{"id":44568,"date":"2024-09-05T18:00:40","date_gmt":"2024-09-05T10:00:40","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=44568"},"modified":"2026-01-06T14:26:56","modified_gmt":"2026-01-06T06:26:56","slug":"%e5%a4%9a%e8%ae%8a%e5%a4%9a%e5%b7%b4%e8%83%ba%e7%ac%ac%e4%b8%89%e9%83%a8","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=44568","title":{"rendered":"\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e09\u90e8\uff1a\u597d\u5947\u5075\u63a2DAN\u7684\u8b8a\u8001"},"content":{"rendered":"

\u672c\u7bc7\u8981\u4ecb\u7d39\u7684\u662f\u6703\u653e\u96fb\u7684\u5de5\u4f5c\u7d30\u80de\uff0c\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN) \u662f\u4e3b\u89d2\uff0c\u800c\u795e\u7d93\u905e\u8cea\u5316\u5b78\u7269\u8cea\u591a\u5df4\u80fa\u59d1\u5a18\u662f\u914d\u89d2\uff0c\u4ed6\u5011\u5169\u4f4d\u5728\u5169\u500b\u95dc\u9375\u7684\u5927\u8166\u5340\u57df\u4e2d\u5de5\u4f5c\u6642\uff0cDAN\u626e\u6f14\u8457\u611b\u597d\u65b0\u5947\u89e3\u8b0e\u7684\u798f\u723e\u6469\u65af\uff0c\u4e3b\u5c0e\u5c0b\u627e\u65b0\u5947\u4e8b\u7269\u7684\u76f8\u95dc\u795e\u7d93\u6a5f\u5236\uff0c\u4e26\u4e14\u4e5f\u662f\u9023\u63a5\u597d\u5947\u548c\u795e\u7d93\u5143\u6d3b\u52d5\u70ba\u95dc\u9375\u3002\u4f46\u9019\u88e1\u6709\u4e00\u500b\u554f\u984c\uff1a\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\uff0cDAN\u5c07\u6703\u6f38\u6f38\u5931\u53bb\u5c0b\u6c42\u65b0\u5947\u7684\u80fd\u529b\u3002\u7a76\u7adf\u70ba\u4ec0\u9ebc\u6703\u9019\u6a23\u5462\uff1f\u5c0e\u81f4\u597d\u5947\u5fc3\u4e0b\u964d\u7684\u80cc\u5f8c\u795e\u7d93\u6a5f\u5236\u53c8\u662f\u4ec0\u9ebc\u5462\uff1f<\/strong><\/span><\/p>\n

\u64b0\u6587\uff5cA. H.<\/strong><\/p>\n

\u4f60\u77e5\u9053\u55ce\uff1f\u5728\u4f60\u7684\u5927\u8166\u4e2d\uff0c\u5b58\u5728\u8457\u4e00\u7a2e\u5916\u89c0\u9577\u5f97\u50cf\u662f\u7626\u9577\u7684\u4eba\u8518\uff0c\u751a\u81f3\u9084\u5177\u6709\u9577\u5f97\u50cf\u8518\u9b1a\u822c\u7684\u6a39\u7a81\u7684\u7d30\u80de\uff0c\u4ed6\u5c31\u662f\u5de5\u4f5c\u7d30\u80de\u2014\u2014\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (dopaminergic neuron, DAN)\u3002\u7576\u6211\u5011\u9047\u5230\u65b0\u5947\u4e8b\u7269\u6642\uff0c\u4ed6\u5c31\u6703\u9ede\u71c3\u5927\u8166\u795e\u7d93\u8ff4\u8def\u4e2d\u7684\u7279\u6b8a\u706b\u82b1\uff0c\u9a45\u4f7f\u4eba\u985e\u53bb\u9032\u884c\u63a2\u7d22\u3001\u5b78\u7fd2\u548c\u767c\u73fe\u7b49\u884c\u70ba\u3002\u4ed6\u5c31\u50cf\u662f\u5927\u8166\u4e2d\u937e\u60c5\u63a5\u89f8\u65b0\u5947\u4e8b\u7269\u7684\u5075\u63a2\uff0c\u559c\u6b61\u88ab\u6fc0\u767c\u7591\u60d1\uff0c\u4e5f\u6e34\u671b\u7372\u53d6\u65b0\u77e5\u3002<\/p>\n

\u7136\u800c\uff0c\u96a8\u8457\u5e74\u7d00\u7684\u589e\u9577\uff0c\u4eba\u5011\u7684\u597d\u5947\u5fc3\u4f3c\u4e4e\u4e5f\u6703\u6108\u4f86\u6108\u5c11\u3002\u5c31\u50cf\u4e00\u9846\u9010\u6f38\u892a\u8272\u7684\u7159\u706b\u4e00\u6a23\uff0c\u5e74\u9577\u8005\u5011\u5c0d\u793e\u6703\u65b0\u9bae\u4e8b\u7269\u548c\u7121\u751f\u547d\u7684\u65b0\u5947\u611f\u5c07\u6703\u6de1\u8584\uff0c\u6700\u7d42\u518d\u4e5f\u7121\u6cd5\u88ab\u5438\u5f15\u3002\u597d\u5947\u5075\u63a2DAN\u70ba\u4ec0\u9ebc\u6703\u611f\u5230\u597d\u5947\uff1f\u800c\u5e74\u7d00\u7684\u589e\u9577\uff0cDAN\u53c8\u767c\u751f\u4e86\u4ec0\u9ebc\u8b8a\u5316\uff0c\u5c0e\u81f4\u597d\u5947\u5075\u63a2\u4e0d\u518d\u597d\u5947\u4e86\u5462\uff1f\u8b80\u5230\u9019\u88e1\uff0c\u9019\u6a23\u7684\u73fe\u8c61\u662f\u5426\u5df2\u7d93\u6210\u529f\u52fe\u8d77\u4f60\u5927\u8166\u4e2d\u7684\u597d\u5947\u5075\u63a2\u7684\u8208\u81f4\u4e86\u5462\uff1f<\/p>\n

\"\"
\u5716\u4e00\uff1a\u8179\u5074\u84cb\u5340 (VTA)\u3001\u9ed1\u8cea\u7dfb\u5bc6\u90e8 (SNc) \u4ee5\u53ca\u50cf\u4eba\u8518\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN)\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n

\u539f\u4f86\uff0c\u591a\u8b8a\u591a\u5df4\u80fa\u4e0d\u50c5\u548c\u5feb\u6a02\u3001\u617e\u671b\u548c\u52d5\u6a5f\u76ee\u6a19\u6709\u95dc\uff0c\u9019\u7a2e\u795e\u7d93\u905e\u8cea\u4e5f\u548c\u6211\u5011\u7684\u300c\u8a8d\u77e5\u597d\u5947\u300d\u8207\u300c\u540c\u7406\u597d\u5947\u300d\u606f\u606f\u76f8\u95dc\u3002\u7576\u8b80\u5230\u9019\u88e1\uff0c\u4f60\u7684\u5927\u8166\u5be6\u969b\u4e0a\u4fbf\u5df2\u7d93\u505a\u51fa\u4e86\u53cd\u61c9\uff0c\u9019\u5c31\u597d\u50cf\u4f60\u771f\u7684\u6e34\u4e86\u6216\u9913\u4e86\u4e00\u6a23\uff0c\u4e2d\u8166\u7576\u4e2d\u7684\u591a\u5df4\u80fa\u654f\u611f\u5340\u57df\u5c31\u6703\u4eae\u4e86\u8d77\u4f86\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u300c\u8a8d\u77e5\u597d\u5947\u300d\u3002\u800c\u53e6\u5916\u4e00\u7a2e\u597d\u5947\u5fc3\uff0c\u6307\u7684\u662f\u4eba\u985e\u751f\u6d3b\u662f\u5efa\u7acb\u5728\u4eba\u8207\u4eba\u4e4b\u9593\u7684\u4e92\u52d5\u95dc\u4fc2\u4e0a\uff0c\u7576\u6211\u5011\u8655\u65bc\u8212\u9069\u7684\u793e\u4ea4\u5834\u5408\u6642\uff0c\u82e5\u7522\u751f\u4e86\u60f3\u8981\u77ad\u89e3\u4ed6\u4eba\u7684\u60f3\u6cd5\u548c\u611f\u53d7\u6642\uff0c\u4e5f\u6703\u5927\u91cf\u91cb\u653e\u591a\u5df4\u80fa\uff0c\u9019\u5c31\u662f\u6240\u8b02\u7684\u300c\u540c\u7406\u597d\u5947\u300d\u3002\u4eca\u65e5\u597d\u5947\u5075\u63a2DAN\u7684\u6545\u4e8b\uff0c\u5c31\u662f\u8981\u63a2\u8a0e\u89f8\u767c\u9019\u4e8c\u985e\u597d\u5947\u5fc3\u7684\u5927\u8166\u6f5b\u5728\u795e\u7d93\u6a5f\u5236\u8207\u591a\u5df4\u80fa\u4e4b\u9593\u7684\u95dc\u4fc2\u3002<\/p>\n

\u800c\u4ed6\u5011\u95dc\u4fc2\u7684\u89e3\u7b54\u5c31\u85cf\u5728\u8179\u5074\u84cb\u5340 (ventral tegmental area, VTA) \u548c\u9ed1\u8cea\u7dfb\u5bc6\u90e8 (substantia nigra pars compacta, SNc) \u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN) \u6240\u91cb\u653e\u7684\u591a\u5df4\u80fa\u3002\u6839\u64da\u795e\u7d93\u5f71\u50cf\u5b78\u7814\u7a76\u767c\u73fe\uff0c\u9ad8\u5ea6\u7684\u597d\u5947\u5fc3\u548c\u65b0\u5947\u7684\u523a\u6fc0\u6703\u589e\u52a0\u4e2d\u8166\u5340\u57dfDAN\u7684\u6d3b\u52d5\uff0c\u5982\u5716\u4e00\u6240\u793a\u30022023\u5e74\u300a\u81ea\u7136\u300b\u5b50\u671f\u520a\u300a\u901a\u8a0a\u751f\u7269\u5b78\u300b\u7684\u5176\u4e2d\u4e00\u9805\u7814\u7a76\uff0c\u4ee5\u300cVTA \/ SNc\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u6d3b\u6027\u7684\u964d\u4f4e\u662f\u8870\u8001\u76f8\u95dc\u65b0\u5947\u5fc3\u4e0b\u964d\u7684\u57fa\u790e\u300d\u70ba\u984c\uff0c\u6df1\u5165\u63a2\u8a0e\u4e86\u597d\u5947\u5fc3\u7684\u795e\u7d93\u6a5f\u5236\uff0c\u63ed\u793a\u4e86\u5c0d\u65b0\u5947\u4e8b\u7269\u7684\u71b1\u60c5\u6703\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\u800c\u905e\u6e1b\u7684\u539f\u56e0\uff0c\u4e26\u85c9\u7531\u5be6\u9a57\u9f20\u7684\u6e2c\u8a66\uff0c\u6392\u9664\u793e\u6703\u7d93\u6fdf\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u9a57\u8b49\u4e86VTA\u548cSNc\u81ea\u767c\u653e\u96fb\u7684\u6e1b\u5c11\u8207DAN\u6d3b\u6027\u7684\u964d\u4f4e\uff0c\u662f\u8870\u8001\u76f8\u95dc\u7684\u597d\u5947\u5fc3\u4e0b\u964d\u7684\u7d50\u679c\u3002<\/p>\n

\"\"
\u5716\u4e8c\uff1a\u5c0f\u9f20\u548c\u8001\u9f20\u5206\u5225\u6e2c\u8a66\u793e\u6703\u6027\u597d\u5947\u5ea6\u8207\u7121\u751f\u547d\u4e8b\u7269\u597d\u5947\u5ea6\u7684\u5be6\u9a57\u7d50\u679c\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b\uff0f\u6539\u7e6a\u81eashan, Q et. al, 2023<\/figcaption><\/figure>\n

\u8a72\u7814\u7a76\u85c9\u7531\u5be6\u9a57\u9f20\u7684\u6e2c\u8a66\uff0c\u76f4\u63a5\u63a2\u7d22\u5927\u8166\u795e\u7d93\u5143\u8207\u597d\u5947\u5fc3\u7684\u95dc\u4fc2\uff0c\u89e3\u958b\u80cc\u5f8c\u795e\u7d93\u6a5f\u5236\u7684\u56e0\u679c\u95dc\u4fc2\u3002\u5716\u4e8c\u986f\u793a\u4e86\u7814\u7a76\u4e2d\u7684\u5e74\u8f15\u5c0f\u9f20\uff08\u7c21\u7a31\u5c0f\u9f20\uff09\u548c\u5e74\u8001\u5927\u9f20\uff08\u7c21\u7a31\u8001\u9f20\uff09\u5206\u5225\u6e2c\u8a66\u793e\u6703\u6027\u597d\u5947\u5ea6\u8207\u7121\u751f\u547d\u4e8b\u7269\u597d\u5947\u5ea6\u7684\u7d50\u679c\u3002\u79d1\u5b78\u5bb6\u5011\u89c0\u5bdf\u4e86\u5be6\u9a57\u9f20\u7684\u5c0d\u65bc\u5169\u7a2e\u7269\u8cea\u7684\u597d\u5947\u72c0\u614b\uff1aA-\u793e\u4ea4\u65b0\u5947\u6216\u540c\u7406\u597d\u5947\uff08\u7d50\u8b58\u65b0\u7684\u8001\u9f20\u670b\u53cb\uff09\u548cB-\u7121\u751f\u547d\u7684\u65b0\u5947\u6216\u7121\u751f\u547d\u65b0\u7269\u9ad4\uff08\u5982\u9583\u4eae\u7684\u73a9\u5177\uff09\uff0c\u800c\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0c\u5c0f\u9f20\u5c0dAB\u72c0\u614b\u7684\u63a2\u7d22\u5747\u983b\u7e41\u5ea6\u7686\u9ad8\u65bc\u8001\u9f20\uff0c\u800c\u4e14\u5728A\u72c0\u614b\u7684\u6e2c\u8a66\u4e2d\uff0c\u96a8\u8457\u6642\u9593\u7684\u589e\u52a0\uff0c\u5c0f\u9f20\u5c0d\u65b0\u5925\u4f34\u7684\u8208\u8da3\u905e\u6e1b\u8b8a\u5316\u6703\u9010\u6f38\u8b8a\u9ad8\uff0c\u81f3\u65bc\u8001\u9f20\u5c0dAB\u7684\u8b8a\u5316\u5247\u76f8\u5c0d\u7a69\u5b9a\u3002<\/p>\n

\u7e3d\u9ad4\u800c\u8a00\uff0c\u8001\u9f20\u5c0d\u300c\u8a8d\u77e5\u597d\u5947\u300d\u8207\u300c\u540c\u7406\u597d\u5947\u300d\u5747\u6bd4\u5c0f\u9f20\u4f4e\uff0c\u4e14\u8b8a\u5316\u7a69\u5b9a\u3002\u70ba\u78ba\u5b9a\u5be6\u9a57\u7d50\u679c\u8207\u8870\u8001\u5f71\u97ff\u7684\u7d71\u8a08\u986f\u8457\u6027\uff0c\u7814\u7a76\u4eba\u54e1\u4e00\u65b9\u9762\u6a19\u6e96\u5316\u63a2\u7d22\u7387\uff0c\u53e6\u4e00\u65b9\u9762\u5247\u5229\u7528DAN\u7684\u653e\u96fb\u795e\u7d93\u7d30\u80de\u5bb6\u65cf\u7279\u6027\uff1a\u597d\u5947\u7684\u591a\u5df4\u80fa\u706b\u82b1\u5f80\u5f80\u6703\u5728\u8166\u4e2d\u5448\u73fe\u9583\u720d\u7684\u72c0\u614b\uff0c\u8a18\u9304\u4e86\u5c0f\u9f20\u548c\u8001\u9f20VTA\u548cSNc\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u81ea\u767c\u653e\u96fb\u60c5\u6cc1\uff0c\u5176\u7d50\u679c\u4ea6\u9a57\u8b49\u4e86\u8001\u9f20\u7684VTA\u548cSNc\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u81ea\u767c\u653e\u96fb\u5747\u5448\u73fe\u905e\u6e1b\u7684\u72c0\u6cc1\u3002<\/p>\n

\u5176\u6b21\uff0c\u63a1\u7528\u5316\u5b78\u907a\u50b3\u5b78\u65b9\u6cd5\uff0c\u5229\u7528\u7279\u5b9a\u85e5\u7269\u7279\u6027\u4f86\u958b\u555f\uff0f\u95dc\u9589\u591a\u5df4\u80fa\u91cb\u653e\u4f86\u63a7\u5236VTA \/ SNc\u795e\u7d93\u8ff4\u8def\u7684\u795e\u7d93\u5143\u7a81\u767c\u653e\u96fb\u548c\u795e\u7d93\u5143\u5316\u5b78\u6291\u5236\u4e8c\u7a2e\u4f5c\u7528\uff0c\u7d50\u679c\u986f\u793a\uff0c\u5c0d\u65bc\u5c0f\u9f20\u800c\u8a00\uff0c\u6291\u5236VTA \/ SNc\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u6d3b\u6027\u53ef\u6e1b\u5c11\u597d\u5947\u884c\u70ba\u3001\u6e1b\u5c11DAN\u81ea\u767c\u653e\u96fb\uff1b\u76f8\u53cd\u5730\uff0c\u5c0d\u8001\u9f20\u800c\u8a00\uff0c\u589e\u5f37VTA \/ SNc\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u7684\u6d3b\u6027\uff0c\u53ef\u4ee5\u6062\u5fa9\u5c0b\u6c42\u65b0\u5947\u7684\u884c\u70ba\u8207\u589e\u5f37DAN\u81ea\u767c\u653e\u96fb\u3002\u8a72\u7814\u7a76\u6700\u5f8c\u8aaa\u660e\uff0c\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u6578\u91cf\u6703\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\u800c\u6e1b\u5c11\u3002\u5728\u4eba\u985e\u4e2d\uff0c\u6bcf\u5341\u5e74\u6703\u4e1f\u59316%\u7684\u5167\u5074\u548c2%\u7684\u5916\u5074\u795e\u7d93\u5143\uff0c\u9019\u7a2e\u91cf\u7684\u640d\u5931\u8207\u591a\u5df4\u80fa\u53ef\u7528\u6027\u7684\u6e1b\u5c11\u6210\u6b63\u6bd4\u3002<\/p>\n

\u63db\u8a00\u4e4b\uff0c\u5065\u5eb7\u5e74\u5e7c\u7684DAN\u53ef\u4ee5\u5728\u6c92\u6709\u8208\u596e\u6027\u7a81\u89f8\u8f38\u5165\u7684\u60c5\u6cc1\u4e0b\u767c\u5c04\u52d5\u4f5c\u96fb\u4f4d\uff0c\u8868\u73fe\u51fa\u5177\u6709\u76f8\u5c0d\u898f\u5247\u7684\u81ea\u767c\u6027\u653e\u96fb\u81ea\u4e3b\u8abf\u7bc0\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u8001\u5e74\u7684DAN\u5247\u4ee5\u986f\u8457\u8f03\u4f4e\u7684\u983b\u7387\u653e\u96fb\u3001\u57fa\u790e\u6d3b\u6027\u964d\u4f4e\u8207\u597d\u5947\u884c\u70ba\u7684\u4e0b\u964d\u76f4\u63a5\u76f8\u95dc\uff0c\u5982\u540c\u8870\u8001\u7684\u5927\u8166\u5df2\u7d93\u8abf\u6697\u4e86\u597d\u5947\u5fc3\u7684\u71c8\u5149\u4e00\u6a23\u3002\u7136\u800c\uff0c\u85c9\u7531\u589e\u5f37\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u6d3b\u6027\u548c\u96a8\u4e4b\u800c\u4f86\u7684\u591a\u5df4\u80fa\u91cb\u653e\u5e72\u9810\u63aa\u65bd\uff0c\u5247\u53ef\u70ba\u9810\u9632\u3001\u5ef6\u7de9\u548c\u6539\u5584\u8870\u8001\u6216\u963f\u8332\u6d77\u9ed8\u75be\u75c5\u7b49\u9020\u6210\u7684\u8a8d\u77e5\u80fd\u529b \u8207\u597d\u5947\u5fc3\u4e0b\u964d\uff0c\u63d0\u4f9b\u4e86\u91cd\u65b0\u9ede\u71c3\u597d\u5947\u5fc3\u7684\u53ef\u80fd\u9014\u5f91\u3002<\/p>\n

\"\"
\u5716\u4e09\uff1a\u591a\u5df4\u80fa\u4e0d\u540c\u7684\u4ee3\u8868\u4fe1\u865f\uff0c\u5728\u5feb\u6a02\u3001\u617e\u671b\u3001\u52d5\u6a5f\u76ee\u6a19\u7b49\u4e4b\u5916\uff0c\u9084\u6709\u597d\u5947\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n

1950\u5e74\u4ee3\uff0c\u611b\u56e0\u65af\u576663\u6b72\u6642\uff0c\u5728\u5beb\u7d66\u670b\u53cb\u7684\u4fe1\u4e2d\u63d0\u5230\uff1a\u300c\u50cf\u4f60\u6211\u9019\u6a23\u7684\u4eba\uff0c\u96d6\u7136\u548c\u5176\u4ed6\u4eba\u4e00\u6a23\u662f\u51e1\u4eba\uff0c\u4f46\u7121\u8ad6\u6211\u5011\u6d3b\u591a\u4e45\u90fd\u4e0d\u6703\u8b8a\u8001.\u2026\u2026\uff08\u6211\u5011\uff09\u5f9e\u672a\u505c\u6b62\u50cf\u597d\u5947\u7684\u5c0f\u5b69\u4e00\u6a23\u2026\u2026\u3002\u300d\u96d6\u7136\u80fd\u50cf\u611b\u56e0\u65af\u5766\u4e00\u6a23\u4e00\u76f4\u4fdd\u6301\u597d\u5947\uff0c\u6fc0\u767c\u63a2\u7d22\u5b78\u7fd2\u3001\u5f15\u9818\u79d1\u5b78\u5275\u65b0\u52d5\u529b\u7684\u4eba\u4f3c\u4e4e\u4e0d\u591a\uff0c\u4f46\u73fe\u5728\u6211\u5011\u77e5\u9053\uff0c\u597d\u5947\u80cc\u5f8c\u7684\u795e\u7d93\u6a5f\u5236\u8207\u591a\u5df4\u80fa\u59d1\u5a18\u9019\u500b\u5316\u5b78\u7269\u8cea\u548c\u597d\u5947\u5075\u63a2\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN) \u606f\u606f\u76f8\u95dc\u3002\u4e5f\u8a31\u6709\u4e86\u9019\u4e9b\u65b0\u767c\u73fe\uff0c\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\uff0c\u5c45\u4f4f\u5728\u6bcf\u500b\u4eba\u5927\u8166\u4e2d\u7684\u798f\u723e\u6469\u65af\u90fd\u4e0d\u6703\u8f15\u6613\u5730\u65e9\u65e9\u9000\u4f11\uff0c\u5982\u6b64\u4e00\u4f86\uff0c\u6211\u5011\u4e0d\u50c5\u53ef\u4ee5\u512a\u96c5\u5730\u8b8a\u8001\uff0c\u800c\u4e14\u4e5f\u80fd\u597d\u5947\u5730\u8b8a\u8001\u3002<\/p>\n

\n

\u53c3\u8003\u6587\u737b<\/strong><\/p>\n

    \n
  1. Encyclop\u00e6dia Britannica, The Science of Curiosity.<\/a><\/li>\n
  2. \u52a0\u62ff\u5927Western University\u7684BrainsCAN\u8a08\u756b\u7db2\u7ad9<\/a><\/li>\n
  3. Science Photo<\/a><\/li>\n
  4. Shan, Q., Tian, Y., Chen, H. et al. Reduction in the activity of VTA\/SNc dopaminergic neurons underlies aging-related decline in novelty seeking. Commun Biol 6, 1224 (2023).<\/a><\/li>\n
  5. Wikiquote: Albert Einstein.<\/a><\/li>\n<\/ol>\n

     <\/p>\n

    \n

    \u2728\u5ef6\u4f38\u95b1\u8b80\uff1a\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u524d\u50b3<\/a>\u300b\u3001\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e00\u90e8\uff1aChEBI: 18243<\/a>\u300b\u3001\u300a\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e8c\u90e8\uff1a\u5de5\u4f5c\u7d30\u80deDAN<\/a>\u300b<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u672c\u7bc7\u8981\u4ecb\u7d39\u7684\u662f\u6703\u653e\u96fb\u7684\u5de5\u4f5c\u7d30\u80de\uff0c\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN) \u662f\u4e3b\u89d2\uff0c\u800c\u795e\u7d93\u905e\u8cea\u5316\u5b78\u7269\u8cea\u591a\u5df4\u80fa\u59d1\u5a18\u662f\u914d\u89d2\uff0c\u4ed6\u5011\u5169\u4f4d\u5728\u5169\u500b\u95dc\u9375\u7684\u5927\u8166\u5340\u57df\u4e2d\u5de5\u4f5c\u6642\uff0cDAN\u626e\u6f14\u8457\u611b\u597d\u65b0\u5947\u89e3\u8b0e\u7684\u798f\u723e\u6469\u65af\uff0c\u4e3b\u5c0e\u5c0b\u627e\u65b0\u5947\u4e8b\u7269\u7684\u76f8\u95dc\u795e\u7d93\u6a5f\u5236\uff0c\u4e26\u4e14\u4e5f\u662f\u9023\u63a5\u597d\u5947\u548c\u795e\u7d93\u5143\u6d3b\u52d5\u70ba\u95dc\u9375\u3002\u4f46\u9019\u88e1\u6709\u4e00\u500b\u554f\u984c\uff1a\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\uff0cDAN\u5c07\u6703\u6f38\u6f38\u5931\u53bb\u5c0b\u6c42\u65b0\u5947\u7684\u80fd\u529b\u3002\u7a76\u7adf\u70ba\u4ec0\u9ebc\u6703\u9019\u6a23\u5462\uff1f\u5c0e\u81f4\u597d\u5947\u5fc3\u4e0b\u964d\u7684\u80cc\u5f8c\u795e\u7d93\u6a5f\u5236\u53c8\u662f\u4ec0\u9ebc\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":44583,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32,7498,3293,6512],"tags":[2412,7169,7211,7212,4187],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/09\/DA_Curiosity_1.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44568"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44568"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44568\/revisions"}],"predecessor-version":[{"id":44584,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44568\/revisions\/44584"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/44583"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}