{"id":44919,"date":"2024-12-26T18:00:55","date_gmt":"2024-12-26T10:00:55","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=44919"},"modified":"2026-01-06T14:26:13","modified_gmt":"2026-01-06T06:26:13","slug":"%e5%a4%9a%e8%ae%8a%e5%a4%9a%e5%b7%b4%e8%83%ba-%e7%ac%ac%e4%ba%94%e9%83%a8%ef%bc%9a%e6%81%90%e6%87%bc%e4%b9%9f%e4%be%86%e6%b9%8a%e4%b8%80%e8%85%b3","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=44919","title":{"rendered":"\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e94\u90e8\uff1a\u6050\u61fc\u4e5f\u4f86\u6e4a\u4e00\u8173"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u9084\u8a18\u5f97\u4eca\u5e74\u5728\u591a\u5df4\u80fa\u79d1\u5b78\u9032\u5c55\u53f2\u4e0a\uff0c67\u6b72\u7684\u591a\u5df4\u80fa\u59d1\u5a18\u55ce?\u00a0\u5979\u4e8c\u5341\u5e7e\u6b72\u624d\u9010\u6f38\u6210\u70ba\u5feb\u6a02\u4ee3\u8a00\u4eba\uff0c\u7136\u800c\uff0c\u9019\u5feb\u6a02\u7684\u80cc\u5f8c\u5176\u5be6\u662f\u5e36\u9ede\u6050\u61fc (fear) \u7684\u3002\u5728\u7814\u7a76\u521d\u671f\uff0c\u79d1\u5b78\u5bb6\u4f7f\u7528\u57fa\u672c\u5de5\u5177\u63a2\u7d22\u591a\u5df4\u80fa\u7684\u4f5c\u7528\uff0c\u91cd\u9ede\u662f\u548c\u7cbe\u795e\u75c5\u8207\u6297\u7cbe\u795e\u75c5\u85e5\u7269\u6709\u95dc\u3002\u7531\u65bc\u6240\u7528\u7684\u85e5\u7269\u3001\u5de5\u5177\u548c\u6280\u8853\u7684\u4e0d\u8db3\uff0c\u6700\u521d\u95dc\u65bc\u591a\u5df4\u80fa\u53c3\u8207\u6050\u61fc\u5236\u7d04\u7684\u8aaa\u6cd5\u662f\u88ab\u99c1\u65a5\u7684\u3002\u4f46\u662f\uff0c\u79d1\u5b78\u767c\u5c55\u81f3\u4eca\uff0c\u539f\u4f86\u300a\u8166\u7b4b\u6025\u8f49\u5f4e\u300b\u4e2d\u5168\u8eab\u7d2b\u8272\u7684\u300c\u9a5a\u9a5a\u300d\u6216\u300c\u6015\u6015\u300d\u4e5f\u548c\u591a\u5df4\u80fa\u59d1\u5a18\u6709\u4e9b\u4ea4\u60c5\uff0c\u9019\u6b21\u5c31\u8b93\u6211\u5011\u4e00\u8d77\u4f86\u8166\u7b4b\u6025\u8f49\u5f4e\u4e00\u4e0b\u5427\uff01<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5cA.H.<\/strong><\/p>\n<figure id=\"attachment_44923\" aria-describedby=\"caption-attachment-44923\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-44923\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_1_AH20240819-1024x576.png\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_1_AH20240819-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_1_AH20240819-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_1_AH20240819-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_1_AH20240819.png 1280w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-44923\" class=\"wp-caption-text\">\u5716\u4e00\uff1a\u591a\u5df4\u80fa\u3001\u5de5\u4f5c\u7d30\u80deDAN\u548c\u591a\u5df4\u80fa\u53d7\u9ad4\u53c3\u8207\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>\u6211\u5011\u5728\u300c\u56db\u5341\u800c\u4e0d\u60d1\u7684\u591a\u5df4\u80fa\u300d\u4e2d\u5f97\u77e5\uff0c\u56e0\u79d1\u5b78\u7684\u9032\u5c55\u8b93\u5316\u5b78\u5206\u5b50\u591a\u5df4\u80fa(DA)\u4e0d\u518d\u662f\u5feb\u6a02\u5206\u5b50\u4ee3\u8a00\u4eba\u3002\u6709\u8da3\u7684\u662f\u5927\u7d04\u540c\u671f\u768421\u4e16\u7d00\uff0c\u96a8\u8457\u907a\u50b3\u5b78\u3001\u5316\u5b78\u3001\u5149\u5b78\u65b9\u6cd5\u7b49\u66f4\u5148\u9032\u6280\u8853\u7684\u9032\u5c55\uff0c\u79d1\u5b78\u4e0d\u50c5\u4ee5\u524d\u6240\u672a\u6709\u7684\u6e05\u6670\u5ea6\u660e\u77ad\u591a\u5df4\u80fa\u3001\u591a\u5df4\u80fa\u795e\u7d93\u5143\uff08\u5de5\u4f5c\u7d30\u80deDAN\uff09\u8207\u591a\u5df4\u80fa\u53d7\u9ad4\u7684\u52d5\u614b\u4ea4\u4e92\uff0c\u9019\u4e9b\u7a81\u7834\u4e5f\u5e6b\u52a9\u6211\u5011\u8d8a\u4f86\u8d8a\u6df1\u5165\u7406\u89e3DA\u5728\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u7684\u4f5c\u7528\uff0c\u4e26\u70ba\u4e8c\u8005\u63d0\u4f9b\u4e86\u5fc3\u7406\u548c\u795e\u7d93\u751f\u7269\u5b78\u6a5f\u5236\u7684\u56e0\u679c\u8b49\u64da\u3002\u4f8b\u5982\u4e0a\u56de\u6709\u95dc\u591a\u5df4\u80fa\u53d7\u9ad440\u5e74\u7684\u6587\u737b\u56de\u9867\u4e2d\u5176\u5be6\u4e5f\u5305\u542b\u4e86\u6050\u61fc\uff0c\u6587\u737b\u63d0\u5230\u8abf\u7bc0\u548c\u6d88\u9000\u6050\u61fc\u6240\u5fc5\u9700\u7684\u5305\u62ec\u674f\u4ec1\u6838\u4e2d\u7684 D1\u300c\u4fc3\u9032\u300d\u795e\u7d93\u5143\u53ef\u5851\u6027\uff1bD2\u5247\u662f\u300c\u6291\u5236\u300d\u795e\u7d93\u5143\u53ef\u5851\u6027\uff1b\u800c\u8179\u5074\u7d0b\u72c0\u9ad4\uff08\u4f0f\u9694\u6838\u548c\u55c5\u7d50\u7bc0\uff09\u7684D3\u53cd\u6620\u4e86\u6050\u61fc\u3001\u7126\u616e\u548c\u6182\u9b31\u7b49\u529f\u80fd\u3002<\/p>\n<p>\u82e5\u9032\u4e00\u6b65\u4ee5\u52a0\u62ff\u5927\u79d1\u5b78\u5bb6Hamati\u7b49\u4eba\u56de\u986765\u5e74\uff08\u81f32023\u5e74\uff09\u7cfb\u7d71\u7814\u7a76\u4f86\u770b\uff0c\u300c\u591a\u5df4\u80fa\u59d1\u5a18\u7684\u6050\u61fc\u300d\u5be6\u969b\u4e0a\u5e7e\u4e4e66\u6b72\u4e86\u3002\u90a3\u9ebc\uff0c\u70ba\u4ec0\u9ebc\u4e00\u822c\u804a\u591a\u5df4\u80fa\u5f88\u5c11\u63d0\u5230\u6050\u61fc\uff1f\u9664\u4e86\u65e9\u671f\u65b9\u6cd5\u7684\u9650\u5236\u5916\uff0c\u904e\u53bb\u5927\u591a\u662f\u52d5\u7269\u7814\u7a76\uff0c\u76f8\u6bd4\u4e4b\u4e0b\u4eba\u985e\u7814\u7a76\u9084\u8655\u65bc\u8d77\u6b65\u968e\u6bb5\u3002\u7136\u800c\u6050\u61fc\u5c31\u50cf\u5feb\u6a02\u4e00\u6a23\uff0c\u662f\u4eba\u985e\u6700\u666e\u901a\u3001\u6700\u7c21\u55ae\u3001\u6700\u76f4\u63a5\u7684\u60c5\u7dd2\uff0c\u591a\u5df4\u80fa\u65e2\u7136\u53c3\u4e86\u4e00\u8173\uff0c\u6211\u5011\u5c31\u85c9\u7531Hamati\u7b49\u4eba\u7684\u7d9c\u5408\u7814\u7a76\uff0c\u5c07\u54ea\u4e9b\u5927\u8166\u5340\u57df\u5728\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u671f\u9593\u8868\u73fe\u51faDA\u548cDAN\u6d3b\u6027\u3001\u54ea\u4e9bDA\u53d7\u9ad4\u6709\u52a9\u65bc\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u3001\u4ee5\u53ca\u5b83\u5011\u7684\u5340\u57df\u7570\u8cea\u6027\u7b49\u9019\u4e9b\u6211\u5011\u4e0d\u719f\u6089\u7684\u8cc7\u8a0a\uff0c\u5faa\u5e8f\u6f38\u9032\u7684\u518d\u6b21\u8a34\u8aaa\u591a\u5df4\u80fa\u7684\u975e\u51e1\u591a\u8b8a\u6a23\u8c8c\u6545\u4e8b\u3002<\/p>\n<figure id=\"attachment_44924\" aria-describedby=\"caption-attachment-44924\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-44924 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_2_AH20240819-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_2_AH20240819-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_2_AH20240819-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_2_AH20240819-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_2_AH20240819.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-44924\" class=\"wp-caption-text\">\u5716\u4e8c\uff1a\u6050\u61fc (fear) MeSH: D005239\u77e5\u8b58\u6a39\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>\u9996\u5148\uff0c\u6211\u5011\u5148\u904b\u7528\u77e5\u8b58\u672c\u9ad4--\u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928\u91ab\u5b78\u79d1\u76ee\u6a19\u984c (MeSH) \u77e5\u8b58\u6a39\u8fc5\u901f\u638c\u63e1\u6050\u61fc (MeSH:D005239) \u5728\u884c\u70ba\u548c\u884c\u70ba\u6a5f\u5236\u4e2d\u7684\u77e5\u8b58\u67b6\u69cb\u5982\u5716\u4e8c\u3001\u5bc6\u897f\u6839\u5927\u5b78\u91ab\u5b78\u9662\u7684\u795e\u7d93\u884c\u70ba\u672c\u9ad4\u8ad6 (Neuro Behavior Ontology, NBO) \u7684\u6050\u61fc\u5236\u7d04 (NBO:0000209) \u5982\u5716\u4e09\u3002\u6839\u64daNBO\u5c0d\u6050\u61fc\u5236\u7d04\u7684\u5b9a\u7fa9: \u4e00\u7a2e\u806f\u60f3\u5b78\u7fd2\uff0c\u5141\u8a31\u751f\u7269\u9ad4\u5728\u7279\u5b9a\u74b0\u5883\u6216\u523a\u6fc0\uff0c\u53ef\u9810\u898b\u5730\u900f\u904e\u53ad\u60e1\u74b0\u5883\u5f15\u767c\u6050\u61fc\u7684\u60c5\u6cc1\u4e0b\u7372\u5f97\u60c5\u7dd2\u53cd\u61c9\u3002\u63db\u53e5\u8a71\u8aaa\uff0c\u6050\u61fc\u5236\u7d04\u662f\u4e00\u500b\u904e\u7a0b\uff0c\u5b83\u8aac\u660e\u6211\u5011\u7684\u5927\u8166\u5b78\u6703\u5c07\u67d0\u4e9b\u4e8b\u60c5\u8207\u6050\u61fc\u806f\u7e6b\u8d77\u4f86\u3002\u9019\u7a2e\u6a5f\u5236\u5728\u6211\u5011\u5982\u4f55\u61c9\u5c0d\u6f5b\u5728\u5a01\u8105\u60c5\u6cc1\u65b9\u9762\u767c\u63ee\u81f3\u95dc\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4e5f\u5c31\u662f\u5927\u8166\u5728\u666e\u901a\u4e8b\u7269\u548c\u53ef\u6015\u4e8b\u7269\u4e4b\u9593\u5efa\u7acb\u806f\u7e6b\u3002<\/p>\n<figure id=\"attachment_44925\" aria-describedby=\"caption-attachment-44925\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-44925 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_3_AH20240819-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_3_AH20240819-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_3_AH20240819-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_3_AH20240819-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_3_AH20240819.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-44925\" class=\"wp-caption-text\">\u5716\u4e09\uff1a\u6050\u61fc\u5236\u7d04NBO: 0000209\u77e5\u8b58\u6a39\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>Hamati\u7b49\u4eba\u5728\u8a0e\u8ad6\u591a\u5df4\u80fa\u4e4b\u65bc\u7d93\u5178\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u7684\u7de8\u78bc\u6050\u61fc\u904e\u7a0b\u4e2d\u7d04\u7565\u5305\u62ec\u5e7e\u500b\u968e\u6bb5: \u5f62\u6210\u3001\u56fa\u5316\u3001\u6aa2\u7d22\u3001\u66f4\u65b0\u548c\u6d88\u9000\u8a18\u61b6\u3002\u4e8b\u5be6\u4e0a\uff0cDA\u5728\u6050\u61fc\u4f5c\u7528\u4e2d\u6700\u5438\u5f15\u4eba\u7684\u5c31\u662f\u5b83\u7684\u96d9\u91cd\u6027\u8cea\uff0c\u96d6\u7136\u5b83\u6709\u52a9\u65bc\u7de8\u78bc\u6050\u61fc\uff0c\u4f46\u5b83\u4e5f\u5728\u9019\u4e9b\u8a18\u61b6\u7684\u6d88\u9000\u4e2d\u8d77\u4f5c\u7528\u3002\u7814\u7a76\u4ee5\u53e4\u5178\u5236\u7d04\u7406\u8ad6\u4e2d\u7684\u6050\u61fc\u5236\u7d04\u523a\u6fc0(CS+)\u4e4b\u7fd2\u5f97\u548c\u56de\u61b6\u4ee3\u8868\u4e86\u5b78\u7fd2\u6050\u61fc\u7684\u80fd\u529b; \u5b89\u5168\u5236\u7d04\u523a\u6fc0(CS\u2212)\u7684\u7fd2\u5f97\u548c\u56de\u61b6\u4ee5\u53ca\u6d88\u9000\u8a13\u7df4\u548c\u6d88\u9000\u56de\u61b6\u4ee3\u8868\u4e86\u6291\u5236\u7fd2\u5f97\u6050\u61fc\u7684\u80fd\u529b\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u90fd\u6539\u8b8a\u4e86\u5de5\u4f5c\u7d30\u80deDAN\u7684\u6d3b\u6027\uff0c\u4e26\u6539\u8b8a\u4e86\u591a\u500b\u5927\u8166\u5340\u57df\u7684DA\u6fc3\u5ea6\u6c34\u6e96\uff0c\u53c3\u898b\u5716\u56db\u3002<\/p>\n<figure id=\"attachment_44920\" aria-describedby=\"caption-attachment-44920\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-44920 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_4_AH20240819-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_4_AH20240819-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_4_AH20240819-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_4_AH20240819-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_4_AH20240819.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-44920\" class=\"wp-caption-text\">\u5716\u56db\uff1a\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u968e\u6bb5\u5c0d\u5927\u8166\u4e2dDA\u6c34\u6e96\u7684\u5f71\u97ff\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b\uff0c\u6539\u7de8\u81eaHamati\u7b49\u4eba\u88682<\/figcaption><\/figure>\n<ul>\n<li><strong>DA<\/strong><strong>\u6d3b\u6027\u6c34\u6e96\u5347\u9ad8\u5340\u57df\uff1a<\/strong>\u674f\u4ec1\u6838\u662f\u6050\u61fc\u5236\u7d04\u4e2d\u6700\u95dc\u9375\u7684\u5340\u57df\uff0c\u5728\u7fd2\u5f97\u548c\u56de\u61b6\u968e\u6bb5DA\u5347\u9ad8\uff0c\u540c\u6642\u524d\u984d\u8449\u76ae\u8cea\u672b\u68a2\u6d3b\u52d5\u548c\u7d55\u5927\u591a\u6578\u8179\u5074\u4e2d\u8166\u5c0e\u6c34\u7ba1\u5468\u570d\u7070\u8cea (PAG)\uff0f\u80cc\u5074\u7e2b\u6838 (DRN) \u5340\uff0cDA\u5747\u63d0\u5347\u3002<\/li>\n<li><strong>\u6839\u64da\u5176\u4f4d\u7f6e\u800c\u8b8a\u5316\uff1a<\/strong>\u8179\u5074\u84cb\u5340 (VTA) \u52d5\u7269\u6587\u737b\u8868\u660e\uff0cDA\u5728\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u7684\u6240\u6709\u968e\u6bb5\u90fd\u5728\u5167\u5074\u524d\u984d\u8449\u76ae\u5c64 (mPFC) \u4e2d\u91cb\u653e\uff0c\u4f46\u5167\u5074\u548c\u5916\u5074VTA\u7684DAN\u6d3b\u52d5\u53ef\u80fd\u53d6\u6c7a\u65bc\u89e3\u5256\u4f4d\u7f6e\u548c\u7a2e\u985e\u3002\u9ed1\u8cea\u7dfb\u5bc6\u90e8 (SNpc) \u56e0\u6d3b\u52d5\u7684DAN\u6578\u91cf\u5728\u6050\u61fc\u7fd2\u5f97\u5f8c\u6c92\u6709\u6539\u8b8a\uff0c\u56e0\u6b64\u5728\u6700\u521d\u7814\u7a76\u4e2d\u4e26\u4e0d\u652f\u6301SNpc\u53c3\u8207\u6050\u61fc\u5236\u7d04\uff0c\u800c\u5f8c\u96a8\u8457\u6280\u8853\u7684\u9032\u6b65\uff0c\u5728\u6050\u61fc\u7fd2\u5f97\u904e\u7a0b\u4e2d\uff0cSNpc\u80cc\u5916\u5074\u5340\u57df\u7684DAN\u6d3b\u52d5\u8da8\u65bc\u589e\u52a0\uff0c\u8179\u5167\u5074\u5340\u57df\u6d3b\u52d5\u8da8\u65bc\u6e1b\u5c11\u7684\u767c\u73fe\u8868\u660e\uff0c\u8207VTA\u985e\u4f3c\uff0cSNpc\u7684DA\u795e\u7d93\u5143\u6d3b\u52d5\u6839\u64da\u5176\u4f4d\u7f6e\u800c\u8b8a\u5316\u3002<\/li>\n<li><strong>\u4e0d\u78ba\u5b9a\u5340\u57df\uff1a<\/strong>\u7d0b\u72c0\u9ad4\u96d6\u8207\u674f\u4ec1\u6838\u4e00\u8d77\u88ab\u8a8d\u70ba\u662f\u5354\u8abf\u6050\u61fc\u53cd\u61c9\u7684\u6a1e\u7d10\u3001\u4e14\u76f8\u5c0d\u65bc\u5176\u4ed6\u5927\u8166\u5340\u57df\u4e5f\u5177\u6709\u6700\u9ad8\u7684DA \u53d7\u9ad4\u5bc6\u5ea6\uff0c\u4f46\u76ee\u524d\u56e0\u6280\u8853\u7684\u5dee\u7570\uff0c\u5c0dDA\u6050\u61fc\u7684\u56e0\u679c\u8a0e\u8ad6\u4ecd\u4e0d\u4e00\u81f4\u3002<\/li>\n<\/ul>\n<p>\u540c\u6642\uff0c\u591a\u5df4\u80fa\u7684\u985eD1\u548c\u985eD2\u53d7\u9ad4\u90fd\u6709\u52a9\u65bc\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\uff0c\u5176\u4e2d\u985eD1\u5c0d\u65bc\u8a18\u61b6\u7fd2\u5f97\u548c\u56fa\u5316\u66f4\u70ba\u91cd\u8981\uff0c\u985eD2\u5247\u4e3b\u8981\u53cd\u6620\u5728\u56fa\u5316\u548c\u56de\u61b6\u671f\u3002\u95dc\u65bc\u53d7\u9ad4\u7684\u5340\u57df\u7570\u8cea\u6027\uff0c\u985eD1\u548c\u985eD2\u5728\u5927\u8166\u5340\u57df\u5167\u53ef\u80fd\u5177\u6709\u91cd\u758a\u4f5c\u7528\uff0c\u4e5f\u53ef\u80fd\u4ee3\u8868\u7368\u7279\u901a\u8def\uff0c\u5716\u4e94\u986f\u793a\u5de5\u4f5c\u7d30\u80deDAN\u900f\u904e\u540c\u6642\u6295\u5c04\u591a\u500b\u5340\u57df\u4f86\u5354\u8abf\u6050\u61fc\u5b78\u7fd2\uff0c\u4e26\u900f\u904e\u4f5c\u7528\u65bc\u985eD1\u548c\u985eD2\u53d7\u9ad4\u4ee5\u52d5\u614b\u4e92\u52d5\u7684\u65b9\u5f0f\u66f4\u65b0\u6050\u61fc\u5b78\u7fd2\uff0c\u6b78\u7d0d\u5340\u57df\u7570\u8cea\u6027\u5305\u62ec\u674f\u4ec1\u6838\u548c\u524d\u984d\u8449\u76ae\u8cea\u3001\u5167\u5074\u524d\u984d\u8449\u76ae\u8cea (mPFC)\u3001\u6d77\u99ac\u8ff4\u8207\u4e18\u8166\u3002<\/p>\n<figure id=\"attachment_44921\" aria-describedby=\"caption-attachment-44921\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-44921 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_5_AH20240819-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_5_AH20240819-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_5_AH20240819-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_5_AH20240819-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_5_AH20240819.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-44921\" class=\"wp-caption-text\">\u5716\u4e94\uff1a\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u7d81\u5b9a\u53d7\u9ad4\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b\uff0c\u6539\u7de8\u81eaHamati\u7b49\u4eba\u57163<\/figcaption><\/figure>\n<ul>\n<li>\u674f\u4ec1\u6838\u548c\u524d\u984d\u8449\u76ae\u8cea\u5747\u5728\u6050\u61fc\u5236\u7d04\u548c\u6d88\u9000\u4e2d\u4f5c\u7528\uff0c\u985eD1\u548c\u985eD2\u53d7\u9ad4\u5177\u6709\u91cd\u758a\u4f5c\u7528\u3002\u5728\u674f\u4ec1\u6838\u5167\uff0cDA \u8207\u985eD1 \u548c D2 \u53d7\u9ad4\u7d50\u5408\u6703\u7522\u751f\u9577\u671f\u589e\u5f37\u548c\u6182\u9b31\u7684\u74b0\u5883\uff0c\u6709\u52a9\u65bc\u6050\u61fc\u5236\u7d04\u7684\u5f62\u6210\u548c\u7a69\u5b9a\u3002\u6b64\u5916\uff0c\u91cd\u65b0\u8868\u9054(\u900f\u904e\u56de\u61b6)\u91cd\u65b0\u6fc0\u6d3b\u7a69\u5b9a\u7684\u8ff4\u8def\uff0c\u800c\u6050\u61fc\u6291\u5236(\u900f\u904e\u6d88\u9000\u8a13\u7df4\u6216\u900f\u904eCS\u2212\u7684\u6291\u5236)\u5275\u9020\u4e00\u500b\u65b0\u7684\u3001\u76f8\u53cd\u7684\u8ff4\u8def\u4f86\u6291\u5236\u6050\u61fc\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6574\u500b\u5167\u5074\u524d\u984d\u8449\u76ae\u8cea(mPFC)\u4e2d\u7684DA\u53ef\u80fd\u6703\u4fc3\u9032\u6050\u61fc\u6291\u5236DA\uff0c\u4e0d\u50c5\u53d7\u5230\u524d\u984d\u8449\u76ae\u8cea\u4e9e\u5340\u7684\u5f71\u97ff\uff0c\u4e14\u53d7\u8a72\u4e9e\u5340\u57df\u5167\u76ae\u5c64\u8f38\u51fa\u795e\u7d93\u5143\u7684\u7279\u5b9a\u985e\u578b\u5f71\u97ff\u3002\u7d0b\u72c0\u9ad4\u53d6\u6c7a\u65bc\u4e9e\u5340\u7684\u5dee\u7570\uff0c\u6050\u61fc\u5236\u7d04\u6703\u56e0\u985eD1\u548c\u985eD2\u53d7\u9ad4\u8868\u9054\u7684\u795e\u7d93\u5143\u800c\u6539\u8b8a\u3002<\/li>\n<li>\u6d77\u99ac\u8ff4CA1\u90e8\u4f4d\u4e2d\u7684\u985eD1\u548c\u985eD2\u53c3\u8207\u6050\u61fc\u7fd2\u5f97\u3001\u56de\u61b6\u548c\u6d88\u9000\u8a13\u7df4\u7684\u56fa\u5316\u3002<\/li>\n<li>\u4e18\u8166\u4e2d\u6050\u61fc\u5236\u7d04\u7531D2\u4ecb\u5c0e\uff0c\u6050\u61fc\u6d88\u9000\u5247\u7531D1\u4ecb\u5c0e\u3002<\/li>\n<li>\u55c5\u7d50\u7bc0\uff0c\u4f0f\u9694\u6838\u6700\u8179\u5074\u7684\u5ef6\u4f38\uff0c\u795e\u7d93\u5143\u8868\u9054DA\u53d7\u9ad4\uff0c\u4e26\u5c0d\u5236\u7d04\u7dda\u7d22\u505a\u51fa\u53cd\u61c9\u3002<\/li>\n<\/ul>\n<p>\u4ee5\u524d\uff0c\u6211\u5011\u5c0d\u591a\u5df4\u80fa\u7684\u8a8d\u8b58\u4e3b\u8981\u5728\u65bc\u5feb\u6a02\u3001\u617e\u671b\u3001\u6fc0\u52f5\u52d5\u6a5f\u8207\u76ee\u6a19\u8a2d\u5b9a\u3002\u4e0d\u904e\u591a\u8b8a\u7684\u591a\u5df4\u80fa\u56e0\u8457\u79d1\u5b78\u9032\u5c55\u800c\u591a\u8b8a\uff0c\u591a\u5df4\u80fa\u548c\u5de5\u4f5c\u7d30\u80deDAN\u5c31\u50cf\u8b1b\u6545\u4e8b\u7684\u4eba\u4e00\u6a23\uff0c\u4e5f\u7de8\u78bc\u8457\u597d\u5947\u3001\u6050\u61fc\u548c\u5b89\u5168\u7684\u6558\u8ff0\u3002\u540c\u6642\u4e5f\u53cd\u6620\u51fa\u6211\u5011\u7684\u5927\u8166\u4e0d\u662f\u975c\u614b\u7684\u8a18\u61b6\u5eab\uff0c\u800c\u662f\u4e0d\u65b7\u8b8a\u5316\u7684\u666f\u89c0\uff0c\u4e0d\u65b7\u88ab\u6211\u5011\u7684\u7d93\u9a57\u8a18\u61b6\u6539\u5beb\u3002\u5b83\u5011\u901a\u904e\u53d7\u9ad4\u901a\u8def\u767c\u9001\u8a0a\u865f\uff0c\u9019\u4e9b\u8a0a\u865f\u6709\u52a9\u65bc\u5f62\u6210\u3001\u56fa\u5316\u548c\u6aa2\u7d22\u6050\u61fc\u548c\u6d88\u9000\u7684\u8a18\u61b6\uff0c\u6bcf\u4e00\u500b\u6050\u61fc\uff0c\u6bcf\u4e00\u500b\u6050\u6016\u7684\u6642\u523b\uff0c\u90fd\u88ab\u5316\u5b78\u7269\u8cea\u7684\u5fae\u5999\u76f8\u4e92\u4f5c\u7528\u8755\u523b\u5728\u795e\u7d93\u7d50\u69cb\u4e2d\u3002<\/p>\n<p>\u5728\u9019\u88e1\uff0c\u591a\u5df4\u80fa\u4e0d\u50c5\u50c5\u662f\u4e00\u500b\u65c1\u89c0\u8005\uff0c\u800c\u662f\u4e00\u500b\u95dc\u9375\u89d2\u8272\uff0c\u6050\u61fc\u5236\u7d04\u544a\u8a34\u6211\u5011\u5927\u8166\u5b78\u6703\u6050\u61fc\u5bb3\u6015\u3002\u5728\u6b64\u904e\u7a0b\u4e2d\uff0c\u5de5\u4f5c\u7d30\u80deDAN\u6703\u767c\u5149\uff0c\u7de8\u78bc\u6050\u61fc\u8a18\u61b6\uff0c\u4e26\u5411\u5927\u8166\u7684\u5404\u90e8\u4f4d\u767c\u9001\u8a0a\u865f\uff0c\u5305\u62ec\u8655\u7406\u6050\u61fc\u7684\u95dc\u9375\u89d2\u8272\u7684\u674f\u4ec1\u6838\u548c\u524d\u984d\u8449\u76ae\u8cea\u3002\u6050\u61fc\u6d88\u9000\u662f\u5fd8\u8a18\u6050\u61fc\u7684\u904e\u7a0b\uff0c\u5c31\u50cf\u5728\u9ed1\u6697\u7684\u623f\u9593\u6253\u958b\u4e00\u76de\u71c8\uff0c\u9010\u6f38\u9a45\u6563\u9670\u5f71\u3002\u5728\u6d88\u9000\u904e\u7a0b\u4e2d\uff0c\u5927\u8166\u77ad\u89e3\u5230\u4ee5\u524d\u7684\u6050\u61fc\u523a\u6fc0\u4e0d\u518d\u662f\u5a01\u8105\u3002DA\u5145\u7576\u6050\u61fc\u95dc\u9375\u8abf\u7bc0\u5291\u7684\u96d9\u91cd\u4f5c\u7528\uff0c\u548c\u5de5\u4f5c\u7d30\u80deDAN\u8207\u53d7\u9ad4\u7684\u5354\u529b\u5408\u4f5c\uff0c\u66f4\u65b0\u548c\u8986\u84cb\u6050\u61fc\u8a18\u61b6\uff0c\u6050\u61fc\u6210\u70ba\u4e00\u7a2e\u9069\u61c9\u6027\u7684\u60c5\u7dd2\uff0c\u5728\u8207\u5371\u96aa\u5c0d\u6297\u6642\u8abf\u52d5\u9632\u79a6\u8cc7\u6e90\uff0c\u6700\u7d42\uff0c\u6050\u61fc\u8207\u5b89\u5168\u9593\u7684\u52d5\u614b\u5e73\u8861\u4e5f\u5c31\u5927\u529f\u544a\u6210\u4e86\u3002<\/p>\n<figure id=\"attachment_44922\" aria-describedby=\"caption-attachment-44922\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-44922 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_6_AH20240819-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_6_AH20240819-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_6_AH20240819-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_6_AH20240819-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_6_AH20240819.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-44922\" class=\"wp-caption-text\">\u5716\u516d\uff1a\u591a\u5df4\u80fa\u4e0d\u540c\u7684\u4ee3\u8868\u4fe1\u865f\u548c\u5feb\u6a02\u3001\u617e\u671b\u3001\u52d5\u6a5f\u76ee\u6a19\u3001\u597d\u5947\u7b49\u4e4b\u5916\u5c1a\u6709\u6050\u61fc\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li>Kawahata, I., Finkelstein, D. I., &amp; Fukunaga, K. (2024). <a href=\"https:\/\/www.mdpi.com\/2813-2564\/3\/2\/9\">Dopamine D1\u2013D5 Receptors in Brain Nuclei: Implications for Health and Disease<\/a>. Receptors, 3(2), 155-181.<\/li>\n<li>Hamati, Rami, et al. \"<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/ejn.16157\">65 years of research on dopamine's role in classical fear conditioning and extinction: A systematic review<\/a>.\" European Journal of Neuroscience 59.6 (2024): 1099-1140.:\u81ea5\u5343\u9918\u6587\u737b\u4e2d\u7be9\u9078\u51fa292\u9805\u7814\u7a76\u4e26\u9032\u884c\u5b9a\u6027\u5206\u6790\uff1b\u5176\u4e2d\u4eba\u985e\u7814\u7a76(\u5305\u542b\u52d5\u7269\u8907\u5408\u7814\u7a76)\u7d04\u53608%\u3002<\/li>\n<li><strong>\u5716\u4f8b\u8aaa\u660e<\/strong>\uff1a<a href=\"http:\/\/id.nlm.nih.gov\/mesh\/D005239\">MeSH:D005239 <\/a>\uff1b<a href=\"https:\/\/meshb.nlm.nih.gov\/record\/ui?ui=D005239\" target=\"_blank\" rel=\"noopener\">\u77e5\u8b58\u6a39<\/a>\uff1b\u00a0<a href=\"https:\/\/bioportal.bioontology.org\/ontologies\/NBO\" target=\"_blank\" rel=\"noopener\">NBO ontology (2023-07-04)<\/a> \uff1b<a href=\"http:\/\/purl.obolibrary.org\/obo\/NBO_0000209\" target=\"_blank\" rel=\"noopener\">NBO: 0000209<\/a>\uff1b <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/ejn.16157#FIGURE%203\">\u5716\u56db\u5716\u4e94:\u6539\u7de8\u81eaHamati\u7b49\u4eba(2024)\u4e4b\u88682\u8207\u57163<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u9084\u8a18\u5f97\u4eca\u5e74\u5728\u591a\u5df4\u80fa\u79d1\u5b78\u9032\u5c55\u53f2\u4e0a\uff0c67\u6b72\u7684\u591a\u5df4\u80fa\u59d1\u5a18\u55ce?\u00a0\u5979\u4e8c\u5341\u5e7e\u6b72\u624d\u9010\u6f38\u6210\u70ba\u5feb\u6a02\u4ee3\u8a00\u4eba\uff0c\u7136\u800c\uff0c\u9019\u5feb\u6a02\u7684\u80cc\u5f8c\u5176\u5be6\u662f\u5e36\u9ede\u6050\u61fc (fear) \u7684\u3002\u5728\u7814\u7a76\u521d\u671f\uff0c\u79d1\u5b78\u5bb6\u4f7f\u7528\u57fa\u672c\u5de5\u5177\u63a2\u7d22\u591a\u5df4\u80fa\u7684\u4f5c\u7528\uff0c\u91cd\u9ede\u662f\u548c\u7cbe\u795e\u75c5\u8207\u6297\u7cbe\u795e\u75c5\u85e5\u7269\u6709\u95dc\u3002\u7531\u65bc\u6240\u7528\u7684\u85e5\u7269\u3001\u5de5\u5177\u548c\u6280\u8853\u7684\u4e0d\u8db3\uff0c\u6700\u521d\u95dc\u65bc\u591a\u5df4\u80fa\u53c3\u8207\u6050\u61fc\u5236\u7d04\u7684\u8aaa\u6cd5\u662f\u88ab\u99c1\u65a5\u7684\u3002\u4f46\u662f\uff0c\u79d1\u5b78\u767c\u5c55\u81f3\u4eca\uff0c\u539f\u4f86\u300a\u8166\u7b4b\u6025\u8f49\u5f4e\u300b\u4e2d\u5168\u8eab\u7d2b\u8272\u7684\u300c\u9a5a\u9a5a\u300d\u6216\u300c\u6015\u6015\u300d\u4e5f\u548c\u591a\u5df4\u80fa\u59d1\u5a18\u6709\u4e9b\u4ea4\u60c5\uff0c\u9019\u6b21\u5c31\u8b93\u6211\u5011\u4e00\u8d77\u4f86\u8166\u7b4b\u6025\u8f49\u5f4e\u4e00\u4e0b\u5427\uff01<\/p>\n","protected":false},"author":20,"featured_media":44923,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32,7498,3293,6512],"tags":[2412,116,592,5562],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/12\/DA_fear_1_AH20240819.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44919"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44919"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44919\/revisions"}],"predecessor-version":[{"id":44926,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44919\/revisions\/44926"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/44923"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}