{"id":44411,"date":"2024-08-01T18:00:53","date_gmt":"2024-08-01T10:00:53","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=44411"},"modified":"2026-01-06T14:27:13","modified_gmt":"2026-01-06T06:27:13","slug":"%e5%a4%9a%e8%ae%8a%e5%a4%9a%e5%b7%b4%e8%83%ba-%e7%ac%ac%e4%ba%8c%e9%83%a8%ef%bc%9a%e5%b7%a5%e4%bd%9c%e7%b4%b0%e8%83%9edan","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=44411","title":{"rendered":"\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e8c\u90e8\uff1a\u5de5\u4f5c\u7d30\u80deDAN"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u6bcf\u5929\u5728\u5927\u8166\u4e2d\u5e6b\u4f60\u5de5\u4f5c\u7684\u7d30\u80de-\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143(DAN)\u662f\u4ec0\u9ebc\uff1f\u4ed6\u7684\u5bb6\u4e16\u3001\u65e5\u5e38\u5de5\u4f5c\uff0c\u8a66\u8a66\u770b\uff0c\u8b93\u6211\u5011\u4f7f\u7528\u300c\u77e5\u8b58\u8aaa\u660e\u66f8\u300d\u2014\u2014 \u672c\u9ad4\uff0c\u900f\u904eDAN\u7684\u8eab\u5206\u8b49\u865f\u78bc: 0000700\u958b\u59cb\uff0c\u5e7e\u5f35\u5716\u5c07\u4ed6\u548c\u591a\u5df4\u80fa\u7684\u91cd\u8981\u95dc\u4fc2\u8108\u7d61\uff0c\u5177\u9ad4\u5448\u73fe\u3002\u4e00\u65e6\u4f60\u6709\u4e86DAN \u76f8\u95dc\u77e5\u8b58\u5716\u8b5c\u7684\u6982\u5ff5\uff0c\u662f\u5426\u53c8\u6703\u548c\u8166\u6d77\u4e2d\u6b63\u5728\u5de5\u4f5c\u7684DAN\u8207\u591a\u5df4\u80fa\uff0c\u78b0\u649e\u6fc0\u767c\u51fa\u5c6c\u65bc\u4f60\u500b\u4eba\uff0c\u4ec0\u9ebc\u6a23\u7684\u8a8d\u77e5\u65b0\u4e16\u754c\u706b\u82b1\u5462\uff1f<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5cA. H.<\/strong><\/p>\n<p>\u5927\u5bb6\u597d\uff0c\u6211\u662f\u6709\u8457\u591a\u91cd\u8eab\u5206\u7684\u591a\u8b8a\u591a\u5df4\u80fa\u59d1\u5a18\u3002\u4f5c\u70ba\u4e00\u500b\u6709\u6a5f\u5316\u5408\u7269\uff0c\u6211\u662f\u5316\u5b78\u5bb6\u53e3\u4e2d\u7684ChEBI: 18243\uff08\u6b32\u77ad\u89e3\u591a\u5df4\u80fa\u7684\u5316\u5b78\u6027\u8cea\u8005\uff0c\u8acb\u898b\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44277\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u7b2c\u4e00\u90e8\u2014\u2014\uff1aChEBI: 18243<\/a>\u300b\u3002\u7576\u7136\uff0c\u591a\u8b8a\u7684\u6211\u53ef\u4e0d\u55ae\u55ae\u53ea\u6709\u5316\u5b78\u4e0a\u7684\u8eab\u5206\uff0c\u8207\u4f60\u5011\u4eba\u985e\u4e5f\u662f\u606f\u606f\u76f8\u95dc\u7684\uff01\u8981\u8ac7\u9019\u5c64\u95dc\u4fc2\u53ef\u5c31\u8981\u5f9e\u751f\u7269\u5b78\u5bb6\u5b9a\u7fa9\u7684\u7d30\u80de\u77e5\u8b58\u672c\u9ad4 (Cell Ontology) \u8eab\u5206\u8b49\u5b57\u865f0000700\u958b\u59cb\u804a\u8d77\u4e86\u3002\u8a71\u4e0d\u591a\u8aaa\uff0c\u5148\u900f\u904e\u4e00\u5f35\u5716\u4f86\u8a8d\u8b58\u5de5\u4f5c\u7d30\u80de\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (dopaminergic neuron, DAN, <a href=\"https:\/\/www.ebi.ac.uk\/ols4\/ontologies\/cl\/entities\/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000700\" target=\"_blank\" rel=\"noopener\">CL: 0000700<\/a>) \u2014\u2014\u4e00\u500b\u4f7f\u7528\u591a\u5df4\u80fa\u4f5c\u70ba\u795e\u7d93\u905e\u8cea\u7684\u795e\u7d93\u5143\uff08\u7d30\u80de\uff09\u2014\u2014\u7684\u5de5\u4f5c\u7279\u8cea\u8207\u77e5\u8b58\u65cf\u8b5c\u5427\u3002<\/p>\n<figure id=\"attachment_44416\" aria-describedby=\"caption-attachment-44416\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-44416\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_1-1-1024x573.png\" alt=\"\" width=\"600\" height=\"336\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_1-1-1024x573.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_1-1-300x168.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_1-1-768x430.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_1-1-1536x860.png 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_1-1-2048x1146.png 2048w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-44416\" class=\"wp-caption-text\">\u5716\u4e00\uff1a\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u5728\u7d30\u80de\u77e5\u8b58\u672c\u9ad4 (CL) \u4e2d\u5c6c\u65bc\u795e\u7d93\u3001\u5206\u6ccc\u4ee5\u53ca\u96fb\u4fe1\u6d3b\u6027\u7d30\u80de\u5bb6\u65cf\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>\u900f\u904e\u7d30\u80de\u672c\u9ad4 (CL) \u7684\u67b6\u69cb\u4f86\u77ad\u89e3\u7d30\u80de\u548c\u591a\u5df4\u80fa\uff0c\u4e3b\u8981\u662f\u56e0\u70baCL\u6240\u63cf\u8ff0\u7684\u7d30\u80de\u77e5\u8b58\u6210\u719f\u4e14\u5b8c\u6574\uff08\u81ea2004\u5e74\u8fc4\u4eca\u5df2\u7d2f\u7a4d20\u5e74\uff09\uff0c\u6db5\u84cb\u4e86\u5f9e\u539f\u6838\u751f\u7269\u5230\u54fa\u4e73\u52d5\u7269\u7684\u7d30\u80de\u985e\u578b\uff0c\u4f46\u4e0d\u5305\u62ec\u690d\u7269\u7d30\u80de\u3002CL\u7684\u8c50\u5bcc\u591a\u5143\u53ef\u5f9e\u5c0e\u5165\u4e8617\u7a2e\u5916\u90e8\u672c\u9ad4\u8207\u88ab86\u7a2e\u5916\u90e8\u672c\u9ad4\u91cd\u8907\u4f7f\u7528\u89c0\u5bdf\u5f97\u77e5\uff0c\u6b64\u5916\uff0cCL\u4e5f\u88ab\u753199\u570b\uff0c3\u5343\u591a\u540d\u751f\u7269\u5b78\u5bb6\u3001\u8cc7\u8a0a\u5b78\u5bb6\u3001\u81e8\u5e8a\u91ab\u751f\u7b49\u6240\u7d44\u6210\u7684\u570b\u969b\u7814\u7a76\u806f\u76df\u5ee3\u6cdb\u5730\u61c9\u7528\u3002\u57282016\u5e74\u5275\u7acb\u7684\u4eba\u985e\u7d30\u80de\u5716\u8b5c (the Human Cell Atlas) \u548c\u7f8e\u570b\u570b\u7acb\u885b\u751f\u7814\u7a76\u9662\u7684<a href=\"https:\/\/www.humancellatlas.org\/\" target=\"_blank\" rel=\"noopener\">\u4eba\u985e\u751f\u7269\u5206\u5b50\u5716\u8b5c<\/a> (<a href=\"https:\/\/portal.hubmapconsortium.org\/\" target=\"_blank\" rel=\"noopener\">HuBMAP<\/a>) \u8a08\u5283\u4e2d\u4e5f\u5747\u63a1\u7528CL\u4f5c\u70ba\u6838\u5fc3\u8cc7\u6e90\u3002<\/p>\n<p>\u5728\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44277\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e00\u90e8\uff1aChEBI: 18243<\/a>\u300b\u4e2d\uff0c\u6211\u5011\u4ecb\u7d39\u4e86\u77e5\u8b58\u672c\u9ad4\u4e2d\u7684\u7236\u5b50\u95dc\u4fc2\uff0c\u4e5f\u5c31\u662f\u77e5\u8b58\u67b6\u69cb\u7684\u4e0a\u4e0b\u95dc\u4fc2\uff0c\u6216\u7a31\u672c\u9ad4\u7684\u300c\u6df1\u5ea6\u300d\u3002\u5be6\u969b\u4e0a\uff0c\u5728CL\u4e2d\u6df1\u5ea6\u7684\u8868\u9054\u53ef\u905431\u5c64\u4e4b\u6df1\uff0c\u4e5f\u5c31\u662f\u767d\u8a71\u4e2d\u5bb6\u8b5c\u768431\u4ee3\u3002\u5728\u5716\u4e00\u4e2d\u53ef\u4ee5\u770b\u51fa\uff0cDAN\u7684\u76f4\u63a5\u4e0a\u5c64\u662f\u91cb\u653e\u5152\u8336\u915a\u80fa\u4f5c\u70ba\u795e\u7d93\u905e\u8cea\u7684\u795e\u7d93\u5143\u2014\u2014<a href=\"http:\/\/purl.obolibrary.org\/obo\/CL_4033050\" target=\"_blank\" rel=\"noopener\">\u5152\u8336\u915a\u80fa\u80fd\u795e\u7d93\u5143<\/a>\uff0c\u4e5f\u5c31\u662fDAN\u7684\u7236\u89aa\uff0c\u7e7c\u627f\u4e86\u795e\u7d93\u3001\u5206\u6ccc\u53ca\u96fb\u4fe1\u6d3b\u6027\u4e09\u5927\u7d30\u80de\u5bb6\u65cf\u7684\u4e00\u4e9b\u7279\u6027\uff0c\u7531\u6b64\u4fbf\u80fd\u5e6b\u52a9\u6211\u5011\u8f15\u6613\u638c\u63e1DAN\u4f5c\u70ba\u5206\u6ccc\u591a\u5df4\u80fa\u7684\u5de5\u4f5c\u7d30\u80de\u4e4b\u7279\u6027\u3002<\/p>\n<p>\u5176\u6b21\uff0c\u6211\u5011\u5c0d\u5bb6\u4f4f\u5728\u4e2d\u8166\u7684DAN\u4e5f\u901a\u5e38\u4e0d\u964c\u751f\uff0c\u56e0\u70ba\u9019\u88e1\u7684DAN\u8207\u5e38\u807d\u805e\u7684\u5e15\u91d1\u68ee\u6c0f\u75c7\u606f\u606f\u76f8\u95dc\uff0c\u9020\u6210\u8a72\u75c5\u75c7\u7684\u4e3b\u8981\u795e\u7d93\u9000\u5316\u75c5\u8b8a\u6a19\u9776\u7d44\u7e54\u4fbf\u662f\u9019\u88e1\u3002\u800cDAN\u5728CL\u63cf\u8ff0\u4e2d\u9084\u6709\u5169\u500b\u4e0b\u5c64\u5b50\u985e\uff0c\u5176\u4e2d\u7684<a href=\"http:\/\/purl.obolibrary.org\/obo\/CL_2000097\" target=\"_blank\" rel=\"noopener\">\u4e2d\u8166\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143<\/a>\u5373\u662fDAN\u7684\u5b50\u5973\u3002\u7531\u65bcDAN\u6703\u96a8\u5e74\u7d00\u8b8a\u8001\u6216\u75be\u75c5\u7b49\u56e0\u7d20\u9000\u5316\u6216\u6e1b\u5c11\uff0c\u82e5\u8166\u5167\u7121\u6cd5\u7522\u751f\u8db3\u5920\u7684\u591a\u5df4\u80fa\uff0c\u8ca0\u8cac\u50b3\u905e\u8a0a\u606f\u7684\u5de5\u4f5c\u4fbf\u7121\u6cd5\u6b63\u5e38\u57f7\u884c\uff0c\u4e5f\u56e0\u6b64\u5bb9\u6613\u5c0e\u81f4\u80a2\u9ad4\u884c\u52d5\u9000\u5316\u3001\u8a8d\u77e5\u611f\u5b98\u60c5\u7dd2\u6216\u8cc0\u723e\u8499\u8abf\u7bc0\u7b49\u76f8\u95dc\u75be\u75c5\u3002<\/p>\n<p>\u53e6\u4e00\u7fa4\u4f4f\u5728\u8996\u7db2\u819c\u5167\u6838\u5c64\u4e2d\u7684\u795e\u7d93\u5143\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u7684<a href=\"http:\/\/purl.obolibrary.org\/obo\/CL_0011105\" target=\"_blank\" rel=\"noopener\">\u591a\u5df4\u80fa\u80fd\u53e2\u9593\u7d30\u80de<\/a>\u4ea6\u662fDAN\u7684\u5b50\u5973\uff0c\u4e0d\u904e\u6b64\u985e\u591a\u5df4\u80fa\u5728\u4e00\u822c\u7684\u4ecb\u7d39\u4e2d\u4e26\u4e0d\u5e38\u898b\uff0c\u76f8\u95dc\u7684\u7814\u7a76\u4e5f\u76f8\u5c0d\u7a00\u5c11\u3002\u4ed6\u5011\u7684\u5c08\u9577\u662f\u5229\u7528\u591a\u5df4\u80fa\u8abf\u7bc0\u795e\u7d93\u5728\u8996\u7db2\u819c\u4e2d\u9069\u61c9\u5149\u7684\u4f5c\u7528\uff0c\u5018\u82e5\u4ed6\u5011\u80fd\u4f7f\u7528\u7684\u591a\u5df4\u80fa\u4e0d\u5920\u591a\uff0c\u4e5f\u53ef\u80fd\u5c0e\u81f4\u5e15\u91d1\u68ee\u6c0f\u75c7\u60a3\u8005\u7684\u8996\u89ba\u969c\u7919\u3002<\/p>\n<p>\u7136\u800c\uff0c\u76f8\u5c0d\u65bcDAN\u7684\u7236\u5b50\u95dc\u4fc2\uff0c\u4ed6\u7684\u5144\u5f1f\u59ca\u59b9\uff08\u5de6\u53f3\u95dc\u4fc2\uff09\u8f03\u70ba\u8907\u96dc\u3002CL\u672c\u9ad4\u63cf\u8ff0\u4e86\u8d85\u904e2700\u591a\u500b\u7d30\u80de\u985e\u578b\uff0c\u5176\u4e2d\u7684\u795e\u7d93\u7d30\u80de\u6709660\u985e\u3001\u795e\u7d93\u5143\u8d85\u904e540\u985e\u3002\u5982\u6b64\u9f90\u5927\u7684\u8cc7\u6599\u91cf\u8b93\u4eba\u982d\u6688\u773c\u82b1\uff0c\u9084\u597d\u6211\u5011\u9084\u6709\u53e6\u4e00\u500b\u672c\u9ad4\u5e6b\u6d3e\u53ef\u4ee5\u6551\u63f4\u3002\u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928\u7684\u91ab\u5b78\u79d1\u76ee\u6a19\u984c (Medical Subject Headings, MeSH) \u4eca\u5e74\u5df270\u6b72\u4e86\uff08\u81ea1954\u5e74\u51fa\u7248\uff09\u3002\u7531<a href=\"https:\/\/meshb.nlm.nih.gov\/record\/ui?ui=D059290\" target=\"_blank\" rel=\"noopener\">MeSH\u77e5\u8b58\u6a39<\/a>\u4e2d\uff0c\u4ed6\u7684\u5176\u4ed6\u795e\u7d93\u5143\u7d30\u80de\u5144\u5f1f\u59ca\u59b9\u7684\u6982\u6cc1\u3002<\/p>\n<figure id=\"attachment_44417\" aria-describedby=\"caption-attachment-44417\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-44417\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_2-1-1024x562.png\" alt=\"\" width=\"600\" height=\"329\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_2-1-1024x562.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_2-1-300x165.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_2-1-768x421.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_2-1-1536x842.png 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_2-1-2048x1123.png 2048w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-44417\" class=\"wp-caption-text\">\u5716\u4e8c\uff1a\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN) \u7684MeSH\u77e5\u8b58\u6a39\u8868\u9054\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>\u5728\u77e5\u8b58\u672c\u9ad4\u4e2d\uff0c\u7236\u5b50\u5144\u5f1f\u59ca\u59b9\u95dc\u4fc2\u662f\u57fa\u672c\u7684\u300c\u8840\u7de3\u300d\uff0c\u800c\u53e6\u5916\u4e00\u7a2e\u95dc\u4fc2\u5305\u6db5\u4e86\u8207\u5916\u90e8\u77e5\u8b58\u7684\u63cf\u8ff0\uff0c\u4ea6\u662f\u672c\u9ad4\u53b2\u5bb3\u4e4b\u8655\u3002\u5c31\u50cf\u5beb\u50b3\u8a18\u4e00\u6a23\uff0c\u7956\u5b6b\u4e09\u4ee3\u4ea4\u4ee3\u5b8c\u5f8c\uff0c\u91cd\u982d\u6232\u5c31\u662f\u6558\u8ff0\u4e3b\u89d2\u7684\u7d93\u6b77\u8207\u6709\u610f\u7fa9\u7684\u4e8b\u4ef6\u3002\u5982\u4e4b\u524d\u4ecb\u7d39\u7684\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44277\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e00\u90e8\uff1aChEBI: 18243<\/a>\u300b\u5177\u6709\u7c21\u55ae\u7684\u5305\u542b\u3001\u985e\u4f3c\u548c\u61c9\u7528\u95dc\u4fc2\uff0c\u5728\u7b2c\u4e8c\u90e8\u4e2d\uff0c\u6211\u5011\u7684\u4e3b\u89d2\u662f\u6709\u751f\u547d\u7684\u7d30\u80de\u5be6\u9ad4\u2014\u2014\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN)\uff0c\u56e0\u6b64\u300c\u751f\u7269\u904e\u7a0b\u300d\u6210\u70ba\u4e86\u8a6e\u91cb\u77e5\u8b58\u4e0d\u53ef\u6216\u7f3a\u7684\u8981\u4ef6\u3002\u85c9\u7531CL\u672c\u9ad4\u5c0e\u5165\u7684\u5916\u90e8\u57fa\u56e0\u77e5\u8b58\u672c\u9ad4 (Gene Ontology, GO)\uff0c\u6211\u5011\u53ef\u4ee5\u66f4\u9032\u4e00\u6b65\u77ad\u89e3\u7d30\u80deDAN\u7684\u751f\u7269\u904e\u7a0b\u65e5\u5e38\u5de5\u4f5c\u72c0\u6cc1\uff08\u5716\u4e09\uff09\u3002<\/p>\n<figure id=\"attachment_44418\" aria-describedby=\"caption-attachment-44418\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-44418\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_3-1-1024x565.png\" alt=\"\" width=\"600\" height=\"331\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_3-1-1024x565.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_3-1-300x166.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_3-1-768x424.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_3-1-1536x848.png 1536w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_3-1-2048x1130.png 2048w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-44418\" class=\"wp-caption-text\">\u5716\u4e09\uff1a\u7a81\u89f8\u5373\u5169\u500b\u795e\u7d93\u5143\u9593\u3001\u6216\u795e\u7d93\u5143\u8207\u817a\u9ad4\u3001\u6216\u808c\u8089\u7d30\u80de\u9593\u7684\u50b3\u905e\u795e\u7d93\u96fb\u885d\u90e8\u4f4d\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p>\u5de5\u4f5c\u7d30\u80deDAN\u662f\u85c9\u7531\u7a81\u89f8 (synapse) \u91cb\u653e\u591a\u5df4\u80fa\u7684\u795e\u7d93\u5143\u3002\u6839\u64da<a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0045202\" target=\"_blank\" rel=\"noopener\">GO\u672c\u9ad4\u5c0d\u7a81\u89f8\u7684\u5b9a\u7fa9<\/a>\uff1a\u4e00\u500b\u795e\u7d93\u5143\u7684\u8ef8\u7a81\u8207\u53e6\u4e00\u500b\u795e\u7d93\u5143\u7684\u6a39\u7a81\u3001\u808c\u7e96\u7dad\u6216\u795e\u7d93\u81a0\u8cea\u7d30\u80de\u4e4b\u9593\u7684\u9023\u63a5\u8655\u3002<\/p>\n<ul>\n<li>\u7576\u8ef8\u7a81\u63a5\u8fd1\u7a81\u89f8\u6642\uff0c\u6703\u64f4\u5927\u6210\u4e00\u7a2e\u7279\u6b8a\u7d50\u69cb\uff0c\u5373\u7a81\u89f8\u524d\u7aef\u68d2\u982d\uff0c\u5176\u4e2d\u5305\u542b\u7c92\u7dda\u9ad4\u548c\u7a81\u89f8\u56ca\u6ce1\u3002<\/li>\n<li>\u672b\u7aef\u68d2\u982d\u7684\u5c16\u7aef\u662f\u7a81\u89f8\u524d\u819c\uff1b\u9762\u5c0d\u5b83\u4e26\u9694\u958b\u4e00\u500b\u5fae\u5c0f\u88c2\u7e2b\uff08\u7a81\u89f8\u9593\u9699\uff09\u7684\u662f\u63a5\u6536\u7d30\u80de\u4e0a\u4e00\u500b\u7279\u6b8a\u7684\u819c\u5340\u57df\uff0c\u7a31\u70ba\u7a81\u89f8\u5f8c\u819c\u3002<\/li>\n<li>\u70ba\u4e86\u56de\u61c9\u795e\u7d93\u96fb\u885d\u7684\u5230\u4f86\uff0c\u7a81\u89f8\u524d\u672b\u68a2\u5c07\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u5982\u591a\u5df4\u80fa\uff0c\u5206\u6ccc\u5230\u9593\u9699\u3002\u5b83\u5011\u64f4\u6563\u7a7f\u904e\u9593\u9699\uff0c\u4e26\u5c07\u8a0a\u865f\u50b3\u5230\u7a81\u89f8\u5f8c\u819c\u3002<\/li>\n<\/ul>\n<p>\u5728CL\u548cGO\u672c\u9ad4\u5354\u529b\u6240\u63cf\u8ff0\u7684DAN (CL: 0000700) \u4e4b\u751f\u7269\u904e\u7a0b\u5982\u5716\u56db\uff0c\u6216\u7528\u6587\u6cd5\u4f86\u6bd4\u55bb\u77e5\u8b58\u672c\u9ad4\u4e2d\u7684\u300c\u95dc\u4fc2\u300d\uff0c\u5373\u662f\u52d5\u8a5e\uff1a<\/p>\n<ul>\n<li>\u6709\u53c3\u8207\u8005 (has participant)<\/li>\n<li>\u6709\u7d50\u675f\u4f4d\u7f6e (has end location)<\/li>\n<li>\u5c0e\u81f4\u7372\u5f97\u7279\u5fb5 (results in acquisition of features of)<\/li>\n<\/ul>\n<figure id=\"attachment_44414\" aria-describedby=\"caption-attachment-44414\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-44414\" src=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_4-1024x576.png\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_4-1024x576.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_4-300x169.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_4-768x432.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_4.png 1280w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-44414\" class=\"wp-caption-text\">\u5716\u56db\uff1a\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143 (DAN, CL: 0000700) \u7684\u751f\u7269\u904e\u7a0b\u95dc\u4fc2\u63cf\u8ff0\uff0cCL\u5c0e\u5165GO\u672c\u9ad4\uff5c\u4f86\u6e90\uff1a\u4f5c\u8005\u63d0\u4f9b<\/figcaption><\/figure>\n<p><a href=\"#_ednref1\" name=\"_edn1\"><\/a><\/p>\n<p>\u800c\u53c3\u8207\u751f\u7269\u904e\u7a0b\u7684\u5be6\u9ad4\uff08\u6bd4\u55bb\u70ba\u540d\u8a5e\uff09\u5206\u5225\u70ba\uff1a<\/p>\n<ul>\n<li><a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0001963\" target=\"_blank\" rel=\"noopener\">\u7a81\u89f8\u50b3\u905e\u2013\u591a\u5df4\u80fa\u80fd<\/a>\uff1a\u6307\u591a\u5df4\u80fa\u81ea\u56ca\u6ce1\u91cb\u653e\uff0c\u5f9e\u7a81\u89f8\u524d\u7a7f\u904e\u5316\u5b78\u7a81\u89f8\uff0c\u96a8\u5f8c\u5728\u9776\u7d30\u80de\u7684\u7a81\u89f8\u5f8c\u555f\u52d5\u591a\u5df4\u80fa\u53d7\u9ad4\uff0c\u4ee5\u53ca\u9019\u7a2e\u555f\u52d5\u5c0d\u7a81\u89f8\u5f8c\u819c\u96fb\u4f4d\u548c\u7a81\u89f8\u5f8c\u80de\u8cea\u6eb6\u81a0\u7684\u96e2\u5b50\u7d44\u6210\u7684\u5f71\u97ff\u3002\u904e\u7a0b\u5305\u62ec\u8a98\u767c\u50b3\u905e\u59cb\u65bc\u7a81\u89f8\u524d\u7684\u52d5\u4f5c\u96fb\u4f4d\u3001\u795e\u7d93\u905e\u8cea\u7684\u81ea\u767c\u548c\u8a98\u767c\u91cb\u653e\uff0c\u4ee5\u53ca\u7a81\u89f8\u56ca\u6ce1\u7684\u80de\u5410\u4f5c\u7528\u3002<\/li>\n<li><a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0071542\">\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u5206\u5316<\/a>\uff1a\u6307\u795e\u7d93\u6bcd\u7d30\u80de\u7372\u5f97DAN\u7684\u7279\u6b8a\u7d50\u69cb\u548c\u529f\u80fd\u7279\u5fb5\u7684\u904e\u7a0b\u3002<\/li>\n<li><a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0036520\">\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u2013\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u4fe1\u865f\u50b3\u5c0e<\/a>\uff1a\u6307\u4ecb\u5c0e\u5f9e\u661f\u72c0\u7d30\u80de\u5230DAN\u7d30\u80de\u9593\u8a0a\u865f\u7684\u50b3\u5c0e\u3002<\/li>\n<\/ul>\n<p>\u638c\u63e1\u4e86\u591a\u5df4\u80fa\u9019\u500b\u5316\u5b78\u7269\u8cea\u548c\u5de5\u4f5c\u7d30\u80deDAN\u7684\u4e00\u4e9b\u57fa\u672c\u77e5\u8b58\u67b6\u69cb\u5f8c\uff0c\u518d\u60f3\u60f3\u770b\uff0c\u5982\u679c\u8aaa\u591a\u8b8a\u591a\u5df4\u80fa\u5f88\u591a\u8b8a\uff0c\u90a3\u9ebc\u4f4f\u5728\u4e2d\u8166\u7684DAN\u91cb\u653e\u591a\u5df4\u80fa\u5f8c\uff0c\u5c0d\u751f\u7269\u7684\u5f71\u97ff\u7121\u7591\u61c9\u8a72\u4e5f\u662f\u591a\u8b8a\u7684\u3002\u5982\u6b64\u9019\u822c\uff0c\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u53c8\u5c07\u5e36\u7d66\u6211\u5011\u4ec0\u9ebc\u610f\u5916\u7684\u79d1\u5b78\u9a37\u52d5\u5462\uff1f\uff08\u5f85\u7e8c\uff09<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u53c3\u8003\u6587\u737b<\/strong><\/p>\n<ol>\n<li><a href=\"https:\/\/obofoundry.org\/ontology\/cl.html\">Cell Ontology<\/a> (\u7248\u672c2024-04-05); DAN: <a href=\"http:\/\/purl.obolibrary.org\/obo\/CL_0000700\">CL: 0000700<\/a> ; \u5152\u8336\u915a\u80fa\u80fd\u795e\u7d93\u5143: <a href=\"http:\/\/purl.obolibrary.org\/obo\/CL_4033050\">CL: 4033050<\/a> ; \u4e2d\u8166\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143: <a href=\"http:\/\/purl.obolibrary.org\/obo\/CL_2000097\">CL:2000097<\/a>; \u591a\u5df4\u80fa\u80fd\u53e2\u9593\u7d30\u80de: <a href=\"http:\/\/purl.obolibrary.org\/obo\/CL_0011105\">CL: 0011105<\/a><\/li>\n<li>Khadjevand, Fatemeh, Sohrab Shahzadi, and Abdolhossein Abbassian. \"<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0042698909005483\">Reduction of negative afterimage duration in Parkinson\u2019s disease patients: A possible role for dopaminergic deficiency in the retinal Interplexiform cell layer<\/a>.\" Vision research 50.3 (2010): 279-283.<\/li>\n<li><a href=\"https:\/\/www.nlm.nih.gov\/mesh\/\">NIH Medical Subject Headings<\/a> (MeSH\u7248\u672c2024); <a href=\"https:\/\/meshb.nlm.nih.gov\/record\/ui?ui=D059290\">DAN: D059290<\/a><\/li>\n<li><a href=\"https:\/\/geneontology.org\/docs\/ontology-documentation\/\">Gene Ontology<\/a> (\u7248\u672c2024-04-24); \u7a81\u89f8: <a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0045202\">GO:0045202<\/a> ; \u7a81\u89f8\u50b3\u905e\uff0c\u591a\u5df4\u80fa\u80fd: <a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0001963\">GO:0001963<\/a>; \u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u5206\u5316: <a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0071542\">GO_0071542<\/a>; \u661f\u5f62\u81a0\u8cea\u7d30\u80de-\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u4fe1\u865f\u50b3\u5c0e: <a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0036520\">GO:0036520<\/a><\/li>\n<li>\u5716\u4e09\u6574\u5408\u6539\u7de8\u81ea\u7a81\u89f8: <a href=\"http:\/\/purl.obolibrary.org\/obo\/GO_0045202\">GO:0045202<\/a>\u63cf\u8ff0\u8207<a href=\"https:\/\/www.britannica.com\/science\/synapse\">\u5927\u82f1\u767e\u79d1\u7684\u7a81\u89f8\u8aaa\u660e\u5716<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>\u2728\u5ef6\u4f38\u95b1\u8b80\uff1a\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44043\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u524d\u50b3<\/a>\u300b\u3001\u300a<a href=\"https:\/\/case.ntu.edu.tw\/blog\/?p=44277\" target=\"_blank\" rel=\"noopener\">\u591a\u8b8a\u591a\u5df4\u80fa\u2014\u2014\u7b2c\u4e00\u90e8\uff1aChEBI: 18243<\/a>\u300b<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6bcf\u5929\u5728\u5927\u8166\u4e2d\u5e6b\u4f60\u5de5\u4f5c\u7684\u7d30\u80de-\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143(DAN)\u662f\u4ec0\u9ebc\uff1f\u4ed6\u7684\u5bb6\u4e16\u3001\u65e5\u5e38\u5de5\u4f5c\uff0c\u8a66\u8a66\u770b\uff0c\u8b93\u6211\u5011\u4f7f\u7528\u300c\u77e5\u8b58\u8aaa\u660e\u66f8\u300d\u2014\u2014 \u672c\u9ad4\uff0c\u900f\u904eDAN\u7684\u8eab\u5206\u8b49\u865f\u78bc: 0000700\u958b\u59cb\uff0c\u5e7e\u5f35\u5716\u5c07\u4ed6\u548c\u591a\u5df4\u80fa\u7684\u91cd\u8981\u95dc\u4fc2\u8108\u7d61\uff0c\u5177\u9ad4\u5448\u73fe\u3002\u4e00\u65e6\u4f60\u6709\u4e86DAN \u76f8\u95dc\u77e5\u8b58\u5716\u8b5c\u7684\u6982\u5ff5\uff0c\u662f\u5426\u53c8\u6703\u548c\u8166\u6d77\u4e2d\u6b63\u5728\u5de5\u4f5c\u7684DAN\u8207\u591a\u5df4\u80fa\uff0c\u78b0\u649e\u6fc0\u767c\u51fa\u5c6c\u65bc\u4f60\u500b\u4eba\uff0c\u4ec0\u9ebc\u6a23\u7684\u8a8d\u77e5\u65b0\u4e16\u754c\u706b\u82b1\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":44416,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32,7498,3293,6512],"tags":[7169,1172,7170,7171],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2024\/07\/DAN_1-1.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44411"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44411"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44411\/revisions"}],"predecessor-version":[{"id":44419,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/44411\/revisions\/44419"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/44416"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}