{"id":44815,"date":"2024-11-14T18:00:20","date_gmt":"2024-11-14T10:00:20","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=44815"},"modified":"2026-01-06T14:26:36","modified_gmt":"2026-01-06T06:26:36","slug":"%e5%a4%9a%e8%ae%8a%e5%a4%9a%e5%b7%b4%e8%83%ba-%e7%ac%ac%e5%9b%9b%e9%83%a8%ef%bc%9a%e7%b6%81%e5%ae%9a%e7%9a%84%e5%8f%97%e9%ab%94d1%ef%bd%9ed5","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=44815","title":{"rendered":"\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u56db\u90e8\uff1a\u7d81\u5b9a\u7684\u53d7\u9ad4D1\uff5eD5"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u591a\u8b8a\u591a\u5df4\u80fa<\/strong><strong>\u4e4b\u6240\u4ee5\u591a\u8b8a\uff0c\u4e0d\u50c5\u56e0\u70ba\u5b83\u5177\u6709\u795e\u7d93\u905e\u8cea\u7684\u5316\u5b78\u7279\u6027\u3001\u6709\u6642\u4e5f\u53ef\u4ee5\u662f\u6703\u653e\u96fb\u7684\u5de5\u4f5c\u7d30\u80de\uff0c\u9084\u56e0\u70ba\u5728\u7d30\u80de\u819c\u4e0a\u8ca0\u8cac\u63a5\u6536\u5b83\u7684\u7279\u6b8a\u86cb\u767d\u8cea\u2014\u2014\u300c\u591a\u5df4\u80fa\u53d7\u9ad4\u300d\u76f8\u7576\u591a\u8b8a\u3002\u524d\u9762\u5169\u500b\u8b8a\u5316\u578b\u5df2\u7d93\u5728\u5148\u524d\u7684\u6587\u7ae0\u4ecb\u7d39\u904e\u4e86\uff0c\u90a3\u53d7\u9ad4\u53c8\u662f\u4ec0\u9ebc\u602a\u6771\u897f\u5462\uff1f\u60f3\u5fc5\u6b64\u6642\u6b64\u523b\u5927\u5bb6\u8166\u6d77\u4e2d\u53ef\u80fd\u5df2\u7d93\u9583\u9583\u4eae\u8d77\u4e86\u591a\u5df4\u80fa\u597d\u5947\u3002\u5176\u5be6\u53d7\u9ad4\u66fe\u56e0\u524d\u5e7e\u5e74\u8086\u8650\u5168\u7403\u7684\u65b0\u51a0\u75c5\u6bd2\u800c\u8072\u540d\u5927\u566a\uff0c\u5728\u4e0d\u5c11\u7814\u7a76\u5831\u5c0e\u4e2d\u6240\u63d0\u5230\u7684\u300cACE2\u300d\u5c31\u662f\u300c\u958b\u9396\u300d\u8b93\u65b0\u51a0\u75c5\u6bd2\u9032\u5165\u9ad4\u5167\u7684\u7279\u6b8a\u53d7\u9ad4\u3002\u6216\u8a31\u7528\u6b64\u6982\u5ff5\u4f86\u770b\uff0c\u5927\u5bb6\u5c31\u5f88\u5bb9\u6613\u8a8d\u8b58\u9019\u4e9b\u88ab\u591a\u5df4\u80fa\u7d81\u5b9a\u7684\u53d7\u9ad4\u4e86\u5427\uff1f<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5cA. H.<\/strong><\/p>\n<p>\u7d30\u80de\u819c\u8868\u9762\u7684\u300c\u53d7\u9ad4\u300d\u662f\u7d30\u80de\u63a5\u53d7\u8a0a\u865f\u7684\u7b2c\u4e00\u7dda\u89d2\u8272\uff0c\u800c\u795e\u7d93\u905e\u8cea\u6703\u900f\u904e\u80de\u819c\u8868\u9762\u53d7\u9ad4\u8abf\u63a7\u80de\u819c\u5167\u7684G\u86cb\u767d\u6d3b\u6027\uff0c\u5728\u80de\u5167\u7522\u751f\u7b2c\u4e8c\u8a0a\u606f\uff0c\u50ac\u5316\u4e0b\u6e38\u7d30\u80de\u7684\u751f\u5316\u53cd\u61c9\uff0c\u9019\u4e9b\u53d7\u9ad4\u5c31\u662f\u6240\u8b02\u7684G\u86cb\u767d\u5076\u806f\u53d7\u9ad4 (GPCRs)\uff0c\u4e00\u7a2e\u6700\u5927\u7684\u53d7\u9ad4\u985e\u5225\uff0c\u5e7e\u4e4e\u5f71\u97ff\u4eba\u985e\u751f\u7406\u7684\u5404\u65b9\u9762\uff0c\u6240\u6709\u6838\u51c6\u7684\u85e5\u7269\u4e2d\u7d04\u6709\u56db\u6210\u4f5c\u7528\u662f\u5728GPCRs\u3002\u5176\u4e2d\uff0c\u591a\u5df4\u80fa\u53d7\u9ad4 (Dopamine Receptors) \u5c31\u662f\u5728\u5927\u8166\u548c\u5168\u8eab\u5176\u4ed6\u795e\u7d93\u5143\u4e2d\u767c\u73fe\u7684\u4e00\u7a2eGPCRs\u3002\u7576\u591a\u5df4\u80fa (DA) \u4fe1\u865f\u63a5\u8fd1\u9644\u8fd1\u7684\u795e\u7d93\u5143\u6642\uff0cDA\u6703\u8207\u8a72\u795e\u7d93\u5143\u7d30\u80de\u819c\u4e0a\u7684\u7279\u5b9a\u53d7\u9ad4\u7d50\u5408\uff0c\u8abf\u7bc0\u611f\u89ba\u548c\u795e\u7d93\u8a0a\u865f\u50b3\u5c0e\u4ee5\u53ca\u8207\u7d30\u80de\u7a69\u614b\u3001\u751f\u9577\u7b49\u76f8\u95dc\u751f\u7406\u904e\u7a0b\u3002<\/p>\n<figure id=\"attachment_44817\" aria-describedby=\"caption-attachment-44817\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-44817\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_1_AH-1024x576.png\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_1_AH-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_1_AH-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_1_AH-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_1_AH.png 1280w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-44817\" class=\"wp-caption-text\">\u5716\u4e00\uff1a\u591a\u5df4\u80fa\u53d7\u9ad4\u8207\u591a\u5df4\u80fa\u7d50\u5408\u4ee5\u53ca\u9470\u5319\u548c\u9396\u6bd4\u55bb\u793a\u610f\u5716 \uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b\uff0c\u591a\u5df4\u80fa\u53d7\u9ad4\u90e8\u5206\u5716\u793a\u4f7f\u7528BioRender\u5143\u4ef6<\/figcaption><\/figure>\n<p>\u5716\u4e00\u986f\u793a\u5316\u5b78\u5c0f\u5206\u5b50DA\u9644\u8457\u5728\u591a\u5df4\u80fa\u53d7\u9ad4\uff08\u5927\u5206\u5b50\uff09\u4e0a\uff0c\u901a\u904e\u5f15\u8d77\u63a5\u6536\u4fe1\u865f\u7684\u795e\u7d93\u5143\u767c\u751f\u8b8a\u5316\u4f86\u50b3\u905e\u5316\u5b78\u8a0a\u865f\uff0c\u800c\u795e\u7d93\u905e\u8cea\u5c0f\u5206\u5b50\u548c\u53d7\u9ad4\u5927\u5206\u5b50\u5c31\u50cf\u4e00\u5c0d\u9470\u5319\u548c\u9396\u982d\uff0cDA\u4f5c\u70ba\u9470\u5319\u5728\u751f\u7269\u5316\u5b78\u4e2d\u7a31\u70ba\u914d\u9ad4 (ligand)\uff0c\u662f\u4e00\u7a2e\u6703\u8207\u751f\u7269\u5206\u5b50\u5f62\u6210\u8907\u5408\u7269\u4ee5\u9054\u5230\u751f\u7269\u5b78\u76ee\u7684\u7684\u7269\u8cea\uff0c\u8a5e\u6e90\u6e90\u65bc\u62c9\u4e01\u8a9eligare\uff0c\u610f\u601d\u662f\u300c\u7d81\u5b9a\u300d\u3002\u914d\u9ad4\u5fc5\u9808\u6709\u76f8\u5c0d\u5951\u5408\u300c\u7d81\u5b9a\u7684\u53d7\u9ad4\u300d\uff0c\u5c31\u50cf\u300c\u9396\u982d\uff0f\u9470\u5319\u5b54\u300d\u7684\u914d\u5c0d\u7d50\u5408\uff0c\u624d\u80fd\u6d3b\u5316\u6216\u6291\u5236\u86cb\u767d\u8cea\u6d3b\u52d5\uff0c\u9032\u800c\u555f\u52d5\u6216\u95dc\u9589\u7d30\u80de\u53cd\u61c9\u3002<\/p>\n<p>\u63a5\u4e0b\u4f86\uff0c\u8b93\u6211\u5011\u518d\u4e00\u6b21\u4f7f\u7528\u77e5\u8b58\u672c\u9ad4\u4e00\u7aba\u591a\u5df4\u80fa\u53d7\u9ad4\u7684\u77e5\u8b58\u67b6\u69cb\u8207\u5c08\u5bb6\u5b9a\u7fa9\u3002\u5716\u4e8c\u70ba\u6839\u64da\u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928\u91ab\u5b78\u79d1\u76ee\u6a19\u984c (MeSH)\uff0c\u591a\u5df4\u80fa\u53d7\u9ad4\u7684\u8eab\u5206\u8b49\u865f\u78bc\u662f<a href=\"http:\/\/id.nlm.nih.gov\/mesh\/D011954\">D011954<\/a>\uff0c\u5b9a\u7fa9\u70ba\uff1a\u7d30\u80de\u8868\u9762\u86cb\u767d\uff0c\u4ee5\u9ad8\u89aa\u548c\u529b\u7d50\u5408\u591a\u5df4\u80fa\u4e26\u89f8\u767c\u7d30\u80de\u5167\u8b8a\u5316\uff0c\u5f71\u97ff\u7d30\u80de\u884c\u70ba\u3002\u7531MeSH\u6a39\u72c0\u5716\u53ef\u77e5\uff0c\u5176\u7236\u5b50\u95dc\u4fc2\u70ba\u591a\u5df4\u80fa\u53d7\u9ad4\u5c6c\u86cb\u767d\u8cea\u5bb6\u65cf\uff0c\u540c\u6642\u4e5f\u662f\u795e\u7d93\u905e\u8cea\u53d7\u9ad4\u3001\u751f\u7269\u80fa\u53d7\u9ad4\u8207GPCRs\u7684\u5bb6\u65cf\uff0c\u548c\u814e\u4e0a\u817a\u7d20\u80fd\u53d7\u9ad4\u662f\u5144\u5f1f\uff1b\u5b50\u985e\u5305\u62ecD1\u548cD2\u8207\u5176\u5404\u81ea\u7684\u5b6b\u8f29D5\u548cD3\u3001D4\uff0c\u5176\u5b9a\u7fa9\u5206\u8ff0\u5982\u4e0b\uff1a<\/p>\n<p><a href=\"#_ednref1\" name=\"_edn1\"><\/a><\/p>\n<figure id=\"attachment_44818\" aria-describedby=\"caption-attachment-44818\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-44818 size-large\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_2_AH-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_2_AH-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_2_AH-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_2_AH-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_2_AH.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-44818\" class=\"wp-caption-text\">\u5716\u4e8c\uff1a\u591a\u5df4\u80fa\u53d7\u9ad4MeSH: D011954\u77e5\u8b58\u6a39\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>D1<strong>\uff1a<\/strong>GPCRs\u7684\u4e00\u500b\u4e9e\u5bb6\u65cf\uff0c\u53ef\u7d50\u5408\u795e\u7d93\u905e\u8ceaDA\u4e26\u8abf\u7bc0\u5176\u4f5c\u7528\u3002D1\u985e\u53d7\u9ad4\u57fa\u56e0<em>\u7f3a\u4e4f<\/em>\u63d2\u5165\u5e8f\u5217 (INTRONS)\uff0c\u53d7\u9ad4<strong><em>\u523a\u6fc0<\/em><\/strong>\u817a\u82f7\u9178\u74b0\u5316\u9176\u3002<\/p>\n<ul>\n<li>D5\uff1a\u591a\u5df4\u80faD1\u53d7\u9ad4\u7684\u4e00\u7a2e\u4e9e\u578b\uff0c\u5c0d\u591a\u5df4\u80fa\u5177\u6709\u66f4\u9ad8\u7684\u89aa\u548c\u529b\uff0c\u4e26\u8207GTP\u7d50\u5408\u86cb\u767d\uff08\u5145\u7576\u5206\u5b50\u958b\u95dc\u7684\u8abf\u7bc0\u86cb\u767d\uff09\u6709\u5dee\u7570\u5076\u806f\u3002<\/li>\n<\/ul>\n<p>D2\uff1aGPCRs\u7684\u4e00\u500b\u4e9e\u5bb6\u65cf\uff0c\u53ef\u7d50\u5408\u795e\u7d93\u905e\u8cea\u591a\u5df4\u80fa\u4e26\u8abf\u7bc0\u5176\u4f5c\u7528\u3002D2\u985e\u53d7\u9ad4\u57fa\u56e0<em>\u542b\u6709<\/em>\u63d2\u5165\u5e8f\u5217\uff0c\u53d7\u9ad4<strong><em>\u6291\u5236<\/em><\/strong>\u817a\u82f7\u9178\u74b0\u5316\u9176\u3002<\/p>\n<ul>\n<li>D3:\u591a\u5df4\u80fa D2\u53d7\u9ad4\u7684\u4e00\u7a2e\u4e9e\u578b\uff0c\u5728\u5927\u8166\u7684\u908a\u7de3\u7cfb\u7d71\u4e2d\u9ad8\u5ea6\u8868\u9054\u3002<\/li>\n<li>D4:\u591a\u5df4\u80fa D2\u53d7\u9ad4\u7684\u4e00\u7a2e\u4e9e\u578b\uff0c\u5c0d\u6297\u7cbe\u795e\u75c5\u85e5\u6c2f\u6c2e\u5e73\u5177\u9ad8\u89aa\u548c\u529b\u3002<\/li>\n<\/ul>\n<p>\u7c21\u55ae\u7684\u8aaa\uff0c\u591a\u5df4\u80fa\u53d7\u9ad4\u6839\u64da\u5b83\u5011\u5c0d\u817a\u82f7\u9178\u74b0\u5316\u9176\uff08\u4e00\u7a2e\u7d30\u80de\u5167\u4fe1\u865f\u8f49\u5c0e\uff0c\u53c3\u8207\u7d30\u80de\u8abf\u63a7\u7684\u95dc\u9375\u9176\uff09\u7684\u5f71\u97ff\uff0c\u88ab\u5206\u70ba\u5169\u500b\u4e0d\u540c\u7684\u5bb6\u65cf\uff1aD1\u548cD2\uff0c\u6216\u7a31\u300c\u985e\u7b2c\u4e00\u578b\u53d7\u9ad4\u300d(D1 like receptors: D1,D5) \u8207\u300c\u985e\u7b2c\u4e8c\u578b\u53d7\u9ad4 (D2 like receptors: D2,D3, D4)\uff0c\u53d6\u6c7a\u65bc\u5b83\u5011\u7684\u6d3b\u5316\u662f\u5426\u5c0e\u81f4\u8a72\u9176\u7684\u523a\u6fc0\u6216\u6291\u5236\uff0c\u4ee5\u53ca\u85e5\u7406\u5b78\u4e0a\u7684\u5dee\u7570\u3002\u5176\u6b21\uff0c\u57fa\u65bc\u540c\u6e90\u6027\u3001\u85e5\u7406\u5b78\u548c\u751f\u5316\u7279\u6027\uff0c\u518d\u7d30\u5206\u4e0d\u540c\u7684\u5b50\u5b6b\u5bb6\u65cf\u3002\u5167\u6e90\u6027\u591a\u5df4\u80fa\u6216\u5916\u6e90\u6027\u591a\u5df4\u80fa\u85e5\u7269\u6703\u6d3b\u5316\u53d7\u9ad4\uff0c\u4ea6\u7a31\u70ba\u591a\u5df4\u80fa\u53d7\u9ad4\u4f5c\u7528\u5291\uff0f\u6a5f\u52d5\u5291 (agonists)\uff0c\u800c\u6d3b\u5316\u86cb\u767d\u8cea\u6d3b\u52d5\u4fbf\u80fd\u5920\u555f\u52d5\u7d30\u80de\u53cd\u61c9\uff0c\u589e\u52a0\u5927\u8166\u4e2d\u7684\u591a\u5df4\u80fa\u80fd\u6d3b\u52d5\uff0c\u6709\u52a9\u65bc\u6e1b\u8f15\u5e15\u91d1\u68ee\uff08\u591a\u5df4\u80fa\u7f3a\u4e4f\uff09\u75c7\u72c0\uff1b\u53cd\u4e4b\uff0c\u62ee\u6297\u5291 (antagonists) \u5247\u662f\u6291\u5236\u86cb\u767d\u8cea\u6d3b\u52d5\uff0c\u95dc\u9589\u7d30\u80de\u53cd\u61c9\uff0c\u7528\u65bc\u591a\u5df4\u80fa\u904e\u5ea6\u6d3b\u8e8d\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u7b49\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u591a\u5df4\u80fa\u53d7\u9ad4\u548c\u751f\u7269\u795e\u7d93\u5fc3\u7406\u529f\u80fd\u4ea6\u606f\u606f\u76f8\u95dc\u3002\u5be6\u8cea\u4e0a\uff0c\u591a\u5df4\u80fa\u53d7\u9ad4\u7684\u7814\u7a76\u5927\u7d04\u665a\u4e86\u591a\u5df4\u80fa\u7814\u7a76\u7d0415\uff5e20\u5e74\uff0c\u300a<em>Nature<\/em>\u300b\u7684\u300a\u795e\u7d93\u7cbe\u795e\u85e5\u7406\u5b78\u300b\u671f\u520a\u5728\u60bc\u5ff5\u4ee5\u591a\u5df4\u80fa\u53d7\u9ad4\u805e\u540d\u7684\u5df2\u6545\u52a0\u62ff\u5927\u85e5\u7406\u5b78\u52a0\u83f2\u529b\u6d66\uff0e\u897f\u66fc (Philip Seeman) \u4e2d\u63d0\u5230\uff0c\u4eba\u5011\u610f\u8b58\u5230\u5b58\u5728\u5169\u7a2e\u591a\u5df4\u80fa\u53d7\u9ad4\u4e9e\u578b\uff08\u5f8c\u6307\u5b9a\u70baD2\uff09\u59cb\u65bc1974\u5e74\u897f\u66fc\u6559\u6388\u7684\u6297\u7cbe\u795e\u75c5\u85e5\u7269\u7814\u7a76\u30022024\u5e74\uff0c\u65e5\u672c\u6771\u5317\u5927\u5b78\u548c\u6fb3\u6d32\u58a8\u723e\u672c\u5927\u5b78\u79d1\u5b78\u5bb6Kawahata\u7b49\u4eba\u56de\u9867\u4e86\u8fd140\u5e74\u7684\u7814\u7a76 (1984~2023)\uff0c\u6574\u7406\u51fa\u4e86\u5927\u8166\u4e2d\u591a\u5df4\u80faD1-D5\u53d7\u9ad4\u5c0d\u5065\u5eb7\u548c\u75be\u75c5\u7684\u5f71\u97ff\uff0c\u5728\u8ad6\u6587\u4e2d\u6307\u51fa\uff0c\u591a\u5df4\u80fa\u53d7\u9ad4\u7684\u751f\u7269\u5b78\u529f\u80fd\u8d85\u8d8a\u4e86\u904b\u52d5\u3001\u8a8d\u77e5\u8a18\u61b6\u3001\u52d5\u6a5f\u548c\u85e5\u7269\u6210\u766e\u7b49\u529f\u80fd\uff0c\u63ed\u793a\u4e86\u591a\u8b8a\u591a\u5df4\u80fa\u4e4b\u6240\u4ee5\u591a\u8b8a\u7684\u53e6\u4e00\u6f5b\u5728\u539f\u56e0\u3002\u6b64\u7814\u7a76\u7d9c\u8ff0\u591a\u5df4\u80faD1-D5\u53d7\u9ad4\u7684\u5206\u5e03\uff0c\u57fa\u65bc\u5927\u8166\u4e2d\u4e0d\u540c\u5340\u57df\u6240\u4ee3\u8868\u7684\u751f\u7406\u610f\u7fa9\u8207\u75be\u75c5\u76f8\u95dc\u6027\uff0c\u4e0d\u50c5\u63a8\u9032\u4e86\u6211\u5011\u5c0d\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u57fa\u790e\u77e5\u8b58\uff0c\u4e14\u70ba\u6cbb\u7642\u5e72\u9810\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u7dda\u7d22\u3002<\/p>\n<p>\u6b78\u7d0dKawahata\u7b49\u4eba\u7814\u7a76\u7684\u91cd\u9ede\u5305\u62ec\u5c0d\u7d0b\u72c0\u9ad4\uff1a\u8179\u5074\u3001\u80cc\u5074\u3001\u4f0f\u9694\u6838\uff1b\u524d\u984d\u8449\u76ae\u5c64\uff1b\u4e18\u8166\u5e95\u6838\uff1a\u8996\u4e18\u4e0b\u6838\uff1b\u908a\u7de3\u7cfb\u7d71\uff1a\u674f\u4ec1\u6838\u3001\u6d77\u99ac\u8ff4\uff1b\u4e2d\u8166\uff1b\u9ed1\u8cea\u7dfb\u5bc6\u90e8 (SNc) \u548c\u8179\u5074\u84cb\u5340 (VTA)\u4e94\u5927\u5340\u57df\u3002\u5716\u4e09\u4e2d\u591a\u5df4\u80fa\u53d7\u9ad4D1\uff5eD5\u7684\u5fc3\u7406\u5b78\u751f\u7406\u529f\u80fd\uff0c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u300c\u5feb\u6a02\u300d\u529f\u80fd\u4e3b\u8981\u5728\u8179\u5074\u7d0b\u72c0\u9ad4\u4e2d\u7684D2\u3002<\/li>\n<li>\u300c\u52d5\u6a5f\u548c\u734e\u52f5\u300d\u5247\u5ee3\u6cdb\u53cd\u61c9\u5728\u7d0b\u72c0\u9ad4D1\uff5eD4\uff1b\u524d\u984d\u8449\u76ae\u8cea\u7684D2\u548cD3\uff1b\u4e18\u8166\u5e95\u6838\u7684D2, D3\uff1b\u674f\u4ec1\u6838\u7684D3\uff1b\u9ed1\u8cea\u7684D2\u53ca\u8179\u5074\u84cb\u5340D1, D3, D4\u3002<\/li>\n<\/ul>\n<figure id=\"attachment_44816\" aria-describedby=\"caption-attachment-44816\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-large wp-image-44816\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_3_AH-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_3_AH-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_3_AH-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_3_AH-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_3_AH.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-44816\" class=\"wp-caption-text\">\u5716\u4e09\uff1a\u591a\u5df4\u80fa\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u5728\u4eba\u985e\u5927\u8166\u7684\u5206\u5e03\u793a\u610f\u5716\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b\uff0c\u4f7f\u7528BioRender\u5143\u4ef6\u8207\u6a21\u677f\u88fd\u6210<\/figcaption><\/figure>\n<p>\u53e6\u5916\uff0c\u5c0d\u65bc\u300c\u65b0\u5947\u4e8b\u7269\u300d\u7684\u53cd\u61c9\uff0c\u4e0a\u56de\u6211\u5011\u4ee5\u5de5\u4f5c\u7d30\u80de\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN) \u70ba\u63a2\u8a0e\u91cd\u9ede\uff0c\u6b64\u6b21\u6211\u5011\u5c31\u80fd\u7d50\u5408\u591a\u5df4\u80fa\u53d7\u9ad4\uff0c\u66f4\u5b8c\u6574\u5730\u77ad\u89e3\u5927\u8166\u795e\u7d93\u5143\u5982\u4f55\u6fc0\u8d77\u597d\u5947\u5fc3\u7684\u706b\u82b1\u3002<\/p>\n<ul>\n<li>\u91dd\u5c0d\u65b0\u5947\u4e8b\u7269\u7684\u53cd\u61c9\uff0cD4\u53d7\u9ad4\u7684\u8ca2\u737b\u53ef\u80fd\u6700\u5927\u3002\u300cD4\u7684\u597d\u5947\u300d\u4e3b\u8981\u5728\u80cc\u5074\u7d0b\u72c0\u9ad4\u3001\u524d\u984d\u8449\u76ae\u8cea\u3001\u4e18\u8166\u5e95\u6838\u548c\u674f\u4ec1\u6838\u4e2d\u53cd\u61c9\uff0c\u4e26\u5728\u9ed1\u8cea\u4e2d\u5177\u6709\u61c9\u5c0d\u65b0\u5947\u4e8b\u7269\u7684\u4f5c\u7528\u3002<\/li>\n<\/ul>\n<p>\u7136\u800c\uff0c\u7531\u65bcD4\u53d7\u9ad4\u548c\u65b0\u5947\u8ffd\u6c42\u7684\u7814\u7a76\u4e0d\u523030\u5e74\uff08\u7d04\u81ea1996\u5e74\uff09\uff0c\u300cD4\u7684\u597d\u5947\u300d\u4f5c\u70ba\u795e\u7d93\u548c\u5fc3\u7406\u5b78\u8b49\u64da\uff0c\u6211\u5011\u4e5f\u5fc5\u9808\u6ce8\u610f\u79d1\u5b78\u7684\u4e0d\u78ba\u5b9a\u6027\u53ef\u80fd\u56e0\u4f7f\u7528\u65cf\u7fa4\u3001\u65b9\u6cd5\u548c\u7d71\u8a08\u6e2c\u8a66\u7684\u4e0d\u540c\u800c\u6709\u5dee\u7570\u3002\u7e3d\u6b78\u4f86\u8aaa\uff0cD1~D5\u6bcf\u7a2e\u53d7\u9ad4\u90fd\u8868\u73fe\u51fa\u7368\u7279\u7684\u7279\u6027\uff0c\u7279\u6b8a\u7684\u795e\u7d93\u5143\u5206\u4f48\u8207\u5c0d\u591a\u5df4\u80fa\u4e0d\u540c\u7684\u89aa\u548c\u529b\u3002\u6709\u8da3\u7684\u662f\uff0c\u8d8a\u4f86\u8d8a\u591a\u7684\u8b49\u64da\u8868\u660e\uff0c\u591a\u5df4\u80fa\u53d7\u9ad4\u7684\u5404\u7a2e\u591a\u5df4\u80fa\u8abf\u63a7\uff0c\u5176\u4e2d\u6709\u4e00\u500b\u4ee5\u6211\u5011\u5f9e\u672a\u61f7\u7591\u904e\u7684\u65b9\u5f0f\u6084\u6084\u5730\u5f71\u97ff\u8457\u6211\u5011\u7684\u5927\u8166\uff0c\u6b64\u523b\u4f60\u7684\u8166\u4e2d\u662f\u5426\u53c8\u518d\u6b21\u9583\u9583\u4eae\u8d77\u4e86\u591a\u5df4\u80fa\u597d\u5947\u4e86\u5462\uff1f\uff08\u5f85\u7e8c\uff09<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li>\u91d1\u514b\u5be7, <a href=\"https:\/\/www.scimonth.com.tw\/archives\/6189\" target=\"_blank\" rel=\"noopener\">\u73fe\u4ee3\u85e5\u7269\u6a19\u9776\u2014G\u86cb\u767d\u5076\u5408\u53d7\u9ad4\u4e4b\u7814\u7a76\u89e3\u6790<\/a>, \u79d1\u5b78\u6708\u520a. 516\u671f. 2012.12.01<\/li>\n<li>\u6797\u66f8\u7464,<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=6809\" target=\"_blank\" rel=\"noopener\">\u3010\u5316\u5b78\u5947\u5883\u3011\u53d7\u9ad4\u2027\u53d7\u9ad4\u2027\u53d7\u9ad4<\/a>, \u53f0\u5927\u79d1\u6559\u4e2d\u5fc3CASE\u5831\u79d1\u5b78, 2010.12.23<\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Ligand_(biochemistry)\" target=\"_blank\" rel=\"noopener\">\u7dad\u57fa\u767e\u79d1\uff1aligand<\/a><\/li>\n<li><a href=\"http:\/\/id.nlm.nih.gov\/mesh\/D011954\" target=\"_blank\" rel=\"noopener\">MeSH\u591a\u5df4\u80fa\u53d7\u9ad4(D011954)<\/a><\/li>\n<li>Madras, B., George, S. <a href=\"https:\/\/www.nature.com\/articles\/s41386-021-00975-x\" target=\"_blank\" rel=\"noopener\">In memoriam professor Philip Seeman<\/a> (February 8, 1934-January 9, 2021). Neuropsychopharmacol. 46, 1229\u20131230 (2021).<\/li>\n<li>Kawahata, I., Finkelstein, D. I., &amp; Fukunaga, K. (2024). <a href=\"https:\/\/doi.org\/10.3390\/receptors3020009\" target=\"_blank\" rel=\"noopener\">Dopamine D1\u2013D5 Receptors in Brain Nuclei: Implications for Health and Disease<\/a>. Receptors, 3(2), 155-181. ; \u7814\u7a76\u50c5\u9650\u5927\u8166\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u591a\u5df4\u80fa\u53d7\u9ad4\uff0c\u5176\u4ed6\u975e\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u591a\u5df4\u80fa\u53d7\u9ad4\u5305\u62ec\u5fc3\u80ba\u3001\u814e\u81df\u7cfb\u7d71\u548c\u80f0\u817a\u4e0d\u5728\u6b64\u7bc4\u570d\u4e2d\u8a0e\u8ad6<\/li>\n<li>Oak, J. N., Oldenhof, J., &amp; Van Tol, H. H. (2000). <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014299900005628\" target=\"_blank\" rel=\"noopener\">The dopamine D4 receptor: one decade of research<\/a>. European journal of pharmacology, 405(1-3), 303-327.; Paterson, A. D., Sunohara, G. A., &amp; Kennedy, J. L. (1999). <a href=\"https:\/\/www.nature.com\/articles\/1395298\" target=\"_blank\" rel=\"noopener\">Dopamine D4 receptor gene: novelty or nonsense<\/a> ? Neuropsychopharmacology, 21(1), 3-16.<\/li>\n<li>BioRender (2022). <a href=\"https:\/\/app.biorender.com\/biorender-templates\/figures\/all\/t-61f80f49524a7e00a0a3197a-distribution-of-dopamine-neurotransmitters-in-the-human-brai\" target=\"_blank\" rel=\"noopener\">Distribution of Dopamine Neurotransmitters in the Human Brain.<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>\u2728\u5ef6\u4f38\u95b1\u8b80\uff1a\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44043\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u524d\u50b3<\/a>\u300b\u3001\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44277\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e00\u90e8\uff1aChEBI: 18243<\/a>\u300b\u3001\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44411\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e8c\u90e8\uff1a\u5de5\u4f5c\u7d30\u80deDAN<\/a>\u300b\u3001\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44568\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e09\u90e8\uff1a\u597d\u5947\u5075\u63a2DAN\u7684\u8b8a\u8001<\/a>\u300b\u3001\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=6809\" target=\"_blank\" rel=\"noopener\">\u3010\u5316\u5b78\u5947\u5883\u3011\u53d7\u9ad4\u2027\u53d7\u9ad4\u2027\u53d7\u9ad4<\/a>\u300b<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u591a\u8b8a\u591a\u5df4\u80fa\u4e4b\u6240\u4ee5\u591a\u8b8a\uff0c\u4e0d\u50c5\u56e0\u70ba\u5b83\u5177\u6709\u795e\u7d93\u905e\u8cea\u7684\u5316\u5b78\u7279\u6027\u3001\u6709\u6642\u4e5f\u53ef\u4ee5\u662f\u6703\u653e\u96fb\u7684\u5de5\u4f5c\u7d30\u80de\uff0c\u9084\u56e0\u70ba\u5728\u7d30\u80de\u819c\u4e0a\u8ca0\u8cac\u63a5\u6536\u5b83\u7684\u7279\u6b8a\u86cb\u767d\u8cea\u2014\u2014\u300c\u591a\u5df4\u80fa\u53d7\u9ad4\u300d\u76f8\u7576\u591a\u8b8a\u3002\u524d\u9762\u5169\u500b\u8b8a\u5316\u578b\u5df2\u7d93\u5728\u5148\u524d\u7684\u6587\u7ae0\u4ecb\u7d39\u904e\u4e86\uff0c\u90a3\u53d7\u9ad4\u53c8\u662f\u4ec0\u9ebc\u602a\u6771\u897f\u5462\uff1f\u60f3\u5fc5\u6b64\u6642\u6b64\u523b\u5927\u5bb6\u8166\u6d77\u4e2d\u53ef\u80fd\u5df2\u7d93\u9583\u9583\u4eae\u8d77\u4e86\u591a\u5df4\u80fa\u597d\u5947\u3002\u5176\u5be6\u53d7\u9ad4\u66fe\u56e0\u524d\u5e7e\u5e74\u8086\u8650\u5168\u7403\u7684\u65b0\u51a0\u75c5\u6bd2\u800c\u8072\u540d\u5927\u566a\uff0c\u5728\u4e0d\u5c11\u7814\u7a76\u5831\u5c0e\u4e2d\u6240\u63d0\u5230\u7684\u300cACE2\u300d\u5c31\u662f\u300c\u958b\u9396\u300d\u8b93\u65b0\u51a0\u75c5\u6bd2\u9032\u5165\u9ad4\u5167\u7684\u7279\u6b8a\u53d7\u9ad4\u3002\u6216\u8a31\u7528\u6b64\u6982\u5ff5\u4f86\u770b\uff0c\u5927\u5bb6\u5c31\u5f88\u5bb9\u6613\u8a8d\u8b58\u9019\u4e9b\u88ab\u591a\u5df4\u80fa\u7d81\u5b9a\u7684\u53d7\u9ad4\u4e86\u5427\uff1f<\/p>\n","protected":false},"author":20,"featured_media":44817,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32,7498,3293,6512],"tags":[585,2412,7169,5562],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/11\/DAR_1_AH.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44815"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44815"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44815\/revisions"}],"predecessor-version":[{"id":44821,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44815\/revisions\/44821"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/44817"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}