{"id":45753,"date":"2025-09-25T18:00:48","date_gmt":"2025-09-25T10:00:48","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=45753"},"modified":"2026-01-06T14:24:52","modified_gmt":"2026-01-06T06:24:52","slug":"%e5%a4%9a%e8%ae%8a%e5%a4%9a%e5%b7%b4%e8%83%ba-%e7%ac%ac%e4%b9%9d%e9%83%a8%ef%bc%9a%e5%92%8c%e4%ba%a6%e6%95%b5%e4%ba%a6%e5%8f%8b%e7%9a%84%e8%a1%80%e6%b8%85%e7%b4%a0%ef%bc%8c%e8%b5%b0","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=45753","title":{"rendered":"\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e5d\u90e8\uff1a\u548c\u4ea6\u6575\u4ea6\u53cb\u7684\u8840\u6e05\u7d20\uff0c\u8d70\u8d70\u7b49\u7b49\uff1f"},"content":{"rendered":"

\u5851\u9020\u6211\u5011\u884c\u70ba\u7684\u5927\u8166\u5316\u5b78\u795e\u7d93\u905e\u8cea\uff0c\u9664\u4e86\u540d\u6eff\u56db\u6d77\u516b\u65b9\u7684\u591a\u5df4\u80fa\u5916\uff0c\u53e6\u4e00\u500b\u8d6b\u8d6b\u6709\u540d\u7684\u5c31\u662f\u8840\u6e05\u7d20\u4e86\u3002\u4e0d\u904e\uff0c\u9019\u662f\u591a\u8b8a\u591a\u5df4\u80fa\u7cfb\u5217\uff0c\u6211\u5011\u70ba\u4ec0\u9ebc\u8981\u63d0\u9019\u500b\u548c\u591a\u5df4\u80fa\u540c\u7956\u8f29\uff08\u55ae\u80fa\uff09\u7684\u5316\u5b78\u7269\u8cea\uff1f\u4e8b\u5be6\u4e0a\uff0c\u904e\u53bb\u7684\u7814\u7a76\u5df2\u8868\u660e\u5927\u8166\u4e2d\u7684\u795e\u7d93\u905e\u8cea\u2014\u2014\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\uff0c\u5728\u734e\u52f5\u5b78\u7fd2\u4e2d\u5747\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u6211\u5011\u4e5f\u77e5\u9053\u5b83\u5011\u900f\u904e\u5f71\u97ff\u8a31\u591a\u76f8\u540c\u7684\u795e\u7d93\u8ff4\u8def\u4f86\u767c\u63ee\u4f5c\u7528\u3002\u90a3\u9ebc\uff0c\u5982\u4f55\u6574\u5408\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u8a0a\u865f\u4f86\u9a45\u52d5\u734e\u52f5\u5b78\u7fd2\u5462\uff1f\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u5728\u6b64\u904e\u7a0b\u4e2d\uff0c\u53c8\u6709\u4ec0\u9ebc\u6a23\u7684\u95dc\u4fc2\u5462\uff1f<\/strong><\/span><\/p>\n

\u64b0\u6587\uff5cA. H.<\/strong><\/p>\n

\"\"
\u5716\u4e00\uff1a\u734e\u52f5\u5b78\u7fd2\u4e2d\u5fc3\u4f0f\u9694\u6838\u532f\u805a\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u8207AI\u5354\u529b\u7e6a\u88fd<\/figcaption><\/figure>\n

\u4ee5\u524d\uff0c\u6211\u5011\u7e3d\u662f\u85c9\u7531\u300c\u806f\u60f3\u5b78\u7fd2\u300d\uff0c\u900f\u904e\u5c07\u523a\u6fc0\uff08\u539f\u56e0\uff09\u8207\u7279\u5b9a\u8f38\u51fa\uff08\u7d50\u679c\uff09\u95dc\u806f\uff0c\u9032\u884c\u95dc\u5bdf\u591a\u5df4\u80fa\u53c3\u8207\u8a8d\u77e5\u884c\u70ba\u4e2d\u7684\u5b78\u7fd2\u8207\u8a18\u61b6\uff0c\u4e26\u4e14\u76f8\u4fe1\u591a\u5df4\u80fa\u5df2\u7cbe\u78ba\u7684\u6355\u6349\u4e86\u795e\u7d93\u884c\u70ba\u4e2d\u6700\u91cd\u8981\u7684\u591a\u7d30\u80de\u751f\u7269\u904e\u7a0b\u3002\u4e0d\u904e\uff0c\u79d1\u5b78\u8fd1\u671f\u7684\u767c\u5c55\u537b\u8b93\u6211\u5011\u767c\u73fe\u548c\u591a\u5df4\u80fa\u5c0d\u7acb\u76f8\u4e92\u4f5c\u7528\uff0c\u6216\u8aaa\u6575\u5c0d\u95dc\u4fc2\u7684\u8840\u6e05\u7d20 (serotonin)\uff0c\u5176\u5be6\u5b83\u7684\u4e00\u8209\u4e00\u52d5\uff0c\u4e5f\u6703\u5f71\u97ff\u5168\u5c40\u3002<\/p>\n

\u90a3\u9ebc\uff0c\u6211\u5011\u9996\u5148\u5feb\u901f\u638c\u63e1\u4e00\u4e0b\u8840\u6e05\u7d20\u548c\u591a\u5df4\u80fa\u7684\u5bb6\u65cf\u95dc\u4fc2\u3002\u672c\u6587\u5148\u4ee5\u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928\u91ab\u5b78\u79d1\u76ee\u6a19\u984c(MeSH)\u77e5\u8b58\u6a39\u7c21\u8981\u8aaa\u660e\uff0c\u5f85\u672a\u4f86\u5c08\u6587\u4ecb\u7d39\u8840\u6e05\u7d20\u7cfb\u5217\u6642\uff0c\u518d\u4ee5\u66f4\u8a73\u76e1\u7684\u300c\u751f\u7269\u611f\u8208\u8da3\u7684\u5316\u5b78\u5be6\u9ad4\u300d(ChEBI)\u8aaa\u660e\u3002\u5716\u4e8c\u986f\u793a\u591a\u5df4\u80fa\uff08MeSH:D004298\u6216 ChEBI:18243\uff09\u548c\u8840\u6e05\u7d20\uff08 MeSH:D012701\u6216ChEBI:28790\uff09\u7684MeSH\u77e5\u8b58\u6a39\u6982\u6cc1\uff0c\u4e8c\u8005\u5747\u96b8\u5c6c\u751f\u7269\u55ae\u80fa\u5bb6\u65cf\uff0c\u800c\u8840\u6e05\u7d20\u5247\u70ba\u8272\u80fa\u985e\u5b50\u8f29\uff08\u8a3b\u4e00\uff09\u3002<\/p>\n

\"\"
\u5716\u4e8c\uff1a\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u7684MeSH\u77e5\u8b58\u6a39\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n

\u82e5\u5f9e\u795e\u7d93\u79d1\u5b78\u53f2\u4e0a\u89c0\u5bdf\uff0c\u7406\u8ad6\u5c64\u9762\u7684\u6575\u5c0d\u95dc\u4fc2\u6216\u5c0d\u7acb\u5047\u8aaa (opponency hypothesis) \u5177\u6709\u60a0\u4e45\u6b77\u53f2\u3002\u5728\u5be6\u969b\u5f62\u5f0f\u4e2d\uff0c\u6575\u5c0d\u95dc\u4fc2\u4f7f\u7528\u5169\u500b\u7cfb\u7d71\u5c0d\u4e8b\u4ef6(\u5982\u60c5\u611f\u4e8b\u4ef6)\u9032\u884c\u7de8\u78bc\u7684\u7c21\u55ae\u60f3\u6cd5\u958b\u59cb\uff0c\u4e00\u500b\u7cfb\u7d71\u5831\u544a\u7a4d\u6975\u53cd\u61c9\uff08\u98df\u617e\u4e8b\u4ef6\uff09\uff0c\u53e6\u4e00\u7cfb\u7d71\u5247\u5831\u544a\u8ca0\u9762\u53cd\u61c9\uff08\u53ad\u60e1\u4e8b\u4ef6\uff09\uff0c\u4ee5\u53ca\u7cfb\u7d71\u9593\u76f8\u4e92\u6291\u5236\u548c\uff0f\u6216\u5c0d\u5171\u540c\u8f38\u51fa\u7684\u76f8\u53cd\u5f71\u97ff\u3002\u5f9e\u751f\u7406\u5b78\u89d2\u5ea6\u4f86\u770b\uff0c\u9019\u7684\u78ba\u5de7\u5999\u5730\u898f\u907f\u4e86\u8ca0\u9762\u5f71\u97ff\u7684\u7f3a\u5931\u3002\u800c\u8840\u6e05\u7d20\u548c\u591a\u5df4\u80fa\u9593\u7684\u5c0d\u7acb\u76f8\u4e92\u4f5c\u7528\uff0c\u5728\u6b64\u5047\u8aaa\u4e2d\u5373\u662f\u5169\u8005\u4f5c\u70ba\u5c0d\u7acb\u529b\u91cf\u4f86\u5e73\u8861\u6211\u5011\u7684\u6c7a\u5b9a: \u591a\u5df4\u80fa\u6566\u4fc3\u7acb\u5373\u63a1\u53d6\u884c\u52d5\uff0c\u800c\u8840\u6e05\u7d20\u5247\u76f8\u53cd\u7684\u5efa\u8b70\u6211\u5011\u8981\u6709\u8010\u5fc3\u3002\u63db\u53e5\u8a71\u8aaa\uff0c\u591a\u5df4\u80fa\u9f13\u52f5\u884c\u70ba\uff0c\u800c\u8840\u6e05\u7d20\u6291\u5236\u884c\u70ba\uff0c\u4ee5\u5e6b\u52a9\u751f\u7269\u505a\u51fa\u6b63\u78ba\u9078\u64c7\u4e26\u898f\u907f\u98a8\u96aa\u3002<\/p>\n

\u53e6\u4e00\u7a2e\u7406\u8ad6\u7a31\u70ba\u7d9c\u6548\u5047\u8aaa (synergy hypothesis)\uff0c\u8a8d\u70ba\u591a\u5df4\u80fa\u8655\u7406\u77ed\u671f\u734e\u52f5\uff0c\u800c\u8840\u6e05\u7d20\u5247\u7ba1\u7406\u9577\u671f\u5229\u76ca\u3002\u5047\u8a2d\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u5206\u5225\u651c\u5e36\u6709\u95dc\u77ed\u671f\u548c\u9577\u671f\u6642\u9593\u5c3a\u5ea6\u4e0a\u7684\u734e\u52f5\u671f\u671b\u8a0a\u865f\uff0c\u5f9e\u800c\u7d9c\u5408\u4e86\u95dc\u65bc\u591a\u5df4\u80fa\u5728\u6642\u9593\u5dee\u7570\u5b78\u7fd2\u4e2d\u7684\u529f\u80fd\u3001\u4ee5\u53ca\u8840\u6e05\u7d20\u5728\u8abf\u7bc0\u60c5\u7dd2\u4e2d\u7684\u4f5c\u7528\u3002\u5728\u6b64\u4e8c\u5927\u7406\u8ad6\u5047\u8a2d\u7684\u80cc\u666f\u4e0b\uff0c\u904e\u53bb\u56e0\u6280\u8853\u4e0a\u7121\u6cd5\u5728\u55ae\u7368\u53d7\u8a66\u5c0d\u8c61\u4e2d\u7cbe\u78ba\u7684\u64cd\u7e31\u591a\u500b\u795e\u7d93\u8abf\u7bc0\u7cfb\u7d71\uff0c\u81f4\u4f7f\u9019\u4e9b\u5047\u8a2d\u5747\u5c1a\u672a\u5f97\u5230\u76f4\u63a5\u7684\u9a57\u8b49\u3002<\/p>\n

\"\"
\u5716\u4e09\uff1a\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u7684\u4ea6\u6575\u4ea6\u53cb\u95dc\u4fc2\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u8207AI\u5354\u529b\u7e6a\u88fd<\/figcaption><\/figure>\n

\u8fd1\u671f\u53f2\u5766\u798f\u5927\u5b78\u7684\u4e00\u9805\u65b0\u7814\u7a76\uff0c2024\u5e7411\u670825\u65e5\u767c\u8868\u5728\u300a\u81ea\u7136\u300b\u4ee5\u300c\u5c0d\u624b\u900f\u904e\u7d0b\u72c0\u9ad4\u7684\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u63a7\u5236\u5f37\u5316\uff08\u5b78\u7fd2\uff09\u300d\u70ba\u984c\uff0c\u9996\u6b21\u5c55\u793a\u4e86\u65b0\u7684\u5be6\u9a57\u65b9\u6cd5\u548c\u6a21\u578b\uff0c\u76f4\u63a5\u9a57\u8b49\u4e86\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u5982\u4f55\u4e00\u8d77\u5de5\u4f5c\uff0c\u4e14\u662f\u4ee5\u300c\u76f8\u53cd\u7684\u300d\u4f5c\u7528\uff0c\u4f86\u5171\u540c\u5851\u9020\u6211\u5011\u7684\u884c\u70ba\u3002\u6b64\u7814\u7a76\u5718\u968a\u958b\u767c\u4e86\u540c\u6642\u5b58\u53d6\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u7cfb\u7d71\u7684\u907a\u50b3\u7b56\u7565\uff0c\u65b0\u5c0f\u9f20\u6a21\u578b\u904b\u5141\u8a31\u79d1\u5b78\u5bb6\u5728\u540c\u4e00\u96bb\u5c0f\u9f20\u4e2d\u7368\u7acb\u89c0\u5bdf\u548c\u7814\u7a76\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u7cfb\u7d71\u3002<\/p>\n

\u5728\u5be6\u9a57\u6848\u4f8b\u4e2d\uff0c\u5718\u968a\u9996\u5148\u91dd\u5c0d\u540c\u4e00\u5c0f\u9f20\u5927\u8166\u4e2d\u7684\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u795e\u7d93\u5143\uff0c\u63a1\u7528\u4e0d\u540c\u7684\u87a2\u5149\u86cb\u767d\u6a19\u8a18\uff08\u7d05\u8272\u548c\u7da0\u8272\uff09\u3002\u7136\u5f8c\uff0c\u5c0b\u627e\u5176\u4ed6\u5927\u8166\u5340\u57df\u4e2d\u7d05\u8272\u548c\u7da0\u8272\u8ef8\u7a81\u9593\u7684\u91cd\u758a\uff0c\u4ee5\u91d0\u6e05\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u8a0a\u865f\u5728\u54ea\u88e1\u532f\u805a\u7684\u554f\u984c\u3002\u7d50\u679c\u78ba\u5b9a\u7d0b\u72c0\u9ad4\u7684\u4e00\u500b\u5b50\u5340\uff0c\u4f0f\u9694\u6838 (nucleus accumbens, NAc) \u5f8c\u5167\u5074\u662f\u532f\u805a\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u8f38\u5165\u7684\u71b1\u9ede\u5340\u57df\u3002\u5176\u6b21\uff0c\u91dd\u5c0d\u5c0f\u9f20\u57f7\u884c\u7c21\u55ae\u7684\u734e\u52f5\u5b78\u7fd2\u4efb\u52d9\uff0c\u6aa2\u6e2c\u9019\u4e9b\u8f38\u5165\u7684\u795e\u7d93\u905e\u8cea\u6d3b\u52d5\u662f\u4ec0\u9ebc\u6a23\u7684\u60c5\u6cc1\u3002\u900f\u904e\u591a\u7a2e\u5be6\u9a57\u65b9\u6cd5\uff0c\u7814\u7a76\u4e00\u81f4\u767c\u73fe\u4e86\u540c\u6a23\u7684\u4e8b\u60c5\uff1a\u7576\u5c0f\u9f20\u6d88\u8017\u734e\u52f5\u6642\uff0c\u591a\u5df4\u80fa\u4e0a\u5347\uff0c\u8840\u6e05\u7d20\u4e0b\u964d\u3002<\/p>\n

\u70ba\u4e86\u6e2c\u8a66\u9019\u4e9b\u8a0a\u865f\u5c0d\u65bc\u5b78\u7fd2\u662f\u5426\u662f\u5fc5\u8981\u7684\uff0c\u7814\u7a76\u4f7f\u7528\u5149\u907a\u50b3\u5b78\uff08\u4e00\u7a2e\u5229\u7528\u5149\u4f86\u63a7\u5236\u8f49\u57fa\u56e0\u795e\u7d93\u5143\u7684\u6280\u8853\uff0c\u5728\u734e\u52f5\u5b78\u7fd2\u904e\u7a0b\u4e2d\uff0c\u80fd\u9078\u64c7\u6027\u5730\u6e1b\u5f31\u6bcf\u500b\u7cfb\u7d71\u7684\u6b63\u5e38\u8a0a\u865f\u50b3\u5c0e\u2014\u2014\u7121\u8ad6\u662f\u55ae\u7368\u9084\u662f\u7d44\u5408\uff09\uff0c\u4f86\u963b\u65b7\u591a\u5df4\u80fa\u548c\uff0f\u6216\u8840\u6e05\u7d20\u734e\u52f5\u53cd\u61c9\u3002\u7d50\u679c\u8868\u660e\u5931\u53bb\u5169\u7a2e\u795e\u7d93\u905e\u8cea\u7cfb\u7d71\u734e\u52f5\u53cd\u61c9\u7684\u5c0f\u9f20\uff0c\u5b8c\u5168\u7121\u6cd5\u5b78\u7fd2\u63d0\u793a-\u734e\u52f5\u7684\u95dc\u806f\uff0c\u800c\u4eba\u5de5\u91cd\u65b0\u5275\u9020\u591a\u5df4\u80fa\u548c\u8840\u6e05\u7d20\u734e\u52f5\u53cd\u61c9\uff0c\u5247\u6bd4\u55ae\u7368\u7684\u4efb\u4f55\u4e00\u7a2e\u64cd\u4f5c\u66f4\u6709\u6548\u5730\u63a8\u52d5\u5b78\u7fd2\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u4e8c\u500b\u795e\u7d93\u905e\u8cea\u7cfb\u7d71\u540c\u6642\u57f7\u884c\u300c\u591a\u5df4\u80fa\u523a\u6fc0\u300d\u8207\u300c\u8840\u6e05\u7d20\u6291\u5236\u300d\u6642\uff0c\u6bd4\u55ae\u7368\u5c0d\u591a\u5df4\u80fa\u523a\u6fc0\u7684\u7d50\u679c\u66f4\u70ba\u5f37\u5316\u5e6b\u52a9\u5927\u8166\u5f9e\u734e\u52f5\u4e2d\u5b78\u7fd2\u3002<\/p>\n

\"\"
\u5716\u56db\uff1a\u7576\u5c0f\u9f20\u6d88\u8017\u734e\u52f5\u6642\uff0c\u591a\u5df4\u80fa\u4e0a\u5347\uff0c\u8840\u6e05\u7d20\u4e0b\u964d\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n

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 <\/p>\n

\n

\u8a3b\u91cb<\/strong><\/p>\n

\u8a3b\u4e00\uff1a\u300c\u806f\u60f3\u5b78\u7fd2\u300d\u53c3\u95b1\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e94\u90e8<\/a>\u300b\u5716\u4e09\u7684\u795e\u7d93\u884c\u70ba\u672c\u9ad4\u8ad6\u77e5\u8b58\u6a39\u3002\u300c\u751f\u7269\u611f\u8208\u8da3\u7684\u5316\u5b78\u5be6\u9ad4\u300d(ChEBI)\u53c3\u95b1\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e00\u90e8<\/a>\u300b\u3002<\/p>\n

 <\/p>\n

\n

\u53c3\u8003\u6587\u737b<\/strong><\/p>\n

    \n
  1. MeSH:D004298<\/a>\u6216 ChEBI:18243<\/a><\/li>\n
  2. \u00a0MeSH:D012701<\/a>\u6216ChEBI:28790<\/a><\/li>\n
  3. Cardozo Pinto, D. F., Pomrenze, M. B., Guo, M. Y., Touponse, G. C., Chen, A. P., Bentzley, B. S., ... & Malenka, R. C. (2024). Opponent control of reinforcement by striatal dopamine and serotonin. Nature, 1-3.<\/a><\/li>\n
  4. Weiler, N. Dopamine and serotonin work in opposition to shape learning., Neuroscience News, Stanford University. Nov 25 2024.<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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