{"id":45323,"date":"2025-05-08T18:00:26","date_gmt":"2025-05-08T10:00:26","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=45323"},"modified":"2026-01-06T14:25:36","modified_gmt":"2026-01-06T06:25:36","slug":"%e5%a4%9a%e8%ae%8a%e5%a4%9a%e5%b7%b4%e8%83%ba-%e7%ac%ac%e4%b8%83%e9%83%a8%ef%bc%9a%e8%bd%89%e9%81%8b%e9%ab%94dat%e5%90%b8%e5%a1%b5%e5%99%a8","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=45323","title":{"rendered":"\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e03\u90e8\uff1a\u8f49\u904b\u9ad4DAT\u5438\u5875\u5668"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u5728\u591a\u5df4\u80fa\u72c2\u559c\u523a\u6fc0\u6d3e\u5c0d\u7d50\u675f\u5f8c\uff0c\u963f\u4e39\u9019\u500b\u5de5\u4f5c\u7d30\u80deDAN\u7684\u6e9d\u901a\u7ba1\u9053\u7a7a\u9699\u4e2d\uff0c\u5e03\u6eff\u4e86\u591a\u5df4\u80fa\u4e94\u5f69\u788e\u5c51\u3002\u9019\u6642\uff0c\u578b\u865fSLC6A3\u667a\u6167\u578b\u5438\u5875\u5668:\u591a\u5df4\u80fa\u8f49\u904b\u9ad4 (DAT)\uff0c\u5177\u5099\u6700\u7cbe\u78ba\u7d30\u7dfb\u7684\u795e\u7d93\u905e\u8cea\u50b3\u905e\u6a21\u578b\uff0c\u6191\u85c9\u6e05\u9664\u56de\u6536\u591a\u5df4\u80fa\u9ad8\u6548\u884c\u52d5\u7684\u6548\u7387\u529f\u80fd\uff0c\u5728\u795e\u7d93\u901a\u8def\u4e0a\u81ea\u52d5\u6ed1\u884c\uff0c\u5438\u8d70\u6bcf\u4e00\u9ede\u591a\u9918\u7684\u591a\u5df4\u80fa\u788e\u5c51\u3002\u5728\u9019\u5834\u904e\u5269\u8207\u79e9\u5e8f\u9593\u6c38\u7121\u6b62\u5883\u7684\u5faa\u74b0\u4e2d\uff0cDAT\uff0c\u5c31\u8b93\u6211\u5011\u66ab\u4e14\u66b1\u7a31\u4ed6\u70ba\u591a\u5df4\u80faT\u4ed4\uff0c\u662f\u6211\u5011\u7121\u8072\u7684\u5b88\u8b77\u8005\uff0c\u5b88\u8b77\u6211\u5011\u6df1\u611b\u5927\u8166\u7684\u548c\u8ae7\u8207\u5e73\u8861\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5cA. H.<\/strong><\/p>\n<p>\u8a71\u8aaa\u904e\u53bb\u6211\u5011\u4e86\u89e3\u91cb\u51fa\u5f8c\u7684\u591a\u5df4\u80fa\uff0c\u597d\u4e0d\u5bb9\u6613\u627e\u5230\u4e86\u5979\u5011\u5c08\u5c6c\u7684\u795e\u7d93\u53d7\u9ad4\uff0c\u9032\u800c\u638c\u63a7\u591a\u8b8a\u7684\u751f\u7269\u795e\u7d93\u5fc3\u7406\u60c5\u7dd2\uff0c\u4f46\u662f\u6545\u4e8b\u4e26\u672a\u5c31\u6b64\u7d50\u675f\u3002\u63a5\u4e0b\u4f86\uff0c\u9084\u5fc5\u9808\u901a\u904e\u56de\u6536\u591a\u5df4\u80fa\u7684\u904e\u7a0b\uff0c\u8b93\u591a\u5df4\u80fa\u56de\u5230\u539f\u4f86\u7684\u795e\u7d93\u7d30\u80de\u518d\u5229\u7528\uff0c\u9019\u6a23\u624d\u80fd\u5b8c\u6210\u5b8c\u6574\u7684\u795e\u7d93\u905e\u8cea\u50b3\u5c0e\u3002\u82e5\u4ee5\u795e\u7d93\u79d1\u5b78\u5bb6\u7684\u6bd4\u55bb\u4f86\u8aaa\uff0c\u5047\u8a2d\u5927\u8166\u4e2d\u6709\u5f37\u5927\u9ad8\u6548\u7684\u591a\u5df4\u80fa\u300c\u5438\u5875\u5668\u300d\uff0c\u90a3\u9ebc\u5c0d\u65bc\u6211\u5011\u7406\u89e3\u591a\u5df4\u80fa\u662f\u5982\u4f55\u9032\u51fa\u8166\u7d30\u80de\u7684\u57fa\u672c\u6a5f\u5236\u5c31\u8b8a\u5f97\u975e\u5e38\u7c21\u55ae\u8207\u5bb9\u6613\u4e86\uff0c\u800c\u9019\u81fa\u5438\u5875\u5668\uff0c\u5c31\u662f\u300c\u591a\u5df4\u80fa\u8f49\u904b\u9ad4 (Dopamine Transporter, DAT)\u300d\u3002<\/p>\n<figure id=\"attachment_45330\" aria-describedby=\"caption-attachment-45330\" style=\"width: 450px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-45330\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-1.png\" alt=\"\" width=\"450\" height=\"435\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-1.png 678w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-1-300x290.png 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-45330\" class=\"wp-caption-text\">\u5716\u4e00\uff1a\u591a\u5df4\u80fa\u8f49\u904b\u9ad4 (DAT) \u5438\u5875\u5668\u6bd4\u55bb\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b\/AI\u5354\u540c\u88fd\u5716<\/figcaption><\/figure>\n<p>\u7576\u300c\u5438\u5875\u5668\u300d\u6b63\u5e38\u5de5\u4f5c\u6642\uff0c\u591a\u5df4\u80fa\u6700\u7d42\u6703\u88abDAT\u300c\u5438\u56de\u300d\u795e\u7d93\u5143\uff0c\u4f7f\u5927\u8166\u6062\u5fa9\u5230\u53d7\u523a\u6fc0\u8f03\u5c11\u7684\u72c0\u614b\u3002\u554f\u984c\u662f\u5982\u679c\u9019\u4e9b\u591a\u5df4\u80fa\uff0c\u6c92\u80fd\u9069\u6642\u56de\u6536\uff0c\u90a3\u9ebc\u5c0d\u65bc\u591a\u5df4\u80fa\u5728\u7a81\u89f8\u9593\u7684\u6fc3\u5ea6\u5c07\u6703\u8b8a\u5f97\u904e\u9ad8\uff0c\u56e0\u800c\u9020\u6210\u4e0b\u6e38\u795e\u7d93\u7d30\u80de\u7684\u523a\u6fc0\u904e\u5927\u3002\u800c\u5931\u63a7\u7684DAT\u5c07\u5c0e\u81f4\u591a\u5df4\u80fa\u6fc3\u5ea6\u904e\u9ad8\uff0c\u800c\u53ef\u80fd\u7f79\u60a3\u7cbe\u795e\u75c7\u72c0\u548c\u601d\u89ba\u5931\u8abf\uff0c\u6fc3\u5ea6\u904e\u4f4e\u5247\u8207\u5e15\u91d1\u68ee\u6c0f\u75c7\u6709\u95dc\u3002\u9019\u500b\u4e0d\u53ef\u6216\u7f3a\u7684\u95dc\u9375\u5be6\u9ad4\uff1a\u591a\u5df4\u80fa\u8de8\u819c\u8f49\u904b\u86cb\u767d\uff0c\u53c8\u7a31\u591a\u5df4\u80fa\u651c\u5e36\u8005 (Dopamine Carriers) \u6216\u591a\u5df4\u80fa\u8f49\u904b\u86cb\u767d (DAT)\u3002<\/p>\n<p>\u9867\u540d\u601d\u7fa9\uff0cDAT\u662f\u651c\u5e36\u591a\u5df4\u80fa\u3001\u53c3\u8207\u96e2\u5b50\u3001\u5c0f\u5206\u5b50\u548c\u5927\u5206\u5b50\uff08\u5982\u53e6\u4e00\u7a2e\u86cb\u767d\u8cea\uff09\u7a7f\u904e\u751f\u7269\u819c\u7684\u904b\u52d5\u819c\u86cb\u767d\u3002DAT\u6210\u70ba\u4e00\u7a2e\u7368\u7279\u7684\u8f49\u904b\u86cb\u767d\u79d1\u5b78\u5be6\u9ad4\u7d04\u65bc20\u4e16\u7d0060\u5e74\u4ee3\u672b\u671f\uff0c\u63a5\u4e0b\u4f86\u7684\u4e8c\u5341\u5e74\u4e3b\u8981\u7528\u65bc\u7814\u7a76\u8f49\u904b\u86cb\u767d\u7684\u85e5\u7406\u5b78\u63a2\u7d22\u6a19\u7684\uff0c\u81f390\u5e74\u4ee3\u5247\u53d7\u76ca\u65bc\u8f49\u904b\u86cb\u767d\u5168\u9762\u7814\u7a76\u7684\u84ec\u52c3\u767c\u5c55\u3002<\/p>\n<figure id=\"attachment_45328\" aria-describedby=\"caption-attachment-45328\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-45328\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-2-1024x576.png\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-2-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-2-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-2-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-2.png 1280w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-45328\" class=\"wp-caption-text\">\u5716\u4e8c\uff1a\u795e\u7d93\u905e\u8cea\u5f9e\u91cb\u653e\u5f8c\u81f3\u7d42\u6b62\u6d89\u53ca\u7684\u6a5f\u5236\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u6539\u7e6a\u81eaIversen (1971) \u57161\/\u589e\u52a0DAT\u7b26\u865f<\/figcaption><\/figure>\n<p>\u82e5\u89c0\u5bdf\u82f1\u570b\u795e\u7d93\u85e5\u7406\u5b78\u5bb6\u840a\u65af\u5229\uff0e\u827e\u5f17\u68ee (Leslie L. Iversen,1937\u20132020) \u65bc1970\u5e74\u7684\u8b1b\u5ea7\u5167\u5bb9\uff0c\u4ed6\u6240\u63d0\u51fa\u7684\u905e\u8cea\u651d\u53d6\u6a5f\u5236\u5047\u8a2d\uff0c\u5f37\u8abf\u900f\u904e\u4f4d\u65bc\u7a81\u89f8\u9593\u9699\u9644\u8fd1\u7684\u300c\u8de8\u819c\u8f49\u904b\u7cfb\u7d71\u300d(membrane transport system)\uff0c\u5728\u7a81\u89f8\u524d\u5f8c\u795e\u7d93\u5143\u9593\u53bb\u9664\u91cb\u653e\u7684\u905e\u8cea\u5982\u5716\u4e8c\u6240\u793a\uff1a\u795e\u7d93\u905e\u8cea\u50b3\u5c0e\u7684\u53bb\u6d3b\u6027\u904e\u7a0b\uff0c\u5305\u62ec\u4e86\u5728\u7a81\u89f8\u524d\u5f8c\u7684\u5438\u6536\uff0f\u651d\u53d6\u3001\u4ee3\u8b1d\u3001\u64f4\u6563\u548c\u518d\u5229\u7528\u7b49\u7a0b\u5e8f\u3002\u6b64\u63cf\u8ff0\u5960\u5b9a\u4e86\u5f8c\u4f86\u7684\u79d1\u5b78\u5bb6\u7406\u89e3\u591a\u5df4\u80fa\u91cb\u653e\u5230\u7a81\u89f8\u9593\u9699\u5f8c\uff0c\u5982\u4f55\u88ab\u5e36\u56de\u795e\u7d93\u5143\u7684\u57fa\u790e\u3002<\/p>\n<p>\u6309\u7167\u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928\u7684\u91ab\u5b78\u79d1\u76ee\u6a19\u984c (MeSH: D050483) \u5b9a\u7fa9\uff1aDAT\u662f\u6c2f\u5316\u9209\u4f9d\u8cf4\u6027\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u7684\u540c\u5411\u8f49\u904b\u86cb\u767d\uff0c\u4e3b\u8981\u4f4d\u65bc\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u7d30\u80de\u819c\u4e0a\u3002\u5b83\u5011\u900f\u904e\u7a81\u89f8\u524d\u7aef\u7684\u9ad8\u89aa\u548c\u529b\u91cd\u65b0\u651d\u53d6\uff0c\u5f9e\u7d30\u80de\u5916\u7a7a\u9593\u53bb\u9664\u591a\u5df4\u80fa\uff0c\u4e26\u4e14\u662f\u591a\u5df4\u80fa\u651d\u53d6\u6291\u5236\u5291\u7684\u6a19\u9776\u3002<\/p>\n<p>\u9032\u4e00\u6b65\u4e86\u89e3DAT\u57fa\u790e\u53ef\u5f9e\u77e5\u8b58\u6a39\u4e2d\u5b83\u7684\u4e09\u500b\u7236\u8f29\u5982\u5716\u4e09\u6240\u793a\uff1a\u5152\u8336\u915a\u80fa\u8cea\u819c\u8f49\u904b\u86cb\u767d (Catecholamine Plasma Membrane Transport Proteins)\u3001\u540c\u5411\u8f49\u904b\u9ad4 (Symporters) \u548c\u6eb6\u8cea\u8f09\u9ad4\u86cb\u767d (Solute Carrier Proteins, SLC) \u4e00\u7aba\u7a76\u7adf\u3002\u6309\u7167MeSH\u5b9a\u7fa9\u5206\u5225\u70ba\uff1a<\/p>\n<ul>\n<li><strong>\u5152\u8336\u915a\u80fa\u8cea\u819c\u8f49\u904b\u86cb\u767d<\/strong>\uff1a\u53c8\u7a31\u5152\u8336\u915a\u80fa\u8f09\u9ad4 (Catecholamine Carrier)\u3002\u4e00\u7d44\u819c\u8f49\u904b\u86cb\u767d\uff0c\u53ef\u8de8\u7d30\u80de\u819c\u8f49\u904b\u5152\u8336\u915a\u7684\u751f\u7269\u80fa\u884d\u751f\u7269\u3002\u5b83\u8abf\u7bc0\u795e\u7d93\u50b3\u905e\u4ee5\u53ca\u5152\u8336\u915a\u80fa\u4ee3\u8b1d\u548c\u518d\u5faa\u74b0\u3002<\/li>\n<li><strong>\u540c\u5411\u8f49\u904b\u9ad4<\/strong>\uff1a\u53c8\u7a31\u5354\u540c\u8f49\u904b\u86cb\u767d (Co-Transporter)\u3002\u8de8\u819c\u4ee5\u76f8\u540c\u65b9\u5411\u5171\u540c\u904b\u9001\u5169\u500b\u6216\u591a\u500b\u4e0d\u540c\u5206\u5b50\u7684\u819c\u8f49\u904b\u86cb\u767d\u3002\u901a\u5e38\uff0c\u4e00\u500b\u96e2\u5b50\u6216\u5206\u5b50\u7684\u50b3\u8f38\u8207\u5176\u96fb\u5316\u5b78\u68af\u5ea6\u76f8\u53cd\uff08\u96e2\u5b50\u8de8\u819c\u904b\u52d5\u800c\u7522\u751f\u7684\u96fb\u5316\u5b78\u96fb\u4f4d\u68af\u5ea6\uff0c\u901a\u5e38\u5305\u62ec\u96fb\u4f4d\u68af\u5ea6\u548c\u6fc3\u5ea6\u68af\u5ea6\uff09\uff0c\u4e26\u7531\u53e6\u4e00\u500b\u96e2\u5b50\u6216\u5206\u5b50\u4ee5\u5176\u96fb\u5316\u5b78\u68af\u5ea6\u7684\u904b\u52d5\u63d0\u4f9b\u52d5\u529b\u3002<\/li>\n<li><strong>\u6eb6\u8cea\u8f09\u9ad4\u86cb\u767d<\/strong>\uff1a\u4e00\u5927\u985e\u4e0d\u540c\u7684\u819c\u8f49\u904b\u86cb\u767d\uff0c\u5176\u5bb6\u65cf\u901a\u5e38\u6703\u6839\u64da\u529f\u80fd\u9032\u884c\u5206\u985e\u3002\u5927\u591a\u6578SLC\u5b9a\u4f4d\u65bc\u7d30\u80de\u819c\uff1b\u7136\u800c\uff0c\u4e00\u4e9b\u5bb6\u65cf\uff08\u4f8b\u5982SLC25\uff09\u5b9a\u4f4d\u65bc\u7c92\u7dda\u9ad4\u819c\u6216\u5176\u4ed6\u7d30\u80de\u5668\u3002<\/li>\n<\/ul>\n<figure id=\"attachment_45329\" aria-describedby=\"caption-attachment-45329\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-45329 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-3-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-3-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-3-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-3-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-3.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-45329\" class=\"wp-caption-text\">\u5716\u4e09\uff1a\u591a\u5df4\u80fa\u8de8\u6a21\u8f49\u904b\u86cb\u767dMeSH\u77e5\u8b58\u6a39\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u6539\u7e6a\u81ea\u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928\u8cc7\u6599<\/figcaption><\/figure>\n<p>DAT\u7236\u8f29\u662f\u5152\u8336\u915a\u80fa\u8f09\u9ad4\u5c0d\u65bc\u6211\u5011\u800c\u8a00\u4e26\u4e0d\u964c\u751f\uff0c\u548c\u591a\u5df4\u80fa\u4e00\u6a23\u7e7c\u627f\u5152\u8336\u915a\u80fa\u7684\u7279\u6027\uff0c\u5728MeSH\u77e5\u8b58\u6a39\u4e2d\u89c0\u5bdf\uff0c\u8207\u5169\u5927\u5bb6\u65cf\u76f8\u6bd4\uff0c\u5144\u5f1f\u59ca\u59b9\u6700\u5c11\u3002\u800c\u540c\u5411\u8f49\u904b\u9ad4\u4ed6\u5011\u5229\u7528\u4e00\u500b\u5206\u5b50\u7684\u5411\u5167\u79fb\u52d5\u4f86\u9006\u68af\u5ea6\u62c9\u5165\u53e6\u4e00\u500b\u5206\u5b50\uff0c\u5c31DAT\u800c\u8a00\uff0c\u6d89\u53ca\u9209\u96e2\u5b50\u548c\u6c2f\u96e2\u5b50\u904b\u52d5 (Na+\/Cl\u2212dependent neurotransmitter transporters) \u7684\u6a5f\u5236\uff0c\u4e5f\u5c31\u662f\u6839\u64da\u7d30\u80de\u819c\u5169\u5074\u96e2\u5b50\u6fc3\u5ea6\u7684\u5dee\u7570\uff0c\u4fc3\u9032\u591a\u5df4\u80fa\u91cd\u65b0\u651d\u53d6\u5230\u7d30\u80de\u4e2d\uff0c\u5f9e\u800c\u91cd\u7f6e\u591a\u5df4\u80fa\u8a0a\u865f\u3002\u53e6\u5916\uff0cDAT\u53e6\u4e00\u500b\u5e38\u898b\u7684\u540d\u7a31\u5373\u662f\u6839\u64da\u6eb6\u8cea\u8f09\u9ad4\u5bb6\u65cf\u5206\u985e\u800c\u547d\u540d\u70ba\u5bb6\u65cf6\u6210\u54e13\u86cb\u767d (SLC6A3 Protein)\u3002<\/p>\n<p>\u7c21\u800c\u8a00\u4e4b\uff0c\u9748\u6d3b\u63a7\u5236\u591a\u5df4\u80fa\u8a0a\u865f\u50b3\u5c0e\u7684DAT\uff0c\u53c3\u8207\u591a\u5df4\u80fa\u751f\u7269\u5408\u6210\u904e\u7a0b\uff0c\u5305\u62ec\u591a\u5df4\u80fa\u651d\u53d6\u53c3\u8207\u7a81\u89f8\u50b3\u905e\u3001\u795e\u7d93\u905e\u8cea\u751f\u7269\u5408\u6210\u3001\u8abf\u7bc0\u591a\u5df4\u80fa\u5206\u89e3\u4ee3\u8b1d\u8207\u8de8\u819c\u8f49\u904b\u7b49\u3002DAT\u8ca0\u8cac\u5c07\u795e\u7d93\u9593\u9699\u4e2d\u7684\u591a\u5df4\u80fa\u91cd\u65b0\u6c72\u53d6\u56de\u795e\u7d93\u9593\u9699\u524d\u795e\u7d93\u5143\uff0c\u65bc\u662f\uff0c\u8f49\u904b\u9ad4DAT\u7684\u529f\u80fd\u662f\u5426\u6b63\u5e38\u5de5\u4f5c\uff0c\u4e5f\u5c31\u95dc\u4fc2\u8457\u591a\u5df4\u80fa\u6fc3\u5ea6\u662f\u53ef\u5426\u7dad\u6301\u5e73\u8861\u3002<\/p>\n<p>\u5982\u679c\u8aaa\uff0c\u6211\u5011\u7684\u5927\u8166\u50cf\u662f\u4e00\u500b\u5de8\u5927\u7684\u901a\u8a0a\u7db2\u8def\uff0c\u4e0d\u65b7\u5730\u4f86\u56de\u767c\u9001\u8a0a\u606f\u3002\u591a\u5df4\u80fa\u5c31\u50cf\u9019\u500b\u7db2\u8def\u4e2d\u7684\u95dc\u9375\u8a0a\u865f\u4e4b\u4e00\uff0c\u767c\u9001\u7684\u300c\u7c21\u8a0a\u300d\u5982\u904b\u52d5\u3001\u76ee\u6a19\u3001\u52d5\u6a5f\u734e\u52f5\u3001\u60c5\u7dd2\u3001\u6050\u61fc\u6216\u9ad4\u9a57\u65b0\u5947\u4e8b\u7269\u3001\u751a\u81f3\u5275\u696d\u52d5\u529b\u7b49\u3002\u73fe\u5728\uff0c\u70ba\u4e86\u4fdd\u6301\u4e00\u5207\u9806\u5229\u9032\u884c\uff0c\u5927\u8166\u4e2d\u53e6\u4e00\u500b\u7a31\u70ba\u591a\u5df4\u80fa\u8f49\u904b\u9ad4 (DAT) \u7684\u7279\u6b8a\u86cb\u767d\u8cea\uff0c\u5c31\u50cf\u662f\u5927\u8166\u4e2d\u7684\u6383\u5730\u6a5f\u5668\u4eba\uff1a\u591a\u5df4\u80fa\u767c\u9001\u8cc7\u8a0a\u5f8c\uff0cDAT\u51fa\u73fe\uff0c\u62fe\u53d6\u5269\u9918\u7684\u591a\u5df4\u80fa\uff0c\u4e26\u5c07\u5176\u5e36\u56de\u8166\u7d30\u80de\u9032\u884c\u56de\u6536\u518d\u5229\u7528\u6216\u5132\u5b58\u3002\u5982\u679c\u6c92\u6709\u9019\u4e9b\u8f49\u904b\u86cb\u767d\uff0c\u591a\u5df4\u80fa\u5c31\u6703\u5f98\u5f8a\u4e0d\u53bb\uff0c\u8a0a\u865f\u5c31\u6703\u6df7\u5728\u4e00\u8d77\uff0c\u6709\u9ede\u50cf\u4e00\u6b21\u6536\u5230\u592a\u591a\u7c21\u8a0a\uff0c\u624b\u6a5f\u5c31\u6703\u958b\u59cb\u5361\u5361\u800c\u51fa\u73fe\u554f\u984c\u3002\u7531\u6b64\u53ef\u898b\uff0cDAT\u6709\u52a9\u65bc\u4fdd\u6301\u5927\u8166\u901a\u8a0a\u7cfb\u7d71\u7684\u9ad8\u6548\u548c\u6574\u6f54\uff0c\u78ba\u4fdd\u6211\u5011\u7684\u60c5\u7dd2\u548c\u52d5\u6a5f\u7b49\u8a0a\u865f\u6e05\u6670\u6709\u6548\u3002\u56e0\u6b64\uff0c\u4e0b\u6b21\u7576\u60a8\u611f\u5230\u90a3\u7a2e\u5feb\u611f\u6216\u52d5\u529b\u6642\uff0c\u8acb\u5411\u9019\u4f4d\u6026\u7136\u5fc3\u52d5\u7684\u6574\u7406\u9ad8\u624bDAT\u62db\u62db\u624b\u2014\u2014\u9019\u4f4d\u5177\u5099\u6e05\u9664\u56de\u6536\u529f\u80fd\u7684\u5e55\u5f8c\u64cd\u76e4\u624b\uff0c\u6700\u559c\u6b61\u6574\u7406\u8166\u4e2d\u7684\u591a\u5df4\u80fa\uff0c\u4fdd\u6301\u4e00\u5207\u6709\u689d\u4e0d\u7d0a\uff0c\u78ba\u4fdd\u5927\u8166\u4e0d\u6703\u56e0\u591a\u5df4\u80fa\u8d85\u8ca0\u8377\u800c\u8b8a\u5f97\u904e\u65bc\u6d3b\u8e8d\uff0c\u6210\u4e86\u72c2\u6b61\u8005\u7684\u6d3e\u5c0d\u5929\u5802\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li><a href=\"https:\/\/neurosciencenews.com\/dopamine-transporter-neuroscience-3485\/\">Neuroscience News. How Dopamine is Transported Within the Brain. Jan 26.2016.<\/a><\/li>\n<li><a href=\"https:\/\/lawdata.com.tw\/tw\/detail.aspx?no=244435\">\u5f35\u5fd7\u73b2, \u8abf\u63a7\u7cbe\u795e\u8207\u60c5\u7dd2\u7684\u64cd\u76e4\u624b\uff0d\uff0d\u591a\u5df4\u80fa\u8f49\u904b\u9ad4, \u79d1\u5b78\u767c\u5c55\u6708\u520a, 2015.03 (507\u671f), 72-73\u3002<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014299997000654\">Reith, M. E., Xu, C., &amp; Chen, N. H. (1997). Pharmacology and regulation of the neuronal dopamine transporter. European journal of pharmacology, 324(1), 1-10.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1702772\/pdf\/brjpharm00554-0008.pdf\">Iversen, L. L. (1971). Role of transmitter uptake mechanisms in synaptic neurotransmission. British journal of pharmacology, 41(4), 571.<\/a><\/li>\n<li><a href=\"http:\/\/id.nlm.nih.gov\/mesh\/D050483\">MeSH: D050483.<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u591a\u5df4\u80fa\u72c2\u559c\u523a\u6fc0\u6d3e\u5c0d\u7d50\u675f\u5f8c\uff0c\u963f\u4e39\u9019\u500b\u5de5\u4f5c\u7d30\u80deDAN\u7684\u6e9d\u901a\u7ba1\u9053\u7a7a\u9699\u4e2d\uff0c\u5e03\u6eff\u4e86\u591a\u5df4\u80fa\u4e94\u5f69\u788e\u5c51\u3002\u9019\u6642\uff0c\u578b\u865fSLC6A3\u667a\u6167\u578b\u5438\u5875\u5668:\u591a\u5df4\u80fa\u8f49\u904b\u9ad4 (DAT)\uff0c\u5177\u5099\u6700\u7cbe\u78ba\u7d30\u7dfb\u7684\u795e\u7d93\u905e\u8cea\u50b3\u905e\u6a21\u578b\uff0c\u6191\u85c9\u6e05\u9664\u56de\u6536\u591a\u5df4\u80fa\u9ad8\u6548\u884c\u52d5\u7684\u6548\u7387\u529f\u80fd\uff0c\u5728\u795e\u7d93\u901a\u8def\u4e0a\u81ea\u52d5\u6ed1\u884c\uff0c\u5438\u8d70\u6bcf\u4e00\u9ede\u591a\u9918\u7684\u591a\u5df4\u80fa\u788e\u5c51\u3002\u5728\u9019\u5834\u904e\u5269\u8207\u79e9\u5e8f\u9593\u6c38\u7121\u6b62\u5883\u7684\u5faa\u74b0\u4e2d\uff0cDAT\uff0c\u5c31\u8b93\u6211\u5011\u66ab\u4e14\u66b1\u7a31\u4ed6\u70ba\u591a\u5df4\u80faT\u4ed4\uff0c\u662f\u6211\u5011\u7121\u8072\u7684\u5b88\u8b77\u8005\uff0c\u5b88\u8b77\u6211\u5011\u6df1\u611b\u5927\u8166\u7684\u548c\u8ae7\u8207\u5e73\u8861\u3002<\/p>\n","protected":false},"author":20,"featured_media":45330,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32,7498,3293,6512],"tags":[7369,5562,7370],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/05\/DAT-1.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45323"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45323"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45323\/revisions"}],"predecessor-version":[{"id":45679,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45323\/revisions\/45679"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/45330"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45323"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}