\u5099\u3002\u9019\u985e\u65b9\u6cd5\u7684\u6700\u5927\u512a\u52e2\u5728\u65bc\u5b89\u5168\u6027\u9ad8\u3001\u64cd\u4f5c\u7c21\u4fbf\u3001\u6210\u672c\u4f4e\u5ec9\uff0c\u4e14\u6709\u671b\u767c\u5c55\u6210\u6a19\u6e96\u5316\u88fd\u7a0b\u3002\u7136\u800c\u76ee\u524d\u5728\u88fd\u9020\u6548\u7387\u4e0a\u4ecd\u53d7\u5230\u9650\u5236\uff0c\u5c0d\u5291\u91cf\u8207\u6642\u6a5f\u7684\u63a7\u5236\u8981\u6c42\u6975\u9ad8\uff0c\u4ee5\u53ca\u662f\u5426\u8207\u5229\u7528\u8f49\u9304\u56e0\u5b50\u7de8\u6210\u7684 iPS \u7d30\u80de\u6709\u6240\u7570\u540c\u4ecd\u5f85\u8003\u8b49\u3002<\/p>\n<figure id=\"attachment_46056\" aria-describedby=\"caption-attachment-46056\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-46056 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/12\/Untitled-2-1024x717.png\" alt=\"\" width=\"800\" height=\"560\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/12\/Untitled-2-1024x717.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/12\/Untitled-2-300x210.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/12\/Untitled-2-768x538.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/12\/Untitled-2-1536x1075.png 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/12\/Untitled-2-2048x1434.png 2048w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/12\/Untitled-2-130x90.png 130w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-46056\" class=\"wp-caption-text\">\u73fe\u884c\u5728\u91cd\u65b0\u7de8\u7a0b\u51fa iPS \u7d30\u80de\u4e0a\u6709\u8a31\u591a\u505a\u6cd5\uff0c\u9664\u4e86\u4f7f\u7528\u75c5\u6bd2\u8f09\u9ad4\u8f38\u5165\u8f49\u9304\u56e0\u5b50\u5916\uff0c\u4e5f\u53ef\u4ee5\u5229\u7528\u86cb\u767d\u8cea\u3001RNA\u3001\u8cea\u9ad4\u7b49\u975e\u75c5\u6bd2\u8f09\u9ad4\u9032\u884c\u8f38\u5165\uff1b\u8fd1\u5e74\u4f86\u4e5f\u6709\u4f7f\u7528\u5c0f\u5206\u5b50\u7269\u8cea\u9032\u884c\u91cd\u65b0\u7de8\u7a0b\u7684\u6210\u529f\u6848\u4f8b\uff5c\u4f86\u6e90\uff1aBiorender<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>\u512a\u5316\u91cd\u65b0\u7de8\u7a0b\u5e73\u81fa\u7684\u95dc\u9375\u6311\u6230<\/strong><\/span><\/h6>\n<p>\u5118\u7ba1iPS\u6280\u8853\u5df2\u53d6\u5f97\u9577\u8db3\u9032\u5c55\uff0c\u4f46\u8981\u771f\u6b63\u9032\u5165\u81e8\u5e8a\u8207\u7522\u696d\u61c9\u7528\uff0c\u4ecd\u9700\u89e3\u6c7a\u82e5\u5e72\u6838\u5fc3\u6311\u6230\u3002\u9996\u5148\u662f\u91cd\u65b0\u7de8\u7a0b\u6548\u7387\u8207\u901f\u5ea6\u7684\u63d0\u5347\u3002\u76ee\u524d\u7814\u7a76\u805a\u7126\u65bc\u767c\u6398\u66f4\u6709\u6548\u7684\u8f49\u9304\u56e0\u5b50\u7d44\u5408\u3001\u6dfb\u52a0\u4fc3\u9032\u91cd\u65b0\u7de8\u7a0b\u7684\u5c0f\u5206\u5b50\u4ee5\u53ca\u512a\u5316\u57f9\u990a\u689d\u4ef6\uff0c\u4ee5\u7e2e\u77ed\u88fd\u7a0b\u6642\u9593\u4e26\u63d0\u5347\u6210\u529f\u7387\u3002\u5176\u6b21\u662f\u54c1\u8cea\u63a7\u5236\uff0c\u4e26\u975e\u6240\u6709iPS\u7d30\u80de\u90fd\u5177\u5099\u7b49\u540c\u7684\u5206\u5316\u6f5b\u80fd\u8207\u57fa\u56e0\u7a69\u5b9a\u6027\uff0c\u6709\u4e9b\u53ef\u80fd\u4fdd\u7559\u539f\u59cb\u9ad4\u7d30\u80de\u7684\u8868\u89c0\u8a18\u61b6\uff0c\u6216\u5728\u9577\u671f\u57f9\u990a\u4e2d\u7522\u751f\u7a81\u8b8a\uff0c\u56e0\u6b64\u5fc5\u9808\u5efa\u7acb\u4e00\u5957\u56b4\u8b39\u7684\u6aa2\u6e2c\u7cfb\u7d71\uff0c\u8a55\u4f30\u5176\u591a\u529f\u80fd\u6027\u3001\u57fa\u56e0\u7d44\u5b8c\u6574\u6027\u8207\u8868\u89c0\u907a\u50b3\u72c0\u614b\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u50b3\u7d71\u5e79\u7d30\u80de\u57f9\u990a\u5f80\u5f80\u4f9d\u8cf4\u52d5\u7269\u8840\u6e05\u6216\u6ecb\u990a\u5c64\u7d30\u80de\uff0c\u9019\u4e9b\u7570\u6e90\u6210\u5206\u5e36\u4f86\u514d\u75ab\u98a8\u96aa\u8207\u4e0d\u53ef\u9810\u6e2c\u6027\u3002\u958b\u767c\u7121\u8840\u6e05\u3001\u6210\u5206\u660e\u78ba\u4e14\u53ef\u81ea\u6211\u7dad\u6301\u7684\u57f9\u990a\u7cfb\u7d71\uff0c\u5c07\u6709\u52a9\u65bc\u78ba\u4fdd\u88fd\u7a0b\u6a19\u6e96\u5316\u8207\u81e8\u5e8a\u61c9\u7528\u5b89\u5168\u3002\u96a8\u8457\u81e8\u5e8a\u9700\u6c42\u65e5\u589e\uff0c\u5982\u4f55\u9032\u884c iPSC \u7684\u898f\u6a21\u5316\u751f\u7522\u4e5f\u6210\u70ba\u7576\u524d\u91cd\u8981\u8b70\u984c\u3002\u5229\u7528\u81ea\u52d5\u5316\u8a2d\u5099\u8207\u751f\u7269\u53cd\u61c9\u5668\u5efa\u7acb\u6a19\u6e96\u5316\u6d41\u7a0b\uff0c\u4e0d\u50c5\u80fd\u5927\u5e45\u63d0\u5347\u7522\u80fd\uff0c\u4e5f\u80fd\u78ba\u4fdd\u7522\u54c1\u7684\u4e00\u81f4\u6027\u8207\u53ef\u8ffd\u6eaf\u6027\u3002\u7279\u5225\u7684\u662f\uff0c\u81fa\u7063\u5728\u81ea\u52d5\u5316\u751f\u7522\u9818\u57df\u5177\u6709\u512a\u52e2\uff0c\u82e5\u80fd\u5c07 iPS \u7d30\u80de\u88fd\u4f5c\u8207\u81ea\u52d5\u5316\u751f\u7522\u7d50\u5408\uff0c\u5c07\u6709\u671b\u9054\u5230\u9ad8\u6548\u7387\u7684\u5927\u898f\u6a21\u88fd\u5099\uff0c\u6210\u70ba\u81fa\u7063\u5728\u6b64\u9818\u57df\u7684\u91cd\u8981\u7af6\u722d\u529b\uff0c\u70ba iPSC \u7684\u5ee3\u6cdb\u61c9\u7528\u5960\u5b9a\u57fa\u790e\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #0000ff;\"><strong>\u5f9e\u5be6\u9a57\u5ba4\u5230\u81e8\u5e8a\u61c9\u7528\u7684\u95dc\u9375\u4e00\u54e9\u8def<\/strong><\/span><\/h6>\n<p>iPSC \u6280\u8853\u7684\u767c\u5c55\uff0c\u5f9e\u65e9\u671f\u7684\u6982\u5ff5\u6027\u7a81\u7834\uff0c\u9010\u6f38\u8f49\u5316\u70ba\u4e00\u9580\u9ad8\u5ea6\u5de5\u7a0b\u5316\u7684\u7d30\u80de\u88fd\u9020\u6d41\u7a0b\u3002\u5f9e\u75c5\u6bd2\u8f09\u9ad4\u5230\u5316\u5b78\u91cd\u65b0\u7de8\u7a0b\uff0c\u6bcf\u4e00\u6b65\u6280\u8853\u7684\u6f14\u9032\u90fd\u53cd\u6620\u51fa\u5c0d\u6548\u7387\u3001\u5b89\u5168\u8207\u81e8\u5e8a\u61c9\u7528\u7684\u9ad8\u5ea6\u91cd\u8996\u3002\u800c\u5728\u4e0b\u4e00\u7bc7\u4e2d\uff0c\u6211\u5011\u5c07\u9032\u4e00\u6b65\u63a2\u8a0e\uff1a\u9019\u4e9b\u88ab\u9006\u8f49\u547d\u904b\u7684\u7d30\u80de\uff0c\u7a76\u7adf\u5982\u4f55\u88ab\u61c9\u7528\u65bc\u75be\u75c5\u7814\u7a76\u3001\u85e5\u7269\u958b\u767c\u4ee5\u53ca\u7d30\u80de\u7642\u6cd5\uff1f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>iPS 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