{"id":45956,"date":"2025-11-20T18:00:27","date_gmt":"2025-11-20T10:00:27","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=45956"},"modified":"2025-11-20T11:29:21","modified_gmt":"2025-11-20T03:29:21","slug":"2025%e5%b9%b4%e8%ab%be%e8%b2%9d%e7%88%be%e7%94%9f%e7%90%86%e9%86%ab%e5%ad%b8%e7%8d%8e%ef%bc%9a%e6%8f%ad%e9%96%8b%e5%85%8d%e7%96%ab%e7%b3%bb%e7%b5%b1%e3%80%8c%e7%85%9e%e8%bb%8a%e6%a9%9f%e5%88%b6","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=45956","title":{"rendered":"2025\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u91ab\u5b78\u734e\uff1a\u63ed\u958b\u514d\u75ab\u7cfb\u7d71\u300c\u715e\u8eca\u6a5f\u5236\u300d\u7684\u795e\u7955\u9762\u7d17"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>2025\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u91ab\u5b78\u734e\u9812\u7d66\u5742\u53e3\u5fd7\u6587\u3001\u746a\u9e97\uff0eE\uff0e\u5e03\u6717\u67ef\u8207\u4f5b\u745e\u5fb7\uff0e\u85cd\u65af\u5fb7\u723e\uff0c\u4ee5\u8868\u5f70\u4ed6\u5011\u63ed\u793a\u514d\u75ab\u7cfb\u7d71\u300c\u715e\u8eca\u6a5f\u5236\u300d\u7684\u95dc\u9375\u8ca2\u737b\u3002\u4ed6\u5011\u767c\u73fe\u8abf\u7bc0\u6027T\u7d30\u80de (Treg) \u53ca\u5176\u6838\u5fc3\u57fa\u56e0<em>Foxp3<\/em>\uff0c\u89e3\u91cb\u4e86\u4eba\u9ad4\u5982\u4f55\u9632\u6b62\u514d\u75ab\u7cfb\u7d71\u8aa4\u653b\u81ea\u8eab\u7d44\u7e54\u3002\u5742\u53e3\u5fd7\u6587\u8b49\u660eCD25\u207aT\u7d30\u80de\u80fd\u6291\u5236\u81ea\u9ad4\u514d\u75ab\u53cd\u61c9\uff0c\u800c\u5e03\u6717\u67ef\u8207\u85cd\u65af\u5fb7\u723e\u5247\u5728\u300cscurfy\u300d\u5c0f\u9f20\u8207IPEX\u75c7\u5019\u7fa4\u4e2d\u767c\u73fe<em>Foxp3<\/em>\u7a81\u8b8a\u662f\u75be\u75c5\u6839\u6e90\u3002\u6b64\u767c\u73fe\u4e0d\u50c5\u6539\u5beb\u4e86\u514d\u75ab\u5b78\u6559\u79d1\u66f8\uff0c\u4e5f\u958b\u555f\u4e86Treg\u70ba\u57fa\u790e\u7684\u6cbb\u7642\u6642\u4ee3\u2014\u2014\u5f9e\u7cd6\u5c3f\u75c5\u3001\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u5230\u5668\u5b98\u79fb\u690d\u8207\u764c\u75c7\u514d\u75ab\u6cbb\u7642\uff0c\u7686\u5c55\u73fe\u5ee3\u5927\u6f5b\u529b\u3002\u9019\u4e00\u6210\u679c\u5f70\u986f\u57fa\u790e\u7814\u7a76\u7684\u9577\u9060\u50f9\u503c\u8207\u5c0d\u81e8\u5e8a\u91ab\u5b78\u7684\u6df1\u9060\u5f71\u97ff\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5c\u6797\u6cf3\u4ea8<\/strong><\/p>\n<p>2025\u5e7410\u67086\u65e5\uff0c\u745e\u5178\u5361\u7f85\u6797\u65af\u5361\u91ab\u5b78\u9662\u5ba3\u5e03\uff0c\u5c07\u672c\u5e74\u5ea6\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u6388\u4e88\u4e09\u4f4d\u5728\u514d\u75ab\u5b78\u9818\u57df\u505a\u51fa\u9769\u547d\u6027\u8ca2\u737b\u7684\u79d1\u5b78\u5bb6\uff1a\u65e5\u672c\u5927\u962a\u5927\u5b78\u7684\u5742\u53e3\u5fd7\u6587 (Shimon Sakaguchi) \u6559\u6388\u3001\u7f8e\u570b\u7cfb\u7d71\u751f\u7269\u5b78\u7814\u7a76\u6240\u7684\u746a\u9e97\uff0eE\uff0e\u5e03\u6717\u67ef (Mary E. Brunkow) \u535a\u58eb\uff0c\u4ee5\u53ca\u7f8e\u570b\u7d22\u8afe\u746a\u751f\u7269\u7642\u6cd5\u516c\u53f8\u7684\u4f5b\u745e\u5fb7\uff0e\u85cd\u65af\u5fb7\u723e (Fred Ramsdell) \u535a\u58eb\u3002\u4e09\u4f4d\u79d1\u5b78\u5bb6\u56e0\u5176\u5728\u300c\u5468\u908a\u514d\u75ab\u8010\u53d7\u300d (peripheral immune tolerance) \u6a5f\u5236\u7684\u958b\u5275\u6027\u767c\u73fe\u800c\u7372\u6b64\u6b8a\u69ae\uff0c\u7279\u5225\u662f\u767c\u73fe\u4e86\u8abf\u7bc0\u6027T\u7d30\u80de (Regulatory T cells, Treg) \u53ca\u5176\u95dc\u9375\u57fa\u56e0<em>Foxp3<\/em>\uff0c\u70ba\u73fe\u4ee3\u514d\u75ab\u5b78\u7814\u7a76\u958b\u95e2\u4e86\u5168\u65b0\u7684\u9053\u8def\u3002<\/p>\n<figure id=\"attachment_45959\" aria-describedby=\"caption-attachment-45959\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-45959\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/1.jpg\" alt=\"\" width=\"600\" height=\"600\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/1.jpg 754w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/1-300x300.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/1-150x150.jpg 150w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-45959\" class=\"wp-caption-text\">\u5716\u4e00\uff1a2025\u8afe\u8c9d\u723e\u751f\u7406\u91ab\u5b78\u734e\u4e09\u4f4d\u5f97\u4e3b\uff0c\u7531\u5de6\u81f3\u53f3\u70ba\u7f8e\u570b\u7cfb\u7d71\u751f\u7269\u5b78\u7814\u7a76\u6240\u7684\u746a\u9e97\uff0eE\uff0e\u5e03\u6717\u67ef (Mary E. Brunkow) \u535a\u58eb\u3001\u7f8e\u570b\u7d22\u8afe\u746a\u751f\u7269\u7642\u6cd5\u516c\u53f8\u7684\u4f5b\u745e\u5fb7\uff0e\u85cd\u65af\u5fb7\u723e (Fred Ramsdell) \u535a\u58eb\u4ee5\u53ca\u65e5\u672c\u5927\u962a\u5927\u5b78\u7684\u5742\u53e3\u5fd7\u6587 (Shimon Sakaguchi) \u6559\u6388\uff5c\u4f86\u6e90\uff1a<a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/popular-information\/\" target=\"_blank\" rel=\"noopener\">\u8afe\u8c9d\u723e\u734e\u5b98\u7db2<\/a><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #993300;\">\u514d\u75ab\u7cfb\u7d71\u7684\u96d9\u5203\u528d\u96e3\u984c<\/span><\/h6>\n<p>\u4eba\u9ad4\u7684\u514d\u75ab\u7cfb\u7d71\u662f\u4e00\u500b\u7cbe\u5bc6\u7684\u9632\u79a6\u7db2\u7d61\uff0c\u6bcf\u5929\u90fd\u8981\u8b58\u5225\u4e26\u5c0d\u6297\u6578\u4ee5\u5343\u8a08\u4e0d\u540c\u7a2e\u985e\u7684\u75c5\u6bd2\u3001\u7d30\u83cc\u548c\u5176\u4ed6\u5fae\u751f\u7269\u7684\u5165\u4fb5\u3002\u7136\u800c\uff0c\u514d\u75ab\u7cfb\u7d71\u9762\u81e8\u8457\u4e00\u500b\u8907\u96dc\u7684\u6311\u6230\uff1a\u5b83\u5fc5\u9808\u80fd\u5920\u7cbe\u6e96\u8b58\u5225\u300c\u6575\u4eba\u300d\u4e26\u767c\u52d5\u653b\u64ca\uff0c\u540c\u6642\u53c8\u4e0d\u80fd\u8aa4\u50b7\u81ea\u8eab\u7684\u7d44\u7e54\u7d30\u80de\u3002<\/p>\n<p>\u9577\u671f\u4ee5\u4f86\uff0c\u7814\u7a76\u4eba\u54e1\u8a8d\u70ba\u300c\u4e2d\u6a1e\u514d\u75ab\u8010\u53d7\u300d (central tolerance) \u662f\u552f\u4e00\u7684\u4fdd\u8b77\u6a5f\u5236\u3002\u5728\u9019\u500b\u6a5f\u5236\u4e2d\uff0c\u672a\u6210\u719f\u7684T\u7d30\u80de\u5728\u80f8\u817a\u767c\u80b2\u904e\u7a0b\u4e2d\u6703\u63a5\u53d7\u56b4\u683c\u7684\u300c\u8a13\u7df4\u300d\uff0c\u90a3\u4e9b\u5c0d\u81ea\u8eab\u6297\u539f\u53cd\u61c9\u904e\u5f37\u7684T\u7d30\u80de\u6703\u88ab\u76f4\u63a5\u6e05\u9664\u3002\u7136\u800c\uff0c\u9019\u500b\u7be9\u9078\u904e\u7a0b\u4e26\u975e\u5b8c\u7f8e\u7121\u7f3a\uff0c\u5176\u6548\u7387\u50c5\u670960-70%\uff0c\u4ecd\u6709\u90e8\u5206\u81ea\u9ad4\u53cd\u61c9\u6027T\u7d30\u80de\u6703\u9003\u812b\u5230\u5468\u908a\u8840\u6db2\u5faa\u74b0\u4e2d\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><strong><span style=\"color: #993300;\">\u5742\u53e3\u5fd7\u6587\u7684\u5805\u6301\uff1a\u767c\u73fe\u514d\u75ab\u7cfb\u7d71\u7684\u300c\u5b89\u5168\u5b88\u885b\u300d<\/span><\/strong><\/h6>\n<p>\u6545\u4e8b\u8981\u5f9e1980\u5e74\u4ee3\u521d\u671f\u8aaa\u8d77\u3002\u7576\u6642\u5728\u65e5\u672c\u611b\u77e5\u764c\u75c7\u4e2d\u5fc3\u7814\u7a76\u6240\u5de5\u4f5c\u7684\u5e74\u8f15\u7814\u7a76\u54e1\u5742\u53e3\u5fd7\u6587\uff0c\u958b\u59cb\u63a2\u7d22\u4e00\u500b\u88ab\u8a31\u591a\u540c\u884c\u8996\u70ba\u300c\u4e0d\u88ab\u770b\u597d\u300d\u7684\u7814\u7a76\u65b9\u5411\u3002\u4ed6\u9032\u884c\u4e86\u4e00\u7cfb\u5217\u5de7\u5999\u7684\u5be6\u9a57\uff1a\u5c07\u51fa\u751f\u50c5\u4e09\u5929\u7684\u5c0f\u9f20\u80f8\u817a\u6458\u9664\uff0c\u7d50\u679c\u9019\u4e9b\u5c0f\u9f20\u767c\u5c55\u51fa\u56b4\u91cd\u7684\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u3002\u4f46\u66f4\u4ee4\u4eba\u9a5a\u8a1d\u7684\u662f\uff0c\u7576\u4ed6\u5411\u9019\u4e9b\u5c0f\u9f20\u6ce8\u5165\u4f86\u81ea\u5065\u5eb7\u5c0f\u9f20\u7684\u6210\u719fT\u7d30\u80de\u5f8c\uff0c\u81ea\u9ad4\u514d\u75ab\u75c7\u72c0\u5f97\u5230\u4e86\u6291\u5236\u3002\u9019\u500b\u5be6\u9a57\u7d50\u679c\u8b93\u5742\u53e3\u5fd7\u6587\u5805\u4fe1\uff1a\u514d\u75ab\u7cfb\u7d71\u4e2d\u5fc5\u5b9a\u5b58\u5728\u4e00\u7a2e\u300c\u5b89\u5168\u5b88\u885b\u300d\uff0c\u80fd\u5920\u4e3b\u52d5\u6291\u5236\u5176\u4ed6T\u7d30\u80de\u7684\u904e\u5ea6\u53cd\u61c9\u3002\u9019\u500b\u6982\u5ff5\u5728\u7576\u6642\u4e26\u4e0d\u88ab\u4e3b\u6d41\u5b78\u754c\u63a5\u53d7\uff0c\u4f46\u5742\u53e3\u6559\u6388\u4e26\u672a\u653e\u68c4\u3002<\/p>\n<p>\u7d93\u904e\u5341\u591a\u5e74\u7684\u4e0d\u61c8\u52aa\u529b\uff0c1995\u5e74\uff0c\u5742\u53e3\u5fd7\u6587\u5728\u7406\u5316\u5b78\u7814\u7a76\u6240 (RIKEN) \u7b51\u6ce2\u751f\u547d\u79d1\u5b78\u7814\u7a76\u4e2d\u5fc3\u767c\u8868\u4e86\u5283\u6642\u4ee3\u7684\u7814\u7a76\u6210\u679c\u3002\u4ed6\u5728\u300a\u514d\u75ab\u5b78\u96dc\u8a8c\u300b(Journal of Immunology) \u4e0a\u8b49\u660e\uff0c\u5728CD4\u207aT\u7d30\u80de\u4e2d\uff0c\u90a3\u4e9b\u8868\u9054CD25\u86cb\u767d\uff08IL-2\u53d7\u9ad4\u03b1\u93c8\uff09\u7684\u7d30\u80de\u5177\u6709\u6291\u5236\u81ea\u9ad4\u514d\u75ab\u53cd\u61c9\u7684\u80fd\u529b\u3002\u7576\u79fb\u9664\u9019\u4e9bCD25\u207aT\u7d30\u80de\u5f8c\uff0c\u5c0f\u9f20\u6703\u767c\u5c55\u51fa\u591a\u5668\u5b98\u7684\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u3002\u9019\u9805\u7814\u7a76\u9996\u6b21\u660e\u78ba\u5b9a\u7fa9\u4e86\u8abf\u7bc0\u6027T\u7d30\u80de\u7684\u6982\u5ff5\uff0c\u88ab\u8afe\u8c9d\u723e\u59d4\u54e1\u6703\u8b7d\u70ba\u300c\u6291\u5236\u6027T\u7d30\u80de\u7814\u7a76\u7684\u5fa9\u8208\u300d\u3002<\/p>\n<figure id=\"attachment_45957\" aria-describedby=\"caption-attachment-45957\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-45957 size-full\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/2.jpg\" alt=\"\" width=\"1024\" height=\"518\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/2.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/2-300x152.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/2-768x389.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption id=\"caption-attachment-45957\" class=\"wp-caption-text\">\u5716\u4e8c\uff1a\u5742\u53e3\u5fd7\u6587\u767c\u73fe\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u7684\u5b58\u5728\uff1a\u5742\u53e3\u5fd7\u6587\u900f\u904e\u5c0f\u9f20\u5be6\u9a57\u767c\u73fe\uff0cCD4\u207aT\u7d30\u80de\u4e2d\u8868\u9054CD25\u7684\u4e00\u7fa4\u7d30\u80de\u80fd\u6291\u5236\u81ea\u9ad4\u514d\u75ab\u53cd\u61c9\u3002\u82e5\u79fb\u9664\u9019\u4e9bCD25\u207a\u7d30\u80de\uff0c\u5c0f\u9f20\u6703\u51fa\u73fe\u591a\u5668\u5b98\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\uff1b\u53cd\u4e4b\uff0c\u88dc\u56de\u9019\u4e9b\u7d30\u80de\u53ef\u4f7f\u5c0f\u9f20\u7dad\u6301\u5065\u5eb7\uff0c\u63ed\u793a\u514d\u75ab\u7cfb\u7d71\u4e2d\u5b58\u5728\u80fd\u300c\u8e29\u715e\u8eca\u300d\u7684T\u7d30\u80de\u65cf\u7fa4\uff5c\u4f86\u6e90\uff1a<a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/popular-information\/\" target=\"_blank\" rel=\"noopener\">\u8afe\u8c9d\u723e\u734e\u5b98\u7db2<\/a><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #993300;\"><strong>\u7834\u89e3\u5206\u5b50\u5bc6\u78bc\uff1a<em>Foxp3<\/em>\u57fa\u56e0\u7684\u767c\u73fe<\/strong><\/span><\/h6>\n<p>\u96d6\u7136\u5742\u53e3\u5fd7\u6587\u767c\u73fe\u4e86\u8abf\u7bc0\u6027T\u7d30\u80de\u7684\u5b58\u5728\uff0c\u4f46\u5176\u80cc\u5f8c\u7684\u5206\u5b50\u6a5f\u5236\u4ecd\u662f\u500b\u8b0e\u30022001\u5e74\uff0c\u9019\u500b\u8b0e\u5718\u88ab\u5e03\u6717\u67ef\u548c\u85cd\u65af\u5fb7\u723e\u5718\u968a\u6240\u89e3\u958b\u3002\u7576\u6642\u5728\u7f8e\u570b\u83ef\u76db\u9813\u5dde\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8Celltech Chiroscience\u5de5\u4f5c\u7684\u5e03\u6717\u67ef\u548c\u85cd\u65af\u5fb7\u723e\uff0c\u5c07\u7814\u7a76\u76ee\u5149\u6295\u5411\u4e00\u500b\u7279\u6b8a\u7684\u5c0f\u9f20\u54c1\u7cfb\u2014\u2014\u300cscurfy\u300d\uff08\u610f\u70ba\u300c\u9c57\u72c0\u76ae\u819a\u300d\uff09\u5c0f\u9f20\u3002\u9019\u500b\u54c1\u7cfb\u65bc1949\u5e74\u5728\u6a61\u6a39\u5dba\u570b\u5bb6\u5be6\u9a57\u5ba4 (Oak Ridge National Laboratory) \u56e0\u81ea\u767c\u7a81\u8b8a\u800c\u7522\u751f\uff0c\u96c4\u6027\u5c0f\u9f20\u6703\u51fa\u73fe\u9c57\u72c0\u76ae\u819a\u3001\u6dcb\u5df4\u7d50\u548c\u813e\u81df\u816b\u5927\u7b49\u75c7\u72c0\uff0c\u4e26\u5728\u51fa\u751f\u5f8c16-25\u5929\u5167\u6b7b\u4ea1\u3002\u7531\u65bc\u53ea\u6709\u96c4\u6027\u8868\u73fe\u75c7\u72c0\uff0c\u7814\u7a76\u4eba\u54e1\u63a8\u6e2c\u9019\u662f\u4e00\u500bX\u67d3\u8272\u9ad4\u9023\u9396\u7684\u907a\u50b3\u7f3a\u9677\u3002<\/p>\n<p>\u901a\u904e13\u5e74\u7cbe\u7d30\u7684\u57fa\u56e0\u5b9a\u4f4d\u548c\u7269\u7406\u5716\u8b5c\u69cb\u5efa\uff0c\u5e03\u6717\u67ef\u5718\u968a\u5c07\u5019\u9078\u5340\u57df\u7e2e\u5c0f\u5230\u50c5\u5305\u542b20\u500b\u57fa\u56e0\u7684\u7bc4\u570d\u3002\u4ed6\u5011\u9010\u4e00\u6e2c\u5e8f\u9019\u4e9b\u57fa\u56e0\uff0c\u7d42\u65bc\u5728\u7b2c20\u500b\u57fa\u56e0\u4e2d\u767c\u73fe\u4e86\u81f4\u75c5\u7a81\u8b8a\u2014\u2014\u4e00\u500b\u5169\u500b\u9e7c\u57fa\u7684\u63d2\u5165\u5c0e\u81f4\u57fa\u56e0\u6846\u67b6\u79fb\u4f4d\uff0c\u4f7f\u86cb\u767d\u8cea\u7f3a\u5931\u4e86\u95dc\u9375\u7684\u53c9\u982d\u7d50\u69cb\u57df (forkhead domain)\u3002\u7814\u7a76\u4eba\u54e1\u5c07\u9019\u500b\u65b0\u767c\u73fe\u7684\u57fa\u56e0\u547d\u540d\u70ba<em>Foxp3<\/em> (Forkhead box P3)\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u5011\u901a\u904e\u57fa\u56e0\u4e92\u88dc\u5be6\u9a57\u8b49\u660e\uff1a\u5c0e\u5165\u6b63\u5e38\u7684<em>Foxp3<\/em>\u57fa\u56e0\u80fd\u5920\u62ef\u6551scurfy\u5c0f\u9f20\uff0c\u4f7f\u5176\u514d\u65bc\u75be\u75c5\u3002\u5e7e\u4e4e\u540c\u6642\uff0c\u7814\u7a76\u4eba\u54e1\u4e5f\u767c\u73fe\u4eba\u985e\u7684IPEX\u75c7\u5019\u7fa4\uff08\u514d\u75ab\u5931\u8abf\u3001\u591a\u5167\u5206\u6ccc\u75c5\u8b8a\u3001\u8178\u75c5\u8b8a\u3001X\u67d3\u8272\u9ad4\u9023\u9396\u75c7\u5019\u7fa4\uff09\u6b63\u662f\u7531<em>Foxp3<\/em>\u57fa\u56e0\u7a81\u8b8a\u6240\u5f15\u8d77\u3002\u9019\u7a2e\u7f55\u898b\u7684\u907a\u50b3\u75be\u75c5\u6703\u5c0e\u81f4\u56b4\u91cd\u7684\u81ea\u9ad4\u514d\u75ab\u53cd\u61c9\uff0c\u60a3\u5152\u901a\u5e38\u57282-3\u6b72\u524d\u6b7b\u4ea1\u3002<\/p>\n<figure id=\"attachment_45958\" aria-describedby=\"caption-attachment-45958\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-45958 size-full\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/3.jpg\" alt=\"\" width=\"1024\" height=\"572\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/3.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/3-300x168.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/3-768x429.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption id=\"caption-attachment-45958\" class=\"wp-caption-text\">\u5716\u4e09\uff1aBrunkow\u8207Ramsdell\u9396\u5b9a\u514d\u75ab\u5931\u8861\u7684\u95dc\u9375\u57fa\u56e0Foxp3\uff1a\u7814\u7a76\u4eba\u54e1\u767c\u73fe\uff0cscurfy\u5c0f\u9f20\u56e0X\u67d3\u8272\u9ad4\u4e0aFoxp3\u57fa\u56e0\u7a81\u8b8a\u800c\u5c0e\u81f4\u514d\u75ab\u7cfb\u7d71\u5931\u63a7\u3002Brunkow\u8207Ramsdell\u900f\u904e\u57fa\u56e0\u5b9a\u4f4d\uff0c\u5c07\u7a81\u8b8a\u7bc4\u570d\u7e2e\u5c0f\u81f3\u50c550\u842c\u9e7c\u57fa\u5c0d\u3001\u7d0420\u500b\u57fa\u56e0\u7684\u5340\u57df\uff0c\u6700\u7d42\u78ba\u8a8dFoxp3\u662f\u8abf\u7bc0\u6027T\u7d30\u80de (Treg) \u767c\u80b2\u8207\u529f\u80fd\u7684\u6838\u5fc3\u57fa\u56e0\uff5c\u4f86\u6e90\uff1a<a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/popular-information\/\" target=\"_blank\" rel=\"noopener\">\u8afe\u8c9d\u723e\u734e\u5b98\u7db2<\/a><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #993300;\"><strong>\u8abf\u7bc0\u6027T\u7d30\u80de\u7684\u5de5\u4f5c\u539f\u7406<\/strong><\/span><\/h6>\n<p>\u8abf\u7bc0\u6027T\u7d30\u80de\u5360\u6240\u6709CD4\u207aT\u7d30\u80de\u7684\u7d045%\uff0c\u4f46\u5176\u4f5c\u7528\u537b\u6975\u70ba\u95dc\u9375\u3002\u5b83\u5011\u5c31\u50cf\u514d\u75ab\u7cfb\u7d71\u7684\u300c\u715e\u8eca\u7cfb\u7d71\u300d\uff0c\u901a\u904e\u591a\u7a2e\u6a5f\u5236\u4f86\u6291\u5236\u904e\u5ea6\u7684\u514d\u75ab\u53cd\u61c9\u3002\u9996\u5148\uff0cTreg\u7d30\u80de\u7684\u8b58\u5225\u6a19\u8a18\u5305\u62ec\u8868\u9762\u7684CD4\u3001CD25\u86cb\u767d\uff0c\u4ee5\u53ca\u7d30\u80de\u6838\u5167\u7684<em>Foxp3<\/em>\u8f49\u9304\u56e0\u5b50\u3002<em>Foxp3<\/em>\u4e3b\u8981\u4f5c\u70ba\u8f49\u9304\u6291\u5236\u56e0\u5b50\uff0c\u6291\u5236\u53c3\u8207T\u7d30\u80de\u6d3b\u5316\u548c\u6548\u61c9\u529f\u80fd\u7684\u95dc\u9375\u57fa\u56e0\uff0c\u5305\u62ec\uff1aIL-2\u3001IL-4\u3001IL-17A\u548c\u5e72\u64fe\u7d20-\u03b3\u7b49\u4fc3\u708e\u7d30\u80de\u6fc0\u7d20\u7684\u5408\u6210\u3002\u540c\u6642\uff0c<em>Foxp3<\/em>\u8ce6\u4e88\u9019\u4e9b\u7d30\u80de\u5f37\u5927\u7684\u6291\u5236\u529f\u80fd\u3002<\/p>\n<p>Treg\u7d30\u80de\u901a\u904e\u591a\u7a2e\u9014\u5f91\u767c\u63ee\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3002\u5b83\u5011\u53ef\u4ee5\u5206\u6ccc\u6291\u5236\u6027\u7d30\u80de\u6fc0\u7d20\uff0c\u5982IL-10\u548cTGF-\u03b2\uff1b\u901a\u904e\u9ad8\u8868\u9054CTLA-4\u5206\u5b50\u8207\u6297\u539f\u5448\u73fe\u7d30\u80de\u7af6\u722d\u5171\u523a\u6fc0\u4fe1\u865f\uff1b\u6216\u662f\u5438\u6536\u74b0\u5883\u4e2d\u7684IL-2\uff0c\u525d\u596a\u6548\u61c9T\u7d30\u80de\u6240\u9700\u7684\u751f\u9577\u56e0\u5b50\u3002\u6b64\u5916\uff0cTreg\u7d30\u80de\u9084\u80fd\u900f\u904e\u7d30\u80de\u63a5\u89f8\u4f9d\u8cf4\u7684\u65b9\u5f0f\u76f4\u63a5\u6291\u5236\u5176\u4ed6\u514d\u75ab\u7d30\u80de\u7684\u6d3b\u5316\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8abf\u7bc0\u6027T\u7d30\u80de\u5206\u70ba\u5169\u5927\u985e\uff1a\u4e00\u985e\u662f\u5728\u80f8\u817a\u767c\u80b2\u904e\u7a0b\u4e2d\u7522\u751f\u7684\u300c\u80f8\u817a\u4f86\u6e90\u8abf\u7bc0\u6027T\u7d30\u80de\u300d\uff0c\u53e6\u4e00\u985e\u662f\u5728\u5468\u908a\u6dcb\u5df4\u7d44\u7e54\u4e2d\uff0c\u7531\u666e\u901aT\u7d30\u80de\u5728\u7279\u5b9a\u689d\u4ef6\u4e0b\uff08\u5982\u8178\u9053\u76f8\u95dc\u6dcb\u5df4\u7d44\u7e54\uff09\u8f49\u5316\u800c\u4f86\u7684\u300c\u5468\u908a\u8a98\u5c0e\u8abf\u7bc0\u6027T\u7d30\u80de\u300d\u3002\u5169\u985e\u7d30\u80de\u7684<em>Foxp3<\/em>\u57fa\u56e0\u555f\u52d5\u5b50\u5340\u57df\u90fd\u6703\u767c\u751f\u53bb\u7532\u57fa\u5316\u4fee\u98fe\uff0c\u9019\u662f\u5b83\u5011\u7a69\u5b9a\u8868\u9054<em>Foxp3<\/em>\u7684\u95dc\u9375\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #993300;\">\u589e\u5f37Treg\u529f\u80fd\uff1a\u6cbb\u7642\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u8207\u5668\u5b98\u79fb\u690d\u6392\u65a5<\/span><\/h6>\n<p>\u7576\u514d\u75ab\u7cfb\u7d71\u904e\u5ea6\u6d3b\u5316\u6642\uff0c\u589e\u52a0Treg\u7d30\u80de\u7684\u6578\u91cf\u6216\u589e\u5f37\u5176\u529f\u80fd\u53ef\u4ee5\u6062\u5fa9\u514d\u75ab\u5e73\u8861\u3002\u9019\u7a2e\u7b56\u7565\u5728\u6cbb\u7642\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u65b9\u9762\u5c55\u73fe\u51fa\u5de8\u5927\u6f5b\u529b\u3002<\/p>\n<p>\u5728\u7b2c\u4e00\u578b\u7cd6\u5c3f\u75c5\u65b9\u9762\uff0c\u7f8e\u570b\u52a0\u5dde\u5927\u5b78\u820a\u91d1\u5c71\u5206\u6821\u548c\u8036\u9b6f\u5927\u5b78\u91ab\u5b78\u9662\u5df2\u5b8c\u6210\u4e86\u9996\u500bTreg\u7d30\u80de\u6cbb\u7642\u7684\u7b2c\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u7814\u7a76\u4eba\u54e1\u5f9e\u60a3\u8005\u9ad4\u5167\u5206\u96e2\u51faTreg\u7d30\u80de\uff0c\u5728\u9ad4\u5916\u5927\u91cf\u64f4\u589e\u5f8c\u56de\u8f38\u7d66\u60a3\u8005\uff0c\u6700\u9ad8\u5291\u91cf\u9054\u523026\u5104\u500b\u7d30\u80de\uff0c\u7d50\u679c\u986f\u793a\u6cbb\u7642\u5b89\u5168\u6027\u826f\u597d\uff0c\u70ba\u5f8c\u7e8c\u7642\u6548\u8a66\u9a57\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u985e\u4f3c\u7684\u7b56\u7565\u4e5f\u6b63\u5728\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u3001\u7d05\u6591\u6027\u72fc\u7621\u7b49\u591a\u7a2e\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u4e2d\u9032\u884c\u63a2\u7d22\u3002<\/p>\n<p>\u5728\u5668\u5b98\u79fb\u690d\u9818\u57df\uff0cTreg\u7d30\u80de\u7642\u6cd5\u66f4\u662f\u88ab\u8996\u70ba\u5be6\u73fe\u300c\u514d\u75ab\u8010\u53d7\u300d\u7684\u8056\u676f\u3002\u76ee\u524d\u91dd\u5c0d\u814e\u81df\u3001\u809d\u81df\u548c\u80f0\u5cf6\u79fb\u690d\u7684\u591a\u500b\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u9032\u884c\u4e2d\u3002\u7814\u7a76\u986f\u793a\uff0c\u904e\u7e7c\u8f38\u6ce8Treg\u7d30\u80de\u53ef\u4ee5\u6e1b\u5c11\u6025\u6027\u6392\u65a5\u53cd\u61c9\uff0c\u751a\u81f3\u6709\u671b\u8b93\u60a3\u8005\u6700\u7d42\u64fa\u812b\u5c0d\u514d\u75ab\u6291\u5236\u85e5\u7269\u7684\u4f9d\u8cf4\u3002\u66f4\u5148\u9032\u7684CAR-Treg\uff08\u5d4c\u5408\u6297\u539f\u53d7\u9ad4\u8abf\u7bc0\u6027T\u7d30\u80de\uff09\u6280\u8853\u80fd\u4f7fTreg\u7d30\u80de\u7cbe\u6e96\u8b58\u5225\u79fb\u690d\u5668\u5b98\u7684\u7279\u5b9a\u6297\u539f\uff0c\u9032\u4e00\u6b65\u63d0\u9ad8\u6cbb\u7642\u7684\u7279\u7570\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: 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\/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li>Sakaguchi, Shimon, et al. \"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.\"\u00a0<em>Journal of immunology (Baltimore, Md.: 1950)<\/em>3 (1995): 1151-1164.<\/li>\n<li>Brunkow, Mary E., et al. \"Disruption of a new forkhead\/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.\"\u00a0<em>Nature genetics<\/em>1 (2001): 68-73.<\/li>\n<li>Bennett, Craig L., et al. \"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.\"\u00a0<em>Nature genetics<\/em>1 (2001): 20-21.<\/li>\n<li>Attias, M., T. Al-Aubodah, and C. A. Piccirillo. \"Mechanisms of human FoxP3+ Treg cell development and function in health and disease.\"\u00a0<em>Clinical &amp; experimental immunology<\/em>1 (2019): 36-51.<\/li>\n<li>Velikova, Tsvetelina, et al. \"Regulatory T cell-based therapies for type 1 diabetes: a narrative review.\"\u00a0<em>Metabolism and Target Organ Damage<\/em>2 (2025): N-A.<\/li>\n<li>Proics, Emma, et al. \"Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation.\"\u00a0<em>Gene Therapy<\/em>3 (2023): 309-322.<\/li>\n<li>Tanaka, Atsushi, and Shimon Sakaguchi. \"Targeting Treg cells in cancer immunotherapy.\"\u00a0<em>European journal of immunology<\/em>8 (2019): 1140-1146.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>2025\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u91ab\u5b78\u734e\u9812\u7d66\u5742\u53e3\u5fd7\u6587\u3001\u746a\u9e97\uff0eE\uff0e\u5e03\u6717\u67ef\u8207\u4f5b\u745e\u5fb7\uff0e\u85cd\u65af\u5fb7\u723e\uff0c\u4ee5\u8868\u5f70\u4ed6\u5011\u63ed\u793a\u514d\u75ab\u7cfb\u7d71\u300c\u715e\u8eca\u6a5f\u5236\u300d\u7684\u95dc\u9375\u8ca2\u737b\u3002\u4ed6\u5011\u767c\u73fe\u8abf\u7bc0\u6027T\u7d30\u80de (Treg) \u53ca\u5176\u6838\u5fc3\u57fa\u56e0Foxp3\uff0c\u89e3\u91cb\u4e86\u4eba\u9ad4\u5982\u4f55\u9632\u6b62\u514d\u75ab\u7cfb\u7d71\u8aa4\u653b\u81ea\u8eab\u7d44\u7e54\u3002\u5742\u53e3\u5fd7\u6587\u8b49\u660eCD25\u207aT\u7d30\u80de\u80fd\u6291\u5236\u81ea\u9ad4\u514d\u75ab\u53cd\u61c9\uff0c\u800c\u5e03\u6717\u67ef\u8207\u85cd\u65af\u5fb7\u723e\u5247\u5728\u300cscurfy\u300d\u5c0f\u9f20\u8207IPEX\u75c7\u5019\u7fa4\u4e2d\u767c\u73feFoxp3\u7a81\u8b8a\u662f\u75be\u75c5\u6839\u6e90\u3002\u6b64\u767c\u73fe\u4e0d\u50c5\u6539\u5beb\u4e86\u514d\u75ab\u5b78\u6559\u79d1\u66f8\uff0c\u4e5f\u958b\u555f\u4e86Treg\u70ba\u57fa\u790e\u7684\u6cbb\u7642\u6642\u4ee3\u2014\u2014\u5f9e\u7cd6\u5c3f\u75c5\u3001\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u5230\u5668\u5b98\u79fb\u690d\u8207\u764c\u75c7\u514d\u75ab\u6cbb\u7642\uff0c\u7686\u5c55\u73fe\u5ee3\u5927\u6f5b\u529b\u3002\u9019\u4e00\u6210\u679c\u5f70\u986f\u57fa\u790e\u7814\u7a76\u7684\u9577\u9060\u50f9\u503c\u8207\u5c0d\u81e8\u5e8a\u91ab\u5b78\u7684\u6df1\u9060\u5f71\u97ff\u3002<\/p>\n","protected":false},"author":20,"featured_media":45959,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1027,3293,1025],"tags":[702,7480,177],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/11\/1.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45956"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45956"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45956\/revisions"}],"predecessor-version":[{"id":45960,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45956\/revisions\/45960"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/45959"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}