{"id":45016,"date":"2025-02-10T17:00:12","date_gmt":"2025-02-10T09:00:12","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=45016"},"modified":"2025-02-07T13:45:05","modified_gmt":"2025-02-07T05:45:05","slug":"%e3%80%90%e6%8e%a2%e7%b4%a232-1%e3%80%91%e6%b6%b2%e6%85%8b%e6%aa%a2%e9%ab%94%e5%9c%a8%e7%b2%be%e6%ba%96%e9%86%ab%e5%ad%b8%e7%99%bc%e5%b1%95%e8%b6%a8%e5%8b%a2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=45016","title":{"rendered":"\u3010\u63a2\u7d2232-1\u3011\u6db2\u614b\u6aa2\u9ad4\u5728\u7cbe\u6e96\u91ab\u5b78\u767c\u5c55\u8da8\u52e2"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u6db2\u614b\u6aa2\u9ad4\uff08liquid biopsy\uff09\u662f\u4e00\u7a2e\u5229\u7528\u8eab\u9ad4\u5404\u7a2e\u9ad4\u6db2\u4e2d\u7684\u751f\u7269\u5206\u5b50\uff08\u5982\u6838\u9178\u3001\u86cb\u767d\u8cea\u7b49\uff09\u9032\u884c\u751f\u7406\u548c\u75c5\u7406\u6aa2\u6e2c\u7684\u6280\u8853\u3002\u53ef\u4ee5\u900f\u904e\u5c11\u91cf\u7684\u8840\u6db2\u3001\u5c3f\u6db2\u6216\u553e\u6db2\u7b49\u6a23\u672c\uff0c\u79d1\u5b78\u5bb6\u53ef\u4ee5\u6aa2\u6e2c\u7279\u5b9a\u7684\u751f\u7269\u5206\u5b50\uff0c\u4e26\u7d50\u5408\u5927\u6578\u64da\u5206\u6790\u751a\u81f3\u9810\u6e2c\u4e0d\u540c\u751f\u7406\u6216\u662f\u75c5\u7406\u7684\u72c0\u6cc1\u3002\u76f8\u8f03\u65bc\u50b3\u7d71\u624b\u8853\u53d6\u5f97\u7d44\u7e54\u6a23\u672c\uff0c\u6db2\u614b\u6aa2\u9ad4\u6e1b\u5c11\u4e86\u5c0d\u75c5\u4eba\u7684\u4fb5\u5165\u6027\u7684\u63a1\u6a23\u5275\u50b7\uff0c\u4e26\u63d0\u5347\u4e86\u6aa2\u6e2c\u7684\u9748\u654f\u5ea6\u548c\u6240\u9700\u7684\u6210\u672c\u3002\u6db2\u614b\u6aa2\u9ad4\u5728\u764c\u75c7\u8a3a\u65b7\u3001\u75c5\u7a0b\u76e3\u63a7\u548c\u8a3a\u65b7\u8a55\u4f30\u7686\u53ef\u5ee3\u6cdb\u61c9\u7528\uff0c\u5982\uff0c\u900f\u904e\u6709\u6548\u5730\u6aa2\u6e2c\u5faa\u74b0\u816b\u7624\u7d30\u80de\u3001\u7d30\u80de\u5916\u816b\u7624DNA\u4ee5\u53ca\u5916\u6ccc\u9ad4\u7b49\u6a19\u7684\uff0c\u70ba\uff08\u764c\u75c7\uff09\u7cbe\u6e96\u91ab\u5b78\u7684\u767c\u5c55\u63d0\u4f9b\u4e86\u65b0\u5951\u6a5f\u3002<\/strong><\/span><\/p>\n<p><strong>\u8b1b\u8005\uff5c\u81fa\u7063\u5927\u5b78\u690d\u7269\u75c5\u7406\u8207\u5fae\u751f\u7269\u5b78\u7cfb \u6c88\u6e6f\u9f8d \u6559\u6388\u517c\u7cfb\u4e3b\u4efb<\/strong><\/p>\n<p><strong>\u5f59\u6574\u3001\u64b0\u7a3f\uff5c\u97d3\u55ac\u878d<\/strong><\/p>\n<div class=\"fitvids-video\"><iframe title=\"\u6db2\u614b\u6aa2\u9ad4\u5728\u7cbe\u6e96\u91ab\u5b78\u767c\u5c55\u8da8\u52e2\uff5c\u6c88\u6e6f\u9f8d\uff5c\u63a2\u7d2232\u91ab \u65b0\u8208\u91ab\u7642\u79d1\u6280\u8a3a\u65b7\u8207\u6cbb\u7642\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/Idz2sCUW52Y?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #99ccff;\"><strong>\u4f55\u8b02\u6db2\u614b\u6aa2\u9ad4\uff08<\/strong><strong>liquid biopsy<\/strong><strong>\uff09<\/strong><strong>?<\/strong><\/span><\/h6>\n<p>\u6db2\u614b\u6aa2\u9ad4\uff08liquid biopsy\uff09\u662f\u4e00\u7a2e\u5229\u7528\u8eab\u9ad4\u5404\u5f0f\u9ad4\u6db2\u4e2d\u7684\u751f\u7269\u5206\u5b50\uff08\u6216\u751f\u7269\u6a19\u8a18\uff0c\u5982\u6838\u9178\u3001\u86cb\u767d\u8cea\u7b49\uff09\u9032\u884c\u751f\u7406\u548c\u75c5\u7406\u6aa2\u6e2c\u7684\u6280\u8853\u3002\u900f\u904e\u73fe\u4ee3\u751f\u7269\u6280\u8853\u548c\u9ad8\u6548\u80fd\u7684\u5100\u5668\u53ca\u5be6\u9a57\u65b9\u6cd5\uff0c\u5c0d\u9019\u4e9b\u751f\u7406\u548c\u75c5\u7406\u6a19\u8a8c\u9032\u884c\u6975\u5fae\u91cf\u4e14\u9ad8\u7cbe\u5ea6\u7684\u6aa2\u6e2c\uff0c\u4e26\u5229\u7528\u5927\u6578\u64da\u5206\u6790\u751a\u81f3\u9810\u6e2c\u5176\u8207\u751f\u7406\u6216\u75c5\u7406\u4e4b\u9593\u7684\u95dc\u806f\u6027\u3002\u9019\u985e\u6aa2\u6e2c\u53ea\u9700\u5c11\u91cf\u8840\u6db2\u3001\u5c3f\u6db2\u6216\u553e\u6db2\u7b49\u6a23\u672c\uff0c\u4e26\u901a\u904e\u9ad8\u6548\u80fd\u7684\u5100\u5668\u548c\u65b9\u6cd5\u4f86\u9032\u884c\u5206\u6790\u3002\u76f8\u6bd4\u50b3\u7d71\u9700\u900f\u904e\u624b\u8853\u53d6\u5f97\u7d44\u7e54\u6a23\u672c\u7684\u65b9\u6cd5\uff0c\u6db2\u614b\u6aa2\u9ad4\u4e0d\u50c5\u52a0\u5feb\u4e86\u6aa2\u6e2c\u901f\u5ea6\uff0c\u9084\u5927\u5927\u964d\u4f4e\u4e86\u5c0d\u75c5\u4eba\u7684\u50b7\u5bb3\u3002\u6b64\u5916\uff0c\u7531\u65bc\u6db2\u614b\u6aa2\u9ad4\u4e2d\u7684\u5206\u5b50\u5728\u8840\u6db2\u4e2d\u5747\u52fb\u5206\u5e03\uff0c\u80fd\u6709\u6548\u907f\u514d\u56e0\u764c\u7d30\u80de\u5206\u4f48\u4e0d\u5747\u800c\u5c0e\u81f4\u7684\u63a1\u6a23\u8aa4\u5dee\u6216\u662f\u8aa4\u8a3a\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #99ccff;\"><strong>\u6db2\u614b\u6aa2\u9ad4\u7684\u6b77\u53f2\u8d77\u6e90<\/strong><\/span><\/h6>\n<figure id=\"attachment_45017\" aria-describedby=\"caption-attachment-45017\" style=\"width: 300px\" class=\"wp-caption alignright\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-45017\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01673-300x170.jpg\" alt=\"\" width=\"300\" height=\"170\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01673-300x170.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01673-1024x580.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01673-768x435.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01673-1536x869.jpg 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01673-2048x1159.jpg 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-45017\" class=\"wp-caption-text\">\u4f86\u6e90\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3<\/figcaption><\/figure>\n<p>\u4e8b\u5be6\u4e0a\uff0c\u6db2\u614b\u6aa2\u9ad4\u7684\u6982\u5ff5\u53ef\u4ee5\u8ffd\u6eaf\u5230\u53e4\u4ee3\u3002\u4f8b\u5982\uff0c\u300a\u9ec3\u5e1d\u5167\u7d93\u300b\u8a18\u8f09\u4e86\u901a\u904e\u89c0\u5bdf\u5c3f\u6db2\u7684\u984f\u8272\u548c\u6df7\u6fc1\u5ea6\u4f86\u8a3a\u65b7\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u6548\u679c\uff1b\u53e4\u5e0c\u81d8\u7684\u91ab\u5b78\u4e5f\u63d0\u51fa\u901a\u904e\u8840\u6db2\u3001\u75f0\u6db2\u548c\u81bd\u6c41\u7684\u984f\u8272\u4f86\u8a55\u4f30\u75c5\u4eba\u7684\u5065\u5eb7\u3002\u523019\u4e16\u7d00\u672b\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\u764c\u7d30\u80de\u6703\u9032\u5165\u8840\u6db2\u4e2d\uff0c\u5f9e\u800c\u958b\u555f\u4e86\u6db2\u614b\u6aa2\u6e2c\u764c\u75c7\u7684\u53ef\u80fd\u300220\u4e16\u7d00\uff0c\u7814\u7a76\u8005\u767c\u73fe\u8840\u6db2\u4e2d\u9664\u4e86\u7d30\u80de\uff0c\u9084\u5b58\u5728\u764c\u7d30\u80de\u91cb\u653e\u7684DNA\u548cRNA\u5206\u5b50\u30022000\u5e74\u4ee5\u5f8c\uff0c\u9019\u4e00\u6280\u8853\u9010\u6b65\u61c9\u7528\u65bc\u81e8\u5e8a\u3002\u76f4\u52302016\u5e74\uff0c\u7f8e\u570b\u7684FDA\u6838\u53ef\u901a\u904e\u4ee5\u6aa2\u6e2c\u8840\u6db2\u4e2dEGFR\uff08epidermal growth factor receptor\uff0c\u4e00\u7a2e\u548c\u764c\u75c7\u816b\u7624\u751f\u6210\u76f8\u95dc\u7684\u57fa\u56e0\uff09\u7684\u7a81\u8b8a\u57fa\u56e0\u5e8f\u5217\u7528\u65bc\u7279\u5b9a\u764c\u75c7\u7684\u8a3a\u65b7\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<h6><span style=\"color: #99ccff;\"><strong>\u7cbe\u6e96\u91ab\u5b78\u8207\u6db2\u614b\u6aa2\u9ad4\u7684\u95dc\u4fc2\uff1f<\/strong><\/span><\/h6>\n<p>\u524d\u7f8e\u570b\u7e3d\u7d71\u6b50\u5df4\u99ac\u65bc2015\u5e74\u63d0\u51fa\u4e86\u300c\u7cbe\u6e96\u91ab\u5b78\u300d\u7684\u6982\u5ff5\uff0c\u65e8\u5728\u5229\u7528\u4f4e\u4fb5\u5165\u6027\u3001\u9ad8\u6548\u7387\u7684\u65b9\u5f0f\u4f86\u6aa2\u6e2c\u500b\u4eba\u5316\u5065\u5eb7\u7684\u72c0\u6cc1\u3002\u6db2\u614b\u6aa2\u9ad4\u6b63\u7b26\u5408\u9019\u4e00\u7406\u5ff5\uff0c\u901a\u904e\u6aa2\u6e2c\u8840\u6db2\u4e2d\u7684\u6838\u9178\u3001\u7d30\u80de\u7b49\u751f\u7269\u5206\u5b50\uff0c\u4e26\u7d50\u5408\u5927\u6578\u64da\u5206\u6790\uff0c\u53ef\u4ee5\u6e96\u78ba\u8a55\u4f30\u6216\u662f\u9810\u6e2c\u500b\u5225\u60a3\u8005\u5be6\u969b\u7684\u5065\u5eb7\u6216\u662f\u75be\u75c5\u7684\u72c0\u6cc1\uff0c\u907f\u514d\u624b\u8853\u5e36\u4f86\u7684\u98a8\u96aa\u548c\u50b7\u5bb3\uff0c\u63d0\u5347\u91ab\u7642\u63aa\u65bd\u7684\u7cbe\u6e96\u5ea6\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #99ccff;\"><strong>\u5e38\u898b\u7684\u6db2\u614b\u6aa2\u9ad4\u7a2e\u985e<\/strong><\/span><\/h6>\n<figure id=\"attachment_45018\" aria-describedby=\"caption-attachment-45018\" style=\"width: 300px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-medium wp-image-45018\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01693-300x170.jpg\" alt=\"\" width=\"300\" height=\"170\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01693-300x170.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01693-1024x580.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01693-768x435.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01693-1536x869.jpg 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01693-2048x1159.jpg 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-45018\" class=\"wp-caption-text\">\u4f86\u6e90\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3<\/figcaption><\/figure>\n<p>\u5e38\u898b\u7684\u6db2\u614b\u6aa2\u9ad4\u5305\u62ec\u9ad4\u6db2\u3001\u8840\u6db2\u3001\u553e\u6db2\u3001\u5c3f\u6db2\uff0c\u4ee5\u53ca\u8179\u6c34\u7b49\uff0c\u91dd\u5c0d\u4e0d\u540c\u7684\u75be\u75c5\u6240\u9069\u7528\u7684\u6aa2\u9ad4\u7a2e\u985e\u4e5f\u6703\u6709\u6240\u5dee\u7570\u3002\u5728\u6aa2\u6e2c\u9019\u4e9b\u6aa2\u9ad4\u6642\uff0c\u6700\u5e38\u5075\u6e2c\u7684\u751f\u7269\u5206\u5b50\u5305\u62ec\uff1a\u5faa\u74b0\u816b\u7624\u7d30\u80de\uff08circulating tumor cells, CTC\uff09\u3001\u5faa\u74b0\u816b\u7624DNA\uff08circulating tumor DNA, ctDNA\uff09\uff0c\u4ee5\u53ca\u5916\u6ccc\u9ad4\uff08exosomes\uff09\u3002\u4e00\u822c\u5728\u7372\u5f97\u8840\u6db2\u6aa2\u9ad4\u5f8c\uff0c\u6703\u5148\u5c07\u8840\u6f3f\u5206\u96e2\u4e26\u91dd\u5c0d\u8840\u6db2\u4e2d\u7684\u764c\u7d30\u80de\uff08\u4f8b\u5982CTC\uff09\u6aa2\u6e2c\u662f\u5426\u5b58\u5728\u4f86\u5224\u65b7\u7f79\u764c\u75c5\u4eba\u7684\u816b\u7624\u662f\u5426\u53ef\u80fd\u9032\u884c\u764c\u8f49\u79fb\u3001\u764c\u7d30\u80deDNA\u5206\u5b50\uff08\u4f8b\u5982ctDNA\uff09\u662f\u5426\u6709\u7a81\u8b8a\uff0c\u7814\u5224\u5176\u7a81\u8b8a\u662f\u5426\u5c0d\u65bc\u67d0\u4e9b\u85e5\u7269\u7684\u53cd\u61c9\u72c0\u6cc1\uff0c\u6216\u662f\u91dd\u5c0d\u5916\u6ccc\u9ad4\u7684RNA (\u5982miRNA)\u3001\u4ee3\u8b1d\u7269\u3001\u86cb\u767d\u8cea\u3001DNA\u7b49\u9032\u884c\u6aa2\u6e2c\u4f86\u53cd\u6620\u548c\u9810\u6e2c\u764c\u7d30\u80de\u53ef\u80fd\u7684\u884c\u70ba\u72c0\u614b\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #99ccff;\"><strong>\u6db2\u614b\u6aa2\u9ad4\u5728\u764c\u75c7\u8a3a\u65b7\u4e2d\u7684\u61c9\u7528<\/strong><\/span><\/h6>\n<p>\u6db2\u614b\u6aa2\u9ad4\u5728\u764c\u75c7\u6aa2\u6e2c\u4e2d\u7684\u61c9\u7528\u65e5\u76ca\u5ee3\u6cdb\u3002\u901a\u904e\u62bd\u8840\u6aa2\u6e2cCTC\u3001ctDNA\u548c\u5916\u6ccc\u9ad4\u4e2d\u7684\u5206\u5b50\uff0c\u53ef\u4ee5\u9032\u884c\u65e9\u671f\u764c\u75c7\u8a3a\u65b7\u3001\u75c5\u7a0b\u76e3\u63a7\u548c\u7642\u6548\u8a55\u4f30\u3002\u900f\u904ePCR\uff08\u805a\u5408\u9176\u93c8\u9396\u53cd\u61c9\uff09\u53ef\u4ee5\u9748\u654f\u6709\u6548\u5730\u5075\u6e2c\u76ee\u6a19\u6838\u9178\u57fa\u56e0\uff0c\u6216\u662f\u5229\u7528\u8cea\u8b5c\u7684\u65b9\u5f0f\u4e5f\u53ef\u4ee5\u5075\u6e2c\u662f\u5426\u6709\u764c\u75c7\u76f8\u95dc\u7684\u86cb\u767d\u8cea\u3001\u5316\u5408\u7269\u7684\u7d44\u6210\u3002\u9019\u4e9b\u6aa2\u6e2c\u6a19\u7684\u7684\u7279\u5b9a\u751f\u7269\u5206\u5b50\uff0c\u5c07\u7531\u5927\u6578\u64da\u8207\u751f\u7406\u75c5\u7406\u76f8\u95dc\u6027\u4ee5\u53ca\u751f\u7269\u8cc7\u8a0a\u7684\u5206\u6790\uff0c\u53ef\u505a\u70ba\u8a55\u4f30\u751f\u7406\u548c\u75c5\u7406\u7684\u72c0\u614b\u3002<\/p>\n<p>\u8fd1\u5e74\u7684\u7814\u7a76\u767c\u73fe\uff0c\u5916\u6ccc\u9ad4\u5167\u6240\u651c\u5e36\u7684\u751f\u7269\u5206\u5b50\u5728\u9ad4\u6db2\u4e2d\u6709\u8f03\u76f8\u5c0d\u7684\u7a69\u5b9a\u6027\uff0c\u540c\u6642\u6613\u65bc\u5206\u96e2\u64cd\u4f5c\u548c\u4fdd\u5b58\uff0c\u9032\u4e00\u6b65\u63d0\u5347\u4e86\u6db2\u614b\u6aa2\u9ad4\u7684\u61c9\u7528\u4fbf\u5229\u6027\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #99ccff;\"><strong>\u5916\u6ccc\u9ad4\uff08<\/strong><strong>exosomes<\/strong><strong>\uff09\u662f\u4ec0\u9ebc\uff1f<\/strong><\/span><\/h6>\n<figure id=\"attachment_45019\" aria-describedby=\"caption-attachment-45019\" style=\"width: 300px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-medium wp-image-45019\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01692-300x170.jpg\" alt=\"\" width=\"300\" height=\"170\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01692-300x170.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01692-1024x580.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01692-768x435.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01692-1536x869.jpg 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01692-2048x1159.jpg 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-45019\" class=\"wp-caption-text\">\u4f86\u6e90\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3<\/figcaption><\/figure>\n<p>\u5916\u6ccc\u9ad4\u662f\u4e00\u7a2e\u7531\u78f7\u8102\u8cea\u56ca\u6ce1\u5305\u88f9\u8457\u751f\u7269\u5206\u5b50\u7d44\u6210\u7684\u8907\u5408\u7269\uff0c\u5176\u5167\u542b\u7684\u751f\u7269\u5206\u5b50\u5305\u542b\u4e00\u4e9b\u4ee3\u8b1d\u7269\u3001RNA\u3001DNA\u3001\u7d30\u80de\u4ee3\u8b1d\u7269\u548c\u86cb\u767d\u8cea\uff0c\u5305\u62ec\u8f49\u9304\u56e0\u5b50\u3001\u9175\u7d20\u7b49\uff0c\u5e7e\u4e4e\u6240\u6709\u4eba\u985e\u7684\u7d30\u80de\uff08\u4e0d\u8ad6\u662f\u764c\u7d30\u80de\u3001\u809d\u7d30\u80de\u3001\u76ae\u819a\u7d30\u80de\u3001\u514d\u75ab\u7d30\u80de\u7b49\uff09\u751a\u81f3\u690d\u7269\u7d30\u80de\u90fd\u53ef\u4ee5\u5206\u6ccc\u5916\u6ccc\u9ad4\uff0c\u4e26\u91cb\u653e\u5230\u7d30\u80de\u5916\u548c\u7d44\u7e54\u6db2\u7b49\u9ad4\u6db2\u4e2d\u3002\u91cd\u8981\u5730\uff0c\u7d30\u80de\u548c\u7d30\u80de\u4e4b\u9593\u53ef\u4ee5\u900f\u904e\u5916\u6ccc\u9ad4\u76f8\u4e92\u7684\u50b3\u9001\u8a0a\u606f\u4f86\u9032\u884c\u6e9d\u901a\u3002\u4e0d\u904e\uff0c\u5916\u6ccc\u9ad4\u7684\u7d44\u6210\u6210\u5206\u662f\u975e\u5e38\u52d5\u614b\u8b8a\u5316\u7684\uff0c\u53ef\u4f9d\u64da\u7d30\u80de\u6240\u8655\u5728\u7684\u74b0\u5883\u548c\u672c\u8eab\u7684\u72c0\u614b\uff0c\u5176\u6240\u5206\u6ccc\u7684\u5916\u6ccc\u9ad4\u5167\u7684\u7d44\u6210\u548c\u5206\u6ccc\u7684\u6578\u91cf\u4e5f\u6703\u96a8\u4e4b\u6539\u8b8a\u3002\u9019\u4f7f\u5f97\u5916\u6ccc\u9ad4\u6210\u70ba\u75be\u75c5\u8a3a\u65b7\u548c\u9032\u5c55\u76e3\u6e2c\u7684\u6f5b\u529b\u5de5\u5177\u3002\u76ee\u524d\u570b\u5167\u5916\u5c0d\u65bc\u5916\u6ccc\u9ad4\u7684\u7814\u7a76\u525b\u958b\u59cb\u8d77\u6b65\u800c\u5438\u5f15\u5f88\u591a\u7684\u79d1\u5b78\u5bb6\u6216\u91ab\u5e2b\u5c0d\u5b83\u7684\u8208\u8da3\uff0c\u7136\u800c\u6211\u5011\u5c0d\u65bc\u5916\u6ccc\u9ad4\u7684\u751f\u6210\u7684\u904e\u7a0b\u548c\u6a5f\u8f49\u90fd\u9084\u4e0d\u592a\u4e86\u89e3\uff0c\u56e0\u6b64\u9084\u6709\u5f88\u591a\u90e8\u5206\u503c\u5f97\u79d1\u5b78\u5bb6\u7e7c\u7e8c\u7a4d\u6975\u548c\u6df1\u5165\u7684\u63a2\u7d22\u3002<\/p>\n<p>\u6709\u8da3\u7684\u662f\uff0c\u5916\u6ccc\u9ad4\u7684\u7d50\u69cb\u8207\u7d30\u80de\u6709\u76f8\u4f3c\u4e4b\u8655\uff0c\u5176\u5916\u5c64\u70ba\u7686\u70ba\u96d9\u5c64\u78f7\u8102\u8cea\u819c\uff0c\u985e\u4f3c\u65bc\u7d30\u80de\u819c\uff0c\u9019\u4f7f\u5f97\u5916\u6ccc\u9ad4\u5728\u5f9e\u8840\u6db2\u4e2d\u5206\u96e2\u5f8c\u80fd\u5920\u7a69\u5b9a\u4fdd\u5b58\u6578\u5929\u3002\u5176\u5be6\uff0c\u6700\u65e9\u767c\u73fe\u5916\u6ccc\u9ad4\u7684\u6642\u5019\uff0c\u79d1\u5b78\u5bb6\u8a8d\u70ba\u9019\u662f\u7d30\u80de\u7684\u300c\u5783\u573e\u888b\u300d\uff0c\u7528\u4f86\u5b58\u653e\u591a\u9918\u6216\u662f\u4e0d\u9700\u8981\u7684\u6838\u9178\u6216\u86cb\u767d\u8cea\u7b49\u751f\u7269\u5206\u5b50\uff0c\u56e0\u70ba\u5982\u679c\u76f4\u63a5\u628a\u9019\u4e9b\u751f\u7269\u5206\u5b50\u4e1f\u5230\u7d30\u80de\u5916\u5bb9\u6613\u5f15\u8d77\u767c\u708e\u7684\u53cd\u61c9\u3002\u7136\u800c\uff0c1987\u5e74\u7814\u7a76\u767c\u73fe\uff0c\u5916\u6ccc\u9ad4\u4e0d\u50c5\u50c5\u6392\u653e\u5ee2\u7269\uff0c\u9084\u8207\u8840\u7403\u7d30\u80de\u5206\u5316\u6709\u95dc\u3002\u800c1990\u5e74\u5f8c\uff0c\u5916\u6ccc\u9ad4\u66f4\u9032\u4e00\u6b65\u767c\u73fe\u53c3\u8207\u514d\u75ab\u8abf\u7bc0\u800c\u958b\u59cb\u88ab\u91cd\u8996\u3002\u52302007\u5e74\uff0c\u745e\u5178\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\u764c\u7d30\u80de\u6240\u5206\u6ccc\u7684\u5916\u6ccc\u9ad4\u4e2d\u542b\u6709\u5fae\u5c0fRNA\uff0c\u9019\u4e9b\u5206\u5b50\u53ef\u5f71\u50cf\u764c\u75c7\u5468\u908a\u5fae\u74b0\u5883\u9032\u800c\u5f71\u97ff\u764c\u7d30\u80de\u7684\u9032\u5c55\u548c\u8f49\u79fb\u3002\u8fd1\u5e74\u4f86\uff0c\u66f4\u591a\u7684\u7814\u7a76\u63ed\u793a\u4e86\u5916\u6ccc\u9ad4\u5728\u6240\u591a\u75be\u75c5\u8a3a\u65b7\u548c\u6cbb\u7642\u4e2d\u7684\u6f5b\u529b\uff0c\u7279\u5225\u662f\u5176\u5728\u7d30\u80de\u9593\u50b3\u905e\u8a0a\u606f\u5206\u5b50\u7684\u80fd\u529b\u4e0a\u986f\u5f97\u5728\u751f\u7406\u548c\u75c5\u7406\u5c24\u70ba\u91cd\u8981\u3002\u4e8b\u5be6\u4e0a\uff0c\u5916\u6ccc\u9ad4\u4f5c\u70ba\u7d30\u80de\u9593\u7684\u300c\u4fe1\u4f7f\u8005\u300d\uff0c\u5176\u8a0a\u606f\u5206\u5b50\u7684\u50b3\u905e\u5177\u6709\u7d30\u80de\u6216\u7d44\u7e54\u5c08\u4e00\u6027\uff0c\u7279\u5b9a\u7684\u5916\u6ccc\u9ad4\u53ea\u80fd\u5230\u9054\u7279\u5b9a\u7684\u5668\u5b98\uff0c\u70ba\u75be\u75c5\u8a3a\u65b7\u548c\u6cbb\u7642\u63d0\u4f9b\u4e86\u65b0\u7684\u524d\u666f\u3002<\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #99ccff;\"><strong>\u5916\u6ccc\u9ad4\u5728\u764c\u75c7\u8f49\u79fb\u4e2d\u7684\u4f5c\u7528<\/strong><\/span><\/h6>\n<p>\u8fd1\u5e74\u4f86\uff0c\u6211\u5011\u7684\u570b\u969b\u7814\u7a76\u5718\u968a\u767c\u73fe\u4e86\u764c\u7d30\u80de\u5206\u6ccc\u7684\u5916\u6ccc\u9ad4\u5176\u8868\u9762\u4e0a\u7684\u7279\u5b9a\u86cb\u767d\u8cea\u6709\u985e\u4f3c\u65bc\u90f5\u905e\u5340\u865f\u7684\u529f\u80fd\uff0c\u53ef\u4ee5\u5c07\u5916\u6ccc\u9ad4\u5c08\u4e00\u7684\u6a19\u9776\u5230\u7279\u5b9a\u5668\u5b98\uff0c\u4e4b\u5f8c\u900f\u904e\u91cb\u653e\u76f8\u95dc\u7684RNA\u3001DNA\u548c\u86cb\u767d\u8cea\u7b49\u4f86\u5f71\u97ff\u6a19\u9776\u5668\u5b98\u5167\u6b63\u5e38\u5065\u5eb7\u7684\u7d30\u80de\u800c\u5efa\u69cb\u4e86\u764c\u8f49\u79fb\u524d\u7684\u5fae\u74b0\u5883\uff0c\u5373\u5728\u9060\u7aef\u7684\u5668\u5b98\u5148\u884c\u5efa\u7acb\u4e86\u300c\u7058\u982d\u5821\u300d\uff0c\u4ee5\u5229\u764c\u7d30\u80de\u5f8c\u7e8c\u6613\u65bc\u8f49\u79fb\u5230\u9019\u4e9b\u5df2\u7d93\u5efa\u7acb\u7058\u982d\u5821\u7684\u9060\u7aef\u5668\u5b98\u3002\u900f\u904e\u8840\u6db2\u6aa2\u6e2c\u5916\u6ccc\u9ad4\u4e0a\u7684\u9019\u4e9b\u86cb\u767d\u5206\u5b50\u6a19\u8a8c\uff0c\u53ef\u4ee5\u4e86\u89e3\u76ee\u524d\u764c\u75c7\u8f49\u79fb\u7684\u72c0\u6cc1\u3002\u540c\u6a23\u7684\u6982\u5ff5\u4e5f\u5df2\u7d93\u958b\u767c\u5916\u6ccc\u9ad4\u505a\u70ba\u591a\u7a2e\u985e\u764c\u75c7\u4ee5\u53ca\u4e0d\u540c\u75be\u75c5\u7684\u65e9\u671f\u8a3a\u65b7\u3001\u76e3\u63a7\u3001\u9810\u5f8c\u4ee5\u53ca\u6297\u85e5\u6027\u7b49\u7684\u65b0\u8208\u751f\u7269\u6a19\u8a8c\u3002\u7d50\u5408\u4eba\u5de5\u667a\u6167\u4f86\u6bd4\u8f03\u5927\u91cf\u7684\u75c5\u4eba\u5176\u5916\u6ccc\u9ad4\u4e2d\u7684\u67d0\u4e9b\u5206\u5b50\u548c\u7279\u5b9a\u75be\u75c5\u57fa\u56e0\u505a\u76f8\u95dc\u6027\u5206\u6790\uff0c\u85c9\u6b64\u7cbe\u6e96\u7684\u5224\u65b7\u75be\u75c5\u767c\u751f\u7684\u968e\u6bb5\u548c\u56e0\u61c9\u7b56\u7565\u7b49\uff0c\u79d1\u5b78\u5bb6\u5df2\u9010\u6f38\u5efa\u69cb\u51fa\u53ef\u4ee5\u5354\u52a9\u7cbe\u6e96\u7684\u8a3a\u65b7\u548c\u53ca\u6642\u6cbb\u7642\u3002\u4e8b\u5be6\u4e0a\uff0c\u6db2\u614b\u6aa2\u9ad4\u6b63\u5728\u6539\u8b8a\u764c\u75c7\u548c\u8a31\u591a\u75be\u75c5\u7684\u6cbb\u7642\u7ba1\u7406\u6a21\u5f0f\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<figure id=\"attachment_45020\" aria-describedby=\"caption-attachment-45020\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-45020 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01729-1024x580.jpg\" alt=\"\" width=\"800\" height=\"453\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01729-1024x580.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01729-300x170.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01729-768x435.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01729-1536x869.jpg 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/DSC01729-2048x1159.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-45020\" class=\"wp-caption-text\">\u5716\u5de6\u70ba\u4e3b\u6301\u4eba\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3 \u8cf4\u4ea6\u5fb7 \u57f7\u884c\u9577\u3001\u5716\u53f3\u70ba\u8b1b\u5e2b \u6c88\u6e6f\u9f8d \u6559\u6388\uff5c\u4f86\u6e90\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>\u2728\u5ef6\u4f38\u95b1\u8b80\uff1a\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44661\" target=\"_blank\" rel=\"noopener\">\u3010\u4eba\u7269\u5c08\u8a2a\u3011\u5f9e\u690d\u7269\u75c5\u7406\u5230\u764c\u75c7\u6aa2\u6e2c\u2014\u2014\u5c08\u8a2a\u81fa\u5927\u690d\u7269\u75c5\u7406\u8207\u5fae\u751f\u7269\u5b78\u7cfb\u6c88\u6e6f\u9f8d\u6559\u6388<\/a>\u300b<\/p>\n<hr \/>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-45021\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2025\/02\/\u5831\u79d1\u5b781019-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" 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