{"id":39532,"date":"2022-03-29T08:00:05","date_gmt":"2022-03-29T00:00:05","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=39532"},"modified":"2022-03-24T16:47:14","modified_gmt":"2022-03-24T08:47:14","slug":"%e6%ac%a1%e4%b8%96%e4%bb%a3%e5%ae%9a%e5%ba%8f%e7%94%a8%e6%96%bc%e6%aa%a2%e6%b8%accovid-19%e7%97%85%e6%af%92%e5%8f%8a%e9%98%b2%e6%ad%a2%e6%93%b4%e6%95%a3","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=39532","title":{"rendered":"\u6b21\u4e16\u4ee3\u5b9a\u5e8f\u7528\u65bc\u6aa2\u6e2c COVID-19 \u75c5\u6bd2\u53ca\u9632\u6b62\u64f4\u6563"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2 SARS-CoV-2 \u5df2\u5f15\u8d77\u5168\u7403\u5927\u7bc4\u570d\u50b3\u64ad\u548c\u6301\u7e8c\u5927\u6d41\u884c\u3002\u7576\u524d\u7528\u65bc COVID-19 \u8a3a\u65b7\u7684\u6e2c\u8a66\u65b9\u6cd5\u5305\u62ec\u6297\u539f\u5feb\u7be9\u3001PCR \u6838\u9178\u6aa2\u6e2c\u53ca\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff08Next-Generation Sequencing, NGS\uff09\uff0c\u56e0 COVID-19 \u75c5\u6bd2\u7684\u5feb\u901f\u8b8a\u7570\uff0cNGS \u5728\u8a31\u591a\u65b9\u9762\u767c\u63ee\u8457\u6975\u91cd\u8981\u7684\u4f5c\u7528\u3002NGS \u53ef\u7528\u65bc\u63a2\u7d22\u75c5\u6bd2\u4f86\u6e90\u3001\u5075\u6e2c\u8b8a\u7a2e\u75c5\u6bd2\u53ca\u9810\u6e2c\u5176\u6f14\u5316\u8da8\u52e2\u4ee5\u963b\u6b62\u5927\u898f\u6a21\u50b3\u64ad\uff0c\u6709\u6f5b\u529b\u9032\u4e00\u6b65\u7528\u65bc COVID-19 \u7684\u65b0\u8a3a\u65b7\u65b9\u6cd5\u548c\u65b0\u6cbb\u7642\u9776\u9ede\u7684\u958b\u767c\u3002NGS \u7684\u5ee3\u6cdb\u61c9\u7528\u5c07\u63d0\u4f9b\u5f37\u800c\u6709\u529b\u7684\u652f\u6301\uff0c\u4ee5\u61c9\u5c0d\u672a\u4f86\u7684\u7a81\u767c\u516c\u5171\u885b\u751f\u4e8b\u4ef6\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n<p style=\"text-align: center;\">&nbsp;<\/p>\n<p><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-large wp-image-39534\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-1024x683.jpg\" alt=\"\" width=\"800\" height=\"534\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-1024x683.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-300x200.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-768x512.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-600x400.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-800x533.jpg 800w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u4f86\u6e90\uff1aMotionElements<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #008080;\"> \u25cf COVID-19 \u75c5\u6bd2\u6aa2\u6e2c\u7684\u4e3b\u8981\u65b9\u6cd5<\/span><\/p>\n<p>\u76ee\u524d\u6aa2\u6e2c COVID-19 \u75c5\u6bd2\u611f\u67d3\u7684\u65b9\u6cd5\u53ef\u5206\u70ba\u4ee5\u4e0b\u4e09\u5927\u985e\uff08\u8868\u4e00\uff09\u3002<\/p>\n<p>1. \u6297\u539f\u5feb\u7be9\uff08Rapid antigen screening\uff09<\/p>\n<p>\u6297\u539f\u5feb\u7be9\u8a66\u5291\u53ef\u5728\u4e00\u822c\u5546\u5e97\u8cfc\u8cb7\u5230\uff0c\u539f\u7406\u662f\u85c9\u7531\u8a2d\u8a08\u904e\u7684\u5c08\u4e00\u6027\u6297\u9ad4\u8207\u75c5\u6bd2\u6a19\u7684\u86cb\u767d\u8cea\u9032\u884c\u5c08\u4e00\u6027\u914d\u5c0d\u7d50\u5408\uff0c\u512a\u9ede\u662f\u53d6\u5f97\u7d50\u679c\u5feb\u901f\uff08\u7d04 20~30 \u5206\u9418\uff09\u3001\u6548\u7387\u9ad8\u53ca\u8cbb\u7528\u4fbf\u5b9c\uff0c\u9069\u7528\u65bc\u5927\u91cf\u7be9\u6aa2\uff0c\u53ef\u5feb\u901f\u7be9\u9078\u51fa\u5e36\u539f\u8005\uff1b\u7f3a\u9ede\u662f\u7cbe\u6e96\u5ea6\u8f03\u4f4e\uff0c\u5bb9\u6613\u51fa\u73fe\u507d\u9670\u6027\u3001\u507d\u967d\u6027\u7b49\u72c0\u6cc1\uff0c\u53ef\u4fe1\u5ea6\u50c5\u7d04 70% \u3002\u56e0\u6b64\uff0c\u901a\u5e38\u9700\u642d\u914d PCR \u6838\u9178\u6aa2\u6e2c\u4f5c\u9032\u4e00\u6b65\u7684\u78ba\u8a8d\u3002<\/p>\n<p>2. \u805a\u5408\u9176\u9023\u9396\u53cd\u61c9\u6838\u9178\u6aa2\u6e2c\uff08Polymerase Chain Reaction nucleic acid test\uff09<\/p>\n<p>PCR \u6838\u9178\u6aa2\u6e2c\u662f\u76ee\u524d\u5168\u4e16\u754c\u8a3a\u65b7 COVID-19 \u6700\u6a19\u6e96\u7684\u65b9\u5f0f\uff0c\u5fc5\u9808\u7531\u5c08\u696d\u4eba\u54e1\u4f7f\u7528\u7cbe\u5bc6\u7684\u5100\u5668\u53ca\u8a2d\u5099\u5728\u5c08\u9580\u7684\u5be6\u9a57\u5ba4\u5167\u9032\u884c\uff0c\u5229\u7528\u5c08\u4e00\u6027\u7684\u6838\u9178\u5e8f\u5217\u4f5c\u70ba\u5f15\u5b50\uff08primer\uff09\uff0c\u9032\u884c PCR \u4ee5\u6aa2\u6e2c\u6aa2\u9ad4\u4e2d\u662f\u5426\u542b\u6709\u75c5\u6bd2\u7684\u6838\u9178\u7247\u6bb5\uff0c\u53ef\u63a8\u7b97\u75c5\u6bd2\u542b\u91cf\uff08viral load\uff09\uff0c\u4e26\u4ee5\u75c5\u6bd2\u542b\u91cf\u4f5c\u70ba\u5075\u6e2c\u611f\u67d3\u7a0b\u5ea6\u7684\u6839\u64da\uff0c\u6aa2\u6e2c\u6642\u9593\u7d04\u9700 4 \u5c0f\u6642\uff0c\u53ef\u4fe1\u5ea6\u53ef\u9054 95% \u4ee5\u4e0a\uff0c\u7cbe\u78ba\u5ea6\u8207\u654f\u611f\u6027\u5747\u9060\u9ad8\u65bc\u6297\u539f\u5feb\u7be9\u3002<\/p>\n<p>3. \u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff08NGS\uff09<\/p>\n<p>NGS \u6709\u5225\u65bc PCR \u6838\u9178\u6aa2\u6e2c\u5229\u7528\u75c5\u6bd2\u7684\u6838\u9178\u7247\u6bb5\uff0c\u800c\u662f\u6aa2\u6e2c\u75c5\u6bd2\u7684\u7279\u5b9a\u57fa\u56e0\u4f86\u5075\u6e2c\u6709\u7121\u611f\u67d3\uff0c\u4e26\u9032\u884c\u57fa\u56e0\u89e3\u78bc\uff0c\u53ef\u5206\u6790\u75c5\u6bd2\u7684\u6240\u6709\u57fa\u56e0\u5e8f\u5217\uff0c\u6240\u4ee5\u5177\u6709\u5075\u6e2c\u75c5\u6bd2\u7a81\u8b8a\u7a2e\u53ca\u8ffd\u8e64\u50b3\u64ad\u93c8\u7684\u80fd\u529b\uff0c\u5206\u6790\u6642\u9593\u8f03\u4e45\uff08\u7d04\u9700\u6578\u5929\uff09\u3002\u512a\u9ede\u662f\u4e0d\u50c5\u53ef\u4ee5\u6e96\u78ba\u8fa8\u8a8d\u611f\u67d3\u8005\u9ad4\u5167\u7684\u75c5\u6bd2\u7a2e\u985e\uff0c\u9084\u53ef\u85c9\u7531\u5927\u898f\u6a21\u6bd4\u5c0d\u8b8a\u7a2e\u75c5\u6bd2\u7684\u7279\u6027\uff0c\u7528\u65bc\u9810\u6e2c\u75c5\u6bd2\u7684\u6f14\u5316\u8da8\u52e2\uff0c\u56e0\u800c\u80fd\u5728\u65b0\u7684\u8b8a\u7a2e\u75c5\u6bd2\u51fa\u73fe\u4e4b\u524d\uff0c\u4fbf\u5148\u4f5c\u597d\u9810\u9632\u7684\u5de5\u4f5c\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\">\u8868\u4e00\uff1aCOVID-19 \u6aa2\u6e2c\u6280\u8853\u7684\u6bd4\u8f03 (\u4f86\u6e90\uff1a\u9673\u6df5\u9293)<a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/\u9673\u6df5\u9293-NGS-\u8868\u4e00.png\"><br \/>\n<img decoding=\"async\" class=\"aligncenter size-large wp-image-39535\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/\u9673\u6df5\u9293-NGS-\u8868\u4e00-1024x272.png\" alt=\"\" width=\"800\" height=\"213\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/\u9673\u6df5\u9293-NGS-\u8868\u4e00-1024x272.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/\u9673\u6df5\u9293-NGS-\u8868\u4e00-300x80.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/\u9673\u6df5\u9293-NGS-\u8868\u4e00-768x204.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/\u9673\u6df5\u9293-NGS-\u8868\u4e00.png 1357w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><br \/>\n&nbsp;<\/p>\n<p><span style=\"color: #008080;\">\u25cf NGS \u6301\u7e8c\u76e3\u6e2c\u75c5\u6bd2\u6f14\u5316\uff0c\u53ef\u963b\u6b62\u75ab\u60c5\u6301\u7e8c\u5ef6\u71d2<\/span><\/p>\n<p>COVID-19 \u75c5\u6bd2\u7684\u55ae\u80a1 RNA \u7531\u5927\u7d04 30,000 \u500b\u6838\u82f7\u9178\u7d44\u6210\uff0c\u542b\u6709\u611f\u67d3\u3001\u8907\u88fd\u53ca\u50b3\u64ad\u76f8\u95dc\u7684\u57fa\u56e0\u5bc6\u78bc\uff0c\u7576 RNA \u6838\u9178\u5e8f\u5217\u7522\u751f\u8b8a\u5316\u6642\uff0c\u75c5\u6bd2\u7684\u50b3\u67d3\u6027\u3001\u6aa2\u6e2c\u53ca\u5c0d\u75ab\u82d7\u7684\u53cd\u61c9\u90fd\u53ef\u80fd\u96a8\u4e4b\u6539\u8b8a\u3002\u5728\u8b8a\u7a2e\u75c5\u6bd2\u8086\u8650\u7684\u60c5\u6cc1\u4e0b\uff0cPCR \u7684\u6e96\u78ba\u7387\u96d6\u7136\u6bd4\u8f03\u9ad8\uff0c\u4ea6\u53ef\u7528\u65bc\u5927\u898f\u6a21\u7be9\u6aa2\uff0c\u4f46\u82e5\u8981\u78ba\u8a8d\u611f\u67d3\u5230\u4f55\u7a2e\u8b8a\u7a2e\u75c5\u6bd2\uff0c\u5c31\u9700\u8981\u4ee5\u57fa\u56e0\u5b9a\u5e8f\u4f86\u5927\u898f\u6a21\u89e3\u78bc\u57fa\u56e0\u8a0a\u606f\u3002\u900f\u904e NGS \u6280\u8853\u5927\u91cf\u5206\u6790\u75c5\u6bd2\u7684 RNA \u57fa\u56e0\u9ad4\u5e8f\u5217\uff0c\u53ef\u4ee5\u8fa8\u8b58\u75c5\u6bd2\u7a2e\u985e\u3001\u638c\u63e1\u75c5\u6bd2\u6f14\u8b8a\u6a21\u5f0f\u3001\u5373\u6642\u6aa2\u6e2c\u50b3\u64ad\u60c5\u5f62\u53ca\u78ba\u8a8d\u8207\u611f\u67d3\u8005\u9593\u7684\u95dc\u806f\u6027\u3002\u73fe\u5728\u5df2\u6709\u8a31\u591a\u751f\u7269\u79d1\u6280\u516c\u53f8\u6295\u5165\u4f7f\u7528 NGS \u6280\u8853\u76e3\u6e2c\u8b8a\u7a2e\u75c5\u6bd2\u7684\u958b\u767c\uff0c\u5168\u7403\u7b2c\u4e00\u500b COVID-19 \u75c5\u6bd2\u57fa\u56e0\u9ad4\u5373\u662f\u900f\u904e Illumina \u5e73\u53f0\u5b9a\u5e8f\u89e3\u78bc\uff0c\u9019\u9805\u7a81\u7834\u986f\u8457\u63a8\u9032 PCR \u6aa2\u6e2c\u8207\u75ab\u82d7\u7814\u767c\u7684\u901f\u5ea6\uff0c\u4e26\u5728\u75ab\u60c5\u7206\u767c\u521d\u671f\u626e\u6f14\u8ffd\u6eaf\u75c5\u6bd2\u4f86\u6e90\u3001\u5075\u6e2c\u8b8a\u7a2e\u75c5\u6bd2\u53ca\u516c\u885b\u9632\u6cbb\u7684\u95dc\u9375\u89d2\u8272\u3002\u4f8b\u5982\uff1aIllumina \u7684 COVIDSeq&#x2122; Test\u5728 2020 \u5e74\u7372\u5f97\u7f8e\u570b FDA \u7684\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\uff08EUA\uff09\uff0c\u800c\u6210\u70ba\u5168\u7403\u7b2c\u4e00\u500b\u7528\u65bc\u8a3a\u65b7 COVID-19 \u75c5\u6bd2\u7684 NGS&nbsp; \u6aa2\u6e2c\u65b9\u6cd5\uff0c\u53ef\u4ee5\u9748\u654f\u5730\u7be9\u6aa2\u75c5\u6bd2\u4e14\u7cbe\u6e96\u5730\u8fa8\u8b58\u8b8a\u7570\u682a\uff0c\u4e26\u9069\u7528\u65bc\u5927\u898f\u6a21\u7684\u57fa\u56e0\u5b9a\u5e8f\u8207\u5206\u6790\u3002<\/p>\n<p><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-2.jpg\"><img decoding=\"async\" class=\"size-large wp-image-39533\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-2-1024x577.jpg\" alt=\"\" width=\"800\" height=\"451\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-2-1024x577.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-2-300x169.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test-2-768x433.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u4f86\u6e90\uff1aMotionElements<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #008080;\">\u25cf \u51dd\u805a\u5168\u7403\u529b\u91cf\uff0c\u5171\u540c\u9632\u6cbb\u65b0\u51a0\u75c5\u6bd2<\/span><\/p>\n<p>\u4ee5\u9999\u6e2f\u70ba\u4f8b\uff0c\u6e2f\u5e9c\u96d6\u5728\u904e\u53bb\u5169\u5e74\u6709\u6548\u63a7\u5236\u4f4f&nbsp; COVID-19 \u75ab\u60c5\uff0c\u4f46\u81ea\u4eca\u5e74\uff082022\uff09\u521d\u4ee5\u4f86\uff0c\u56e0\u50b3\u67d3\u6027\u6975\u5f37\u7684\u8b8a\u7a2e\u75c5\u6bd2 Omicron \u81ea\u5883\u5916\u79fb\u5165\u800c\u5c0e\u81f4\u75ab\u60c5\u5927\u7206\u767c\uff0c\u66f4\u5728\u8fd1\u65e5\u5275\u4e0b\u55ae\u65e5\u78ba\u8a3a\u6578 5.5 \u842c\u4f8b\u53ca\u6b7b\u4ea1\u7387\u5168\u7403\u6700\u9ad8\u7684\u7d00\u9304\u3002\u70ba\u63a7\u5236\u75ab\u60c5\uff0c\u9999\u6e2f\u653f\u5e9c\u5be6\u65bd\u4e86\u56b4\u683c\u7684\u9632\u75ab\u63aa\u65bd\u548c\u75ab\u82d7\u901a\u95dc\u5236\u5ea6\uff0c\u6566\u4fc3\u66f4\u591a\u6e2f\u4eba\u63a5\u7a2e\u75ab\u82d7\u3002\u6b64\u5916\uff0c\u9999\u6e2f\u653f\u5e9c\u8a08\u756b\u900f\u904e\u5efa\u7acb 500 \u500b\u7be9\u6aa2\u4e2d\u5fc3\uff0c\u5c0d\u5883\u5167\u4eba\u6c11\u5be6\u65bd\u4e09\u6b21\u7684\u5927\u898f\u6a21 PCR \u6838\u9178\u6aa2\u6e2c\u3002\u5728\u5168\u6c11\u666e\u7be9\u958b\u59cb\u4e4b\u524d\uff0c\u9999\u6e2f\u653f\u5e9c\u4ea6\u66fe\u767c\u653e\u4e0a\u767e\u842c\u5957\u6297\u539f\u5feb\u7be9\u8a66\u5291\u7d66\u6e2f\u4eba\uff0c\u5e0c\u671b\u900f\u904e\u5927\u898f\u6a21\u7684\u7be9\u6aa2\uff0c\u8fc5\u901f\u5340\u5206\u51fa\u611f\u67d3\u8005\u9032\u884c\u9694\u96e2\uff0c\u4ee5\u9054\u5207\u65b7\u50b3\u64ad\u93c8\u7684\u6548\u679c\u3002\u7136\u800c\uff0c\u9019\u4e9b\u9632\u75ab\u63aa\u65bd\u662f\u5426\u5c0d\u65bc\u50b3\u67d3\u6027\u6975\u5f37\u4e14\u6975\u96e3\u9632\u6cbb\u7684\u8b8a\u7a2e\u75c5\u6bd2\u6709\u6548\uff0c\u4ecd\u5f85\u9032\u4e00\u6b65\u9032\u884c\u6210\u6548\u8a55\u4f30\u624d\u80fd\u78ba\u8a8d\u3002<\/p>\n<p>\u9762\u5c0d COVID-19 \u8b8a\u7a2e\u75c5\u6bd2\u7684\u8086\u8650\uff0c\u57fa\u65bc\u79d1\u5b78\u8b49\u64da\u8ffd\u6eaf\u75c5\u6bd2\u4f86\u6e90\u3001\u5075\u6e2c\u8b8a\u7a2e\u75c5\u6bd2\u53ca\u9810\u6e2c\u5176\u6f14\u5316\u8da8\u52e2\u4f86\u5236\u5b9a\u9632\u6cbb\u5c0d\u7b56\u5df2\u6210\u7576\u52d9\u4e4b\u6025\u3002\u56e0\u6b64\uff0c\u8d8a\u4f86\u8d8a\u591a\u570b\u5bb6\u6839\u64da\u75c5\u6bd2\u57fa\u56e0\u9ad4\u5b78\u8a0a\u606f\u4f86\u8a02\u5b9a\u516c\u5171\u885b\u751f\u653f\u7b56\uff0c\u75c5\u6bd2\u57fa\u56e0\u5b9a\u5e8f\u7684\u9700\u6c42\u4e5f\u66f4\u52a0\u5f37\u70c8\u3002NGS \u662f\u76ee\u524d\u4f7f\u7528\u6700\u5ee3\u6cdb\u7684 COVID-19 \u75c5\u6bd2\u6aa2\u6e2c\u65b9\u6cd5\u4e4b\u4e00\uff0c\u8207\u5176\u4ed6\u6aa2\u6e2c\u65b9\u6cd5\u76f8\u8f03\uff0c\u7279\u9ede\u5728\u65bc\u5229\u7528\u57fa\u56e0\u5b9a\u5e8f\u8cc7\u6599\u53ef\u4ee5\u641c\u5c0b\u7fa4\u805a\u611f\u67d3\u7684\u6e90\u982d\u8207\u95dc\u806f\uff0c\u4e26\u63d0\u524d\u8fa8\u8b58\u65b0\u7684\u75c5\u6bd2\u8b8a\u7570\u682a\u53ca\u5176\u6f14\u8b8a\u8da8\u52e2\u3002\u9762\u5c0d\u4ecd\u6301\u7e8c\u9032\u884c\u7684\u9632\u75ab\u4f5c\u6230\uff0c\u5728\u5f8c\u75ab\u60c5\u6642\u4ee3\u82e5\u80fd\u51dd\u805a\u5c07\u516c\u6709\u53ca\u79c1\u6709\u7684\u529b\u91cf\uff0c\u806f\u5408\u5168\u7403\u516c\u5171\u885b\u751f\u7cfb\u7d71\u5171\u540c\u6297\u75ab\uff0c\u65b9\u80fd\u5e6b\u52a9\u4eba\u985e\u61c9\u5c0d\u672a\u4f86\u7684\u5a01\u8105\uff0c\u65e9\u65e5\u6d88\u9664 COVID-19 \u75ab\u60c5\u9020\u6210\u7684\u885d\u64ca\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<p>1. First NGS-based COVID-19 diagnostic. Nat Biotechnol. 2020 Jul;38(7):777.<a href=\"https:\/\/doi.org\/10.1038\/s41587-020-0608-y\"> doi: 10.1038\/s41587-020-0608-y.<\/a><\/p>\n<p>2. John G, Sahajpal NS, Mondal AK, Ananth S, Williams C, Chaubey A, Rojiani AM, Kolhe R. Next-Generation Sequencing (NGS) in COVID-19: A Tool for SARS-CoV-2 Diagnosis, Monitoring New Strains and Phylodynamic Modeling in Molecular Epidemiology. Curr Issues Mol Biol. 2021 Jul 30;43(2):845-867. <a href=\"https:\/\/doi.org\/10.3390\/cimb43020061\">doi: 10.3390\/cimb43020061.<\/a><\/p>\n<p>3. Chen X, Kang Y, Luo J, Pang K, Xu X, Wu J, Li X, Jin S. Next-Generation Sequencing Reveals the Progression of COVID-19. 2021. Front Cell Infect Microbiol. 2021 Mar 11;11:632490.<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2021.632490\/full\"> doi: 10.3389\/fcimb.2021.632490.&nbsp;<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2 SARS-CoV-2 \u5df2\u5f15\u8d77\u5168\u7403\u5927\u7bc4\u570d\u50b3\u64ad\u548c\u6301\u7e8c\u5927\u6d41\u884c\u3002\u7576\u524d\u7528\u65bc COVID-19 \u8a3a\u65b7\u7684\u6e2c\u8a66\u65b9\u6cd5\u5305\u62ec\u6297\u539f\u5feb\u7be9\u3001PCR \u6838\u9178\u6aa2\u6e2c\u53ca\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff08Next-Generation Sequencing, NGS\uff09\uff0c\u56e0 COVID-19 \u75c5\u6bd2\u7684\u5feb\u901f\u8b8a\u7570\uff0cNGS \u5728\u8a31\u591a\u65b9\u9762\u767c\u63ee\u8457\u6975\u91cd\u8981\u7684\u4f5c\u7528\u3002NGS \u53ef\u7528\u65bc\u63a2\u7d22\u75c5\u6bd2\u4f86\u6e90\u3001\u5075\u6e2c\u8b8a\u7a2e\u75c5\u6bd2\u53ca\u9810\u6e2c\u5176\u6f14\u5316\u8da8\u52e2\u4ee5\u963b\u6b62\u5927\u898f\u6a21\u50b3\u64ad\uff0c\u6709\u6f5b\u529b\u9032\u4e00\u6b65\u7528\u65bc COVID-19 \u7684\u65b0\u8a3a\u65b7\u65b9\u6cd5\u548c\u65b0\u6cbb\u7642\u9776\u9ede\u7684\u958b\u767c\u3002NGS \u7684\u5ee3\u6cdb\u61c9\u7528\u5c07\u63d0\u4f9b\u5f37\u800c\u6709\u529b\u7684\u652f\u6301\uff0c\u4ee5\u61c9\u5c0d\u672a\u4f86\u7684\u7a81\u767c\u516c\u5171\u885b\u751f\u4e8b\u4ef6\u3002<\/p>\n","protected":false},"author":20,"featured_media":39534,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4577,6340,6339,4692],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2022\/03\/PCR-test.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/39532"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39532"}],"version-history":[{"count":6,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/39532\/revisions"}],"predecessor-version":[{"id":39568,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/39532\/revisions\/39568"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/39534"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39532"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39532"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}