{"id":45089,"date":"2025-03-03T17:00:15","date_gmt":"2025-03-03T09:00:15","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=45089"},"modified":"2025-03-05T14:19:14","modified_gmt":"2025-03-05T06:19:14","slug":"%e3%80%90%e6%8e%a2%e7%b4%a232%e3%80%91%e6%96%b0%e6%99%82%e4%bb%a3%e9%86%ab%e7%99%82-%e7%99%8c%e7%97%87%e7%9a%84%e7%b4%b0%e8%83%9e%e5%9f%ba%e5%9b%a0%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=45089","title":{"rendered":"\u3010\u63a2\u7d2232-4\u3011\u65b0\u6642\u4ee3\u91ab\u7642\u2014\u2014\u764c\u75c7\u7684\u7d30\u80de\u57fa\u56e0\u7642\u6cd5"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u764c\u75c7\u662f\u842c\u75c5\u4e4b\u738b\uff0c\u4e5f\u662f\u6211\u5011\u6bcf\u500b\u4eba\u975e\u5e38\u95dc\u6ce8\u7684\u5065\u5eb7\u8b70\u984c\uff1b\u5728\u4e09\u5341\u5e74\u4ee5\u524d\uff0c\u764c\u75c7\u88ab\u8a8d\u70ba\u662f\u4e0d\u6cbb\u4e4b\u75c7\uff0c\u4f46\u4eca\u6642\u4eca\u65e5\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u51fa\u73fe\uff0c\u70ba\u4e16\u754c\u4e0a\u7121\u6578\u7f79\u764c\u60a3\u8005\u5e36\u4f86\u4e00\u7dda\u66d9\u5149\u3002\u672c\u6b21\u63a2\u7d22\u8b1b\u5ea7\u9080\u8acb\u5230\u6c9b\u723e\u751f\u6280\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5275\u8fa6\u4eba\u6797\u6210\u9f8d\u91ab\u5e2b\uff0c\u4ecb\u7d39\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u7684\u6f14\u9032\u8207\u539f\u7406\uff0c\u4e26\u5206\u4eab\u80fd\u6d88\u6ec5\u764c\u75c7\u7684CAR-T\u7642\u6cd5\uff0c\u5728\u8b1b\u8ff0\u91ab\u85e5\u6280\u8853\u7684\u540c\u6642\uff0c\u4e5f\u9ede\u51fa\u91ab\u5b78\u8207\u653f\u7b56\u9593\u7dca\u5bc6\u76f8\u9023\u7684\u95dc\u4fc2\uff0c\u767c\u4eba\u6df1\u7701\u3002<\/strong><\/span><\/p>\n<p><strong>\u8b1b\u8005\uff5c\u6c9b\u723e\u751f\u6280\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8 \u6797\u6210\u9f8d \u5275\u8fa6\u4eba<\/strong><\/p>\n<p><strong>\u5f59\u6574\u3001\u64b0\u6587\uff5c\u4f55\u90c1\u5ead<\/strong><\/p>\n<div class=\"fitvids-video\"><iframe title=\"\u65b0\u6642\u4ee3\u91ab\u7642\u2014\u764c\u75c7\u7684\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\uff5c\u6797\u6210\u9f8d\uff5c\u63a2\u7d2232\u91ab \u65b0\u8208\u91ab\u7642\u79d1\u6280\u8a3a\u65b7\u8207\u6cbb\u7642\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/C-qi_AgWgb4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&nbsp;<\/p>\n<p>\u764c\u75c7\u662f\u842c\u75c5\u4e4b\u738b\uff0c\u4e5f\u662f\u6211\u5011\u6bcf\u500b\u4eba\u975e\u5e38\u95dc\u6ce8\u7684\u5065\u5eb7\u8b70\u984c\u3002\u73fe\u5728\u91ab\u7642\u6280\u8853\u6108\u8da8\u767c\u9054\uff0c\u764c\u75c7\u7642\u6cd5\u9010\u6f38\u767c\u5c55\u51fa\u66f4\u591a\u65b0\u8208\u6cbb\u7642\u65b9\u5f0f\uff0c\u5f9e\u65e9\u671f\u7684\u9019\u4e9b\u5316\u7642\u653e\u7642\u5c0f\u5206\u5b50\u85e5\u7269\u3001\u6a19\u9776\u85e5\u7269\uff0c\u5230\u4eca\u5929\u4ecb\u7d39\u7684\u7d30\u80de\u8207\u57fa\u56e0\u7642\u6cd5\uff0c\u90fd\u5728\u5728\u70ba\u73fe\u5728\u7684\u764c\u75c7\u75c5\u60a3\u5e36\u4f86\u66f4\u591a\u7684\u751f\u6a5f\u3002<\/p>\n<p>\u672c\u6b21\u9080\u8acb\u7684\u8b1b\u8005\u6797\u6210\u9f8d\u662f\u6c9b\u723e\u751f\u6280\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8\u7684\u5275\u8fa6\u4eba\uff0c\u4ed6\u5728\u81fa\u7063\u5b8c\u6210\u91ab\u5b78\u8a13\u7df4\u5f8c\uff0c\u524d\u5f80\u82f1\u570b\u725b\u6d25\u5927\u5b78\u53d6\u5f97\u535a\u58eb\u5b78\u4f4d\uff0c\u4e26\u5148\u5f8c\u5728\u82f1\u570b\u502b\u6566\u5e1d\u570b\u5b78\u9662\u64d4\u4efb\u8b1b\u5ea7\u6559\u6388\u3001\u5728\u9999\u6e2f\u5927\u5b78\u64d4\u4efb\u69ae\u8b7d\u6559\u6388\u3002\u5e7e\u5e74\u524d\uff0c\u6797\u6210\u9f8d\u91ab\u5e2b\u56de\u5230\u81fa\u7063\u5275\u7acb\u6c9b\u723e\u751f\u6280\u91ab\u85e5\u6709\u9650\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u63d0\u5347\u81fa\u7063\u7684\u7d30\u80de\u6cbb\u7642\u9818\u57df\u7684\u9032\u6b65\u3002\u672c\u6b21\u8b1b\u5ea7\uff0c\u6797\u91ab\u5e2b\u5e36\u9818\u807d\u773e\u9032\u5165\u6700\u5148\u7aef\u7684\u7d30\u80de\u8207\u514d\u75ab\u6cbb\u7642\u9818\u57df\uff0c\u6df1\u5165\u6dfa\u51fa\u5730\u4ecb\u7d39\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u7684\u539f\u7406\u8207\u524d\u77bb\u6027\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #cc99ff;\"><strong>\u8ddf\u4e0a\u7b2c\u56db\u5927\u91ab\u7642\u5de5\u696d\uff0c\u5728\u81fa\u7063\u6253\u9020\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u6280\u8853<\/strong><\/span><\/h6>\n<figure id=\"attachment_45090\" aria-describedby=\"caption-attachment-45090\" style=\"width: 300px\" class=\"wp-caption alignright\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-45090\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6118-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6118-300x200.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6118-1024x683.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6118-768x512.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6118-1536x1024.jpg 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6118-2048x1365.jpg 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-45090\" class=\"wp-caption-text\">\u4f86\u6e90\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3<\/figcaption><\/figure>\n<p>\u6f14\u8b1b\u7684\u4e00\u958b\u982d\uff0c\u6797\u91ab\u5e2b\u5373\u8868\u793a\u81ea\u5df1\u56de\u81fa\u4e26\u5275\u7acb\u516c\u53f8\u7684\u76ee\u7684\uff0c\u662f\u70ba\u4e86\u5e6b\u81fa\u7063\u505a\u4e00\u9ede\u4e8b\u3002\u4eba\u985e\u6b77\u53f2\u4e0a\uff0c\u66fe\u7d93\u6b77\u904e\u5c0f\u5206\u5b50\u85e5\u7269\u3001\u75ab\u82d7\u958b\u767c\u3001\u5927\u5206\u5b50\u85e5\u7269\uff08\u6a19\u9776\u85e5\u7269\uff09\u7b49\u4e09\u5927\u91ab\u85e5\u5de5\u696d\u7684\u767c\u5c55\uff1b\u5f9e\u4e8c\u5341\u5e7e\u5e74\u524d\u958b\u59cb\u8d77\u6b65\uff0c\u73fe\u5728\u5df2\u6210\u70ba\u7b2c\u56db\u5927\u91ab\u7642\u5de5\u696d\u7684\u300c\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u300d\uff08Cell and Gene Therapy, CGT\uff09\uff0c\u9700\u8981\u7d50\u5408\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u8207\u57fa\u56e0\u6539\u9020\u7d30\u80de\u7684\u6280\u8853\uff0c\u662f\u975e\u5e38\u91cd\u8981\u7684\u65b0\u8208\u7642\u6cd5\uff0c\u4e5f\u662f\u6797\u91ab\u5e2b\u4e9f\u6b32\u5728\u81fa\u7063\u767c\u5c55\u7684\u95dc\u9375\u91ab\u7642\u6280\u8853\u3002<\/p>\n<p>\u6797\u6210\u9f8d\u91ab\u5e2b\u8aaa\u660e\uff0c\u4e16\u754c\u4e0a\u7684\u524d\u4e09\u5927\u91ab\u7642\u5de5\u696d\uff0c\u81fa\u7063\u90fd\u672a\u80fd\u8d95\u4e0a\uff0c\u6240\u4ee5\u5728\u9019\u4e9b\u7522\u696d\u5167\u6c92\u6709\u5b9a\u50f9\u6b0a\uff0c\u4e5f\u6c92\u6709\u81ea\u4e3b\u6b0a\u3002\u4ed6\u4ee5\u82f1\u570b\u7f79\u60a3\u8840\u764c\u7684\u5973\u5b69\u300cSally\u300d\u70ba\u4e86\u9aa8\u9ad3\u79fb\u690d\u7684\u5065\u4fdd\u7d66\u4ed8\u554f\u984c\u548c\u528d\u6a4b\u90e1\u653f\u5e9c\u6253\u5b98\u53f8\u7684\u6545\u4e8b\uff0c\u6307\u51fa\u82f1\u570b\u5065\u4fdd\u5236\u5ea6\u5728\u9810\u7b97\u5206\u914d\u7684\u5169\u96e3\u3002<\/p>\n<p>\u4ee5B\u7d30\u80de\u6dcb\u5df4\u764c (CD19) \u548c\u591a\u767c\u6027\u9aa8\u9ad3\u7624 (BCMA) \u7684\u7d30\u80de\u57fa\u56e0\u6cbb\u7642\u50f9\u683c\u800c\u8a00\uff0c\u5149\u662f\u4e00\u5291\u85e5\u7269\uff0c\u91d1\u984d\u5c31\u9ad8\u9054\u4e00\u5343\u842c\u81f3\u4e00\u5343\u4e94\u767e\u842c\u81fa\u5e63\u3002\u5728\u8209\u4f8b\u7684\u540c\u6642\uff0c\u6797\u91ab\u5e2b\u63ed\u793a\u4e86\u672a\u4f86\u81fa\u7063\u5065\u4fdd\u82e5\u7d66\u4ed8\u5148\u7aef\u91ab\u7642\u6280\u8853\u7684\u9ad8\u6602\u8cbb\u7528\uff0c\u653f\u5e9c\u8ca1\u52d9\u6703\u6709\u6975\u56b4\u5cfb\u7684\u6311\u6230\uff1b\u82e5\u4e0d\u7d66\u4ed8\uff0c\u5247\u570b\u6c11\u7121\u6cd5\u53d7\u5230\u6551\u6cbb\u3001\u570b\u5167\u7121\u6cd5\u767c\u5c55\u91ab\u7642\u5e02\u5834\u7684\u77db\u76fe\u56f0\u5883\u3002\u56e0\u6b64\uff0c\u8b93\u81fa\u7063\u5728\u91ab\u7642\u7522\u696d\u64c1\u6709\u5c08\u5229\u6b0a\u8207\u81ea\u4e3b\u6b0a\uff0c\u662f\u4e0d\u80fd\u5ffd\u8996\u7684\u8ab2\u984c\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #cc99ff;\"><strong>\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u6f14\u9032\u8207\u539f\u7406<\/strong><\/span><\/h6>\n<figure id=\"attachment_45091\" aria-describedby=\"caption-attachment-45091\" style=\"width: 300px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-medium wp-image-45091\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6212-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6212-300x200.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6212-1024x683.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6212-768x512.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6212-1536x1024.jpg 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6212-2048x1365.jpg 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-45091\" class=\"wp-caption-text\">\u4f86\u6e90\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3<\/figcaption><\/figure>\n<p>\u95dc\u65bc\u7d30\u80de\u57fa\u56e0\u6cbb\u7642\uff0c\u6797\u6210\u9f8d\u91ab\u5e2b\u8aaa\u660e\u76ee\u524d\u6700\u65b0\u7684\u8f38\u5165\u514d\u75ab\u7642\u6cd5\u6280\u8853\u5305\u542b\u53ef\u6d3b\u5316T\u7d30\u80de\u6280\u8853\uff08DC\u7d30\u80de\uff09\u3001\u57fa\u56e0\u6539\u9020T\u7d30\u80de (CAR-T) \u8207\u816b\u7624\u5167T\u7d30\u80de (TIL) \u7b49\uff0c\u5229\u7528T\u7d30\u80de\u6bba\u6b7b\u764c\u7d30\u80de\u7684\u624b\u6bb5\u3002<\/p>\n<p>\u65e9\u671f\u81ea\u9ad4T\u7d30\u80de\u7684\u514d\u75ab\u6cbb\u7642\uff0c\u6797\u91ab\u5e2b\u4ee5\u81ea\u5df1\u56de\u570b\u5f8c\u505a\u7684\u9f3b\u54bd\u764c\u81e8\u5e8a\u5be6\u9a57\u70ba\u4f8b\uff0c\u9032\u884c\u5229\u7528HLA-\u7279\u7570\u4e4b\u80dc\u80bd\u6297\u539f\u523a\u6fc0\u6d3b\u5316\u81ea\u9ad4\u6a39\u7a81\u7d30\u80de\uff0c\u4e26\u5c07\u5176\u6ce8\u5c04\u9032\u6dcb\u5df4\u7d50\u7684\u5be6\u9a57\uff0c\u8aaa\u660e\u9019\u9805\u7642\u6cd5\u78ba\u5be6\u80fd\u6e05\u9664\u9f3b\u54bd\u764c\u4ee5\u53ca\u8f49\u79fb\u81f3\u5176\u4ed6\u90e8\u4f4d\u7684\u764c\u7d30\u80de\u3002<\/p>\n<p>\u8fd1\u5e74\u4f86\uff0c\u66f4\u9ad8\u968e\u7684\u7642\u6cd5\u5df2\u5c07\u81ea\u9ad4\u7d30\u80de\u6539\u70ba\u57fa\u56e0\u6539\u9020T\u7d30\u80de\uff0c\u85c9\u7531\u57fa\u56e0\u5de5\u7a0b\u63d2\u5165\u4eba\u5de5\u57fa\u56e0\u7247\u6bb5\u300cCAR\u300d\uff0c\u6253\u9020\u9ad8\u63a5\u5408\u529b\u548c\u5f37\u6548\u7684CAR-T\u7d30\u80de (Chimeric Antigen Receptor T cell)\uff0c\u5927\u5e45\u63d0\u9ad8\u6bba\u6b7b\u764c\u7d30\u80de\u7684\u80fd\u529b\u3002CAR\u53d7\u9ad4\u7684\u7d50\u69cb\u53ef\u5340\u5206\u70ba\u5f48\u982d (scFv)\u3001\u5f48\u8eab (CD3\u03b6) \u5169\u5340\u57df\uff0c\u5f8c\u7e8c\u7814\u7a76\u4e2d\uff0c\u4e5f\u9010\u6f38\u6dfb\u52a0\u80de\u5167\u5340\u57df\u7684\u7247\u6bb5\uff0c\u63d0\u9ad8\u6301\u4e45\u6027\u8207\u6e05\u9664\u816b\u7624\u7684\u6548\u679c\u3002<\/p>\n<p>\u5177\u9ad4\u800c\u8a00\uff0cCAR-T\u7d30\u80de\u7684\u88fd\u4f5c\u8207\u6cbb\u7642\u6d41\u7a0b\uff0c\u7531\u5206\u96e2\u75c5\u60a3\u8840\u6db2\u4e2d\u7684\u767d\u8840\u7403\u958b\u59cb\uff0c\u7d14\u5316\u51fa\u8db3\u91cf\u7684T\u7d30\u80de\u5f8c\u52a0\u4ee5\u6d3b\u5316\uff0c\u518d\u5229\u7528\u6162\u75c5\u6bd2 (Lentiviral Vectors, LV) \u628a\u57fa\u56e0\u5de5\u7a0b\u88fd\u9020\u7684DNA\u9001\u5165T\u7d30\u80de\uff0c\u4fee\u98feT\u7d30\u80de\u4f7f\u5176\u6210\u70baCAR-T\u7d30\u80de\u5f8c\u52a0\u4ee5\u589e\u6b96\uff0c\u6700\u5f8c\u642d\u914d\u5316\u7642\u4e26\u5c07CAR-T\u8f38\u5165\u75c5\u60a3\u9ad4\u5167\uff0c\u9054\u5230\u6bba\u6b7b\u764c\u7d30\u80de\u7684\u6548\u679c\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #cc99ff;\"><strong>CAR-T\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\uff0c\u9010\u6f38\u653b\u514b\u5404\u9805\u764c\u75c7<\/strong><\/span><\/h6>\n<figure id=\"attachment_45092\" aria-describedby=\"caption-attachment-45092\" style=\"width: 300px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-medium wp-image-45092\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6213-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6213-300x200.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6213-1024x683.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6213-768x512.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6213-1536x1024.jpg 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/IMG_6213-2048x1365.jpg 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-45092\" class=\"wp-caption-text\">\u4f86\u6e90\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3<\/figcaption><\/figure>\n<p>CAR-T\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u662f\u5168\u7403\u7099\u624b\u53ef\u71b1\u7684\u65b0\u8208\u764c\u75c7\u7642\u6cd5\uff0c\u904e\u53bb\u88ab\u8a8d\u70ba\u4e0d\u53ef\u6cbb\u7652\u7684\u7684\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u3001\u96e3\u7e8f\u7684\u8166\u764c\uff0c\u5728\u4eca\u65e5\u90fd\u6210\u70ba\u6709\u6a5f\u6703\u88ab\u6cbb\u7652\u300c\u6162\u6027\u75be\u75c5\u300d\uff0c\u6797\u6210\u9f8d\u91ab\u5e2b\u7528\u570b\u969b\u671f\u520a\u6210\u679c\u8207\u516c\u53f8\u7684\u81e8\u5e8a\u5be6\u9a57\uff0c\u5411\u6240\u6709\u807d\u773e\u50b3\u9054\uff1a\u300c\u706b\u71b1\u7684\u91ab\u85e5\u5e02\u5834\uff0c\u9084\u6703\u518d\u71d920\u5e74\u4ee5\u4e0a\u3002\u300d<\/p>\n<p>\u6797\u91ab\u5e2b\u6210\u7acb\u6c9b\u723e\u5f8c\uff0c\u5718\u968a\u8457\u91cd\u5728B\u7d30\u80de\u6dcb\u5df4\u764c\u3001\u6025\u6027B\u7d30\u80de\u767d\u8840\u75c5\u3001\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u3001\u5375\u5de2\u764c\u7b49\u514d\u75ab\u57fa\u56e0\u5de5\u7a0b\u764c\u75c7\u7642\u6cd5\u7684\u81ea\u4e3b\u6280\u8853\u7814\u767c\uff0c\u5176\u6838\u5fc3\u6280\u8853\u5305\u542b\u6b21\u4e16\u4ee3CAR-T\u5e73\u53f0\u958b\u767c\u3001\u65b0\u578b\u6162\u75c5\u6bd2\u88fd\u9020\u5de5\u85dd\u3001\u8f03\u77ed\u88fd\u7a0b\u8207\u8f03\u9ad8\u54c1\u8ceaCAR-T\u7d30\u80de\u7b49\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u4ee5\u6cbb\u7642\u6dcb\u5df4\u764c\u3001\u8840\u764c\u7b49\u7531\u8840\u7403\u904b\u8f38\u5230\u5168\u8eab\u7684\u300c\u6db2\u9ad4\u764c\u300d\u800c\u8a00\uff0c\u6c9b\u723e\u6b63\u5728\u7814\u767c\u5468\u8f49\u6642\u9593\uff08turn around time\uff09\u66f4\u77ed\u3001\u985e\u5e79\u7d30\u80de\u8a18\u61b6T\u7d30\u80de\uff08stem cell-like memory T cell, Tsmc\uff09\u6bd4\u4f8b\u66f4\u9ad8\u7684CAR-T\u7522\u54c1\u3002\u53e6\u5916\uff0c\u91dd\u5c0d\u80ba\u764c\u3001\u809d\u764c\u3001\u80f0\u81df\u764c\u3001\u5375\u5de2\u764c\u7b49\u591a\u6578\u300c\u5be6\u9ad4\u764c\u300d\uff0c\u5247\u958b\u767c\u9593\u76ae\u7d20\u591a\u93c8CAR-T\uff0c\u63d0\u9ad8\u5171\u523a\u6fc0\u5340\u57df\u8fa8\u8a8d\u764c\u7d30\u80de\u7684\u80fd\u529b\uff0c\u4e26\u52a0\u5f37\u514d\u75ab\u7a81\u89f8\u7684\u7dca\u5bc6\u7a0b\u5ea6\uff0c\u63d0\u9ad8\u6bd2\u6bba\u5be6\u9ad4\u764c\u7d30\u80de\u7684\u6548\u529b\u3002<\/p>\n<p>\u7576\u672a\u4f86\u903c\u8fd1\u773c\u524d\uff0c\u773c\u4e0b\u5c31\u662f\u81fa\u7063\u662f\u5426\u8981\u8ddf\u4e0a\u7b2c\u56db\u5927\u91ab\u7642\u5de5\u696d\u767c\u5c55\u7684\u95dc\u9375\u6642\u523b\u3002\u6797\u6210\u9f8d\u91ab\u5e2b\u5728\u6f14\u8b1b\u7684\u6700\u5f8c\uff0c\u671f\u76fc\u5c07\u66f4\u65b0\u7a4e\u7684CAR-T\u7642\u6cd5\u69cb\u60f3\uff0c\u8f49\u5316\u70ba\u5177\u9ad4\u7684\u6210\u679c\uff0c\u8b93\u81fa\u7063\u8ffd\u4e0a\u4e16\u754c\u7684\u8173\u6b65\uff0c\u63d0\u4f9b\u570b\u4eba\u66f4\u512a\u8cea\u4e5f\u66f4\u6709\u80fd\u529b\u8ca0\u64d4\u7684\u7d30\u80de\u57fa\u56e0\u6cbb\u7642\u65b9\u6848\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li>Lin CL, WF Lo, TH Lee, R Yi , SL Hwang , YF Cheng, CL Chen, YS Chang , SP. Lee, AB Rickinson, PKH Tam. Immunization with Epstein-Barr Virus-specific peptide pulsed-dendritic cells induced functional cytotoxic T cell immunity and tumor regression in patients with nasopharyngeal carcinoma. Cancer Research 2002; 62: 6952-6958 (corresponding)<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<hr \/>\n<figure id=\"attachment_45094\" aria-describedby=\"caption-attachment-45094\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-45094 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/DSC01741-1024x580.jpg\" alt=\"\" width=\"800\" height=\"453\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/DSC01741-1024x580.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/DSC01741-300x170.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/DSC01741-768x435.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/DSC01741-1536x869.jpg 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/DSC01741-2048x1159.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-45094\" class=\"wp-caption-text\">\u5716\u5de6\u70ba\u4e3b\u6301\u4eba\u81fa\u5927\u7378\u91ab\u7cfb \u9673\u6167\u6587 \u6559\u6388\u3001\u5716\u53f3\u70ba\u8b1b\u5e2b \u6797\u6210\u9f8d \u5275\u8fa6\u4eba\uff5c\u4f86\u6e90\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>\u2728\u5ef6\u4f38\u95b1\u8b80\uff1a\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44806\">\u3010\u4eba\u7269\u5c08\u8a2a\u3011\u4eba\u985e\u6587\u660e\u4ee5\u4f86\u7684\u7b2c\u56db\u5927\u91ab\u7642\u7522\u696dCGT\u2014\u2014\u5c08\u8a2a\u6c9b\u723e\u751f\u6280\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8\u6797\u6210\u9f8d\u5275\u8fa6\u4eba<\/a>\u300b<\/p>\n<hr \/>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-44809\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/1123\u5831\u79d1\u5b78\u9996\u5716-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/1123\u5831\u79d1\u5b78\u9996\u5716-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/1123\u5831\u79d1\u5b78\u9996\u5716-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/1123\u5831\u79d1\u5b78\u9996\u5716-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/1123\u5831\u79d1\u5b78\u9996\u5716-1536x864.png 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/1123\u5831\u79d1\u5b78\u9996\u5716.png 1920w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u764c\u75c7\u662f\u842c\u75c5\u4e4b\u738b\uff0c\u4e5f\u662f\u6211\u5011\u6bcf\u500b\u4eba\u975e\u5e38\u95dc\u6ce8\u7684\u5065\u5eb7\u8b70\u984c\uff1b\u5728\u4e09\u5341\u5e74\u4ee5\u524d\uff0c\u764c\u75c7\u88ab\u8a8d\u70ba\u662f\u4e0d\u6cbb\u4e4b\u75c7\uff0c\u4f46\u4eca\u6642\u4eca\u65e5\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u51fa\u73fe\uff0c\u70ba\u4e16\u754c\u4e0a\u7121\u6578\u7f79\u764c\u60a3\u8005\u5e36\u4f86\u4e00\u7dda\u66d9\u5149\u3002\u672c\u6b21\u63a2\u7d22\u8b1b\u5ea7\u9080\u8acb\u5230\u6c9b\u723e\u751f\u6280\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5275\u8fa6\u4eba\u6797\u6210\u9f8d\u91ab\u5e2b\uff0c\u4ecb\u7d39\u7d30\u80de\u57fa\u56e0\u7642\u6cd5\u7684\u6f14\u9032\u8207\u539f\u7406\uff0c\u4e26\u5206\u4eab\u80fd\u6d88\u6ec5\u764c\u75c7\u7684CAR-T\u7642\u6cd5\uff0c\u5728\u8b1b\u8ff0\u91ab\u85e5\u6280\u8853\u7684\u540c\u6642\uff0c\u4e5f\u9ede\u51fa\u91ab\u5b78\u8207\u653f\u7b56\u9593\u7dca\u5bc6\u76f8\u9023\u7684\u95dc\u4fc2\uff0c\u767c\u4eba\u6df1\u7701\u3002<\/p>\n","protected":false},"author":20,"featured_media":45095,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,3293,7232],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/03\/1123-scaled.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45089"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45089"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45089\/revisions"}],"predecessor-version":[{"id":45110,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/45089\/revisions\/45110"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/45095"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}